Glycoside Hydrolase Family 2

Activities in Familyβ-galactosidase (EC 3.2.1.23) ; β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); α-L-arabinofuranosidase (EC 3.2.1.55); mannosylglycoprotein endo-β-mannosidase (EC 3.2.1.152); exo-β-glucosaminidase (EC 3.2.1.165); α-L-arabinopyranosidase (EC 3.2.1.-); β-galacturonidase (EC 3.2.1.-); β-xylosidase (EC 3.2.1.37); β-D-galactofuranosidase (EC 3.2.1.146);
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (22305); Uniprot accession (1656); PDB accession (192); 3D entries (52); cryst (2)
All (20978) Archaea (65) Bacteria (20409) Eukaryota (471) unclassified (33) Structure (52 - 2 cryst) Characterized (184)
| 1 | 2 | 3 | 4 | 5 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 FVRRES_00197   Fusarium venenatum A3/5 CEI63685.1    
 FVRRES_06203   Fusarium venenatum A3/5 CEI61767.1    
 FVRRES_04459 (fragment)   Fusarium venenatum A3/5 CEI60023.1    
 FVRRES_10429   Fusarium venenatum A3/5 CEI70352.1    
 FVRRES_02846   Fusarium venenatum A3/5 CEI66334.1    
 FVRRES_12650   Fusarium venenatum A3/5 CEI39959.1    
 FVRRES_06264   Fusarium venenatum A3/5 CEI61828.1    
 FVRRES_12417   Fusarium venenatum A3/5 CEI39726.1    
 FVRRES_02707   Fusarium venenatum A3/5 CEI66195.1    
 FVRRES_08146   Fusarium venenatum A3/5 CEI68069.1    
 FVRRES_01016   Fusarium venenatum A3/5 CEI64504.1    
 FVRRES_00089   Fusarium venenatum A3/5 CEI63577.1    
 RCJMB04_28l23   Gallus gallus CAG32539.1 Q5ZIA4  
 ORF   Ganoderma boninense VWO95209.1    
 β-glucuronidase (BGLU) (fragment)   Gorilla gorilla AAL56230.1 Q8WNN2  
 β-mannosidase   Gossypium aridum AEN70959.1    
 β-mannosidase   Gossypium armourianum AEN70955.1    
 ManA2   Gossypium barbadense ADZ16125.1    
 ManA2 (fragment)   Gossypium barbadense ADZ16124.1    
 β-mannosidase   Gossypium barbadense var. brasiliense AEN70950.1    
 β-mannosidase (fragment)   Gossypium barbadense var. brasiliense AEN70949.1    
 β-mannosidase   Gossypium barbadense var. peruvianum AEN70952.1    
 β-mannosidase (fragment)   Gossypium barbadense var. peruvianum AEN70951.1    
 β-mannosidase (fragment)   Gossypium darwinii AEN70945.1    
 β-mannosidase   Gossypium darwinii AEN70946.1    
 β-mannosidase   Gossypium davidsonii AEN70957.1    
 β-mannosidase   Gossypium gossypioides AEN70960.1    
 β-mannosidase   Gossypium harknessii AEN70956.1    
 ManA2   Gossypium herbaceum subsp. africanum ADZ16126.1    
 β-mannosidase   Gossypium hirsutum subsp. latifolium AEN70954.1    
 β-mannosidase   Gossypium hirsutum subsp. latifolium AEN70953.1    
 ORF   Gossypium hirsutum TM-1 AAO27794.1
AAK84953.2
ADZ16128.1
ADZ16129.1
Q84XI2
Q93X75
 
