Glycoside Hydrolase Family 30 / Subf 7

Activities in Sub Family	non-reducing end-specific xylobiohydrolase (EC 3.2.1.-);glucuronoxylan endo-β-1,4-xylanase (EC 3.2.1.-);[inverting] oligosaccharide reducing-end xylanase (EC 3.2.1.156);xylan β-1,4-xylosidase (EC 3.2.1.37);endo-β-1,4-xylanase (EC 3.2.1.8)
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) ₈ barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (inferred)
Note	Following St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resources	CAZypedia; Gaucher Disease; PRINTS;
Statistics	GenBank accession (117); Uniprot accession (5); PDB accession (6); 3D entries (4); cryst (1)


Eukaryota
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
exo-β-1,4-xylanase (XylD) (acidic)	3.2.1.37	pubmed	Bispora sp. MEY-1	ADG62369.1	D6MYS9		7
glucuronoxylanase A (Xyn30A; TCE0_047r17950) (Xyn30A)	3.2.1.156	pubmed	Talaromyces cellulolyticus Y-94	GAM43270.1			7
bifunctional endo-glucuronoxylanase and exo-xylobiohydrolase (TcXyn30B) B (Xyn30B; TCE0_018f06110) (Xyn30B)	3.2.1.37 3.2.1.-	pubmed pubmed	Talaromyces cellulolyticus Y-94	GAM36763.1	A0A510NXC4	6IUJ[A,B] 6KRL[A] 6KRN[A]	7
endoxylanase C (TcXyn30C; TCE0_039f12750)	3.2.1.8	pubmed	Talaromyces cellulolyticus Y-94	GAM40414.1	A0A6N4SL16	6M5Z[A,B]	7
endo-β-1,4-xylanase active on arabinoxylan and glucuronoxylan (XynC; XYNC; GH30)	3.2.1.8	pubmed	Talaromyces purpureogenus ATCC MYA-38	AKH40280.1	A0A0F7KIJ8		7
endo-β-1,4-xylanase (TtXyn30A; MYCTH_38558)	3.2.1.8 3.2.1.-	pubmed pubmed	Thermothelomyces thermophilus ATCC 42464	AEO55025.1 G2Q1N4.1		7NCX[A] 7O0E[A,B]	7
glucuronoxylan hydrolase (xylanase cleaving 4-Me-GlcA or GlcA-substituted xylan; TRIREDRAFT_69276)	3.2.1.-	pubmed	Trichoderma reesei QM6a	EGR45006.1	G0RV92		7
exo-xylanase IV (Xyn4;XYN IV)	3.2.1.156	pubmed	Trichoderma reesei Rut C30	AAP64786.1 AAV25955.1		cryst	7
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