Glycoside Hydrolase Family 30 / Subf 1

Activities in Familyendo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (3.2.1.21); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); glucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); glucuronoarabinoxylan endo-β-1,4-xylanase (EC 3.2.1.136); endo-β-1,6-galactanase (EC:3.2.1.164); [reducing end] β-xylosidase (EC 3.2.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (inferred)
NoteFollowing St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resourcesCAZypedia; Gaucher Disease; PRINTS;
Statistics GenBank accession (424); Uniprot accession (56); PDB accession (24); 3D entries (2); cryst (0)
Bacteria
Protein Name EC# OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 STM4426 (SrfJ)   Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 AAL23246.1
NP_463287.1
H9L4C2
Q9KIJ7
2WNW[A,B] 2.00
1
Eukaryota
Protein Name EC# OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 acid β-glucosidase 1 / β-glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal) 3.2.1.45 Homo sapiens ASU47376.1
AAA35873.1
AAA35877.1
AAA35880.1
AAC51820.1
AAC63056.1
AAH03356.1
AAQ41981.1
AAQ41982.1
AAT13636.1
AAT13637.1
AAV20581.1
AAY03281.1
AAY03324.1
ABL21565.1
ACH14936.1
ACJ92748.1
ACM85831.1
ACM97663.1
AID60277.1
AID60278.1
AID60279.1
AID60280.1
ASU47376.1
BAA02545.1
BAF84600.1
BAG58248.1
BAG60020.1
BAH12898.1
BAH13232.1
BAH13357.1
BAH13365.1
BAH13467.1
BAH13605.1
CAC41172.1
CAC41173.1
CAD12720.1
CAD12721.1
CAE85438.1
CAI95090.1
NP_000148.1
B2R6A7
P04062
1OGS[A,B] 2.0
1Y7V[A,B] <carb_like_INS>
2.40
2F61[A,B] 2.50
2J25[A,B] 2.9
2NSX[A,B,C,D] <carb_like_IFM>
2.11
2NT0[A,B,C,D] D-1-deoxy-GlcpNAc
1.79
2NT1[A,B,C,D] 2.30
2V3D[A,B] <carb_like_NBV>
1.96
2V3E[A,B] <carb_like_NND>
2.00
2V3F[A,B] 1.95
2VT0[A,B] <carb_like_CBU>
2.15
2WCG[A,B] <carb_like_MT5>
2.30
2WKL[A,B] 2.70
2XWD[A,B] <carb_like_LGS>
2.66
2XWE[A,B] <carb_like_AMF>
2.31
3GXD[A,B,C,D] 2.50
3GXF[A,B,C,D] <carb_like_IFM>
2.40
3GXI[A,B,C,D] 1.84
3GXM[A,B,C,D] 2.20
3KE0[A,B] 2.70
3KEH[A,B] 2.80
3RIK[A,B,C,D] <carb_like_3RI>
2.48
3RIL[A,B,C,D] <carb_like_3RK>
2.40
1
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