Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (5538); Uniprot accession (686); PDB accession (146); 3D entries (19); cryst (0)
All (5293) Archaea (1) Bacteria (4848) Eukaryota (404) Viruses (34) unclassified (6) Structure (19) Characterized (96)
| 1 | ... | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | ... | 50 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 SAMEA3381491_01596 (Nanb_2)   Streptococcus pneumoniae 2245STDY6093044 VFI13832.1    
 SAMEA3381491_01596 (Nanb_2)   Streptococcus pneumoniae 2245STDY6093044 VFI13832.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6093044 VFI13838.1    
 SAMEA3381491_01293 (Nanb_1)   Streptococcus pneumoniae 2245STDY6093044 VFI13537.1    
 SAMEA3381491_01293 (Nanb_1)   Streptococcus pneumoniae 2245STDY6093044 VFI13537.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6105839 VFI45434.1    
 SAMEA3389228_01536 (NanB)   Streptococcus pneumoniae 2245STDY6105839 VFI45400.1    
 SAMEA3389228_01536 (NanB)   Streptococcus pneumoniae 2245STDY6105839 VFI45400.1    
 SAMEA3389261_01464 (Nana_2)   Streptococcus pneumoniae 2245STDY6105855 VGM83091.1    
 SAMEA3389261_01458 (NanB)   Streptococcus pneumoniae 2245STDY6105855 VGM83073.1    
 SAMEA3389261_01458 (NanB)   Streptococcus pneumoniae 2245STDY6105855 VGM83073.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY6106337 VFI19835.1    
 SAMEA3390054_01590 (NanB)   Streptococcus pneumoniae 2245STDY6106337 VFI19788.1    
 SAMEA3390054_01590 (NanB)   Streptococcus pneumoniae 2245STDY6106337 VFI19788.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6106372 VFI27705.1    
 SAMEA3389940_01191 (Nanb_1)   Streptococcus pneumoniae 2245STDY6106372 VFI25948.1    
 SAMEA3389940_01191 (Nanb_1)   Streptococcus pneumoniae 2245STDY6106372 VFI25948.1    
 SAMEA3389940_01504 (Nanb_2)   Streptococcus pneumoniae 2245STDY6106372 VFI27678.1    
 SAMEA3389940_01504 (Nanb_2)   Streptococcus pneumoniae 2245STDY6106372 VFI27678.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6106384 VFI28196.1    
 SAMEA3389963_01562 (NanB)   Streptococcus pneumoniae 2245STDY6106384 VFI28166.1    
 SAMEA3389963_01562 (NanB)   Streptococcus pneumoniae 2245STDY6106384 VFI28166.1    
 SAMEA3431348_01661 (Nana_3)   Streptococcus pneumoniae 2245STDY6106635 VGM77445.1    
 SAMEA3431348_01275 (Nanb_1)   Streptococcus pneumoniae 2245STDY6106635 VGM77066.1    
 SAMEA3431348_01275 (Nanb_1)   Streptococcus pneumoniae 2245STDY6106635 VGM77066.1    
 SAMEA3431348_01655 (Nanb_2)   Streptococcus pneumoniae 2245STDY6106635 VGM77439.1    
 SAMEA3431348_01655 (Nanb_2)   Streptococcus pneumoniae 2245STDY6106635 VGM77439.1    
 SAMEA3431351_01556 (NanB)   Streptococcus pneumoniae 2245STDY6106637 VFI28040.1    
 SAMEA3431351_01556 (NanB)   Streptococcus pneumoniae 2245STDY6106637 VFI28040.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY6106637 VFI28070.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6106751 VFI23650.1    
 SAMEA3431383_01533 (NanB)   Streptococcus pneumoniae 2245STDY6106751 VFI23614.1    
 SAMEA3431383_01533 (NanB)   Streptococcus pneumoniae 2245STDY6106751 VFI23614.1    
 SAMEA3713867_01281 (Nanb_1)   Streptococcus pneumoniae 2245STDY6178787 VFI38112.1    
 SAMEA3713867_01281 (Nanb_1)   Streptococcus pneumoniae 2245STDY6178787 VFI38112.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6178787 VFI40904.1    
 SAMEA3713867_01662 (Nanb_2)   Streptococcus pneumoniae 2245STDY6178787 VFI40858.1    
 SAMEA3713867_01662 (Nanb_2)   Streptococcus pneumoniae 2245STDY6178787 VFI40858.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6178826 VFI44829.1    
 SAMEA3713960_01711 (NanB)   Streptococcus pneumoniae 2245STDY6178826 VFI44784.1    
 SAMEA3713960_01711 (NanB)   Streptococcus pneumoniae 2245STDY6178826 VFI44784.1    
 SAMEA3713964_01314 (Nanb_1)   Streptococcus pneumoniae 2245STDY6178828 VFI53507.1    
 SAMEA3713964_01314 (Nanb_1)   Streptococcus pneumoniae 2245STDY6178828 VFI53507.1    
 SAMEA3713964_01618 (Nanb_2)   Streptococcus pneumoniae 2245STDY6178828 VFI54416.1    
