Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (4271); Uniprot accession (686); PDB accession (146); 3D entries (19); cryst (0)
All (3963) Archaea (1) Bacteria (3547) Eukaryota (381) Viruses (34) Structure (19) Characterized (96)
| 1 | ... | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | ... | 37 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 BB197_09675   Streptococcus agalactiae SG-M163 ASA82588.1    
 BB164_10280   Streptococcus agalactiae SG-M25 ASA90889.1    
 BB268_09675   Streptococcus agalactiae SG-M29 ASA88743.1    
 BB165_09520   Streptococcus agalactiae SG-M4 ASA99746.1    
 BB313_09670   Streptococcus agalactiae SG-M50 ASA86689.1    
 BB162_09670   Streptococcus agalactiae SG-M6 ASA95066.1    
 BB159_09705   Streptococcus agalactiae SG-M8 ASA93016.1    
 CWQ22_09215   Streptococcus agalactiae SGEHI2015-107 ATZ83650.1    
 CWQ23_09330   Streptococcus agalactiae SGEHI2015-113 ATZ90122.1    
 CWQ20_09480   Streptococcus agalactiae SGEHI2015-25 ATZ85654.1    
 CWQ21_09785   Streptococcus agalactiae SGEHI2015-95 ATZ92169.1    
 RDF_1823   Streptococcus agalactiae SS1 AKI96238.1    
 BBP08_10290   Streptococcus agalactiae WC1535 AOQ21565.1    
 YM001_09075   Streptococcus agalactiae YM001 AKT98804.1    
 SEQ_1612   Streptococcus equi subsp. equi 4047 CAW94606.1 C0MAP0  
 SE071780_01638   Streptococcus equi subsp. equi ATCC 39506 ASB97227.1    
 SeseC_01852   Streptococcus equi subsp. zooepidemicus ATCC 35246 AEJ25722.1    
 Q426_01975   Streptococcus equi subsp. zooepidemicus CY AIA68611.1    
 Sez_1425 (NanA)   Streptococcus equi subsp. zooepidemicus MGCS10565 ACG62759.1 B4U442  
 NCTC11606_01420 (Nana_2)   Streptococcus equi subsp. zooepidemicus NCTC11606 SQF54428.1    
 NCTC11824_01433 (Nana_2)   Streptococcus equi subsp. zooepidemicus NCTC11824 SQG17617.1    
 NCTC12090_01514 (Nana_2)   Streptococcus equi subsp. zooepidemicus NCTC12090 SQF06020.1    
 NCTC6176_01454 (Nana_2)   Streptococcus equi subsp. zooepidemicus NCTC6176 SQF82073.1    
 NCTC7022_01491 (Nana_2)   Streptococcus equi subsp. zooepidemicus NCTC7022 SQE96358.1    
 BMF34_09145   Streptococcus iniae 89353 APD32625.1    
 neuraminidase (NeuA) (fragment)   Streptococcus iniae DGX07 AMW63819.1    
 CTW00_00337 (Nana_2)   Streptococcus iniae FP5228 ATX38579.1    
 DQ08_09165   Streptococcus iniae ISET0901 AHY16600.1    
 DW64_09145   Streptococcus iniae ISNO AHY18466.1    
 neuraminidase (NanA)   Streptococcus iniae QMA0248 ASL35592.1    
 K710_1941   Streptococcus iniae SF1 AGM99689.1    
 SI82_09135   Streptococcus iniae YSFST01-82 AJG26732.1    
 sialidase 3.2.1.18 Streptococcus intermedius ATCC 27335 BAJ15290.1 E0CZJ4  
 neuraminidase (NanA)   Streptococcus intermedius B196 AGU75433.1    
 neuraminidase (NanA)   Streptococcus intermedius C270 AGU77248.1    
 A6J72_05350   Streptococcus intermedius FDAARGOS_233 AVH83551.1    
 SCIM_0012 (NanA)   Streptococcus intermedius JTH08 BAM22666.1    
 RN88_09240   Streptococcus intermedius KCOM 1545 ALF28645.1    
 neuraminidase (Nana_1)   Streptococcus intermedius NCTC11324 SQH51041.1    
 SITYG_00150 (NanA)   Streptococcus intermedius TYG1620 BAW16002.1    
 SAMEA4412692_01537 (NanB) (fragment)   Streptococcus merionis NCTC13788 SNU89542.1    
 smi_0601 (NanA)   Streptococcus mitis B6 CBJ21850.1 D3H7K8  
 RN80_08780   Streptococcus mitis KCOM 1350 (= ChDC B183) ALD68526.1    
 neuraminidase (NanA)   Streptococcus mitis R83E2 ACJ76896.1 B8XTS6  
 AXK38_04810   Streptococcus mitis SVGS_061 AMH88604.1    
 neuraminidase   Streptococcus mitis SVGS_061 AMH88242.1    
 neuraminidase (NanA)   Streptococcus oralis ATCC 10557 APU52327.1    
 CO686_02035   Streptococcus oralis FDAARGOS_367 ATF57787.1    
