Activities in Family	endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (3.2.1.21); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); glucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); glucuronoarabinoxylan endo-β-1,4-xylanase (EC 3.2.1.136); endo-β-1,6-galactanase (EC:3.2.1.164); [reducing end] β-xylosidase (EC 3.2.1.-)
	Activities in Sub Family
Mechanism	Retaining
Clan	GH-A
3D Structure Status	( β / α ) 8
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (inferred)
Note	Following St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resources	CAZypedia; Gaucher Disease; PRINTS;
Statistics	GenBank accession (400); Uniprot accession (56); PDB accession (24); 3D entries (2); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
STM4426 (SrfJ)		Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	AAL23246.1 NP_463287.1	H9L4C2 Q9KIJ7	2WNW[A,B] 2.00	1
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
acid β-glucosidase 1 / β-glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal)	3.2.1.45	Homo sapiens	AAA35880.1 AAA35873.1 AAA35877.1 AAC51820.1 AAC63056.1 AAH03356.1 AAQ41981.1 AAQ41982.1 AAT13636.1 AAT13637.1 AAV20581.1 AAY03281.1 AAY03324.1 ABL21565.1 ACH14936.1 ACJ92748.1 ACM85831.1 ACM97663.1 AID60277.1 AID60278.1 AID60279.1 AID60280.1 BAA02545.1 BAF84600.1 BAG58248.1 BAG60020.1 BAH12898.1 BAH13232.1 BAH13357.1 BAH13365.1 BAH13467.1 BAH13605.1 CAC41172.1 CAC41173.1 CAD12720.1 CAD12721.1 CAE85438.1 CAI95090.1 NP_000148.1	B2R6A7 P04062	1OGS[A,B] 2.0 1Y7V[A,B] <carb_like_INS> 2.40 2F61[A,B] 2.50 2J25[A,B] 2.9 2NSX[A,B,C,D] <carb_like_IFM> 2.11 2NT0[A,B,C,D] D-1-deoxy-GlcpNAc 1.79 2NT1[A,B,C,D] 2.30 2V3D[A,B] <carb_like_NBV> 1.96 2V3E[A,B] <carb_like_NND> 2.00 2V3F[A,B] 1.95 2VT0[A,B] <carb_like_CBU> 2.15 2WCG[A,B] <carb_like_MT5> 2.30 2WKL[A,B] 2.70 2XWD[A,B] <carb_like_LGS> 2.66 2XWE[A,B] <carb_like_AMF> 2.31 3GXD[A,B,C,D] 2.50 3GXF[A,B,C,D] <carb_like_IFM> 2.40 3GXI[A,B,C,D] 1.84 3GXM[A,B,C,D] 2.20 3KE0[A,B] 2.70 3KEH[A,B] 2.80 3RIK[A,B,C,D] <carb_like_3RI> 2.48 3RIL[A,B,C,D] <carb_like_3RK> 2.40	1
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