Glycoside Hydrolase Family 2

Activities in Familyβ-galactosidase (EC 3.2.1.23) ; β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); α-L-arabinofuranosidase (EC 3.2.1.55); mannosylglycoprotein endo-β-mannosidase (EC 3.2.1.152); exo-β-glucosaminidase (EC 3.2.1.165)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (11711); Uniprot accession (1662); PDB accession (120); 3D entries (28); cryst (2)
All (10460) Archaea (46) Bacteria (10105) Eukaryota (290) unclassified (19) Structure (28 - 2 cryst) Characterized (147)
| 1 | 2 | 3 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ALNC14_117850 (Alnc14c309g10482)   Albugo laibachii Nc14 CCA25641.1    
 β-mannosidase (AkMnsD) 3.2.1.25 Aplysia kurodai BAL43431.1    
 At1g09010/F7G19.12 (mannosylglycoprotein endo-β-mannosidase; AtEBM) 3.2.1.152 Arabidopsis thaliana BAD15284.1
AAB70407.1
AAK76608.1
AAM14288.1
AEE28382.1
NP_172375.1
NP_563833.1
O04029
Q75W54
 
 At3g54440/T14E10_10   Arabidopsis thaliana AAM10327.1
AEE79230.1
AEE79231.1
AEE79232.1
BAD95157.1
BAE98865.1
CAB77564.1
NP_680128.1
Q8RWQ2
Q9M1I3
 
 EGX43526.1   Arthrobotrys oligospora ATCC 24927 EGX43526.1    
 ORF   Ascaris suum ADY43651.1    
 ORF (fragment)   Ascaris suum ADY44885.1    
 β-mannosidase (ManB) (probable frameshift) 3.2.1.25 Aspergillus aculeatus F-50 BAA29029.1 O74168  
 ANIA_01107 (AN1107.2) (fragment)   Aspergillus nidulans FGSC A4 EAA66225.1
CBF88126.1
C8VTE0  
 AN2395.2   Aspergillus nidulans FGSC A4 EAA64506.1 C8VNQ2
Q5BAN5
 
 AN6388.2   Aspergillus nidulans FGSC A4 EAA58410.1 C8V0P8
Q5AZ92
 
 AN5361.2   Aspergillus nidulans FGSC A4 EAA62521.1 C8VGR3
Q5B269
 
 AN3200   Aspergillus nidulans FGSC A4 EAA62925.1
AFD22629.1
C8VIB0
Q5B8D0
 
 β-mannosidase (AN3368.2) 3.2.1.25 Aspergillus nidulans FGSC A4 ABF50864.1
EAA63336.1
Q5B7W2  
 AN2824.2   Aspergillus nidulans FGSC A4 EAA63395.1 C8VJG7
Q5B9F6
 
 AN3201 (BgaD)   Aspergillus nidulans FGSC A4 EAA62926.1
ABF50859.1
C8VIA9
Q5B8C9
 
 ANIA_01742 (AN1742.2)   Aspergillus nidulans FGSC A4 EAA64028.1
CBF85479.1
C8VP45
Q5BCI8
 
