Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (5822); Uniprot accession (681); PDB accession (152); 3D entries (21); cryst (0)
All (5582) Archaea (1) Bacteria (5125) Eukaryota (415) Viruses (34) unclassified (7) Structure (21) Characterized (97)
| 1 | ... | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | ... | 53 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 SAMEA3233395_01583 (Nanb_2)   Streptococcus pneumoniae 2245STDY6031034 VFI10236.1    
 SAMEA3233395_01277 (Nanb_1)   Streptococcus pneumoniae 2245STDY6031034 VFI08328.1    
 SAMEA3233395_01277 (Nanb_1)   Streptococcus pneumoniae 2245STDY6031034 VFI08328.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY6031048 VFI04459.1    
 SAMEA3233409_01589 (NanB)   Streptococcus pneumoniae 2245STDY6031048 VFI04413.1    
 SAMEA3233409_01589 (NanB)   Streptococcus pneumoniae 2245STDY6031048 VFI04413.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY6092581 VFI07373.1    
 SAMEA3354333_01626 (NanB)   Streptococcus pneumoniae 2245STDY6092581 VFI07325.1    
 SAMEA3354333_01626 (NanB)   Streptococcus pneumoniae 2245STDY6092581 VFI07325.1    
 SAMEA3354357_01664 (NanB)   Streptococcus pneumoniae 2245STDY6092613 VFI09961.1    
 SAMEA3354357_01664 (NanB)   Streptococcus pneumoniae 2245STDY6092613 VFI09961.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6092613 VFI09988.1    
 SAMEA3381325_01569 (NanB)   Streptococcus pneumoniae 2245STDY6092834 VFI09582.1    
 SAMEA3381325_01569 (NanB)   Streptococcus pneumoniae 2245STDY6092834 VFI09582.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY6092834 VFI09620.1    
 SAMEA3381439_01658 (Nanb_2)   Streptococcus pneumoniae 2245STDY6092949 VFI28817.1    
 SAMEA3381439_01658 (Nanb_2)   Streptococcus pneumoniae 2245STDY6092949 VFI28817.1    
 SAMEA3381439_01266 (Nanb_1)   Streptococcus pneumoniae 2245STDY6092949 VFI26901.1    
 SAMEA3381439_01266 (Nanb_1)   Streptococcus pneumoniae 2245STDY6092949 VFI26901.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6092949 VFI28847.1    
 SAMEA3381491_01596 (Nanb_2)   Streptococcus pneumoniae 2245STDY6093044 VFI13832.1    
 SAMEA3381491_01596 (Nanb_2)   Streptococcus pneumoniae 2245STDY6093044 VFI13832.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6093044 VFI13838.1    
 SAMEA3381491_01293 (Nanb_1)   Streptococcus pneumoniae 2245STDY6093044 VFI13537.1    
 SAMEA3381491_01293 (Nanb_1)   Streptococcus pneumoniae 2245STDY6093044 VFI13537.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6105839 VFI45434.1    
 SAMEA3389228_01536 (NanB)   Streptococcus pneumoniae 2245STDY6105839 VFI45400.1    
 SAMEA3389228_01536 (NanB)   Streptococcus pneumoniae 2245STDY6105839 VFI45400.1    
 SAMEA3389261_01464 (Nana_2)   Streptococcus pneumoniae 2245STDY6105855 VGM83091.1    
 SAMEA3389261_01458 (NanB)   Streptococcus pneumoniae 2245STDY6105855 VGM83073.1    
 SAMEA3389261_01458 (NanB)   Streptococcus pneumoniae 2245STDY6105855 VGM83073.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY6106337 VFI19835.1    
 SAMEA3390054_01590 (NanB)   Streptococcus pneumoniae 2245STDY6106337 VFI19788.1    
 SAMEA3390054_01590 (NanB)   Streptococcus pneumoniae 2245STDY6106337 VFI19788.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6106372 VFI27705.1    
 SAMEA3389940_01191 (Nanb_1)   Streptococcus pneumoniae 2245STDY6106372 VFI25948.1    
 SAMEA3389940_01191 (Nanb_1)   Streptococcus pneumoniae 2245STDY6106372 VFI25948.1    
 SAMEA3389940_01504 (Nanb_2)   Streptococcus pneumoniae 2245STDY6106372 VFI27678.1    
 SAMEA3389940_01504 (Nanb_2)   Streptococcus pneumoniae 2245STDY6106372 VFI27678.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6106384 VFI28196.1    
 SAMEA3389963_01562 (NanB)   Streptococcus pneumoniae 2245STDY6106384 VFI28166.1    
 SAMEA3389963_01562 (NanB)   Streptococcus pneumoniae 2245STDY6106384 VFI28166.1    
 SAMEA3431348_01661 (Nana_3)   Streptococcus pneumoniae 2245STDY6106635 VGM77445.1    
 SAMEA3431348_01275 (Nanb_1)   Streptococcus pneumoniae 2245STDY6106635 VGM77066.1    
 SAMEA3431348_01275 (Nanb_1)   Streptococcus pneumoniae 2245STDY6106635 VGM77066.1    
