Activities in Sub Family	β-1,6-glucosidase (EC 3.2.1.-); β-glucosidase (EC 3.2.1.21); β-glucosylceramidase (EC 3.2.1.45);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (inferred)
Note	Following St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resources	CAZypedia; Gaucher Disease; PRINTS;
Statistics	GenBank accession (44); Uniprot accession (16); PDB accession (48); 3D entries (2); cryst (0)

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Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
ALNC14_004340 (Alnc14c3g399)		Albugo laibachii Nc14	CCA14291.1			1
ORF		Amblyomma maculatum	AEO33650.1			1
ORF (fragment)		Amblyomma maculatum	AEO33785.1			1
ACCB10581		Apis cerana	AEY60937.1			1
ACCB00404.2 (fragment)		Apis cerana	AEY57789.1			1
ACCB00404.3 (fragment)		Apis cerana	AEY57790.1			1
ORF		Ascaris suum	ADY44488.1			1
BEMITA_ LOCUS 10194		Bemisia tabaci	CAH0391594.1			1
Unknown (protein for MGC:137522)		Bos taurus	AAI12824.1			1
MELIAE_ LOCUS 713		Brassicogethes aeneus	CAH0546585.1			1
MELIAE_ LOCUS 438		Brassicogethes aeneus	CAH0546229.1			1
MELIAE_ LOCUS 2626		Brassicogethes aeneus	CAH0549499.1			1
MELIAE_ LOCUS 2480		Brassicogethes aeneus	CAH0549286.1			1
MELIAE_ LOCUS 2626		Brassicogethes aeneus	CAH0549500.1			1
MELIAE_ LOCUS 6726		Brassicogethes aeneus	CAH0555326.1			1
MELIAE_ LOCUS 6726 (fragment)		Brassicogethes aeneus	CAH0555327.1			1
MELIAE_ LOCUS 3963		Brassicogethes aeneus	CAH0551326.1			1
BINO364_ LOCUS 1013		Brenthis ino	CAH0713913.1			1
BINO364_ LOCUS 7595		Brenthis ino	CAH0721502.1			1
L3Y34_002840		Caenorhabditis briggsae isolate QX1410_ONT	ULT92931.1			1
L3Y34_003676		Caenorhabditis briggsae isolate QX1410_ONT	ULT94361.1			1
L3Y34_019626		Caenorhabditis briggsae isolate QX1410_ONT	ULU08548.1			1
L3Y34_019630		Caenorhabditis briggsae isolate QX1410_ONT	ULU08557.1			1
C33C12.3		Caenorhabditis elegans Bristol N2	CCD66449.1 AAB66056.2 ABV68956.1 CCD66450.1 NP_494207.1			1
C33C12.8		Caenorhabditis elegans Bristol N2	AAB66060.1 AAB66060.2 CCD66456.1 NP_494208.1			1
F11E6.1		Caenorhabditis elegans Bristol N2	CAC35807.1 CAA20283.1 CAB02924.1 CAC35813.1 CAD42642.1 CCD31056.1 NP_503118.1 NP_741501.1			1
Y4C6B.6		Caenorhabditis elegans Bristol N2	AAD14768.2 CCD71128.1 NP_500785.1			1
3314		Cafeteria roenbergensis BVI (Cafroe1)				1
ORF (fragment)		Callorhinchus milii	AFP09131.1			1
CEUTPL_ LOCUS 4600		Ceutorhynchus assimilis	CAG9763952.1			1
CHILSU_ LOCUS 5895		Chilo suppressalis	CAH0402649.1			1
CHILSU_ LOCUS 5896 (fragment)		Chilo suppressalis	CAH0402650.1			1
CHILSU_ LOCUS 5897		Chilo suppressalis	CAH0402651.1			1
CHILSU_ LOCUS 5898		Chilo suppressalis	CAH0402652.1			1
CHILSU_ LOCUS 677		Chilo suppressalis	CAH0397603.1			1
CHIRRI_ LOCUS 10081		Chironomus riparius	CAG9807232.1			1
168499		Chrysochromulina tobin CCMP291 (Chrsp_1)				1
181010		Chrysochromulina tobin CCMP291 (Chrsp_1)				1
178616		Chrysochromulina tobin CCMP291 (Chrsp_1)				1
168500		Chrysochromulina tobin CCMP291 (Chrsp_1)				1
171643		Chrysochromulina tobin CCMP291 (Chrsp_1)				1
CINC_ LOCUS 6813		Chrysodeixis includens	CAH0595440.1			1
CINC_ LOCUS 6814 (fragment)		Chrysodeixis includens	CAD0204506.1			1
CINC_ LOCUS 6815		Chrysodeixis includens	CAD0204507.1			1
CINC_ LOCUS 6816		Chrysodeixis includens	CAD0204508.1			1
CINC_ LOCUS 12947		Chrysodeixis includens	CAH0628675.1			1
381796		Ciona intestinalis (Cioin2)				1
214652		Ciona intestinalis (Cioin2)				1
CEUR_LOCUS2963		Colias eurytheme	CAG4933580.1			1
CTOB1V02_LOCUS6254		Cyprideis torosa	CAD7228370.1			1
DSTB1V02_LOCUS2108 (fragment)		Darwinula stevensoni	CAD7242137.1			1
DSTB1V02_LOCUS2107 (fragment)		Darwinula stevensoni	CAD7242136.1			1
