Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (5863); Uniprot accession (681); PDB accession (152); 3D entries (21); cryst (0)
All (5623) Archaea (1) Bacteria (5166) Eukaryota (415) Viruses (35) unclassified (6) Structure (21) Characterized (97)
| 1 | ... | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | ... | 53 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 neuraminidase (NanA)   Streptococcus pneumoniae H051740086 ACJ76917.1    
 neuraminidase (NanA)   Streptococcus pneumoniae H053940080 ACJ76919.1    
 neuraminidase (NanA)   Streptococcus pneumoniae H053940083 ACJ76920.1    
 neuraminidase (NanA)   Streptococcus pneumoniae H060160064 ACJ76921.1    
 BWQ98_07990   Streptococcus pneumoniae HKU1-14 AZT87749.1    
 BWQ98_07965   Streptococcus pneumoniae HKU1-14 AZT87744.1    
 BWQ98_07965   Streptococcus pneumoniae HKU1-14 AZT87744.1    
 SPOH_1543 (Nana_2)   Streptococcus pneumoniae HU-OH BBG37567.1    
 SPOH_1537 (NanB)   Streptococcus pneumoniae HU-OH BBG37561.1    
 SPOH_1537 (NanB)   Streptococcus pneumoniae HU-OH BBG37561.1    
 neuraminidase   Streptococcus pneumoniae Hu15 ARD35965.1    
 SPNHU15_01386   Streptococcus pneumoniae Hu15 ARD37162.1    
 SPNHU15_01386   Streptococcus pneumoniae Hu15 ARD37162.1    
 SPNHU17_01713   Streptococcus pneumoniae Hu17 ARD35268.1    
 SPNHU17_01713   Streptococcus pneumoniae Hu17 ARD35268.1    
 SPNHU17_01392   Streptococcus pneumoniae Hu17 ARD34965.1    
 SPNHU17_01392   Streptococcus pneumoniae Hu17 ARD34965.1    
 neuraminidase   Streptococcus pneumoniae Hu17 ARD35273.1    
 SPH_1797 (NanA)   Streptococcus pneumoniae Hungary19A-6 ACA36706.1
ACJ76911.1
ACJ76914.1
ACJ76922.1
ACJ76926.1
B1I751  
 SPH_1468   Streptococcus pneumoniae Hungary19A-6 ACA36743.1 B1ICD8  
 SPH_1468   Streptococcus pneumoniae Hungary19A-6 ACA36743.1 B1ICD8  
 INV104_14370 (NanB)   Streptococcus pneumoniae INV104 CBW37118.1 E1XSK8  
 INV104_14370 (NanB)   Streptococcus pneumoniae INV104 CBW37118.1 E1XSK8  
 INV104_07470   Streptococcus pneumoniae INV104 CBW36430.1 E1XQR4  
 INV104_07470   Streptococcus pneumoniae INV104 CBW36430.1 E1XQR4  
 INV104_14420 (NanA)   Streptococcus pneumoniae INV104 CBW37123.1 E1XSL3  
 neuraminidase   Streptococcus pneumoniae INV200 CBW34434.1 E1XJC0  
 neuraminidase   Streptococcus pneumoniae INV200 CBW34434.1 E1XJC0  
 neuraminidase (NanB)   Streptococcus pneumoniae INV200 CBW35142.1 E1XL92  
 neuraminidase (NanB)   Streptococcus pneumoniae INV200 CBW35142.1 E1XL92  
 SPNINV200_15140 (NanA)   Streptococcus pneumoniae INV200 CBW35147.1 E1XL97  
 neuraminidase (NanA)   Streptococcus pneumoniae INV200 ACJ76923.1    
 neuraminidase   Streptococcus pneumoniae JJA ACO19629.1    
 SPJ_1581   Streptococcus pneumoniae JJA ACO19530.1 C1CFQ7  
 SPJ_1581   Streptococcus pneumoniae JJA ACO19530.1 C1CFQ7  
 SPJ_1242 (NanC)   Streptococcus pneumoniae JJA ACO20071.1 C1CET1  
 SPJ_1242 (NanC)   Streptococcus pneumoniae JJA ACO20071.1 C1CET1  
 neuraminidase (NanB)   Streptococcus pneumoniae KK0381 BAX31324.1    
 neuraminidase (NanB)   Streptococcus pneumoniae KK0381 BAX31324.1    
 neuraminidase   Streptococcus pneumoniae KK0381 BAX31329.1    
 KK0981_36480   Streptococcus pneumoniae KK0981 BAW85137.1    
 KK0981_36480   Streptococcus pneumoniae KK0981 BAW85137.1    
 neuraminidase   Streptococcus pneumoniae KK0981 BAW85142.1    
 neuraminidase   Streptococcus pneumoniae KK1157 BAX33559.1    
 neuraminidase (NanB)   Streptococcus pneumoniae KK1157 BAX33554.1    
 neuraminidase (NanB)   Streptococcus pneumoniae KK1157 BAX33554.1    
 MDRSPN_00498 (NanA)   Streptococcus pneumoniae MDRSPN001 BBA58704.1    
 MDRSPN_00504 (NanB)   Streptococcus pneumoniae MDRSPN001 BBA58710.1    
