Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (6329); Uniprot accession (681); PDB accession (152); 3D entries (21); cryst (0)
All (6088) Archaea (1) Bacteria (5613) Eukaryota (431) Viruses (37) unclassified (6) Structure (21) Characterized (97)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07401.1 A0PGB5  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07402.1 A0PGB6  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07403.1 A0PGB7  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07404.1 A0PGB8  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07405.1 A0PGB9  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07406.1 A0PGC0  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07407.1 A0PGC1  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07408.1 A0PGC2  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07409.1 A0PGC3  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07410.1 A0PGC4  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07411.1 A0PGC5  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07412.1 A0PGC6  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07413.1 A0PGC7  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07414.1 A0PGC8  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07415.1 A0PGC9  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07416.1 A0PGD0  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07417.1 A0PGD1  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07418.1 A0PGD2  
 85 kDa surface glycoprotein (fragment)   Trypanosoma cruzi AAT07419.1 A0PGD3  
 amastigote surface protein 2 (Asp-2) (partial)   Trypanosoma cruzi BRAZIL AAC47720.1 P90605  
 shed-acute-phase-antigen (SapA)   Trypanosoma cruzi CAI CAA40511.1 Q00773  
 flagellum-associated protein FL-160-3   Trypanosoma cruzi CL CAA50288.1 Q05507  
 P85.1   Trypanosoma cruzi CL AAD13334.1 O61081  
 P85.2   Trypanosoma cruzi CL AAD13335.1 O61082  
 sialidase 85-1.1 3.2.1.18 Trypanosoma cruzi CL AAA30245.1 P18269  
 sialidase 85-1.2 (fragment)   Trypanosoma cruzi CL CAA37618.1 P18270  
 sialidase SA85-1.2 3.2.1.18 Trypanosoma cruzi CL AAA30246.1 Q03625  
 trans-sialidase-like protein   Trypanosoma cruzi CL ABO28970.1 A4GWE6  
 surface antigen (Gp82) (fragment)   Trypanosoma cruzi CL / G AAF02477.1
AAA21303.1
Q26890
Q9U7F3
 
 trans-sialidase (TcTS;Tc00.1047053509495.30) 2.4.1.- Trypanosoma cruzi CL Brener EAN85580.1    
 amastigote surface protein 3 (Asp-3) (partial)   Trypanosoma cruzi CL Brener ACI02313.1 B5U6T8  
 Tcc1j12.1   Trypanosoma cruzi CL BRENER AAL90887.1 Q8T304  
 Tcc1j12.4   Trypanosoma cruzi CL BRENER AAL90890.1 Q8T301  
 Tcc1j12.5   Trypanosoma cruzi CL BRENER AAL90891.1 Q8T300  
 surface antigen PHGST#5   Trypanosoma cruzi CL BRENER AAC79848.2 O96602  
 TcCLB.506331.90 / Tc00.1047053506331.90   Trypanosoma cruzi CL Brener EAN96369.1    
 trans-sialidase (TcTS-12) 2.4.1.- Trypanosoma cruzi CL BRENER ACF17926.1 B3VSM4  
 trans-sialidase (TcTS-15) 2.4.1.- Trypanosoma cruzi CL BRENER ACF17927.1 B3VSM5  
 trans-sialidase (TcTS-24) 2.4.1.- Trypanosoma cruzi CL BRENER ACF17928.1 B3VSM6  
 trans-sialidase (TcTS-46) 2.4.1.- Trypanosoma cruzi CL BRENER ACF17929.1 B3VSM7  
 trans-sialidase (TcTS-49) 2.4.1.- Trypanosoma cruzi CL BRENER ACF17930.1 B3VSM8  
 trans-sialidase, partial (Tsα-1) (fragment)   Trypanosoma cruzi CL Brenner TSA-1 AID66711.1    
 trans-sialidase, partial (Tsα-1) (fragment)   Trypanosoma cruzi CL Brenner TSA-1 AID66712.1    
