| Activities in Family | endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (3.2.1.21); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); glucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); glucuronoarabinoxylan endo-β-1,4-xylanase (EC 3.2.1.136); endo-β-1,6-galactanase (EC:3.2.1.164); [reducing end] β-xylosidase (EC 3.2.1.-) |
|---|---|
| Activities in Sub Family | |
| Mechanism | Retaining |
| Clan | GH-A |
| 3D Structure Status | ( β / α ) 8 |
| Catalytic Nucleophile/Base | Glu (experimental) |
| Catalytic Proton Donor | Glu (inferred) |
| Note | Following St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated. |
| External resources | CAZypedia; Gaucher Disease; PRINTS; |
| Statistics | GenBank accession (400); Uniprot accession (56); PDB accession (24); 3D entries (2); cryst (0) |
| Eukaryota | ||||||||
| Protein Name | EC# | Organism | GenBank | Uniprot | PDB/3D | Subf | ||
| ALNC14_004340 (Alnc14c3g399) | Albugo laibachii Nc14 | CCA14291.1 | 1 | |||||
| ORF (partial) | Amblyomma maculatum | AEO33650.1 | 1 | |||||
| ORF (fragment) | Amblyomma maculatum | AEO33785.1 | 1 | |||||
| ACCB10581 | Apis cerana | AEY60937.1 | 1 | |||||
| ACCB00404.2 (fragment) | Apis cerana | AEY57789.1 | 1 | |||||
| ACCB00404.3 (fragment) | Apis cerana | AEY57790.1 | 1 | |||||
| ORF | Ascaris suum | ADY44488.1 | 1 | |||||
| Unknown (protein for MGC:137522) | Bos taurus | AAI12824.1 | Q2KHZ8 | 1 | ||||
| Unknown (protein for MGC:137522) | Bos taurus | AAI12824.1 | Q2KHZ8 | 1 | ||||
| C33C12.3 | Caenorhabditis elegans Bristol N2 | CCD66449.1 AAB66056.2 ABV68956.1 CCD66450.1 NP_494207.1 |
O16580 | 1 | ||||
| C33C12.8 | Caenorhabditis elegans Bristol N2 | AAB66060.1 AAB66060.2 CCD66456.1 NP_494208.1 |
O16581 | 1 | ||||
| F11E6.1 | Caenorhabditis elegans Bristol N2 | CAC35807.1 CAA20283.1 CAB02924.1 CAC35813.1 CAD42642.1 CCD31056.1 NP_503118.1 NP_741501.1 |
G5EFK0 Q9BH43 Q9XTB0 |
1 | ||||
| Y4C6B.6 | Caenorhabditis elegans Bristol N2 | AAD14768.2 CCD71128.1 NP_500785.1 |
Q9UB00 | 1 | ||||
| ORF (fragment) | Callorhinchus milii | AFP09131.1 | 1 | |||||
| unknown | Dendroctonus ponderosae | AEE63066.1 | 1 | |||||
| Dbus_chr3Rg593 | Drosophila busckii | ALC45843.1 | 1 | |||||
| Dbus_chr3Rg594 | Drosophila busckii | ALC45844.1 | 1 | |||||
| CG31414 | Drosophila melanogaster | AAN13955.3 AAN13955.1 AAN13955.2 AAY55431.1 AAY55467.1 AAY55519.1 AGB96260.1 NP_732892.1 |
Q8IMY3 | 1 | ||||
| CG31148 | Drosophila melanogaster | AAF56165.2 AAL28266.1 NP_651172.1 |
Q9VCJ4 | 1 | ||||
| glucocerebrosidase 1 (Gba1) | Emiliania huxleyi | AID57155.1 | 1 | |||||
