Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); 2-keto-3-deoxynononic acid hydrolase (EC 3.2.1.-); anhydrosialidase (EC 4.2.2.15); 3-deoxy-D-manno-octulosonic-acid hydrolase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (3925); Uniprot accession (686); PDB accession (146); 3D entries (19); cryst (0)
All (3679) Archaea (1) Bacteria (3271) Eukaryota (374) Viruses (33) Structure (19) Characterized (96)
| 1 | ... | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 neuraminidase (NanA)   Streptococcus pneumoniae SPN034183 SNP034183 CCP33195.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994038 SNP994038 CCP31205.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994038 SNP994038 CCP31205.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN994038 SNP994038 CCP31210.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994039 SNP994039 CCP35164.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994039 SNP994039 CCP35164.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN994039 SNP994039 CCP35169.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPNA45 CCM07843.1
CCM07838.1
   
 neuraminidase (NanB)   Streptococcus pneumoniae SPNA45 CCM07843.1
CCM07838.1
   
 MYY_1610   Streptococcus pneumoniae ST556 AFC95267.1    
 MYY_1610   Streptococcus pneumoniae ST556 AFC95267.1    
 neuraminidase   Streptococcus pneumoniae ST556 AFC95272.1    
 neuraminidase   Streptococcus pneumoniae Taiwan19F-14 ACO23538.1    
 SPT_1625   Streptococcus pneumoniae Taiwan19F-14 ACO22908.1 C1CSV0  
 SPT_1625   Streptococcus pneumoniae Taiwan19F-14 ACO22908.1 C1CSV0  
 HMPREF0837_11930 (NanB)   Streptococcus pneumoniae TCH8431/19A ADI70158.1 D6ZMP4  
 HMPREF0837_11930 (NanB)   Streptococcus pneumoniae TCH8431/19A ADI70158.1 D6ZMP4  
 HMPREF0837_11935   Streptococcus pneumoniae TCH8431/19A ADI70163.1 D6ZMP9  
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727 2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
4XE9[A]
4XHB[A]
4XHX[A]
4XIK[A]
4XIL[A]
4XIO[A]
4XJ8[A]
4XJ9[A]
4XJA[A]
4XJU[A]
4XJW[A]
4XJZ[A]
4XMA[A]
4XMI[A]
4XOG[A]
4XYX[A]
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727 2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
4XE9[A]
4XHB[A]
4XHX[A]
4XIK[A]
4XIL[A]
4XIO[A]
4XJ8[A]
4XJ9[A]
4XJA[A]
4XJU[A]
4XJW[A]
4XJZ[A]
4XMA[A]
4XMI[A]
4XOG[A]
4XYX[A]
 neuraminidase (NanA;SpneT_02001817)   Streptococcus pneumoniae TIGR4 ZP_01407762.1   2YA4[A,B]
2YA5[A,B]
2YA6[A,B]
2YA7[A,B,C,D]
2YA8[A,B]
 SP1326 (NanC)   Streptococcus pneumoniae TIGR4 AAK75424.1
NP_345784.1
Q97Q99  
 SP1326 (NanC)   Streptococcus pneumoniae TIGR4 AAK75424.1
ABA35893.1
NP_345784.1
Q97Q99  
 CXP32_06570   Streptococcus pneumoniae Xen35 AUF85063.1    
 CXP32_06570   Streptococcus pneumoniae Xen35 AUF85063.1    
 CXP32_08415   Streptococcus pneumoniae Xen35 AUF85392.1    
 CXP32_08415   Streptococcus pneumoniae Xen35 AUF85392.1    
 SPPN_08220   Streptococcus pseudopneumoniae IS7493 AEL11070.1    
 SPPN_08220   Streptococcus pseudopneumoniae IS7493 AEL11070.1    
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R82E6 ACJ76895.1 B8XTS5  
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R89G3 ACJ76897.1
ACJ76898.1
B8XTS7  
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R98A5 ACJ76899.1 B8XTS9  
 A6J68_10885   Streptococcus sp. group B FDAARGOS_229 ARC25603.1    
 SNAG_0542 (Nana_2)   Streptococcus sp. NPS 308 BAV79420.1    
 AXF18_00720   Streptococcus sp. oral taxon 064 W10853 ANR74557.1    
 AXE83_09040   Streptococcus sp. oral taxon 431 F0610 (5-114) AMD97713.1    
 AXE83_09045   Streptococcus sp. oral taxon 431 F0610 (5-114) AMD97714.1    
 V470_02445   Streptococcus sp. VT 162 AHZ47303.1    
 SSUA7_0867   Streptococcus suis A7 AER44191.1    
 CVO91_07205   Streptococcus suis CZ130302 ATZ03709.1    
 SMD11_1190   Streptomyces albireticuli SMD11 ARZ66851.1    
 SMD44_02481 (fragment)   Streptomyces alboflavus MDJK44 ARX83067.1    
 SMD44_02810   Streptomyces alboflavus MDJK44 ARX83392.1    
 SMD44_07111   Streptomyces alboflavus MDJK44 ARX87630.1    
 neuraminidase   Streptomyces albulus NK660 AIA06974.1    
 neuraminidase   Streptomyces albulus ZPM AKA06828.1    
 SLNHY_5338   Streptomyces albus BK3-25 AOU80029.1    
 neuraminidase   Streptomyces albus BK3-25 AOU75114.1    
 SLNHY_5610   Streptomyces albus BK3-25 AOU80301.1    
 neuraminidase   Streptomyces albus DSM 41398 AJE80803.1    
 SLNWT_5351   Streptomyces albus DSM 41398 AJE85727.1    
 SLNWT_5623   Streptomyces albus DSM 41398 AJE85999.1    
 Salbus254_6115 (NedA)   Streptomyces albus SM254 AMM12544.1    
 SAM23877_6257   Streptomyces ambofaciens ATCC 23877 AKZ59302.1    
 SAM40697_5614   Streptomyces ambofaciens DSM 40697 ANB09570.1    
 BV401_14365   Streptomyces autolyticus CGMCC0516 AQA11494.1    
 BV401_38265   Streptomyces autolyticus CGMCC0516 AQA15388.1    
 BV401_34675   Streptomyces autolyticus CGMCC0516 AQA14795.1    
 SAV1842 (NanH)   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC69553.1
NP_823018.1
   