 surface protein-2   Trypanosoma cruzi CL-BRENER ABQ53588.1 A5JUX3  
 surface protein-2   Trypanosoma cruzi COLOMBIAN ABQ53589.1 A5JUX4  
 trans-sialidase, partial (Tsα-1) (fragment)   Trypanosoma cruzi Esmeraldo cl3 TSA-1 AID66713.1    
 surface glycoprotein GP90, partial   Trypanosoma cruzi G AAM47176.2    
 GP82-related trans-sialidase   Trypanosoma cruzi G ALO20095.1    
 82-kDa surface antigen   Trypanosoma cruzi G AIY32000.2    
 82-kDa surface antigen, partial (fragment)   Trypanosoma cruzi G ALQ10781.1
APG55778.1
   
 surface antigen GP90, partial   Trypanosoma cruzi G APG55782.1    
 surface protein-2   Trypanosoma cruzi G ABQ53592.1 A5JUX7  
 surface protein-2   Trypanosoma cruzi G ABQ53593.1 A5JUX8  
 stage-specific surface protein (Gp82;SL2)   Trypanosoma cruzi G ABR19835.1
ABR19836.1
AIY31990.1
AIY31992.1
AIY31993.1
AIY31994.1
AIY31995.1
AIY31996.1
AIY31999.1
AIY32000.1
ALQ10780.1
APG55781.1
APG55849.1
A9XBF2  
 82-kDa surface antigen, partial (fragment)   Trypanosoma cruzi G AIY31991.1    
 82-kDa surface antigen, partial (fragment)   Trypanosoma cruzi G AIY31997.1    
 82-kDa surface antigen, partial (fragment)   Trypanosoma cruzi G AIY31998.1    
 surface glycoprotein Gp90   Trypanosoma cruzi G (KINETOPLAST) AAM47176.1 Q8M369  
 surface glycoprotein GP90 (fragment)   Trypanosoma cruzi G (KINETOPLAST) AAM47177.1 Q8M368  
 surface glycoprotein GP90 (fragment)   Trypanosoma cruzi G (KINETOPLAST) AAM47178.1 Q8M367  
 glycoprotein 82 kDa (gp82 subfamily A1) (fragment)   Trypanosoma cruzi H1 BAF74641.1 A7BI39  
 glycoprotein 82 kDa (gp82 subfamily A2) (fragment)   Trypanosoma cruzi H1 BAF74642.1 A7BI40  
 glycoprotein 82 kDa (gp82 subfamily C1) (fragment)   Trypanosoma cruzi H1 BAF74652.1 A7BI50  
 glycoprotein 82 kDa (gp82 subfamily A3) (fragment)   Trypanosoma cruzi H20 BAF74643.1 A7BI41  
 glycoprotein 82 kDa (gp82 subfamily A4) (fragment)   Trypanosoma cruzi H20 BAF74644.1 A7BI42  
 glycoprotein 82 kDa (gp82 subfamily C2) (fragment)   Trypanosoma cruzi H20 BAF74653.1 A7BI51  
 trans-sialidase, partial   Trypanosoma cruzi marinkellei TCC426 AHI17183.1    
 trans-sialidase, partial   Trypanosoma cruzi marinkellei TCC426 AHI17184.1    
 glycoprotein 82 kDa (gp82 subfamily A5) (fragment)   Trypanosoma cruzi PERU1 BAF74645.1 A7BI42  
 glycoprotein 82 kDa (gp82 subfamily B1) (fragment)   Trypanosoma cruzi PERU1 BAF74648.1 A7BI46  
 glycoprotein 82 kDa (gp82 subfamily B2) (fragment)   Trypanosoma cruzi PERU1 BAF74649.1 A7BI47  
 glycoprotein 82 kDa (gp82 subfamily C3) (fragment)   Trypanosoma cruzi PERU1 BAF74654.1 A7BI52  
 glycoprotein 82 kDa (gp82 subfamily A6) (fragment)   Trypanosoma cruzi PERU2 BAF74646.1 A7BI39  
 glycoprotein 82 kDa (gp82 subfamily A7) (fragment)   Trypanosoma cruzi PERU2 BAF74647.1 A7BI45  
 glycoprotein 82 kDa (gp82 subfamily B3) (fragment)   Trypanosoma cruzi PERU2 BAF74650.1 A7BI48  
 glycoprotein 82 kDa (gp82 subfamily B4) (fragment)   Trypanosoma cruzi PERU2 BAF74651.1 A7BI49  
 glycoprotein 82 kDa (gp82 subfamily C4) (fragment)   Trypanosoma cruzi PERU2 BAF74655.1 A7BI52  
 trans-sialidase, partial (Tsα-1) (fragment)   Trypanosoma cruzi Silvio X10 cl1 TSA-1 AID66714.1    
 TcC2-ORF6   Trypanosoma cruzi SYLVIO AAP80764.1 Q7YZX6  
 TcC2-ORF3   Trypanosoma cruzi SYLVIO AAP80761.1 Q7YZX9  
 unknown (fragment)   Trypanosoma cruzi SYLVIO AAP80760.1 Q7YZY0  
 surface protein-2   Trypanosoma cruzi SYLVIO X10/4 ABQ53590.1 A5JUX5  
