Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); 2-keto-3-deoxynononic acid hydrolase (EC 3.2.1.-); anhydrosialidase (EC 4.2.2.15); 3-deoxy-D-manno-octulosonic-acid hydrolase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (3694); Uniprot accession (686); PDB accession (146); 3D entries (19); cryst (0)
All (3441) Archaea (1) Bacteria (3035) Eukaryota (372) Viruses (33) Structure (19) Characterized (96)
| 1 | ... | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 neuraminidase   Terriglobus roseus GAS232 SDF06571.1    
 neuraminidase   Terriglobus roseus GAS232 SDE92571.1    
 AciPR4_2821   Terriglobus saanensis SP1PR4 ADV83594.1 E1N2Z3  
 BW733_14130 (fragment)   Tessaracoccus flavescens SST-39T AQP51794.1    
 RPIT_12385   Tessaracoccus flavus RP1T AQP45501.1    
 BKM78_13850   Tessaracoccus sp. T2.5-30 AQX16876.1    
 THTE_2055   Thermogutta terrifontis R1 ASV74657.1    
 THTE_2789   Thermogutta terrifontis R1 ASV75391.1    
 THTE_1431   Thermogutta terrifontis R1 ASV74033.1    
 exo-neuraminidase (TdNeu;TDE0471) 3.2.1.18 Treponema denticola ATCC 35405 AAS10966.1
NP_971085.1
Q73QH2  
 TPE_0275   Treponema pedis str. T A4 AGT42771.1    
 TPE_2363   Treponema pedis str. T A4 AGT44837.1    
 neuraminidase   Trueperella bonasi DSM 17163 AGI95981.1    
 NanP   Trueperella pyogenes AAK98800.1 Q8VPE8  
 sialidase (NanH) 3.2.1.18 Trueperella pyogenes AAK15462.1 Q9AHP2  
 neuraminidase (NanP) (fragment)   Trueperella pyogenes FL-1 ARA90381.1    
 neuraminidase (NanH)   Trueperella pyogenes FL-1 ARA90380.1    
 X956_00875 (fragment)   Trueperella pyogenes TP8 AJC68877.1    
 X956_03635   Trueperella pyogenes TP8 AJC69304.1    
 HGMM_F10C03C23   uncultured Acidobacteria bacterium BAL53855.1    
 ORF (fragment)   uncultured bacterium APO34972.1    
 ORF (fragment)   uncultured bacterium APO32020.1    
 ORF (fragment)   uncultured bacterium fosmid pJB148G3 AIF26887.1    
 sialidase   uncultured bacterium Rlip1 ACM91104.1 C0K074  
 CMV30_05015   Verrucomicrobia bacterium HZ-65 ATC63364.1    
 CMV30_08310   Verrucomicrobia bacterium HZ-65 ATC63952.1    
 IMCC26134_04605   Verrucomicrobia bacterium IMCC26134 AKC83918.1    
 PL85_10365   Vibrio anguillarum DSM 21597 AQM03037.1    
 PL85_10365   Vibrio anguillarum DSM 21597 AQM03037.1    
 PO29_12530   Vibrio anguillarum HI610 AQM17087.1    
 PO29_12530   Vibrio anguillarum HI610 AQM17087.1    
 CMV05_04215   Vibrio anguillarum VIB12 ATC56928.1    
 CMV05_04215   Vibrio anguillarum VIB12 ATC56928.1    
 CK207_04320   Vibrio anguillarum VIB43 ASW80374.1    
 CK207_04320   Vibrio anguillarum VIB43 ASW80374.1    
 VAB027_2456 (NanH)   Vibrio cholerae 10432-62 AKB08334.1    
 VAB027_2456 (NanH)   Vibrio cholerae 10432-62 AKB08334.1    
 neuraminidase (NanH)   Vibrio cholerae 13 AIL52586.1    
 neuraminidase (NanH)   Vibrio cholerae 13 AIL52586.1    
 EN18_12065   Vibrio cholerae 2012EL-2176 AIT29775.1    
 EN18_12065   Vibrio cholerae 2012EL-2176 AIT29775.1    
 BBB50_05755   Vibrio cholerae 2740-80 ANR87208.1    
 BBB50_05755   Vibrio cholerae 2740-80 ANR87208.1    
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1 P37060 1KIT[A]
1W0O[A]
1W0P[A]
6EKS[A]
6EKU[A]
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1 P37060 1KIT[A]
1W0O[A]
1W0P[A]
6EKS[A]
6EKU[A]
 NanH   Vibrio cholerae AMAZONIA 3509 AAW31751.2 Q5IB64
