Glycoside Hydrolase Family 30 / Subf 8

Activities in Familyendo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (3.2.1.21); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); glucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); glucuronoarabinoxylan endo-β-1,4-xylanase (EC 3.2.1.136); endo-β-1,6-galactanase (EC:3.2.1.164); [reducing end] β-xylosidase (EC 3.2.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (inferred)
NoteFollowing St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resourcesCAZypedia; Gaucher Disease; PRINTS;
Statistics GenBank accession (374); Uniprot accession (50); PDB accession (18); 3D entries (6); cryst (0)
Bacteria
Protein Name EC# OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 glucuronoxylan xylanohydrolase (feraxanase) / xylanase C (XynC;YnfF;BSU18150) 3.2.1.136
3.2.1.8
Bacillus subtilis subsp. subtilis str. 168 CAA97612.1
AIY93125.1
AQR81806.1
AQR86020.1
CAB13698.1
NP_389697.1
Q45070
3GTN[A,B] 2.68
3KL0[A,B,C,D] 1.64
3KL3[A,B,C,D] α-D-GlcpA
β-D-GlcpA
2.33
3KL5[A,B,C,D] α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-1)-<non_carb>
α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-4)-β-D-Xylp
2.59
8
 xylanase (CAP0119) (Xyn30A) 3.2.1.8 Clostridium acetobutylicum ATCC 824 AAK76864.1
NP_149282.1
Q97TI2
5CXP[A] 1.77
8
 endo-β-1,4-xylanase (C7I;CpC7I;CpXyn30A;Cpap_2855) (Xyn30A) 3.2.1.8 Clostridium papyrosolvens DSM 2782 EGD48159.1  
4FMV[A] 2.01
8
 glucuronoxylanase / glucuronoxylan-specific endo-β-1,4-xylanase (XynA) 3.2.1.136
3.2.1.8
Dickeya chrysanthemi D1 AAB53151.1 Q46961
1NOF[A] 1.42
2Y24[A] β-D-Xylp-(1-4)[α-D-GlcpA4Me-(1-2)]-β-D-Xylp-(1-4)-β-D-Xylp
1.39
8
 glucuronoxylan-specific xylanase (Xyn30D) 3.2.1.136 Paenibacillus barcinonensis BP-23 AEY82463.1  
4QAW[A,B,C,D,E,F,G,H] 2.40
8
 glucuronoxylan xylanohydrolase (CtXyn30;CtXynGH30;Cthe_3012) (Xyn30A)   Ruminiclostridium thermocellum ATCC 27405 ABN54208.1 A3DJS9
4CKQ[A] 1.40
4UQ9[A] 1.77
4UQA[A] 1.52
4UQB[A] 1.68
4UQC[A] D-1,4-deoxy-Glcp
1.30
4UQD[A] 1.25
4UQE[A] 1.28
5A6L[A] β-D-Xylp-(1-4)-β-D-Xylp
1.80
5A6M[A] β-D-Xylp-(1-4)-β-D-Xylp
1.17
8
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