Glycoside Hydrolase Family 2

Activities in Familyβ-galactosidase (EC 3.2.1.23) ; β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); α-L-arabinofuranosidase (EC 3.2.1.55); mannosylglycoprotein endo-β-mannosidase (EC 3.2.1.152); exo-β-glucosaminidase (EC 3.2.1.165)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (11600); Uniprot accession (1662); PDB accession (119); 3D entries (27); cryst (2)
All (10350) Archaea (46) Bacteria (9994) Eukaryota (291) unclassified (19) Structure (27 - 2 cryst) Characterized (147)
| 1 | 2 | 3 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 unnamed protein product   Fusarium graminearum PH-1 CEF87867.1    
 FGRAMPH1_01T12595   Fusarium graminearum PH-1 SCB65794.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF71940.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF72811.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF74591.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF79733.1    
 ORF   Fusarium oxysporum f. sp. fragariae BAD89519.1 Q5FBG0  
 ORF   Fusarium sp. IFO 7772 BAD89516.1 Q5FBG3  
 RCJMB04_28l23   Gallus gallus CAG32539.1 Q5ZIA4  
 β-glucuronidase (BGLU) (fragment)   Gorilla gorilla AAL56230.1 Q8WNN2  
 β-mannosidase   Gossypium aridum AEN70959.1    
 β-mannosidase   Gossypium armourianum AEN70955.1    
 ManA2   Gossypium barbadense ADZ16125.1    
 ManA2 (fragment)   Gossypium barbadense ADZ16124.1    
 β-mannosidase   Gossypium barbadense var. brasiliense AEN70950.1    
 β-mannosidase (fragment)   Gossypium barbadense var. brasiliense AEN70949.1    
 β-mannosidase   Gossypium barbadense var. peruvianum AEN70952.1    
 β-mannosidase (fragment)   Gossypium barbadense var. peruvianum AEN70951.1    
 β-mannosidase (fragment)   Gossypium darwinii AEN70945.1    
 β-mannosidase   Gossypium darwinii AEN70946.1    
 β-mannosidase   Gossypium davidsonii AEN70957.1    
 β-mannosidase   Gossypium gossypioides AEN70960.1    
 β-mannosidase   Gossypium harknessii AEN70956.1    
 ManA2   Gossypium herbaceum subsp. africanum ADZ16126.1    
 β-mannosidase   Gossypium hirsutum subsp. latifolium AEN70954.1    
 β-mannosidase   Gossypium hirsutum subsp. latifolium AEN70953.1    
 ORF   Gossypium hirsutum TM-1 AAO27794.1
AAK84953.2
ADZ16128.1
ADZ16129.1
Q84XI2
Q93X75
 
 β-mannosidase   Gossypium klotzschianum AEN70958.1    
 β-mannosidase   Gossypium laxum AEN70940.1    
 β-mannosidase   Gossypium lobatum AEN70961.1    
 β-mannosidase   Gossypium mustelinum AEN70944.1    
 β-mannosidase   Gossypium mustelinum AEN70943.1    
 glycosyl hydrolase (Mana2)   Gossypium raimondii ADZ16127.1    
 β-mannosidase   Gossypium schwendimanii AEN70941.1    
 β-mannosidase   Gossypium thurberi AEN70939.1    
 β-mannosidase   Gossypium tomentosum AEN70948.1    
 β-mannosidase (fragment)   Gossypium tomentosum AEN70947.1    
 β-mannosidase   Gossypium trilobum AEN70962.1    
 β-mannosidase   Gossypium turneri AEN70942.1    
 β-glucuronidase b (GusB;GUSB) 3.2.1.31 Homo sapiens AAA52561.1
AAH14142.1
AAQ96851.1
AAR75622.1
ABH92596.1
ACH09936.1
ACM86199.1
BAD97126.1
BAG35619.1
BAG61991.1
BAG64768.1
CAC41170.1
NP_000172.1
P08236 1BHG[A,B]
3HN3[A,B,D,E]
 β-mannosidase (ManBA) 3.2.1.25 Homo sapiens AAC39573.1
AAH15743.1
ABS29701.1
BAD93083.1
BAF84287.1
BAG61830.1
O00462  
 ORF   Hypocrella siamensis MTCC 10142 ANH56497.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56458.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56481.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56492.1    
 ORF   Hypocrella siamensis MTCC 10142 ANH56474.1    
 ORF (GusB)   Ictalurus punctatus AHH39810.1    
 β-galactosidase (Lac4;BgaL) 3.2.1.23 Kluyveromyces lactis CBS2359 AAA35265.1 P00723 3OB8[A,B,C,D]
3OBA[A,B,C,D]
 β-galactosidase (BglKL) 3.2.1.23 Kluyveromyces lactis F61 AHW49176.1    
 β-D-galactosidase, partial (Lac4) (fragment)   Kluyveromyces lactis LMA-437 AEM17344.1    
 β-galactosidase (BgaL;KLLA0B14883g) 3.2.1.23 Kluyveromyces lactis NRRL Y-1140 CAH02587.1 P00723  
 KLMA_30009   Kluyveromyces marxianus DMKU3-1042 BAO39304.1    
 β-galactosidase 3.2.1.23 Kluyveromyces marxianus DSM5418 AAS18310.1 Q6QTF4  
 KMAR_30002   Kluyveromyces marxianus NBRC 1777 BAP70807.1    
 ORF   Leptinotarsa decemlineata AGX25148.1    
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX97149.1 E4ZZN3  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX99479.1 E5A784  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBY01311.1 E5ADM2  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBY01568.1 E5AEC9  
 ORF (fragment)   Leptosphaeria maculans JN3 v23.1.3 CBX93875.1 E4ZRM8  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX94573.1    
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX98985.1 E5A5U0  
 mannosylglycoprotein endo-β-mannosidase (Ebm) 3.2.1.152 Lilium longiflorum BAD89079.2
BAD89079.1
Q5H7P5  
 β-glucuronidase (GUSB) (fragment)   Macaca mulatta AAV98539.1 Q4G3Z5  
 β-mannosidase precursor, partial (ManbA) (fragment)   Macaca mulatta AFE73803.1    
 β-glucuronidase precursor (GusB)   Macaca mulatta AFE77962.1
AFE77963.1
   