 SAMEA3431348_01655 (Nanb_2)   Streptococcus pneumoniae 2245STDY6106635 VGM77439.1    
 SAMEA3431348_01655 (Nanb_2)   Streptococcus pneumoniae 2245STDY6106635 VGM77439.1    
 SAMEA3431351_01556 (NanB)   Streptococcus pneumoniae 2245STDY6106637 VFI28040.1    
 SAMEA3431351_01556 (NanB)   Streptococcus pneumoniae 2245STDY6106637 VFI28040.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY6106637 VFI28070.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6106751 VFI23650.1    
 SAMEA3431383_01533 (NanB)   Streptococcus pneumoniae 2245STDY6106751 VFI23614.1    
 SAMEA3431383_01533 (NanB)   Streptococcus pneumoniae 2245STDY6106751 VFI23614.1    
 SAMEA3713867_01281 (Nanb_1)   Streptococcus pneumoniae 2245STDY6178787 VFI38112.1    
 SAMEA3713867_01281 (Nanb_1)   Streptococcus pneumoniae 2245STDY6178787 VFI38112.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6178787 VFI40904.1    
 SAMEA3713867_01662 (Nanb_2)   Streptococcus pneumoniae 2245STDY6178787 VFI40858.1    
 SAMEA3713867_01662 (Nanb_2)   Streptococcus pneumoniae 2245STDY6178787 VFI40858.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6178826 VFI44829.1    
 SAMEA3713960_01711 (NanB)   Streptococcus pneumoniae 2245STDY6178826 VFI44784.1    
 SAMEA3713960_01711 (NanB)   Streptococcus pneumoniae 2245STDY6178826 VFI44784.1    
 SAMEA3713964_01314 (Nanb_1)   Streptococcus pneumoniae 2245STDY6178828 VFI53507.1    
 SAMEA3713964_01314 (Nanb_1)   Streptococcus pneumoniae 2245STDY6178828 VFI53507.1    
 SAMEA3713964_01618 (Nanb_2)   Streptococcus pneumoniae 2245STDY6178828 VFI54416.1    
 SAMEA3713964_01618 (Nanb_2)   Streptococcus pneumoniae 2245STDY6178828 VFI54416.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6178828 VFI54437.1    
 SAMEA3714019_01609 (NanB)   Streptococcus pneumoniae 2245STDY6178854 VGM82218.1    
 SAMEA3714019_01609 (NanB)   Streptococcus pneumoniae 2245STDY6178854 VGM82218.1    
 SAMEA3714019_01615 (Nana_2)   Streptococcus pneumoniae 2245STDY6178854 VGM82236.1    
 SAMEA3714262_01324 (Nanb_1)   Streptococcus pneumoniae 2245STDY6179186 VFI48247.1    
 SAMEA3714262_01324 (Nanb_1)   Streptococcus pneumoniae 2245STDY6179186 VFI48247.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6179186 VFI48857.1    
 SAMEA3714262_01530 (Nanb_2)   Streptococcus pneumoniae 2245STDY6179186 VFI48840.1    
 SAMEA3714262_01530 (Nanb_2)   Streptococcus pneumoniae 2245STDY6179186 VFI48840.1    
 C4N11_06265   Streptococcus pneumoniae 335 AVD75144.1    
 C4N11_06265   Streptococcus pneumoniae 335 AVD75144.1    
 C4N11_08635   Streptococcus pneumoniae 335 AVD75579.1    
 C4N11_08635   Streptococcus pneumoniae 335 AVD75579.1    
 C4N11_08660   Streptococcus pneumoniae 335 AVD75584.1    
 neuraminidase (NanB)   Streptococcus pneumoniae 521 QBK28617.1    
 neuraminidase (NanB)   Streptococcus pneumoniae 521 QBK28617.1    
 sialidase A (NanA) 3.2.1.18 Streptococcus pneumoniae 6 CAA51473.1
ACJ76903.1
B8XTT3
P62575
Q59959
5KKY[A,B]
 sialidase B (NanB) 3.2.1.18 Streptococcus pneumoniae 6 AAC44396.1
AAW08718.1
Q54727  
 sialidase B (NanB) 3.2.1.18 Streptococcus pneumoniae 6 AAC44396.1 Q54727  
 SP670_0950   Streptococcus pneumoniae 670-6B ADM91015.1 E0TMG6  
 SP670_0950   Streptococcus pneumoniae 670-6B ADM91015.1 E0TMG6  
 SP670_1783   Streptococcus pneumoniae 670-6B ADM91835.1 E0TSF6  
 SP670_1773   Streptococcus pneumoniae 670-6B ADM91827.1 E0TSE8  
 neuraminidase   Streptococcus pneumoniae 70585 ACO17645.1    
 SP70585_1726   Streptococcus pneumoniae 70585 ACO17953.1 C1C8S5  
 SP70585_1726   Streptococcus pneumoniae 70585 ACO17953.1 C1C8S5  
 T308_07725   Streptococcus pneumoniae A026 AGZ48230.1    
 T308_07695   Streptococcus pneumoniae A026 AGZ48224.1    
 T308_07695   Streptococcus pneumoniae A026 AGZ48224.1    
 A66_01518   Streptococcus pneumoniae A66 CRI62229.1    
 A66_01513   Streptococcus pneumoniae A66 CRI62224.1    
 A66_01513   Streptococcus pneumoniae A66 CRI62224.1    
 neuraminidase (NanA)   Streptococcus pneumoniae A66.1 ACJ76912.1 B8XTU2  
 SPAP_1700   Streptococcus pneumoniae AP200 ADM85284.1 E0SWG1  
 SPAP_1354   Streptococcus pneumoniae AP200 ADM84940.1 E0SUC9  
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