 AN2463   Aspergillus nidulans FGSC A4 EAA64169.1 C8VP83
Q5BAG7
 
 intracellular β-galactosidase (BgaD) 3.2.1.23 Aspergillus nidulans WG355 ADM36015.1    
 β-mannosidase (MndA) (Mnd2A) 3.2.1.25 Aspergillus niger CBS 120.49 / N400 CAB63902.1 Q9UUZ3  
 An01g01260   Aspergillus niger CBS 513.88 CAK36851.1 A2Q7M5  
 An01g06630   Aspergillus niger CBS 513.88 CAK43782.1 A2Q948  
 An02g00610   Aspergillus niger CBS 513.88 CAK96276.1 A2QBM9  
 An05g02410   Aspergillus niger CBS 513.88 CAK44902.1 A2QL36  
 β-mannosidase (MndA;AnigerBM2;An11g06540) 3.2.1.25 Aspergillus niger CBS 513.88 CAK96951.1
XP_001394632.2
XP_001394632.2
A2QWU9 cryst
 An12g01850   Aspergillus niger CBS 513.88 CAK48467.1
CAV33671.1
A2QYN2  
 An11g06540 (MndA)   Aspergillus niger CBS 513.88 A2QWU9.1    
 exo-β-glucosaminidase (Csx;AorCsxA) 3.2.1.165 Aspergillus oryzae FL402 AHJ61328.1    
 β-glucuronidase (PGUS;GUS) 3.2.1.31 Aspergillus oryzae Li-3 ABU68712.1 A7XS03 5C70[A,B]
5C71[A,B,C,D]
 AO090005000740 (MndD)   Aspergillus oryzae RIB40 BAE55770.1 Q2URP5  
 AO090001000556   Aspergillus oryzae RIB40 BAE57065.1 Q2UN00  
 AO090003001410   Aspergillus oryzae RIB40 BAE58464.1 Q2UJ01  
 AO090023000053   Aspergillus oryzae RIB40 BAE58640.1 Q2UIH5  
 AO090012000389   Aspergillus oryzae RIB40 BAE60574.1 Q2UCZ1  
 β-glucuronidase (AO090038000009)   Aspergillus oryzae RIB40 BAE63869.1 Q2U3J6  
 AO090010000208 (MndB)   Aspergillus oryzae RIB40 BAE66106.1 Q2TXB7  
 exo-β-glucosaminidase (Csx;ChiA) 3.2.1.165 Aspergillus sp. CJ22-326 ACO94980.1 C3U4R9  
 β-glucuronidase (AtGUS) 3.2.1.31 Aspergillus terreus Li-20 AEP39213.1    
 β-glucuronidase (AuGUS) 3.2.1.31 Aspergillus ustus Li-62 AEK69352.1    
 β-glucuronidase (AuGUS)   Aspergillus ustus Li-62 AFM77719.1    
 Bathy14g01370   Bathycoccus prasinos RCC1105 CCO19627.1    
 β-mannosidase 3.2.1.25 Bos taurus AAC48460.1
AAD39352.1
AAE16437.1
AAI47901.1
NP_776812.1
Q29444
Q9TTG6
 
 Unknown (protein for MGC:155160)   Bos taurus AAI33416.1 A3KMY8  
 glycoside hydrolase family 2 protein (Bofut4_p088120.1)   Botrytis cinerea T4 CCD50749.1    
 BofuT4P114000029001   Botrytis cinerea T4 CCD56258.2
CCD56258.1
   
