Glycoside Hydrolase Family 2

Activities in Familyβ-galactosidase (EC 3.2.1.23) ; β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); α-L-arabinofuranosidase (EC 3.2.1.55); mannosylglycoprotein endo-β-mannosidase (EC 3.2.1.152); exo-β-glucosaminidase (EC 3.2.1.165); α-L-arabinopyranosidase (EC 3.2.1.-); β-galacturonidase (EC 3.2.1.-); β-xylosidase (EC 3.2.1.37); β-D-galactofuranosidase (EC 3.2.1.146);
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (19514); Uniprot accession (1658); PDB accession (175); 3D entries (49); cryst (2)
All (18194) Archaea (64) Bacteria (17665) Eukaryota (432) unclassified (33) Structure (49 - 2 cryst) Characterized (185)
| 1 | 2 | 3 | 4 | 5 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-mannosidase   Gossypium klotzschianum AEN70958.1    
 β-mannosidase   Gossypium laxum AEN70940.1    
 β-mannosidase   Gossypium lobatum AEN70961.1    
 β-mannosidase   Gossypium mustelinum AEN70944.1    
 β-mannosidase   Gossypium mustelinum AEN70943.1    
 glycosyl hydrolase (Mana2)   Gossypium raimondii ADZ16127.1    
 β-mannosidase   Gossypium schwendimanii AEN70941.1    
 β-mannosidase   Gossypium thurberi AEN70939.1    
 β-mannosidase   Gossypium tomentosum AEN70948.1    
 β-mannosidase (fragment)   Gossypium tomentosum AEN70947.1    
 β-mannosidase   Gossypium trilobum AEN70962.1    
 β-mannosidase   Gossypium turneri AEN70942.1    
 ORF   Hesperocyparis arizonica ATA62824.1    
 ORF   Hesperocyparis bakeri ATA62825.1    
 ORF   Hesperocyparis macrocarpa ATA62826.1    
 β-glucuronidase b (GusB;GUSB) 3.2.1.31 Homo sapiens AAA52561.1
AAH14142.1
AAQ96851.1
AAR75622.1
ABH92596.1
ACH09936.1
ACM86199.1
BAD97126.1
BAG35619.1
BAG61991.1
BAG64768.1
CAC41170.1
NP_000172.1
P08236 1BHG[A,B]
3HN3[A,B,D,E]
 β-mannosidase (ManBA) 3.2.1.25 Homo sapiens AAC39573.1
AAH15743.1
ABS29701.1
BAD93083.1
BAF84287.1
BAG61830.1
O00462  
 ORF   Hypocrella siamensis MTCC 10142 ANH56497.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56458.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56481.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56492.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56474.1    
 ORF (GusB)   Ictalurus punctatus AHH39810.1    
 ORF   Juniperus drupacea ATA62827.1    
 ORF   Juniperus flaccida ATA62828.1    
 ORF   Juniperus indica ATA62829.1    
 ORF   Juniperus microsperma ATA62830.1    
 ORF   Juniperus oxycedrus ATA62831.1    
 ORF   Juniperus phoenicea ATA62832.1    
 ORF   Juniperus procera ATA62833.1    
 ORF   Juniperus scopulorum ATA62834.1    
 β-galactosidase (Lac4;BgaL) 3.2.1.23 Kluyveromyces lactis CBS2359 AAA35265.1 P00723 3OB8[A,B,C,D]
3OBA[A,B,C,D]
 β-galactosidase (BglKL) 3.2.1.23 Kluyveromyces lactis F61 AHW49176.1    
 β-D-galactosidase, partial (Lac4) (fragment)   Kluyveromyces lactis LMA-437 AEM17344.1    
 β-galactosidase (BgaL;KLLA0B14883g) 3.2.1.23 Kluyveromyces lactis NRRL Y-1140 CAH02587.1 P00723  
 FIM1_1709   Kluyveromyces marxianus CBS4857 QGN15025.1    
 FIM1_2437 (fragment)   Kluyveromyces marxianus CBS4857 QGN15743.1    
 KLMA_30009   Kluyveromyces marxianus DMKU3-1042 BAO39304.1    
 β-galactosidase 3.2.1.23 Kluyveromyces marxianus DSM5418 AAS18310.1 Q6QTF4  
 KMAR_30002   Kluyveromyces marxianus NBRC 1777 BAP70807.1    
 LSINAPIS_LOCUS3459   Leptidea sinapis VUY90622.1    
 LSINAPIS_LOCUS427   Leptidea sinapis VUY86578.1    
 ORF   Leptinotarsa decemlineata AGX25148.1    
 ORF   Leptosphaeria maculans JN3 CBX97149.1 E4ZZN3  
 ORF   Leptosphaeria maculans JN3 CBX99479.1 E5A784  
 ORF   Leptosphaeria maculans JN3 CBY01311.1 E5ADM2  
 ORF   Leptosphaeria maculans JN3 CBY01568.1 E5AEC9  
 ORF (fragment)   Leptosphaeria maculans JN3 CBX93875.1 E4ZRM8  
 ORF   Leptosphaeria maculans JN3 CBX94573.1    
 ORF   Leptosphaeria maculans JN3 CBX98985.1 E5A5U0  
 mannosylglycoprotein endo-β-mannosidase (Ebm) 3.2.1.152 Lilium longiflorum BAD89079.2
BAD89079.1
Q5H7P5  
 β-glucuronidase (GUSB) (fragment)   Macaca mulatta AAV98539.1 Q4G3Z5  
 β-mannosidase precursor, partial (ManbA) (fragment)   Macaca mulatta AFE73803.1    
 β-glucuronidase precursor (GusB)   Macaca mulatta AFE77962.1
AFE77963.1
   