 trans-sialidase, partial   Trypanosoma cruzi TCC793 AHI17181.1    
 trans-sialidase, partial   Trypanosoma cruzi TCC793 AHI17182.1    
 surface antigen PHGST#5 (fragment)   Trypanosoma cruzi TULAHUEN AAC98688.2 O96579  
 amastigote surface protein 2 (Asp-2) (partial)   Trypanosoma cruzi Tulahuen ADB82626.1 D3KAW2  
 trans-sialidase 2.4.1.- Trypanosoma cruzi TULAHUEN AAA99444.1 Q26969  
 surface protein-2   Trypanosoma cruzi TULAHUEN ABQ53591.1 A5JUX6  
 FL-160-CRP (fragment)   Trypanosoma cruzi Y CL7 CAO78608.1
CAO78611.1
CAO78616.1
A6Q0T2  
 FL-160-CRP (fragment)   Trypanosoma cruzi Y CL7 CAO78609.1
CAO78613.1
A6Q0T3  
 FL-160-CRP (fragment)   Trypanosoma cruzi Y CL7 CAO78610.1 A6Q0T4  
 FL-160-CRP (fragment)   Trypanosoma cruzi Y CL7 CAO78612.1 A6Q0T6  
 FL-160-CRP (fragment)   Trypanosoma cruzi Y CL7 CAO78614.1 A6Q0T8  
 FL-160-CRP (fragment)   Trypanosoma cruzi Y CL7 CAO78615.1 A6Q0T9  
 trans-sialidase (TCTS) 2.4.1.- Trypanosoma cruzi Y-STRAIN CAC34453.1
ABH92692.1
Q9BHJ5  
 trans-sialidase, partial (fragment)   Trypanosoma dionisii TCC211 AHI17188.1    
 trans-sialidase, partial   Trypanosoma dionisii TCC211 AHI17189.1    
 sialidase (TeSA) (partial)   Trypanosoma evansi ACM43506.1 B9VS11  
 trans-sialidase, partial   Trypanosoma evansi AHB33196.1    
 surface glycoprotein (Gp-1)   Trypanosoma rangeli AAY46228.1 Q4W4T2  
 sialidase (TrSA) 3.2.1.18 Trypanosoma rangeli AAC95493.1
AAC95494.1
AAC95495.1
O44049 1MZ5[A]
1MZ6[A]
1N1S[A]
1N1T[A]
1N1V[A]
1N1Y[A]
2A75[A]
2AGS[A]
2FHR[A]
 sialidase 3.2.1.18 Trypanosoma rangeli AAA18835.1 Q08672  
 sialidase (fragment) 3.2.1.18 Trypanosoma rangeli AAC47213.1 Q27063  
 sialidase 3.2.1.18 Trypanosoma rangeli AAC47214.1 Q27064  
 4G07   Trypanosoma rangeli AFX73249.1    
 ORF   Trypanosoma rangeli AGN32966.1    
 ORF   Trypanosoma rangeli AGN32969.1    
 ORF   Trypanosoma rangeli AGN32984.1    
 ORF (fragment)   Trypanosoma rangeli AGN33000.1    
 ORF (fragment)   Trypanosoma rangeli AGN32995.1    
 ORF (fragment)   Trypanosoma rangeli AGN32996.1    
 ORF (fragment)   Trypanosoma rangeli AGN33002.1    
 ORF (fragment)   Trypanosoma rangeli AGN33003.1    
 ORF (fragment)   Trypanosoma rangeli AGN33008.1
AGN33008.2
   
 ORF (fragment)   Trypanosoma rangeli AGN33013.1    
 ORF (fragment)   Trypanosoma rangeli AGN33014.1    
 ORF (fragment)   Trypanosoma rangeli AGN33015.1    
 ORF (fragment)   Trypanosoma rangeli AGN33016.1    
 ORF (fragment)   Trypanosoma rangeli AGN33018.1    
 ORF (fragment)   Trypanosoma rangeli M/CAN/VE/82/DOG82 ACO87648.1 C3U1A4  
 ORF (fragment)   Trypanosoma rangeli M/CAN/VE/82/DOG82 ACO87649.1 C3U1A5  
 TrGP   Trypanosoma rangeli M/CAN/VE/82/DOG82 ACO87650.1 C3U1A6  
 TrGP   Trypanosoma rangeli M/CAN/VE/82/DOG82 ACO87651.1 C3U1A7  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87640.1 C3U196  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87641.1 C3U197  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87642.1 C3U198  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87643.1 C3U199  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87653.1 C3U1A9  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87654.1 C3U1B0  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87655.1 C3U1B1  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87656.1 C3U1B2  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87657.1 C3U1B3  
 trans-sialidase, partial   Trypanosoma rangeli TCC012 AHI17190.1    