 endo-β-mannosidase (Ebm) 3.2.1.152 Brassica oleracea BAE97370.1 Q14U56  
 C33G3.4   Caenorhabditis elegans Bristol N2 CAB01737.1
NP_510342.1
Q93324  
 Y105E8B.n   Caenorhabditis elegans Bristol N2 CAB60857.2
CAC70111.1
NP_493548.1
Q95Q32  
 ORF   Callorhinchus milii AFO97796.1    
 ORF (fragment)   Callorhinchus milii AFO99634.1    
 ORF (fragment)   Callorhinchus milii AFO95551.1    
 CAALFM_CR02800CA   Candida albicans SC5314 AOW31022.1    
 CD36_27860   Candida dubliniensis CD36 CAX39789.1 B9WL84  
 SAMEA4029010_CIC11G00000005750   [Candida] intermedia CBS 141442 SGZ48119.1    
 SAMEA4029010_CIC11G00000003965   [Candida] intermedia CBS 141442 SGZ52529.1    
 SAMEA4029009_CIC11G00000001530   [Candida] intermedia PYCC 4715 SGZ48501.1    
 SAMEA4029009_CIC11G00000001100   [Candida] intermedia PYCC 4715 SGZ57938.1    
 CORT_0A01190   Candida orthopsilosis Co 90-125 CCG20510.1    
 CPAR2_801130   Candida parapsilosis CDC317 CCE41561.1    
 β-glucuronidase (GusB) 3.2.1.31 Canis lupus familiaris AAC48809.1 O18835  
 β-mannosidase 3.2.1.25 Capra hircus (MANBA) AAC48665.1 Q95327  
 β-glucuronidase (GusB)   Chlorocebus aethiops AAC34593.1 O77695  
 β-Gal (fragment)   Citrus medica CAP40294.1 A9J6N5  
 CYFA0S_05e00210g   Cyberlindnera fabianii YJS4271 CDR40387.1    
 β-glucuronidase (GuS) (fragment)   Cynomys ludovicianus ABP87904.1 A4ZYQ9  
 ORF   Danio rerio AAH45360.1
AAH65988.1
NP_956453.1
Q7ZVY7  
 CT573103.7-001 (fragment)   Danio rerio CAN88744.1 A5WW06  
 DEHA0E10021g   Debaryomyces hansenii CBS767 CAG87955.1 Q6BQ01  
 DEHA0G26345g   Debaryomyces hansenii CBS767 CAG91142.1 Q6BGP8  
 unknown   Dendroctonus ponderosae AEE63051.1    
 unknown   Dendroctonus ponderosae AEE61968.1    
 dd_03023   Dictyostelium discoideum AX4 AAM33758.1
AAO52199.1
Q86A04  
 β-galactosidase 7, partial   Diospyros kaki AOR05812.1    
 Dbus_chr2Rg1701   Drosophila busckii ALC42122.1    
 Dbus_chr3Rg913   Drosophila busckii ALC46163.1    
 Dbus_chr3Rg913   Drosophila busckii ALC46163.1    
 Dbus_chr2Rg1703   Drosophila busckii ALC42124.1    
 CG12582   Drosophila melanogaster AAF52172.2
AAF52171.2
AAF52171.3
AAF52171.4
AAN71636.1
AAX33506.1
AFH06218.1
AGB95624.1
AGB95625.1
NP_649436.2
Q8IGB2
Q9VMY5
 
 CG2135   Drosophila melanogaster AAF57195.1
AAQ22542.1
NP_651893.1
Q9V9T9  
 CG15117   Drosophila melanogaster AAM68434.1
AAF57602.2
AAL39474.1
AAS93746.1
AAX52695.1
ACV88434.1
AEZ68804.1
AHN56394.1
AHN56395.1
AHN56396.1
NP_611395.1
NP_725851.1
A1ZBG9  
 ORF (fragment)   Equus caballus AEP98750.1    
 β-glucuronidase (fragment)   Equus caballus ABO86717.1 A4USH5  
 AW171_hschr74493   Eremothecium sinecaudum ATCC 58844 AMD22455.1    
 β-glucuronidase (GusB) 3.2.1.31 Felis catus AAD01498.1
AAD01499.1
O97524  
 ORF (fragment)   Fusarium fujikuroi BAD89523.2 Q5FBF6  
 FFUJ_00422   Fusarium fujikuroi IMI 58289 CCT62972.1    
 FFUJ_14419   Fusarium fujikuroi IMI 58289 CCT66619.1    
 FFUJ_03676   Fusarium fujikuroi IMI 58289 CCT66634.1    
 FFUJ_07764   Fusarium fujikuroi IMI 58289 CCT68937.1    
 FFUJ_09158   Fusarium fujikuroi IMI 58289 CCT70824.1    
 FFUJ_10234   Fusarium fujikuroi IMI 58289 CCT74191.1    
 FFUJ_10765   Fusarium fujikuroi IMI 58289 CCT74702.1    
 FFUJ_10887   Fusarium fujikuroi IMI 58289 CCT74817.1    
 FFUJ_00085   Fusarium fujikuroi IMI 58289 CCT63282.1    
 ORF   Fusarium graminearum F15 BAD89513.1 Q5FBG6  
 FGRAMPH1_01T05857   Fusarium graminearum PH-1 SCB64422.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF84800.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF78036.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF83262.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF87867.1    
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