 β-glucuronidase precursor, partial (GusB) (fragment)   Macaca mulatta AFE67511.1    
 β-mannosidase precursor, partial (ManbA) (fragment)   Macaca mulatta AFE69594.1    
 β-glucuronidase precursor (GusB)   Macaca mulatta AFH28819.1
AFH28820.1
   
 MtrDRAFT_AC151426g18v1 (partial)   Medicago truncatula ABP03323.1    
 BN887_06040 (fragment)   Melanopsichium pennsylvanicum 4 CDI51778.1    
 ORF   Microbiota decussata ATA62835.1    
 MICPUN_51444 (fragment)   Micromonas commoda sp. RCC299 ACO68436.1 C1FDQ8  
 β-glucuronidase (GusB;Gus-S) 3.2.1.31 Mus musculus AAA37696.1
AAA37697.1
AAA63307.1
AAA63308.1
AAA63309.1
AAA98623.1
AAH71226.1
AAQ41980.1
BAE23021.1
BAE29265.1
BAE34865.1
BAE35155.1
BAE35384.1
BAE36917.1
CAC41171.1
NP_034498.1
P12265  
 β-mannosidase 3.2.1.25 Mus musculus AAK18177.1
AAH31409.1
BAE24954.1
BAE38715.1
BAE41690.1
NP_081564.1
Q8K2I4
Q99MS1
6DDT[A]
6DDU[A]
 GusB (fragment)   Mus spretus SPRET/EiJ ALX38052.1    
 ORF   Musca domestica ALHF AFP59583.1    
 ORF (fragment)   Musca domestica ALHF AFP64891.1    
 ORF (fragment)   Musca domestica ALHF AFP65047.1    
 glucuronidase, beta, partial (fragment)   Mustela putorius furo AER99526.1    
 glucuronidase, beta, partial (fragment)   Mustela putorius furo AER99527.1    
 ORF (fragment)   Mustela putorius furo AES01514.1    
 lysosomal β-glucuronidase (fragment)   Mytilus galloprovincialis ABY60966.1 B0FN51  
 NGATSA_3040200 (fragment)   Nannochloropsis gaditana CCMP526 AFJ69043.1    
 NGATSA_3032100 (fragment)   Nannochloropsis gaditana CCMP526 AFJ69547.1    
 NCU00985.1 (B20J13.350)   Neurospora crassa OR74A CAE76354.1
XP_325165.1
Q7SGD7  
 NCU05956.1   Neurospora crassa OR74A XP_325811.1    
 NCU00810 (BgaD)   Neurospora crassa OR74A DAA35009.1
XP_324990.1
   
 NCU09042.1   Neurospora crassa OR74A XP_331434.1 Q7S2T3  
 NCU00890.1   Neurospora crassa OR74A XP_325070.1 Q7SFE1  
 Os01g0952600   Oryza sativa Japonica Group BAD87855.1
BAB64698.1
BAF07335.1
BAS76255.1
BAS76256.1
NP_914661.1
Q5JKZ9  
 Os05g0391500   Oryza sativa Japonica Group BAF17358.1
AAV31255.1
BAS93852.1
Q0DIG5  
 OSTLU_119488   Ostreococcus lucimarinus CCE9901 ABO94678.1 A4RT31  
 Ot07g03490   Ostreococcus tauri OTTH0595 CAL54622.1 Q014Q7  
 β-glucuronidase (Gus) 3.2.1.31 Penicillium canescens DSM1215 AAV91787.1 Q5MJY0  
 β-glucuronidase (Gus) 3.2.1.31 Penicillium canescens RPK AAV91785.1 Q5MJY2  
 Pc12g11750   Penicillium rubens Wisconsin 54-1255 CAP80802.1 B6GXQ4  
 Pc12g13420   Penicillium rubens Wisconsin 54-1255 CAP80969.1 B6GZU1  
 Pc16g06840   Penicillium rubens Wisconsin 54-1255 CAP93354.1
CAV33708.1
B6H7F7  
 Pc16g06900   Penicillium rubens Wisconsin 54-1255 CAP93360.1 B6H7G3  
 Pc21g13810   Penicillium rubens Wisconsin 54-1255 CAP96278.1
CAV33710.1
B6HNQ6  
 Pc22g14540   Penicillium rubens Wisconsin 54-1255 CAP98742.1 B6HUZ1  
 WS02759_M23 (fragment)   Picea sitchensis ABR16858.1 B8LMH8  
 Pa_5_10470   Podospora anserina S mat+ CAP65831.1
CDP30306.1
B2APB4  
 unnamed protein product   Podospora anserina S mat+ CAP59820.1
CDP22463.1
B2A9R0  
 Pa_1_5180 (BgaD)   Podospora anserina S mat+ DAA35011.1
CAP60205.1
CDP22846.1
B2AAU3  
 unnamed protein product   Podospora anserina S mat+ CAP61774.1
CDP28114.1
B2AEA8  
 unnamed protein product   Podospora anserina S mat+ CAP66718.1
CDP28453.1
B2ARE0  
 Pa_1_18330   Podospora anserina S mat+ CAP67962.1
CDP24221.1
B2AU89  
 unnamed protein product   Podospora anserina S mat+ CAP70161.1
CDP26753.1
B2AZW1  
 PODCO_105180   Podospora comata VBB71888.1    
 PODCO_101480   Podospora comata VBB71464.1    
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