 BWR56_1417   Streptococcus oralis S.MIT/ORALIS-351 AQA08706.1    
 SOR_0548 (NanA)   Streptococcus oralis Uo5 CBZ00210.1    
 neuraminidase   Streptococcus pantholopis TA 26 AND79029.1    
 NCTC13784_01611   Streptococcus pasteurianus NCTC13784 SQI09029.1    
 Sequence 3166 from patent US 7074914   Streptococcus pneumoniae ABI03127.1
ABI08168.1
ABJ31684.1
ABJ49297.1
ABL17040.1
ACJ76930.1
ACK13586.1
ACW44305.1
   
 Sequence 3175 from patent US 7074914 (fragment)   Streptococcus pneumoniae ABI03136.1
ABI08177.1
ABJ31693.1
ABJ49306.1
ABL17049.1
ACG90469.1
ACK13595.1
ACW44314.1
   
 neuraminidase (NanA)   Streptococcus pneumoniae 05-2028 ACJ76906.1    
 neuraminidase (NanA)   Streptococcus pneumoniae 05-2084 ACJ76907.1    
 BUM80_05960   Streptococcus pneumoniae 11A AUC45939.1    
 BUM80_05960   Streptococcus pneumoniae 11A AUC45939.1    
 BUM80_05985   Streptococcus pneumoniae 11A AUC45944.1    
 CWI64_03840   Streptococcus pneumoniae 19F AUB32852.1    
 CWI64_03815   Streptococcus pneumoniae 19F AUB32847.1    
 CWI64_03815   Streptococcus pneumoniae 19F AUB32847.1    
 C4N11_06265   Streptococcus pneumoniae 335 AVD75144.1    
 C4N11_06265   Streptococcus pneumoniae 335 AVD75144.1    
 C4N11_08635   Streptococcus pneumoniae 335 AVD75579.1    
 C4N11_08635   Streptococcus pneumoniae 335 AVD75579.1    
 C4N11_08660   Streptococcus pneumoniae 335 AVD75584.1    
 sialidase A (NanA) 3.2.1.18 Streptococcus pneumoniae 6 CAA51473.1
ACJ76903.1
B8XTT3
P62575
Q59959
5KKY[A,B]
 sialidase B (NanB) 3.2.1.18 Streptococcus pneumoniae 6 AAC44396.1
AAW08718.1
Q54727  
 sialidase B (NanB) 3.2.1.18 Streptococcus pneumoniae 6 AAC44396.1 Q54727  
 SP670_0950   Streptococcus pneumoniae 670-6B ADM91015.1 E0TMG6  
 SP670_0950   Streptococcus pneumoniae 670-6B ADM91015.1 E0TMG6  
 SP670_1783   Streptococcus pneumoniae 670-6B ADM91835.1 E0TSF6  
 SP670_1773   Streptococcus pneumoniae 670-6B ADM91827.1 E0TSE8  
 neuraminidase   Streptococcus pneumoniae 70585 ACO17645.1    
 SP70585_1726   Streptococcus pneumoniae 70585 ACO17953.1 C1C8S5  
 SP70585_1726   Streptococcus pneumoniae 70585 ACO17953.1 C1C8S5  
 T308_07725   Streptococcus pneumoniae A026 AGZ48230.1    
 T308_07695   Streptococcus pneumoniae A026 AGZ48224.1    
 T308_07695   Streptococcus pneumoniae A026 AGZ48224.1    
 A66_01518   Streptococcus pneumoniae A66 CRI62229.1    
 A66_01513   Streptococcus pneumoniae A66 CRI62224.1    
 A66_01513   Streptococcus pneumoniae A66 CRI62224.1    
 neuraminidase (NanA)   Streptococcus pneumoniae A66.1 ACJ76912.1 B8XTU2  
 SPAP_1700   Streptococcus pneumoniae AP200 ADM85284.1 E0SWG1  
 SPAP_1354   Streptococcus pneumoniae AP200 ADM84940.1 E0SUC9  
 SPAP_1354   Streptococcus pneumoniae AP200 ADM84940.1 E0SUC9  
 SPAP_1692 (fragment)   Streptococcus pneumoniae AP200 ADM85276.1 E0SWF3  
 neuraminidase   Streptococcus pneumoniae ATCC 700669 CAR69021.1 B8ZK40  
 neuraminidase   Streptococcus pneumoniae ATCC 700669 CAR69021.1 B8ZK40  
 neuraminidase (NanB)   Streptococcus pneumoniae ATCC 700669 CAR69459.1 B8ZMF2  
 neuraminidase (NanB)   Streptococcus pneumoniae ATCC 700669 CAR69459.1 B8ZMF2  
 neuraminidase (NanA)   Streptococcus pneumoniae ATCC 700669 CAR69464.1 B8ZMF7  
 NanA   Streptococcus pneumoniae BC7326 AMQ67148.1    
 NanA   Streptococcus pneumoniae CF6852 AMQ67142.1    
 NanA   Streptococcus pneumoniae CF6857 AMQ67143.1    
 NanA   Streptococcus pneumoniae CF6937 AMQ67144.1    
 sialidase (NanC;SPCG_0853) 3.2.1.18 Streptococcus pneumoniae CGSP14 ACB90105.1 B2IP34  
 sialidase (NanC;SPCG_0853) 3.2.1.18 Streptococcus pneumoniae CGSP14 ACB90105.1 B2IP34  
 SPCG_1660 (NanB)   Streptococcus pneumoniae CGSP14 ACB90912.1 B2IRU3  
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