Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (5621); Uniprot accession (686); PDB accession (146); 3D entries (19); cryst (0)
All (5380) Archaea (1) Bacteria (4935) Eukaryota (404) Viruses (34) unclassified (6) Structure (19) Characterized (96)
| 1 | ... | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | ... | 51 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 SAMEA3389940_01504 (Nanb_2)   Streptococcus pneumoniae 2245STDY6106372 VFI27678.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6106384 VFI28196.1    
 SAMEA3389963_01562 (NanB)   Streptococcus pneumoniae 2245STDY6106384 VFI28166.1    
 SAMEA3389963_01562 (NanB)   Streptococcus pneumoniae 2245STDY6106384 VFI28166.1    
 SAMEA3431348_01661 (Nana_3)   Streptococcus pneumoniae 2245STDY6106635 VGM77445.1    
 SAMEA3431348_01275 (Nanb_1)   Streptococcus pneumoniae 2245STDY6106635 VGM77066.1    
 SAMEA3431348_01275 (Nanb_1)   Streptococcus pneumoniae 2245STDY6106635 VGM77066.1    
 SAMEA3431348_01655 (Nanb_2)   Streptococcus pneumoniae 2245STDY6106635 VGM77439.1    
 SAMEA3431348_01655 (Nanb_2)   Streptococcus pneumoniae 2245STDY6106635 VGM77439.1    
 SAMEA3431351_01556 (NanB)   Streptococcus pneumoniae 2245STDY6106637 VFI28040.1    
 SAMEA3431351_01556 (NanB)   Streptococcus pneumoniae 2245STDY6106637 VFI28040.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY6106637 VFI28070.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6106751 VFI23650.1    
 SAMEA3431383_01533 (NanB)   Streptococcus pneumoniae 2245STDY6106751 VFI23614.1    
 SAMEA3431383_01533 (NanB)   Streptococcus pneumoniae 2245STDY6106751 VFI23614.1    
 SAMEA3713867_01281 (Nanb_1)   Streptococcus pneumoniae 2245STDY6178787 VFI38112.1    
 SAMEA3713867_01281 (Nanb_1)   Streptococcus pneumoniae 2245STDY6178787 VFI38112.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6178787 VFI40904.1    
 SAMEA3713867_01662 (Nanb_2)   Streptococcus pneumoniae 2245STDY6178787 VFI40858.1    
 SAMEA3713867_01662 (Nanb_2)   Streptococcus pneumoniae 2245STDY6178787 VFI40858.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6178826 VFI44829.1    
 SAMEA3713960_01711 (NanB)   Streptococcus pneumoniae 2245STDY6178826 VFI44784.1    
 SAMEA3713960_01711 (NanB)   Streptococcus pneumoniae 2245STDY6178826 VFI44784.1    
 SAMEA3713964_01314 (Nanb_1)   Streptococcus pneumoniae 2245STDY6178828 VFI53507.1    
 SAMEA3713964_01314 (Nanb_1)   Streptococcus pneumoniae 2245STDY6178828 VFI53507.1    
 SAMEA3713964_01618 (Nanb_2)   Streptococcus pneumoniae 2245STDY6178828 VFI54416.1    
 SAMEA3713964_01618 (Nanb_2)   Streptococcus pneumoniae 2245STDY6178828 VFI54416.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6178828 VFI54437.1    
 SAMEA3714019_01609 (NanB)   Streptococcus pneumoniae 2245STDY6178854 VGM82218.1    
 SAMEA3714019_01609 (NanB)   Streptococcus pneumoniae 2245STDY6178854 VGM82218.1    
 SAMEA3714019_01615 (Nana_2)   Streptococcus pneumoniae 2245STDY6178854 VGM82236.1    
 SAMEA3714262_01324 (Nanb_1)   Streptococcus pneumoniae 2245STDY6179186 VFI48247.1    
 SAMEA3714262_01324 (Nanb_1)   Streptococcus pneumoniae 2245STDY6179186 VFI48247.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6179186 VFI48857.1    
 SAMEA3714262_01530 (Nanb_2)   Streptococcus pneumoniae 2245STDY6179186 VFI48840.1    
 SAMEA3714262_01530 (Nanb_2)   Streptococcus pneumoniae 2245STDY6179186 VFI48840.1    
 C4N11_06265   Streptococcus pneumoniae 335 AVD75144.1    
 C4N11_06265   Streptococcus pneumoniae 335 AVD75144.1    
 C4N11_08635   Streptococcus pneumoniae 335 AVD75579.1    
 C4N11_08635   Streptococcus pneumoniae 335 AVD75579.1    
 C4N11_08660   Streptococcus pneumoniae 335 AVD75584.1    
 neuraminidase (NanB)   Streptococcus pneumoniae 521 QBK28617.1    
 neuraminidase (NanB)   Streptococcus pneumoniae 521 QBK28617.1    
 sialidase A (NanA) 3.2.1.18 Streptococcus pneumoniae 6 CAA51473.1
ACJ76903.1
B8XTT3
P62575
Q59959
5KKY[A,B]
 sialidase B (NanB) 3.2.1.18 Streptococcus pneumoniae 6 AAC44396.1
AAW08718.1
Q54727  