DSTB1V02_LOCUS5950		Darwinula stevensoni	CAD7246088.1			1
DSTB1V02_LOCUS2106		Darwinula stevensoni	CAD7242135.1			1
DSTB1V02_LOCUS6040		Darwinula stevensoni	CAD7246183.1			1
unknown		Dendroctonus ponderosae	AEE63066.1			1
DIABBA_ LOCUS 7588 (fragment)		Diabrotica balteata	CAG9834260.1			1
DIABBA_ LOCUS 750		Diabrotica balteata	CAG9826650.1			1
DIABBA_ LOCUS 1660		Diabrotica balteata	CAG9827677.1			1
DIABBA_ LOCUS 10802		Diabrotica balteata	CAH1283300.1			1
DIABBA_ LOCUS 10803		Diabrotica balteata	CAH1283301.1			1
DIABBA_ LOCUS 8618		Diabrotica balteata	CAG9835425.1			1
DIABBA_ LOCUS 10805 (fragment)		Diabrotica balteata	CAG9837854.1			1
DIABBA_ LOCUS 10804		Diabrotica balteata	CAG9837853.1			1
DIATSA_ LOCUS 9217 (fragment)		Diatraea saccharalis	CAG9791613.1			1
DIATSA_ LOCUS 9218 (fragment)		Diatraea saccharalis	CAG9791614.1			1
DIATSA_ LOCUS 9216 (fragment)		Diatraea saccharalis	CAG9791612.1			1
DIATSA_ LOCUS 9722		Diatraea saccharalis	CAG9792167.1			1
Dbus_chr3Rg593		Drosophila busckii	ALC45843.1			1
Dbus_chr3Rg594		Drosophila busckii	ALC45844.1			1
CG31414		Drosophila melanogaster	AAN13955.3 AAN13955.1 AAN13955.2 AAY55431.1 AAY55467.1 AAY55519.1 AGB96260.1 NP_732892.1			1
CG31148		Drosophila melanogaster	AAF56165.2 AAL28266.1 NP_651172.1			1
26592		Ectocarpus siliculosus Ec 32 (Ectsil1)				1
glucocerebrosidase 1 (Gba1)		Emiliania huxleyi	AID57155.1			1
61724		Emiliania huxleyi (Emihu1)				1
64183		Emiliania huxleyi (Emihu1)				1
156475		Fragilariopsis cylindrus CCMP 1102 (Fracy1)				1
GMON_LOCUS9108		Gordionus sp. m RMFG-2023	CAK9303554.1			1
HERILL_LOCUS7854		Hermetia illucens	CAD7084986.1			1
acid β-glucosidase 1 / β-glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal)	3.2.1.45	Homo sapiens	AAA35880.1 AAA35873.1 AAA35877.1 AAC51820.1 AAC63056.1 AAH03356.1 AAQ41981.1 AAQ41982.1 AAT13636.1 AAT13637.1 AAV20581.1 AAY03281.1 AAY03324.1 ABL21565.1 ACH14936.1 ACJ92748.1 ACM85831.1 ACM97663.1 AID60277.1 AID60278.1 AID60279.1 AID60280.1 ASU47376.1 BAA02545.1 BAF84600.1 BAG58248.1 BAG60020.1 BAH12898.1 BAH13232.1 BAH13357.1 BAH13365.1 BAH13467.1 BAH13605.1 CAC41172.1 CAC41173.1 CAD12720.1 CAD12721.1 CAE85438.1 CAI95090.1 NP_000148.1 SJX47168.1	A0A068F579 A0A068F658 A0A068F753 A0A068FB60 A0A223PQI4 B2R6A7 B4DHT6 B4DMV8 B7Z6E6 B7Z6S9 B7Z731 B7Z7G9 P04062	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	1
GBA (pseudogene) (fragment)		Homo sapiens	AID60282.1 AAH00349.2 AAH30240.1 AAH92482.1 AID60281.1 BAA02546.1 BAG52175.1 CAI95088.1 XP_034493.1			1
ORF		Hyalophora cecropia	WWE94447.1			1
ORF		Hyalophora cecropia	WWE94500.1			1
8302		Hyphochytrium catenoides ATCC 18719 (Hypcat1)				1
17597		Hyphochytrium catenoides ATCC 18719 (Hypcat1)				1
ORF (GbA)		Ictalurus punctatus	AHH39476.1			1
ORF (GbA)		Ictalurus punctatus	AHH42685.1			1
IPOD504_ LOCUS 12350		Iphiclides podalirius	CAH2063031.1			1
IPOD504_ LOCUS 8017 (fragment)		Iphiclides podalirius	CAH2051961.1			1
IPOD504_ LOCUS 8016		Iphiclides podalirius	CAH2051960.1			1
IPOD504_ LOCUS 7955		Iphiclides podalirius	CAH2051818.1			1
IPOD504_ LOCUS 8018 (fragment)		Iphiclides podalirius	CAH2051962.1			1
IPOD504_ LOCUS 8018 (fragment)		Iphiclides podalirius	CAH2051962.1			1
6819		Labyrinthula sp. SR_Ha_C (LabyHa_1)				1
LSINAPIS_LOCUS3356 (fragment)		Leptidea sinapis	VUY90489.1			1
LSINAPIS_LOCUS3356 (fragment)		Leptidea sinapis	VUY90488.1			1
LSINAPIS_LOCUS3356 (fragment)		Leptidea sinapis	VUY90487.1			1
LSINAPIS_LOCUS3356 (fragment)		Leptidea sinapis	VUY90490.1			1
LSINAPIS_LOCUS3364		Leptidea sinapis	VUY90498.1			1
glucosylceramidase isoform 1 precursor (GbA)		Macaca mulatta	AFE77708.1 AFH31940.1			1
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