 SAV5934   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC73646.1
NP_827111.1
   
 SAV5606   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC73318.1
NP_826783.1
   
 SBI_02735   Streptomyces bingchenggensis BCW-1 ADI05856.1 D7C0Y4  
 SBI_07687   Streptomyces bingchenggensis BCW-1 ADI10807.1 D7CCW0  
 SBI_08925   Streptomyces bingchenggensis BCW-1 ADI12043.1 D7C003  
 SCO6557 or SC4B5.07c   Streptomyces coelicolor A3(2) CAA22361.1
NP_630638.1
Q9ZBW1  
 SCO0033 or SCJ4.14c   Streptomyces coelicolor A3(2) CAB52948.1
NP_624391.1
Q9S1V9  
 B446_11895   Streptomyces collinus Tu 365 AGS69201.1    
 B446_13015   Streptomyces collinus Tu 365 AGS69421.1    
 neuraminidase   Streptomyces collinus Tu 365 AGS72834.1    
 TU94_27930   Streptomyces cyaneogriseus subsp. noncyanogenus NMWT 1 AJP04710.1    
 BN159_5780   Streptomyces davaonensis JCM 4913 CCK30159.1    
 BN159_6167   Streptomyces davaonensis JCM 4913 CCK30546.1    
 BN159_5931 (fragment)   Streptomyces davaonensis JCM 4913 CCK30310.1    
 KY5_6912c   Streptomyces formicae KY5 ATL31930.1    
 KY5_2262c   Streptomyces formicae KY5 ATL27280.1    
 SFUL_4680   Streptomyces fulvissimus DSM 40593 AGK79576.1    
 B1H19_08245   Streptomyces gilvosporeus F607 ARF59300.1    
 B1H19_32765   Streptomyces gilvosporeus F607 ARF58324.1    
 B1H19_13200   Streptomyces gilvosporeus F607 ARF59408.1    
 AVL59_14305   Streptomyces griseochromogenes ATCC 14511 ANP50638.1    
 AVL59_39820   Streptomyces griseochromogenes ATCC 14511 ANP54925.1    
 AVL59_38345   Streptomyces griseochromogenes ATCC 14511 ANP54677.1    
 SGR_6429   Streptomyces griseus subsp. griseus NBRC 13350 BAG23258.1 B1W5V1  
 SHJG_3753   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY89025.1    
 SHJG_4013   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY89285.1    
 neuraminidase   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY92776.1    
 neuraminidase   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF66932.1    
 SHJGH_3778   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF63443.1    
 SHJGH_3518   Streptomyces hygroscopicus subsp. jinggangensis TL01 AGF63183.1    
 SHL15_2558   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO93707.1    
 SHL15_2303   Streptomyces hygroscopicus subsp. limoneus KCTC 1717 ALO93459.1    
 SHXM_01605   Streptomyces hygroscopicus XM201 AQW48142.1    
 SHXM_02791   Streptomyces hygroscopicus XM201 AQW49328.1    
 SHXM_03802   Streptomyces hygroscopicus XM201 AQW50339.1    
 ABB07_27015 (fragment)   Streptomyces incarnatus NRRL 8089 AKJ13550.1    
 ABB07_06030   Streptomyces incarnatus NRRL 8089 AKJ09590.1    
 ABB07_25670   Streptomyces incarnatus NRRL 8089 AKJ13297.1    
 SIRAN7080   Streptomyces iranensis CDR10828.1    
 SIRAN1596   Streptomyces iranensis CDR04302.1    
 SIRAN2508   Streptomyces iranensis CDR05563.1    
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