| acid β-glucosidase 1 / β-glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal) | 3.2.1.45 | Homo sapiens | AAA35880.1 AAA35873.1 AAA35877.1 AAC51820.1 AAC63056.1 AAH03356.1 AAQ41981.1 AAQ41982.1 AAT13636.1 AAT13637.1 AAV20581.1 AAY03281.1 AAY03324.1 ABL21565.1 ACH14936.1 ACJ92748.1 ACM85831.1 ACM97663.1 AID60277.1 AID60278.1 AID60279.1 AID60280.1 BAA02545.1 BAF84600.1 BAG58248.1 BAG60020.1 BAH12898.1 BAH13232.1 BAH13357.1 BAH13365.1 BAH13467.1 BAH13605.1 CAC41172.1 CAC41173.1 CAD12720.1 CAD12721.1 CAE85438.1 CAI95090.1 NP_000148.1 |
B2R6A7 P04062 |
1OGS[A,B] 1Y7V[A,B] 2F61[A,B] 2J25[A,B] 2NSX[A,B,C,D] 2NT0[A,B,C,D] 2NT1[A,B,C,D] 2V3D[A,B] 2V3E[A,B] 2V3F[A,B] 2VT0[A,B] 2WCG[A,B] 2WKL[A,B] 2XWD[A,B] 2XWE[A,B] 3GXD[A,B,C,D] 3GXF[A,B,C,D] 3GXI[A,B,C,D] 3GXM[A,B,C,D] 3KE0[A,B] 3KEH[A,B] 3RIK[A,B,C,D] 3RIL[A,B,C,D] |
1 | ||
| GBA (pseudogene) | Homo sapiens | AAH92482.1 AAH00349.2 AAH30240.1 AID60281.1 AID60282.1 BAA02546.1 BAG52175.1 CAI95088.1 XP_034493.1 |
1 | |||||
| ORF (GbA) | Ictalurus punctatus | AHH39476.1 | 1 | |||||
| ORF (GbA) | Ictalurus punctatus | AHH42685.1 | 1 | |||||
| glucosylceramidase isoform 1 precursor (GbA) | Macaca mulatta | AFE77708.1 AFH31940.1 |
1 | |||||
| glucosylceramidase isoform 1 precursor (GbA) | Macaca mulatta | AFJ72033.1 | 1 | |||||
| β-glucosidase 1 / β-glucocerebrosidase (Gba;GBA;Gba1) | 3.2.1.45 | Mus musculus | AAA37671.1 AAH06663.1 AAM66757.1 BAC38609.1 NP_032120.1 |
P17439 | 1 | |||
| ORF | Musca domestica ALHF | AFP62917.1 | 1 | |||||
| acid β-glucosidase | Mustela putorius furo | AER98953.1 | 1 | |||||
| RNA-dependent DNA polymerase (GbA) | Oryzias latipes | CDW61513.1 | 1 | |||||
| glucocerebrosidase (Gba) | Pan troglodytes | AAK18162.1 | Q9BDT0 | 1 | ||||
| glucocerebrosidase (Gba) | Pan troglodytes | AAK18162.1 | Q9BDT0 | 1 | ||||
| ORF (fragment) | Papilio xuthus | BAM18760.1 | 1 | |||||
| β-glucosidase / β-xylosidase (Bgx1) | 3.2.1.21 3.2.1.37 |
Phytophthora infestans 88069 | AAK19754.1 | Q9AT27 | 1 | |||
| DKFZp469B0323 | Pongo abelii | CAH90774.1 | Q5R8E3 | 1 | ||||
| DKFZp469K1734 | Pongo abelii | CAH91967.1 | Q5R8E3 | 1 | ||||
| DKFZp469K1734 | Pongo abelii | CAH91967.1 | Q5R8E3 | 1 | ||||
| Unknown protein for MGC:188451 | Rattus norvegicus | AAI66732.1 | B2RYC9 | 1 | ||||
| SRAE_2000264000 | Strongyloides ratti ED321 Heterogonic | CEF67979.1 | 1 | |||||
| GBA | Sus scrofa | CAE06498.1 | Q70KH2 | 1 | ||||
| GBA | Sus scrofa | CAE06498.1 | Q70KH2 | 1 | ||||
| GH30 | Tisochrysis lutea | AHW52384.1 | 1 | |||||
| MGC84284 (fragment) | Xenopus laevis | AAH81165.1 | Q66IW2 | 1 | ||||
| glucocerebrosidase (Zfgba1) | Zygaena filipendulae | SGZ49395.1 | 1 | |||||
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