 β-mannosidase   Gossypium klotzschianum AEN70958.1    
 β-mannosidase   Gossypium laxum AEN70940.1    
 β-mannosidase   Gossypium lobatum AEN70961.1    
 β-mannosidase   Gossypium mustelinum AEN70944.1    
 β-mannosidase   Gossypium mustelinum AEN70943.1    
 glycosyl hydrolase (Mana2)   Gossypium raimondii ADZ16127.1    
 β-mannosidase   Gossypium schwendimanii AEN70941.1    
 β-mannosidase   Gossypium thurberi AEN70939.1    
 β-mannosidase   Gossypium tomentosum AEN70948.1    
 β-mannosidase (fragment)   Gossypium tomentosum AEN70947.1    
 β-mannosidase   Gossypium trilobum AEN70962.1    
 β-mannosidase   Gossypium turneri AEN70942.1    
 ORF   Hesperocyparis arizonica ATA62824.1    
 ORF   Hesperocyparis bakeri ATA62825.1    
 ORF   Hesperocyparis macrocarpa ATA62826.1    
 β-glucuronidase b (GusB;GUSB) 3.2.1.31 Homo sapiens AAA52561.1
AAH14142.1
AAQ96851.1
AAR75622.1
ABH92596.1
ACH09936.1
ACM86199.1
BAD97126.1
BAG35619.1
BAG61991.1
BAG64768.1
CAC41170.1
NP_000172.1
P08236 1BHG[A,B]
3HN3[A,B,D,E]
 β-mannosidase (ManBA) 3.2.1.25 Homo sapiens AAC39573.1
AAH15743.1
ABS29701.1
BAD93083.1
BAF84287.1
BAG61830.1
O00462  
 EmGFP-LacZ TdTom, partial (Emgfp-lacz-e2f-tdtoM)   Homo sapiens CAA9893810.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56497.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56458.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56481.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56492.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56474.1    
 ORF (GusB)   Ictalurus punctatus AHH39810.1    
 ORF   Juniperus drupacea ATA62827.1    
 ORF   Juniperus flaccida ATA62828.1    
 ORF   Juniperus indica ATA62829.1    
 ORF   Juniperus microsperma ATA62830.1    
 ORF   Juniperus oxycedrus ATA62831.1    
 ORF   Juniperus phoenicea ATA62832.1    
 ORF   Juniperus procera ATA62833.1    
 ORF   Juniperus scopulorum ATA62834.1    
 β-galactosidase (Lac4;BgaL) 3.2.1.23 Kluyveromyces lactis CBS2359 AAA35265.1 P00723 3OB8[A,B,C,D]
3OBA[A,B,C,D]
 β-galactosidase (BglKL) 3.2.1.23 Kluyveromyces lactis F61 AHW49176.1    
 β-D-galactosidase, partial (Lac4) (fragment)   Kluyveromyces lactis LMA-437 AEM17344.1    
 β-galactosidase (BgaL;KLLA0B14883g) 3.2.1.23 Kluyveromyces lactis NRRL Y-1140 CAH02587.1 P00723  
 FIM1_1709   Kluyveromyces marxianus CBS4857 QGN15025.1    
 FIM1_2437 (fragment)   Kluyveromyces marxianus CBS4857 QGN15743.1    
 KLMA_30009   Kluyveromyces marxianus DMKU3-1042 BAO39304.1    
 β-galactosidase 3.2.1.23 Kluyveromyces marxianus DSM5418 AAS18310.1 Q6QTF4  
 KMAR_30002   Kluyveromyces marxianus NBRC 1777 BAP70807.1    
 LSINAPIS_LOCUS3459   Leptidea sinapis VUY90622.1    
 LSINAPIS_LOCUS427   Leptidea sinapis VUY86578.1    
 ORF   Leptinotarsa decemlineata AGX25148.1    
 ORF   Leptosphaeria maculans JN3 CBX97149.1 E4ZZN3  
 ORF   Leptosphaeria maculans JN3 CBX99479.1 E5A784  
 ORF   Leptosphaeria maculans JN3 CBY01311.1 E5ADM2  
 ORF   Leptosphaeria maculans JN3 CBY01568.1 E5AEC9  
 ORF (fragment)   Leptosphaeria maculans JN3 CBX93875.1 E4ZRM8  
 ORF   Leptosphaeria maculans JN3 CBX94573.1    
 ORF   Leptosphaeria maculans JN3 CBX98985.1 E5A5U0  
 mannosylglycoprotein endo-β-mannosidase (Ebm) 3.2.1.152 Lilium longiflorum BAD89079.2
BAD89079.1
Q5H7P5  
 β-glucuronidase (GUSB) (fragment)   Macaca mulatta AAV98539.1 Q4G3Z5  
 β-mannosidase precursor, partial (ManbA) (fragment)   Macaca mulatta AFE73803.1    
 β-glucuronidase precursor (GusB)   Macaca mulatta AFE77962.1
AFE77963.1
   
 β-glucuronidase precursor, partial (GusB) (fragment)   Macaca mulatta AFE67511.1    
 β-mannosidase precursor, partial (ManbA) (fragment)   Macaca mulatta AFE69594.1    
 β-glucuronidase precursor (GusB)   Macaca mulatta AFH28819.1
AFH28820.1
   
 Mp_5g08290   Marchantia polymorpha subsp. ruderalis Tak-1 BBN11008.1    
 Mp_6g04460   Marchantia polymorpha subsp. ruderalis Tak-1 BBN13547.1    
 MtrDRAFT_AC151426g18v1 (partial)   Medicago truncatula ABP03323.1    
 BN887_06040 (fragment)   Melanopsichium pennsylvanicum 4 CDI51778.1    
 ORF   Microbiota decussata ATA62835.1    
 MICPUN_51444 (fragment)   Micromonas commoda sp. RCC299 ACO68436.1 C1FDQ8  
 β-glucuronidase (GusB;Gus-S) 3.2.1.31 Mus musculus AAA37696.1
AAA37697.1
AAA63307.1
AAA63308.1
AAA63309.1
AAA98623.1
AAH71226.1
AAQ41980.1
BAE23021.1
BAE29265.1
BAE34865.1
BAE35155.1
BAE35384.1
BAE36917.1
CAC41171.1
NP_034498.1
P12265  
 β-mannosidase 3.2.1.25 Mus musculus AAK18177.1
AAH31409.1
BAE24954.1
BAE38715.1
BAE41690.1
NP_081564.1
Q8K2I4
Q99MS1
6DDT[A]
6DDU[A]
 GusB (fragment)   Mus spretus SPRET/EiJ ALX38052.1    
 ORF   Musca domestica ALHF AFP59583.1    
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