Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (5621); Uniprot accession (686); PDB accession (146); 3D entries (19); cryst (0)
All (5380) Archaea (1) Bacteria (4935) Eukaryota (404) Viruses (34) unclassified (6) Structure (19) Characterized (96)
| 1 | ... | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | ... | 51 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Sez_1425 (NanA)   Streptococcus equi subsp. zooepidemicus MGCS10565 ACG62759.1 B4U442  
 NCTC11606_01420 (Nana_2)   Streptococcus equi subsp. zooepidemicus NCTC11606 SQF54428.1    
 NCTC11824_01433 (Nana_2)   Streptococcus equi subsp. zooepidemicus NCTC11824 SQG17617.1    
 NCTC11854_01901 (Nana_2) (fragment)   Streptococcus equi subsp. zooepidemicus NCTC11854 VTP93991.1    
 NCTC11854_01903 (Nana_3) (fragment)   Streptococcus equi subsp. zooepidemicus NCTC11854 VTP94001.1    
 NCTC11854_01902 (fragment)   Streptococcus equi subsp. zooepidemicus NCTC11854 VTP93997.1    
 NCTC12090_01514 (Nana_2)   Streptococcus equi subsp. zooepidemicus NCTC12090 SQF06020.1    
 NCTC4675_01456 (Nana_2)   Streptococcus equi subsp. zooepidemicus NCTC4675 VTS32517.1    
 NCTC6176_01454 (Nana_2)   Streptococcus equi subsp. zooepidemicus NCTC6176 SQF82073.1    
 NCTC6180_00298 (Nana_1)   Streptococcus equi subsp. zooepidemicus NCTC6180 VEF05361.1    
 NCTC7022_01491 (Nana_2)   Streptococcus equi subsp. zooepidemicus NCTC7022 SQE96358.1    
 BMF34_09145   Streptococcus iniae 89353 APD32625.1    
 neuraminidase (NeuA) (fragment)   Streptococcus iniae DGX07 AMW63819.1    
 CTW00_00337 (Nana_2)   Streptococcus iniae FP5228 ATX38579.1    
 D5R92_04480   Streptococcus iniae GX005 AYB01718.1    
 DQ08_09165   Streptococcus iniae ISET0901 AHY16600.1    
 DW64_09145   Streptococcus iniae ISNO AHY18466.1    
 neuraminidase (NanA)   Streptococcus iniae QMA0248 ASL35592.1    
 K710_1941   Streptococcus iniae SF1 AGM99689.1    
 D5R90_05890   Streptococcus iniae YM011 AYB03796.1    
 SI82_09135   Streptococcus iniae YSFST01-82 AJG26732.1    
 sialidase 3.2.1.18 Streptococcus intermedius ATCC 27335 BAJ15290.1 E0CZJ4  
 neuraminidase (NanA)   Streptococcus intermedius B196 AGU75433.1    
 neuraminidase (NanA)   Streptococcus intermedius C270 AGU77248.1    
 A6J72_05350   Streptococcus intermedius FDAARGOS_233 AVH83551.1    
 SCIM_0012 (NanA)   Streptococcus intermedius JTH08 BAM22666.1    
 RN88_09240   Streptococcus intermedius KCOM 1545 ALF28645.1    
 neuraminidase (Nana_1)   Streptococcus intermedius NCTC11324 SQH51041.1    
 SITYG_00150 (NanA)   Streptococcus intermedius TYG1620 BAW16002.1    
 SAMEA4412692_01537 (NanB) (fragment)   Streptococcus merionis NCTC13788 SNU89542.1    
 smi_0601 (NanA)   Streptococcus mitis B6 CBJ21850.1 D3H7K8  
 RN80_08780   Streptococcus mitis KCOM 1350 (= ChDC B183) ALD68526.1    
 neuraminidase (NanA)   Streptococcus mitis R83E2 ACJ76896.1 B8XTS6  
 AXK38_04810   Streptococcus mitis SVGS_061 AMH88604.1    
 NCTC10920_00836 (NanB)   Streptococcus mutans NCTC10920 VEI59842.1    
 neuraminidase (NanA)   Streptococcus oralis ATCC 10557 APU52327.1    
 neuraminidase (Nana_2)   Streptococcus oralis ATCC 35037 NCTC11427 VEF79444.1    
 CO686_02035   Streptococcus oralis FDAARGOS_367 ATF57787.1    
 BWR56_1417   Streptococcus oralis S.MIT/ORALIS-351 AQA08706.1    
 SOR_0548 (NanA)   Streptococcus oralis Uo5 CBZ00210.1    
 neuraminidase   Streptococcus pantholopis TA 26 AND79029.1    
 NCTC13784_01611   Streptococcus pasteurianus NCTC13784 SQI09029.1    
 SAMEA104035599_01459 (Nanb_2)   Streptococcus pneumoniae VGM81820.1    
 SAMEA104035599_01459 (Nanb_2)   Streptococcus pneumoniae VGM81820.1    
 SAMEA104035599_01123 (Nanb_1)   Streptococcus pneumoniae VGM80830.1    
 SAMEA104035599_01123 (Nanb_1)   Streptococcus pneumoniae VGM80830.1    
 SAMEA2553885_01541 (NanB)   Streptococcus pneumoniae VGM85520.1    
 SAMEA2553885_01541 (NanB)   Streptococcus pneumoniae VGM85520.1    
 SAMEA104035599_01464 (Nana_3)   Streptococcus pneumoniae VGM81835.1    
 SAMEA2553885_01547 (Nana_3)   Streptococcus pneumoniae VGM85526.1    
 Sequence 3166 from patent US 7074914   Streptococcus pneumoniae ABI03127.1
