Glycoside Hydrolase Family 30 / Subf 1

Activities in Familyendo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (3.2.1.21); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); glucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); glucuronoarabinoxylan endo-β-1,4-xylanase (EC 3.2.1.136); endo-β-1,6-galactanase (EC:3.2.1.164); [reducing end] β-xylosidase (EC 3.2.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (inferred)
NoteFollowing St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resourcesCAZypedia; Gaucher Disease; PRINTS;
Statistics GenBank accession (424); Uniprot accession (56); PDB accession (24); 3D entries (2); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 acid β-glucosidase 1 / β-glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal) 3.2.1.45 Homo sapiens ASU47376.1
AAA35873.1
AAA35877.1
AAA35880.1
AAC51820.1
AAC63056.1
AAH03356.1
AAQ41981.1
AAQ41982.1
AAT13636.1
AAT13637.1
AAV20581.1
AAY03281.1
AAY03324.1
ABL21565.1
ACH14936.1
ACJ92748.1
ACM85831.1
ACM97663.1
AID60277.1
AID60278.1
AID60279.1
AID60280.1
ASU47376.1
BAA02545.1
BAF84600.1
BAG58248.1
BAG60020.1
BAH12898.1
BAH13232.1
BAH13357.1
BAH13365.1
BAH13467.1
BAH13605.1
CAC41172.1
CAC41173.1
CAD12720.1
CAD12721.1
CAE85438.1
CAI95090.1
NP_000148.1
B2R6A7
P04062
1OGS[A,B]
1Y7V[A,B]
2F61[A,B]
2J25[A,B]
2NSX[A,B,C,D]
2NT0[A,B,C,D]
2NT1[A,B,C,D]
2V3D[A,B]
2V3E[A,B]
2V3F[A,B]
2VT0[A,B]
2WCG[A,B]
2WKL[A,B]
2XWD[A,B]
2XWE[A,B]
3GXD[A,B,C,D]
3GXF[A,B,C,D]
3GXI[A,B,C,D]
3GXM[A,B,C,D]
3KE0[A,B]
3KEH[A,B]
3RIK[A,B,C,D]
3RIL[A,B,C,D]
1
 β-glucosidase 1 / β-glucocerebrosidase (Gba;GBA;Gba1) 3.2.1.45 Mus musculus AAA37671.1
AAH06663.1
AAM66757.1
BAC38609.1
NP_032120.1
P17439   1
 β-glucosidase / β-xylosidase (Bgx1) 3.2.1.21
3.2.1.37
Phytophthora infestans 88069 AAK19754.1 Q9AT27   1
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