Q5IB64
 
 NanH   Vibrio cholerae AMAZONIA 3509 AAW31751.2
AAW31751.1
Q5IB64
Q5IB64
 
 neuraminidase   Vibrio cholerae C5 APF49319.1    
 neuraminidase   Vibrio cholerae C5 APF49319.1    
 ASZ81_01775   Vibrio cholerae CRC1106 APF56916.1    
 ASZ81_01775   Vibrio cholerae CRC1106 APF56916.1    
 neuraminidase   Vibrio cholerae CRC711 APF53177.1    
 neuraminidase   Vibrio cholerae CRC711 APF53177.1    
 ASZ88_01723 (NanH)   Vibrio cholerae E1320 APF68105.1    
 ASZ88_01723 (NanH)   Vibrio cholerae E1320 APF68105.1    
 neuraminidase   Vibrio cholerae E506 APF60361.1    
 neuraminidase   Vibrio cholerae E506 APF60361.1    
 CSW01_08950   Vibrio cholerae E7946 ATQ46817.1    
 CSW01_08950   Vibrio cholerae E7946 ATQ46817.1    
 neuraminidase   Vibrio cholerae E9120 APF71815.1    
 neuraminidase   Vibrio cholerae E9120 APF71815.1    
 A6J62_08325   Vibrio cholerae FDAARGOS_223 ARB80595.1    
 A6J62_08325   Vibrio cholerae FDAARGOS_223 ARB80595.1    
 neuraminidase   Vibrio cholerae IEC224 AFC58601.1    
 neuraminidase   Vibrio cholerae IEC224 AFC58601.1    
 VCLMA_A1545   Vibrio cholerae LMA3984-4 AEA78761.1    
 VCLMA_A1545   Vibrio cholerae LMA3984-4 AEA78761.1    
 neuraminidase   Vibrio cholerae M2140 APF75003.1    
 neuraminidase   Vibrio cholerae M2140 APF75003.1    
 neuraminidase (NanH)   Vibrio cholerae M66-2 ACP06029.1 C3LNA3  
 neuraminidase (NanH)   Vibrio cholerae M66-2 ACP06029.1 C3LNA3  
 VCD_002587   Vibrio cholerae MJ-1236 ACQ60753.1 C3NPP4  
 VCD_002587   Vibrio cholerae MJ-1236 ACQ60753.1 C3NPP4  
 MS6_1556   Vibrio cholerae MS6 BAP03211.1    
 MS6_1556   Vibrio cholerae MS6 BAP03211.1    
 neuraminidase   Vibrio cholerae NCTC5395 APF79274.1    
 neuraminidase   Vibrio cholerae NCTC5395 APF79274.1    
 neuraminidase (fragment)   Vibrio cholerae NCTC9420 APF83226.1    
 neuraminidase (fragment)   Vibrio cholerae NCTC9420 APF83227.1    
 neuraminidase (fragment)   Vibrio cholerae NCTC9420 APF83227.1    
 neuraminidase (NanH)   Vibrio cholerae O1 biovar El Tor R-5879 AND74814.1    
 neuraminidase (NanH)   Vibrio cholerae O1 biovar El Tor R-5879 AND74814.1    
 VC1784   Vibrio cholerae O1 biovar El Tor str. N16961 AAF94933.1
NP_231419.1
P0C6E9  
 VC1784   Vibrio cholerae O1 biovar El Tor str. N16961 AAF94933.1
NP_231419.1
P0C6E9  
 neuraminidase (NanH)   Vibrio cholerae O1 str. 2010EL-1786 AET26878.1    
 neuraminidase (NanH)   Vibrio cholerae O1 str. 2010EL-1786 AET26878.1    
 N900_05420   Vibrio cholerae O1 str. KW3 ALJ63797.1    
 N900_05420   Vibrio cholerae O1 str. KW3 ALJ63797.1    
 VC0395_A1381   Vibrio cholerae O395 ABQ19703.1
ACP09894.1
A5F7A4  
 VC0395_A1381   Vibrio cholerae O395 ABQ19703.1
ACP09894.1
A5F7A4  
 EN12_08655   Vibrio cholerae TSY216 AKO75305.1    
 EN12_08655   Vibrio cholerae TSY216 AKO75305.1    
 BA953_15595 (fragment)   Vibrio coralliilyticus 58 ANW25509.1    
 BA953_00655   Vibrio coralliilyticus 58 ANW22830.1    
 AL543_04645 (fragment)   Vibrio mimicus ATCC 33654 AMG02312.1    
 VM_15685   Vibrio mimicus SCCF01 AOW84156.1    
 VM_15685   Vibrio mimicus SCCF01 AOW84156.1    
 BA894_20175   Vibrio natriegens CCUG 16374 ANQ28727.1    
 BSZ05_24155   Vibrio shilonii QT6D1 ASI92859.1    
 VEJY3_22196   Vibrio sp. EJY3 AEX24852.1    
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