ABI08168.1
ABJ31684.1
ABJ49297.1
ABL17040.1
ACJ76930.1
ACK13586.1
ACW44305.1
   
 Sequence 3175 from patent US 7074914 (fragment)   Streptococcus pneumoniae ABI03136.1
ABI08177.1
ABJ31693.1
ABJ49306.1
ABL17049.1
ACG90469.1
ACK13595.1
ACW44314.1
   
 neuraminidase (NanA)   Streptococcus pneumoniae 05-2028 ACJ76906.1    
 neuraminidase (NanA)   Streptococcus pneumoniae 05-2084 ACJ76907.1    
 BUM80_05960   Streptococcus pneumoniae 11A AUC45939.1    
 BUM80_05960   Streptococcus pneumoniae 11A AUC45939.1    
 BUM80_05985   Streptococcus pneumoniae 11A AUC45944.1    
 CWI64_03840   Streptococcus pneumoniae 19F AUB32852.1    
 CWI64_03815   Streptococcus pneumoniae 19F AUB32847.1    
 CWI64_03815   Streptococcus pneumoniae 19F AUB32847.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY5562278 VFH37241.1    
 SAMEA2146691_01225 (Nanb_1)   Streptococcus pneumoniae 2245STDY5562278 VFH36906.1    
 SAMEA2146691_01225 (Nanb_1)   Streptococcus pneumoniae 2245STDY5562278 VFH36906.1    
 SAMEA2146691_01561 (Nanb_2)   Streptococcus pneumoniae 2245STDY5562278 VFH37236.1    
 SAMEA2146691_01561 (Nanb_2)   Streptococcus pneumoniae 2245STDY5562278 VFH37236.1    
 SAMEA2148390_01506 (NanB)   Streptococcus pneumoniae 2245STDY5562351 VFH53858.1    
 SAMEA2148390_01506 (NanB)   Streptococcus pneumoniae 2245STDY5562351 VFH53858.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY5562351 VFH53865.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY5562369 VFH47398.1    
 SAMEA2147627_01262 (NanB)   Streptococcus pneumoniae 2245STDY5562369 VFH45166.1    
 SAMEA2147627_01262 (NanB)   Streptococcus pneumoniae 2245STDY5562369 VFH45166.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY5562412 VFH69975.1    
 SAMEA2150192_01646 (NanB)   Streptococcus pneumoniae 2245STDY5562412 VFH69963.1    
 SAMEA2150192_01646 (NanB)   Streptococcus pneumoniae 2245STDY5562412 VFH69963.1    
 SAMEA2145720_01470 (NanB)   Streptococcus pneumoniae 2245STDY5562562 VFH64195.1    
 SAMEA2145720_01470 (NanB)   Streptococcus pneumoniae 2245STDY5562562 VFH64195.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY5562562 VFH64233.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY5562600 VFH58731.1    
 SAMEA2162916_01614 (NanB)   Streptococcus pneumoniae 2245STDY5562600 VFH58700.1    
 SAMEA2162916_01614 (NanB)   Streptococcus pneumoniae 2245STDY5562600 VFH58700.1    
 SAMEA2157525_01535 (Nanb_2)   Streptococcus pneumoniae 2245STDY5562629 VFH45803.1    
 SAMEA2157525_01535 (Nanb_2)   Streptococcus pneumoniae 2245STDY5562629 VFH45803.1    
 SAMEA2157525_01225 (Nanb_1)   Streptococcus pneumoniae 2245STDY5562629 VFH43674.1    
 SAMEA2157525_01225 (Nanb_1)   Streptococcus pneumoniae 2245STDY5562629 VFH43674.1    
 neuraminidase (Nana_4)   Streptococcus pneumoniae 2245STDY5562629 VFH45838.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY5605535 VFH51221.1    
 SAMEA2203271_01678 (Nanb_2)   Streptococcus pneumoniae 2245STDY5605535 VFH51197.1    
 SAMEA2203271_01678 (Nanb_2)   Streptococcus pneumoniae 2245STDY5605535 VFH51197.1    
 SAMEA2203271_01371 (Nanb_1)   Streptococcus pneumoniae 2245STDY5605535 VFH49900.1    
 SAMEA2203271_01371 (Nanb_1)   Streptococcus pneumoniae 2245STDY5605535 VFH49900.1    
 SAMEA2203380_01240 (NanB)   Streptococcus pneumoniae 2245STDY5605669 VFH45769.1    
 SAMEA2203380_01240 (NanB)   Streptococcus pneumoniae 2245STDY5605669 VFH45769.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY5605669 VFH48383.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY5605682 VFH49059.1    
 neuraminidase (Nana_2)   Streptococcus pneumoniae 2245STDY5609197 VFH44725.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae 2245STDY5609237 VFH51511.1    
 SAMEA2204095_01544 (Nanb_2)   Streptococcus pneumoniae 2245STDY5609237 VFH51494.1    
 SAMEA2204095_01544 (Nanb_2)   Streptococcus pneumoniae 2245STDY5609237 VFH51494.1    
 SAMEA2204095_01209 (Nanb_1)   Streptococcus pneumoniae 2245STDY5609237 VFH50122.1    
 SAMEA2204095_01209 (Nanb_1)   Streptococcus pneumoniae 2245STDY5609237 VFH50122.1    
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