Known Activities	β-galactosidase (EC 3.2.1.23) ; β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); mannosylglycoprotein endo-β-mannosidase (EC 3.2.1.152); exo-β-glucosaminidase (EC 3.2.1.165)
Mechanism	Retaining
Clan	GH-A
3D Structure Status	( β / α ) 8
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
External resources	CAZypedia; HOMSTRAD; InterPro; PFAM; PRINTS; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX;
Statistics	GenBank accession (3065); Uniprot accession (1572); PDB accession (83); 3D entries (13); cryst (1)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
exo-β-glucosaminidase / exochitosanase (CsxA)	3.2.1.165	Amycolatopsis orientalis	AAX62629.1 AAX62629.2	Q56F26	2VZO[A,B] 2VZS[A,B] 2VZT[A,B] 2VZU[A,B] 2VZV[A,B] 2X05[A,B] 2X09[A,B]
β-galactosidase (LacZ)	3.2.1.23	Arthrobacter sp. C2-2	CAD29775.1	Q8KRF6	1YQ2[A,B,C,D,E,F]
BF0029		Bacteroides fragilis NCTC 9343	CAH05808.1	Q5LJ68	3FN9[A,B,C,D]
BF0328		Bacteroides fragilis NCTC 9343	CAH06099.1	Q5LIC7	3CMG[A]
β-mannosidase (BT0458;BT_0458) (Man2A)	3.2.1.25	Bacteroides thetaiotaomicron VPI-5482	AAO75565.1 NP_809371.1		2JE8[A,B] 2VJX[A,B] 2VL4[A,B] 2VMF[A,B] 2VO5[A,B] 2VOT[A,B] 2VQT[A,B] 2VQU[A,B] 2VR4[A,B] 2WBK[A,B]
BT3179		Bacteroides thetaiotaomicron VPI-5482	AAO78285.1 NP_812091.1		3DEC[A]
BT1626		Bacteroides thetaiotaomicron VPI-5482	AAO76733.1 NP_810539.1		3BGA[A,B]
BVU_0391		Bacteroides vulgatus ATCC 8482	ABR38109.1	A6KXE5	3GM8[A]
β-galactosidase Z (LacZ;b0344)	3.2.1.23	Escherichia coli K-12 MG1655	AAA24053.1 AAB18068.1 AAC73447.1 AAW06767.1 AAY73171.1 ABN72582.1 AEL16982.1 CAA23573.1 NP_414878.1	B8LFD6 P00722.2	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
β-glucuronidase (UidA;GusA;GurA;b1617)	3.2.1.31	Escherichia coli K-12 MG1655	AAA68923.1 AAB30197.1 AAC74689.1 AAR75623.1 ABE20937.1 ACR88323.1 BAA15368.1 CAJ55495.1 CAJ55496.1 CAJ55497.1 CAJ55498.1 CAJ55499.1 CAJ55500.1 NP_416134.1	P05804.2	1KZ3 1UL8 1YDQ 3K46[A,B] 3K4A[A,B] 3K4D[A,B] 3LPF[A,B] 3LPG[A,B]
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
β-glucuronidase b (GusB)	3.2.1.31	Homo sapiens	AAA52561.1 AAH14142.1 AAQ96851.1 AAR75622.1 ABH92596.1 ACH09936.1 ACM86199.1 BAD97126.1 BAG35619.1 BAG61991.1 BAG64768.1 CAC41170.1 NP_000172.1	P08236.2	1BHG[A,B] 3HN3[A,B,D,E]
exo-β-glucosaminidase (Gls93)	3.2.1.165	Hypocrea jecorina PC-3-7	BAD99604.1	Q4R1C4	cryst
β-galactosidase (Lac4;BgaL)	3.2.1.23	Kluyveromyces lactis CBS2359	AAA35265.1	P00723.2	3OB8[A,B,C,D] 3OBA[A,B,C,D]

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