 SAMEA3713964_01618 (Nanb_2)   Streptococcus pneumoniae 2245STDY6178828 VFI54416.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6178828 VFI54437.1    
 SAMEA3714019_01609 (NanB)   Streptococcus pneumoniae 2245STDY6178854 VGM82218.1    
 SAMEA3714019_01609 (NanB)   Streptococcus pneumoniae 2245STDY6178854 VGM82218.1    
 SAMEA3714019_01615 (Nana_2)   Streptococcus pneumoniae 2245STDY6178854 VGM82236.1    
 SAMEA3714262_01324 (Nanb_1)   Streptococcus pneumoniae 2245STDY6179186 VFI48247.1    
 SAMEA3714262_01324 (Nanb_1)   Streptococcus pneumoniae 2245STDY6179186 VFI48247.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY6179186 VFI48857.1    
 SAMEA3714262_01530 (Nanb_2)   Streptococcus pneumoniae 2245STDY6179186 VFI48840.1    
 SAMEA3714262_01530 (Nanb_2)   Streptococcus pneumoniae 2245STDY6179186 VFI48840.1    
 C4N11_06265   Streptococcus pneumoniae 335 AVD75144.1    
 C4N11_06265   Streptococcus pneumoniae 335 AVD75144.1    
 C4N11_08635   Streptococcus pneumoniae 335 AVD75579.1    
 C4N11_08635   Streptococcus pneumoniae 335 AVD75579.1    
 C4N11_08660   Streptococcus pneumoniae 335 AVD75584.1    
 neuraminidase (NanB)   Streptococcus pneumoniae 521 QBK28617.1    
 neuraminidase (NanB)   Streptococcus pneumoniae 521 QBK28617.1    
 sialidase A (NanA) 3.2.1.18 Streptococcus pneumoniae 6 CAA51473.1
ACJ76903.1
B8XTT3
P62575
Q59959
5KKY[A,B]
 sialidase B (NanB) 3.2.1.18 Streptococcus pneumoniae 6 AAC44396.1
AAW08718.1
Q54727  
 sialidase B (NanB) 3.2.1.18 Streptococcus pneumoniae 6 AAC44396.1 Q54727  
 SP670_0950   Streptococcus pneumoniae 670-6B ADM91015.1 E0TMG6  
 SP670_0950   Streptococcus pneumoniae 670-6B ADM91015.1 E0TMG6  
 SP670_1783   Streptococcus pneumoniae 670-6B ADM91835.1 E0TSF6  
 SP670_1773   Streptococcus pneumoniae 670-6B ADM91827.1 E0TSE8  
 neuraminidase   Streptococcus pneumoniae 70585 ACO17645.1    
 SP70585_1726   Streptococcus pneumoniae 70585 ACO17953.1 C1C8S5  
 SP70585_1726   Streptococcus pneumoniae 70585 ACO17953.1 C1C8S5  
 T308_07725   Streptococcus pneumoniae A026 AGZ48230.1    
 T308_07695   Streptococcus pneumoniae A026 AGZ48224.1    
 T308_07695   Streptococcus pneumoniae A026 AGZ48224.1    
 A66_01518   Streptococcus pneumoniae A66 CRI62229.1    
 A66_01513   Streptococcus pneumoniae A66 CRI62224.1    
 A66_01513   Streptococcus pneumoniae A66 CRI62224.1    
 neuraminidase (NanA)   Streptococcus pneumoniae A66.1 ACJ76912.1 B8XTU2  
 SPAP_1700   Streptococcus pneumoniae AP200 ADM85284.1 E0SWG1  
 SPAP_1354   Streptococcus pneumoniae AP200 ADM84940.1 E0SUC9  
 SPAP_1354   Streptococcus pneumoniae AP200 ADM84940.1 E0SUC9  
 SPAP_1692 (fragment)   Streptococcus pneumoniae AP200 ADM85276.1 E0SWF3  
 ASP0581_16330 (NanA)   Streptococcus pneumoniae ASP0581 BBG82155.1    
 ASP0581_12830 (NanB)   Streptococcus pneumoniae ASP0581 BBG81805.1    
 ASP0581_12830 (NanB)   Streptococcus pneumoniae ASP0581 BBG81805.1    
 SPAT_1555 (Nanb_2)   Streptococcus pneumoniae ATCC 49619 BBG39603.1    
 SPAT_1555 (Nanb_2)   Streptococcus pneumoniae ATCC 49619 BBG39603.1    
 SPAT_1561 (Nana_3)   Streptococcus pneumoniae ATCC 49619 BBG39609.1    
 SPAT_1230 (Nanb_1)   Streptococcus pneumoniae ATCC 49619 BBG39280.1    
 SPAT_1230 (Nanb_1)   Streptococcus pneumoniae ATCC 49619 BBG39280.1    
 neuraminidase   Streptococcus pneumoniae ATCC 700669 CAR69021.1 B8ZK40  
 neuraminidase   Streptococcus pneumoniae ATCC 700669 CAR69021.1 B8ZK40  
 neuraminidase (NanB)   Streptococcus pneumoniae ATCC 700669 CAR69459.1 B8ZMF2  
 neuraminidase (NanB)   Streptococcus pneumoniae ATCC 700669 CAR69459.1 B8ZMF2  
 neuraminidase (NanA)   Streptococcus pneumoniae ATCC 700669 CAR69464.1 B8ZMF7  
 NanA   Streptococcus pneumoniae BC7326 AMQ67148.1    
 NanA   Streptococcus pneumoniae CF6852 AMQ67142.1    
 NanA   Streptococcus pneumoniae CF6857 AMQ67143.1    
 NanA   Streptococcus pneumoniae CF6937 AMQ67144.1    
 sialidase (NanC;SPCG_0853) 3.2.1.18 Streptococcus pneumoniae CGSP14 ACB90105.1 B2IP34  
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