 β-glucuronidase precursor, partial (GusB) (fragment)   Macaca mulatta AFE67511.1    
 β-mannosidase precursor, partial (ManbA) (fragment)   Macaca mulatta AFE69594.1    
 β-glucuronidase precursor (GusB)   Macaca mulatta AFH28819.1
AFH28820.1
   
 MG05890.4   Magnaporthe oryzae 70-15 XP_369574.1 G4N3Y7  
 MG05864.4   Magnaporthe oryzae 70-15 XP_369600.1 G4N3R3  
 MG00583.4   Magnaporthe oryzae 70-15 XP_368661.1 G4NBB5  
 MG09664.4   Magnaporthe oryzae 70-15 XP_364819.1 Q2KHA3  
 MG08964.4   Magnaporthe oryzae 70-15 XP_364119.1 G4MW41  
 MGG_13801   Magnaporthe oryzae 70-15 XP_003710906.1    
 MGG_01178   Magnaporthe oryzae 70-15 XP_003714062.1
XP_363252.1
   
 MGG_13610   Magnaporthe oryzae 70-15 XP_003717495.1    
 MtrDRAFT_AC151426g18v1 (partial)   Medicago truncatula ABP03323.1    
 BN887_06040 (fragment)   Melanopsichium pennsylvanicum 4 CDI51778.1    
 MICPUN_51444 (fragment)   Micromonas commoda sp. RCC299 ACO68436.1 C1FDQ8  
 β-glucuronidase (GusB;Gus-S) 3.2.1.31 Mus musculus AAA37696.1
AAA37697.1
AAA63307.1
AAA63308.1
AAA63309.1
AAA98623.1
AAH71226.1
AAQ41980.1
BAE23021.1
BAE29265.1
BAE34865.1
BAE35155.1
BAE35384.1
BAE36917.1
CAC41171.1
NP_034498.1
P12265  
 β-mannosidase 3.2.1.25 Mus musculus AAK18177.1
AAH31409.1
BAE24954.1
BAE38715.1
BAE41690.1
NP_081564.1
Q8K2I4
Q99MS1
 
 GusB (fragment)   Mus spretus SPRET/EiJ ALX38052.1    
 ORF   Musca domestica ALHF AFP59583.1    
 ORF (fragment)   Musca domestica ALHF AFP64891.1    
 ORF (fragment)   Musca domestica ALHF AFP65047.1    
 glucuronidase, beta, partial (fragment)   Mustela putorius furo AER99526.1    
 glucuronidase, beta, partial (fragment)   Mustela putorius furo AER99527.1    
 ORF (fragment)   Mustela putorius furo AES01514.1    
 lysosomal β-glucuronidase (fragment)   Mytilus galloprovincialis ABY60966.1 B0FN51  
 NGATSA_3040200 (fragment)   Nannochloropsis gaditana CCMP526 AFJ69043.1    
 NGATSA_3032100 (fragment)   Nannochloropsis gaditana CCMP526 AFJ69547.1    
 NCU00985.1 (B20J13.350)   Neurospora crassa OR74A CAE76354.1
XP_325165.1
Q7SGD7  
 NCU05956.1   Neurospora crassa OR74A XP_325811.1    
 NCU00810 (BgaD)   Neurospora crassa OR74A DAA35009.1
XP_324990.1
   
 NCU09042.1   Neurospora crassa OR74A XP_331434.1 Q7S2T3  
 NCU00890.1   Neurospora crassa OR74A XP_325070.1 Q7SFE1  
 Os01g0952600   Oryza sativa Japonica Group BAD87855.1
BAB64698.1
BAF07335.1
BAS76255.1
BAS76256.1
NP_914661.1
Q5JKZ9  
 Os05g0391500   Oryza sativa Japonica Group BAF17358.1
AAV31255.1
BAS93852.1
Q0DIG5  
 OSTLU_119488   Ostreococcus lucimarinus CCE9901 ABO94678.1 A4RT31  
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