 TVY486_0706570 (fragment)   Trypanosoma vivax Y486 CCC49342.1    
 TVY486_0806830   Trypanosoma vivax Y486 CCC50076.1    
 VIGAN_02083000 (Vigan.02g083000) (fragment)   Vigna angularis var. angularis BAT78183.1    
 VIGAN_01471600 (Vigan.01g471600)   Vigna angularis var. angularis BAT76676.1    
 VIGAN_01471500 (Vigan.01g471500)   Vigna angularis var. angularis BAT76675.1    
 DEO72_LG2g758   Vigna unguiculata QCD80437.1    
 DEO72_LG2g758   Vigna unguiculata QCD80437.1    
 Unknown (protein for MGC:81958)   Xenopus laevis AAH74168.1 Q6GMA3  
 Unknown (MGC:181090 IMAGE:8886027)   Xenopus tropicalis PopA AAI60978.1 B1H2F2  
 sialidase 4 (Neu4)   Xiphophorus maculatus BBH51368.1    
 unknown (fragment)   Zea mays ACG41080.1 B6TVE7  
 unknown   Zea mays ACG24666.1
ACN25581.1
   
 unknown (ZM_BFb0001J07) (fragment)   Zea mays B73 ACF79583.1 B4FBU0  
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 GH33, Sialidase   uncultured organism VDS02533.1    
 GH33, Sialidase   uncultured organism VDS02708.1    
 GH33, Sialidase   uncultured organism VDS02649.1    
 GH33, Sialidase   uncultured organism VDS02612.1    
 GH33, Sialidase   uncultured organism VDS02618.1    
 GH33, Sialidase   uncultured organism VDS02578.1    
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 sialidase (Orf1)   Avirulent turkey hemorrhagic enteritis virus VIRGINIA AAX51169.2 Q2TLE1  
 ORF   Corella adenovirus 1 QHB43554.1    
 EhV145_00535   Emiliania huxleyi virus 145 EhV-145 AHA55084.1    
 EhV164_00500   Emiliania huxleyi virus 164 EhV-164 AHA56087.1    
 ENVG_00100   Emiliania huxleyi virus 84 AEO97996.1    
 EOVG_00151   Emiliania huxleyi virus 88 AEP15088.1    
 ORF   Emiliania huxleyi virus 99B1 CAZ69785.1 D2TEV5  
 EhV455   Emiliania huxleyi virus sp. 86 CAI65882.1    
 tail fibers protein   Escherichia phage FEC14 ATW66765.1    
 sialidase 3.2.1.18 Frog adenovirus 1 AAF86921.1
NP_062432.1
Q9III6  
 HCTV5_112   Halovirus HCTV-5 AGM11720.1    
 ORF   Myoviridae environmental samples AVQ10309.1    
 sialidase   Psittacine siadenovirus C QIJ58771.1    
 sialidase   Raptor siadenovirus A AEC32095.1    
 SP029_00952   Salmonella phage FSL SP-029 AGF89170.1    
 SP063_01027   Salmonella phage FSL SP-063 AGF88656.1    
 sialidase   Siadenovirus IDL19-3602 QER78594.1    
 sialidase   Skua siadenovirus A ADP30811.1    
 ORF1, partial   Turkey adenovirus 3 ARC53086.1    
 ORF1, partial   Turkey adenovirus 3 ARC53088.1    
 ORF1, partial   Turkey adenovirus 3 ARC53098.1    
 ORF1, partial   Turkey adenovirus 3 ARC53093.1    
 ORF1, partial   Turkey adenovirus 3 ARC53095.1    
 ORF1, partial   Turkey adenovirus 3 ARC53090.1    
 ORF1, partial   Turkey adenovirus 3 ARC53094.1    
 ORF1, partial   Turkey adenovirus 3 ARC53092.1    
 ORF1, partial   Turkey adenovirus 3 ARC53084.1    
 ORF1, partial   Turkey adenovirus 3 ARC53096.1    
 ORF1, partial   Turkey adenovirus 3 ARC53085.1    
 ORF1, partial   Turkey adenovirus 3 ARC53087.1    
 ORF1, partial   Turkey adenovirus 3 ARC53097.1    
 ORF1, partial   Turkey adenovirus 3 ARC53082.1    
 ORF1, partial   Turkey adenovirus 3 ARC53089.1    
 ORF1, partial   Turkey adenovirus 3 ARC53091.1    
 ORF1, partial   Turkey adenovirus 3 ARC53083.1    
 ORF1   Turkey adenovirus 3 AAC64539.1
NP_047379.1
Q9YUS1  
 ORF1   Turkey adenovirus 3 ABI23691.1
ABI23694.1
ABI23697.1
ABI23700.1
ABI23703.1
ABI23706.1
ABI23709.1
ABI23712.1
ABI23715.1
ABI23718.1
Q0GF95  
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