Glycoside Hydrolase Family 30 / Subf 1

Activities in Familyendo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (3.2.1.21); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); glucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); glucuronoarabinoxylan endo-β-1,4-xylanase (EC 3.2.1.136); endo-β-1,6-galactanase (EC:3.2.1.164); [reducing end] β-xylosidase (EC 3.2.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (inferred)
NoteFollowing St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resourcesCAZypedia; Gaucher Disease; PRINTS;
Statistics GenBank accession (424); Uniprot accession (56); PDB accession (24); 3D entries (2); cryst (0)
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 ALNC14_004340 (Alnc14c3g399)   Albugo laibachii Nc14 CCA14291.1     1
 ORF (partial)   Amblyomma maculatum AEO33650.1     1
 ORF (fragment)   Amblyomma maculatum AEO33785.1     1
 ACCB10581   Apis cerana AEY60937.1     1
 ACCB00404.2 (fragment)   Apis cerana AEY57789.1     1
 ACCB00404.3 (fragment)   Apis cerana AEY57790.1     1
 ORF   Ascaris suum ADY44488.1     1
 Unknown (protein for MGC:137522)   Bos taurus AAI12824.1 Q2KHZ8   1
 Unknown (protein for MGC:137522)   Bos taurus AAI12824.1 Q2KHZ8   1
 C33C12.3   Caenorhabditis elegans Bristol N2 CCD66449.1
AAB66056.2
ABV68956.1
CCD66450.1
NP_494207.1
O16580   1
 C33C12.8   Caenorhabditis elegans Bristol N2 AAB66060.1
AAB66060.2
CCD66456.1
NP_494208.1
O16581   1
 F11E6.1   Caenorhabditis elegans Bristol N2 CAC35807.1
CAA20283.1
CAB02924.1
CAC35813.1
CAD42642.1
CCD31056.1
NP_503118.1
NP_741501.1
G5EFK0
Q9BH43
Q9XTB0
  1
 Y4C6B.6   Caenorhabditis elegans Bristol N2 AAD14768.2
CCD71128.1
NP_500785.1
Q9UB00   1
 ORF (fragment)   Callorhinchus milii AFP09131.1     1
 unknown   Dendroctonus ponderosae AEE63066.1     1
 Dbus_chr3Rg593   Drosophila busckii ALC45843.1     1
 Dbus_chr3Rg594   Drosophila busckii ALC45844.1     1
 CG31414   Drosophila melanogaster AAN13955.3
AAN13955.1
AAN13955.2
AAY55431.1
AAY55467.1
AAY55519.1
AGB96260.1
NP_732892.1
Q8IMY3   1
 CG31148   Drosophila melanogaster AAF56165.2
AAL28266.1
NP_651172.1
Q9VCJ4   1
 glucocerebrosidase 1 (Gba1)   Emiliania huxleyi AID57155.1     1
 acid β-glucosidase 1 / β-glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal) 3.2.1.45 Homo sapiens ASU47376.1
AAA35873.1
AAA35877.1
AAA35880.1
AAC51820.1
AAC63056.1
AAH03356.1
AAQ41981.1
AAQ41982.1
AAT13636.1
AAT13637.1
AAV20581.1
AAY03281.1
AAY03324.1
ABL21565.1
ACH14936.1
ACJ92748.1
ACM85831.1
ACM97663.1
AID60277.1
AID60278.1
AID60279.1
AID60280.1
ASU47376.1
BAA02545.1
BAF84600.1
BAG58248.1
BAG60020.1
BAH12898.1
BAH13232.1
BAH13357.1
BAH13365.1
BAH13467.1
BAH13605.1
CAC41172.1
CAC41173.1
CAD12720.1
CAD12721.1
CAE85438.1
CAI95090.1
NP_000148.1
B2R6A7
P04062
1OGS[A,B]
1Y7V[A,B]
2F61[A,B]
2J25[A,B]
2NSX[A,B,C,D]
2NT0[A,B,C,D]
2NT1[A,B,C,D]
2V3D[A,B]
2V3E[A,B]
2V3F[A,B]
2VT0[A,B]
2WCG[A,B]
2WKL[A,B]
2XWD[A,B]
2XWE[A,B]
3GXD[A,B,C,D]
3GXF[A,B,C,D]
3GXI[A,B,C,D]
3GXM[A,B,C,D]
3KE0[A,B]
3KEH[A,B]
3RIK[A,B,C,D]
3RIL[A,B,C,D]
1
 GBA (pseudogene)   Homo sapiens AAH92482.1
AAH00349.2
AAH30240.1
AID60281.1
AID60282.1
BAA02546.1
BAG52175.1
CAI95088.1
XP_034493.1
    1
 ORF (GbA)   Ictalurus punctatus AHH39476.1     1
 ORF (GbA)   Ictalurus punctatus AHH42685.1     1
 glucosylceramidase isoform 1 precursor (GbA)   Macaca mulatta AFE77708.1
AFH31940.1
    1
 glucosylceramidase isoform 1 precursor (GbA)   Macaca mulatta AFJ72033.1     1
 β-glucosidase 1 / β-glucocerebrosidase (Gba;GBA;Gba1) 3.2.1.45 Mus musculus AAA37671.1
AAH06663.1
AAM66757.1
BAC38609.1
NP_032120.1
P17439   1
 ORF   Musca domestica ALHF AFP62917.1     1
 acid β-glucosidase   Mustela putorius furo AER98953.1     1
 RNA-dependent DNA polymerase (GbA)   Oryzias latipes CDW61513.1     1
 glucocerebrosidase (Gba)   Pan troglodytes AAK18162.1 Q9BDT0   1
 glucocerebrosidase (Gba)   Pan troglodytes AAK18162.1 Q9BDT0   1
 ORF (fragment)   Papilio xuthus BAM18760.1     1
 β-glucosidase / β-xylosidase (Bgx1) 3.2.1.21
3.2.1.37
Phytophthora infestans 88069 AAK19754.1 Q9AT27   1
 DKFZp469B0323   Pongo abelii CAH90774.1 Q5R8E3   1
 DKFZp469K1734   Pongo abelii CAH91967.1 Q5R8E3   1
 DKFZp469K1734   Pongo abelii CAH91967.1 Q5R8E3   1
 Unknown protein for MGC:188451   Rattus norvegicus AAI66732.1 B2RYC9   1
 SRAE_2000264000   Strongyloides ratti ED321 Heterogonic CEF67979.1     1
 GBA   Sus scrofa CAE06498.1 Q70KH2   1
 GBA   Sus scrofa CAE06498.1 Q70KH2   1
 GH30   Tisochrysis lutea AHW52384.1     1
 MGC84284 (fragment)   Xenopus laevis AAH81165.1 Q66IW2   1
 glucocerebrosidase (Zfgba1)   Zygaena filipendulae SGZ49395.1     1
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