 MDRSPN_00504 (NanB)   Streptococcus pneumoniae MDRSPN001 BBA58710.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae NCTC11902 SQG99194.1    
 NCTC11902_01579 (NanB)   Streptococcus pneumoniae NCTC11902 SQG99188.1    
 NCTC11902_01579 (NanB)   Streptococcus pneumoniae NCTC11902 SQG99188.1    
 NCTC12977_01101 (Nanb_2)   Streptococcus pneumoniae NCTC12977 VEE28940.1    
 NCTC12977_01101 (Nanb_2)   Streptococcus pneumoniae NCTC12977 VEE28940.1    
 NCTC12977_00770 (Nanb_1)   Streptococcus pneumoniae NCTC12977 VEE27993.1    
 NCTC12977_00770 (Nanb_1)   Streptococcus pneumoniae NCTC12977 VEE27993.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae NCTC12977 VEE28958.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae NCTC13276 SQG34779.1    
 NCTC13276_01523 (NanB)   Streptococcus pneumoniae NCTC13276 SQG34774.1    
 NCTC13276_01523 (NanB)   Streptococcus pneumoniae NCTC13276 SQG34774.1    
 ERS445053_01120 (NanB)   Streptococcus pneumoniae NCTC7465 COT17505.1    
 ERS445053_01120 (NanB)   Streptococcus pneumoniae NCTC7465 COT17505.1    
 neuraminidase (Nana_1)   Streptococcus pneumoniae NCTC7465 COT17436.1    
 NCTC7466_01531 (NanB)   Streptococcus pneumoniae NCTC7466 SQG02559.1    
 NCTC7466_01531 (NanB)   Streptococcus pneumoniae NCTC7466 SQG02559.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae NCTC7466 SQG02564.1    
 SpnNT_01743 (NanB)   Streptococcus pneumoniae NT_110_58 AJD72676.1    
 SpnNT_01743 (NanB)   Streptococcus pneumoniae NT_110_58 AJD72676.1    
 SpnNT_01752 (Nana_4) (fragment)   Streptococcus pneumoniae NT_110_58 AJD72685.1    
 SPNU_1255 (Nanb_1)   Streptococcus pneumoniae NU83127 BBG35139.1    
 SPNU_1255 (Nanb_1)   Streptococcus pneumoniae NU83127 BBG35139.1    
 SPNU_1595 (Nanb_2)   Streptococcus pneumoniae NU83127 BBG35477.1    
 SPNU_1595 (Nanb_2)   Streptococcus pneumoniae NU83127 BBG35477.1    
 SPNU_1602 (Nana_3)   Streptococcus pneumoniae NU83127 BBG35484.1    
 SPNOXC_14830   Streptococcus pneumoniae OXC141 CBW33136.1 E1XCC8  
 SPNOXC_14830   Streptococcus pneumoniae OXC141 CBW33136.1 E1XCC8  
 SPNOXC_14880   Streptococcus pneumoniae OXC141 CBW33141.1 E1XCD3  
 neuraminidase (NanA)   Streptococcus pneumoniae OXC141 ACJ76924.1    
 SPP_1704   Streptococcus pneumoniae P1031 ACO21913.1 C1CM25  
 SPP_1704   Streptococcus pneumoniae P1031 ACO21913.1 C1CM25  
 neuraminidase   Streptococcus pneumoniae P1031 ACO21301.1    
 NanA   Streptococcus pneumoniae PCD8755 AMQ67145.1    
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae PN13 CAI94569.1 Q4LB78  
 NanA   Streptococcus pneumoniae PN8828 AMQ67147.1    
 sialidase A (NanA)   Streptococcus pneumoniae R6 AAL00340.1
ACJ76904.1
NP_359129.1
P62576 2VVZ[A,B]
2W20[A,B]
3H71[A,B]
3H72[A,B]
3H73[A,B]
 NanB   Streptococcus pneumoniae R6 AAL00335.1
NP_359124.1
Q8CWP8  
 NanB   Streptococcus pneumoniae R6 AAL00335.1
NP_359124.1
Q8CWP8  
 neuraminidase (NanB)   Streptococcus pneumoniae R6CIB17 QEL28833.1    
 neuraminidase (NanB)   Streptococcus pneumoniae R6CIB17 QEL28833.1    
 neuraminidase (NanA)   Streptococcus pneumoniae R6CIB17 QEL28838.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SP14-BS69 ACJ76929.1 B8XTV9  
 neuraminidase (NanA)   Streptococcus pneumoniae SP19-BS75 ACJ76931.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SP3-BS71 ACJ76925.1    
 BMJ42_01308   Streptococcus pneumoniae SP49 APJ30609.1    
 BMJ42_01308   Streptococcus pneumoniae SP49 APJ30609.1    
 BMJ42_01695   Streptococcus pneumoniae SP49 APJ30983.1    
 BMJ42_01695   Streptococcus pneumoniae SP49 APJ30983.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SP49 APJ30989.1    
 BOC71_01535 (Nana_2)   Streptococcus pneumoniae SP61 APJ33021.1    
 BOC71_01529 (NanB)   Streptococcus pneumoniae SP61 APJ33015.1    
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