 sialidase B (NanB) 3.2.1.18 Streptococcus pneumoniae 6 AAC44396.1 Q54727  
 SP670_0950   Streptococcus pneumoniae 670-6B ADM91015.1 E0TMG6  
 SP670_0950   Streptococcus pneumoniae 670-6B ADM91015.1 E0TMG6  
 SP670_1783   Streptococcus pneumoniae 670-6B ADM91835.1 E0TSF6  
 SP670_1773   Streptococcus pneumoniae 670-6B ADM91827.1 E0TSE8  
 neuraminidase   Streptococcus pneumoniae 70585 ACO17645.1    
 SP70585_1726   Streptococcus pneumoniae 70585 ACO17953.1 C1C8S5  
 SP70585_1726   Streptococcus pneumoniae 70585 ACO17953.1 C1C8S5  
 T308_07725   Streptococcus pneumoniae A026 AGZ48230.1    
 T308_07695   Streptococcus pneumoniae A026 AGZ48224.1    
 T308_07695   Streptococcus pneumoniae A026 AGZ48224.1    
 A66_01518   Streptococcus pneumoniae A66 CRI62229.1    
 A66_01513   Streptococcus pneumoniae A66 CRI62224.1    
 A66_01513   Streptococcus pneumoniae A66 CRI62224.1    
 neuraminidase (NanA)   Streptococcus pneumoniae A66.1 ACJ76912.1 B8XTU2  
 SPAP_1700   Streptococcus pneumoniae AP200 ADM85284.1 E0SWG1  
 SPAP_1354   Streptococcus pneumoniae AP200 ADM84940.1 E0SUC9  
 SPAP_1354   Streptococcus pneumoniae AP200 ADM84940.1 E0SUC9  
 SPAP_1692 (fragment)   Streptococcus pneumoniae AP200 ADM85276.1 E0SWF3  
 ASP0581_16330 (NanA)   Streptococcus pneumoniae ASP0581 BBG82155.1    
 ASP0581_12830 (NanB)   Streptococcus pneumoniae ASP0581 BBG81805.1    
 ASP0581_12830 (NanB)   Streptococcus pneumoniae ASP0581 BBG81805.1    
 SPAT_1555 (Nanb_2)   Streptococcus pneumoniae ATCC 49619 BBG39603.1    
 SPAT_1555 (Nanb_2)   Streptococcus pneumoniae ATCC 49619 BBG39603.1    
 SPAT_1561 (Nana_3)   Streptococcus pneumoniae ATCC 49619 BBG39609.1    
 SPAT_1230 (Nanb_1)   Streptococcus pneumoniae ATCC 49619 BBG39280.1    
 SPAT_1230 (Nanb_1)   Streptococcus pneumoniae ATCC 49619 BBG39280.1    
 neuraminidase   Streptococcus pneumoniae ATCC 700669 CAR69021.1 B8ZK40  
 neuraminidase   Streptococcus pneumoniae ATCC 700669 CAR69021.1 B8ZK40  
 neuraminidase (NanB)   Streptococcus pneumoniae ATCC 700669 CAR69459.1 B8ZMF2  
 neuraminidase (NanB)   Streptococcus pneumoniae ATCC 700669 CAR69459.1 B8ZMF2  
 neuraminidase (NanA)   Streptococcus pneumoniae ATCC 700669 CAR69464.1 B8ZMF7  
 NanA   Streptococcus pneumoniae BC7326 AMQ67148.1    
 NanA   Streptococcus pneumoniae CF6852 AMQ67142.1    
 NanA   Streptococcus pneumoniae CF6857 AMQ67143.1    
 NanA   Streptococcus pneumoniae CF6937 AMQ67144.1    
 sialidase (NanC;SPCG_0853) 3.2.1.18 Streptococcus pneumoniae CGSP14 ACB90105.1 B2IP34  
 sialidase (NanC;SPCG_0853) 3.2.1.18 Streptococcus pneumoniae CGSP14 ACB90105.1 B2IP34  
 SPCG_1660 (NanB)   Streptococcus pneumoniae CGSP14 ACB90912.1 B2IRU3  
 SPCG_1660 (NanB)   Streptococcus pneumoniae CGSP14 ACB90912.1 B2IRU3  
 SPCG_1665   Streptococcus pneumoniae CGSP14 ACB90917.1
ACJ76905.1
ACJ76908.1
ACJ76909.1
ACJ76932.1
B2IRU8  
 NanA   Streptococcus pneumoniae CJ9400 AMQ67146.1    
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CL25 = 340 132217 CAI94554.1 Q4LB84  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CL37 = 162 GM123 CAI94567.1 Q4LB80  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae Cl50 = 352- E/208 CAI94551.1
AIL27686.1
Q4LB89  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CL54 = 145 GM92 CAI94566.1 Q4LB86  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CL56 = 381 110K/70 CAI94568.1 Q4LB79  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CL57 = 398 CAI94571.1 Q4LB81  
 DA395_08290   Streptococcus pneumoniae CP2215 AVV91827.1    
 DA395_08290   Streptococcus pneumoniae CP2215 AVV91827.1    
 DA395_08315   Streptococcus pneumoniae CP2215 AVV91832.1    
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CR13 = 884 141926 CAI94555.1 Q4LB83  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CR33 = 910 13B-15F CAI94565.1 Q4LB88  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CR50 = 967 12B-5L CAI94552.1 Q4LB87  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CR51 = 946 12B-21H CAI94556.1 Q4LB82  
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