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Glycoside Hydrolase Family 2

Activities in Familyα-L-arabinopyranosidase (EC 3.2.1.-);
β-1,3-galactosidase (EC 3.2.1.-);
β-galacturonidase (EC 3.2.1.-);
β-galacturonidase RGII specific (EC 3.2.1.-);
Lactase (EC 3.2.1.108);
Glycyrrhizin β-glucuronidase (EC 3.2.1.128);
β-D-galactofuranosidase (EC 3.2.1.146);
Mannosylglycoprotein endo-β-mannosidase (EC 3.2.1.152);
Exo-β-1,4-glucosaminidase (EC 3.2.1.165);
β-glucosidase (EC 3.2.1.21);
β-galactosidase (EC 3.2.1.23);
β-mannosidase (EC 3.2.1.25);
β-glucuronidase (EC 3.2.1.31);
Xylan β-1,4-xylosidase (EC 3.2.1.37);
β-N-acetylhexosaminidase (EC 3.2.1.52);
α-L-arabinofuranosidase (EC 3.2.1.55);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (43405); Uniprot accession (238); PDB accession (242); 3D entries (63); cryst (2)
Summary
Download GH2 (46622) Taxonomic display Structure (63 - 2 cryst) Characterized (216)
| 1 | 2 | 3 |
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 β-galactosidase (LVIS_2259 + LVIS_2258) 3.2.1.23 pubmed
 Levilactobacillus brevis ATCC 367 ABJ65308.1 Q03NB4  
 β-glucuronidase (Gus) 3.2.1.31 pubmed
 Levilactobacillus brevis RO1 ACU21612.1 D2DMF3  
 β-galactosidase (LacLM;LacL+LacM) 3.2.1.23 pubmed
 Limosilactobacillus fermentum K4 AEJ32720.1 F8T7X0  
 β-galactosidase (Lreubgal) (LacL + LacM) 3.2.1.23 pubmed
 Limosilactobacillus reuteri L103 ABF72116.1 Q19R72  
 β-galactosidase (BgaB;MsBgaB;MS0749) 3.2.1.23 pubmed
 [Mannheimia] succiniciproducens MBEL55E AAU37356.1 Q65UK4  
 β-galactosidase (BgaA;MsBgaA;MS0806) 3.2.1.23 pubmed
 [Mannheimia] succiniciproducens MBEL55E AAU37413.1 Q65UE7  
 β-glucuronidase (Rg3GUS) 3.2.1.31 pubmed
 Mediterraneibacter gnavus WP_118581144.1   6MVG[A,B,C]
 β-glucuronidase (UidA) 3.2.1.31 pubmed
 Mediterraneibacter gnavus E1 AAQ76046.1 A0A2N5PVZ8
Q6W7J7		 5Z18[A,B,C,D,E,F]
5Z19[A,B,C,D,E,F]
6EC6[A,B]
6JZ1[A,B]
6JZ2[A,B]
6JZ3[A,B]
6JZ4[A,B]
6JZ5[A,B]
6JZ6[A,B]
6JZ7[A,B]
6JZ8[A,B]
 α-L-arabinopyranosidase (Bgp2) 3.2.1.- pubmed
 Microbacterium esteraromaticum GS514 AFC90218.1 H9A6H2  
 β-galactosidase (GalM) 3.2.1.23 pubmed
 Microvirga sp. MC18 WLC21218.1    
 β-glucuronidase (B160DRAFT_01711) 3.2.1.31 pubmed
 Niabella aurantiaca DSM 17617 WP_018628801.1    
 β-galactosidase A / B / C / D / 91 (Bga; BgaD; β-Gal-A; β-Gal-B; β-Gal-C; β-Gal-D; β-Glα-91; GALA) 3.2.1.23 pubmed
 Niallia circulans ATCC 31382 BAJ61032.1
QEP29033.1		 E5RWQ2 4YPJ[A,B]
 β-galactosidase 3.2.1.23 pubmed
 Niallia circulans ATCC 31382 QJU69416.1 A0A6M5K904 7CWD[A]
7CWI[A]
 β-galactosidase (PbBGal2A) 3.2.1.23 pubmed
 Paenibacillus barengoltzii CAU904 AJP16550.1 A0A0C5GSQ2  
 β-glucuronidase (PBOR_13360) 3.2.1.31 doi
 Paenibacillus borealis DSM 13188 AIQ57810.1 A0A089LCJ8  
 β-mannosidase (ManB; MANB) 3.2.1.25 pubmed
 Paenibacillus polymyxa A-8 / A8 AGX85875.1 U5N3E2  
 β-galactosidase 3.2.1.23 pubmed
 Pantoea agglomerans B1 ABN42680.1 A3FEW8  
 β-glucuronidase (PmGUS; ZP_02032394.1; PARMER_02407) (26901) 3.2.1.31 pubmed
 Parabacteroides merdae ATCC 43184 ZP_02032394.1 A7AG62
K5ZWV5		 6D7J[A,B,C,D]
6DXU[A,B,C,D]
 β-galactosidase (BgaL; ParbDG) 3.2.1.23 pubmed
 Paracoccus sp. 32d ACY69080.1 D1LZK0 5EUV[A,B]
5LDR[A,B]
 agarolytic β-galactosidase (Ph1566) 3.2.1.23 pubmed
 Paraglaciecola hydrolytica S66 QEP52088.1 A0A5C2I9P9  
 β-glucuronidase (BSEG_01974) 3.2.1.31 pubmed
 Phocaeicola dorei 5_1_36/D4 EEO45833.1 C3R9X4 6ED1[A,B,C,D]
 β-galactosidase (BgaBM) 3.2.1.23 pubmed
 Priestia megaterium 2-37-4-1 ABN13675.1 A3FFK4  
 β-galactosidase (BgaM) 3.2.1.23 pubmed
 Priestia megaterium DSM 319 CAA04267.1
ADF38979.1		 O52847  
 β-galactosidase (MbgA;BG04_4479) 3.2.1.23 pubmed
 Priestia megaterium NBRC 15308 = ATCC 14581 AJI24329.1
AAC34375.1		 A0A0B6AWT5
O85167		  
 β-galactosidase (LacZ) 3.2.1.23 pubmed
 Pseudoalteromonas haloplanktis TAE 79 CAA10470.1
AAU97746.1		 P81650  
 β-galactosidase (LacZ) 3.2.1.23 pubmed
 Pseudoalteromonas sp. 22b AAR92204.1 Q6RGS1  
 α-L-arabinofuranosidase (TtAFase;Theth_0328) 3.2.1.55 pubmed
 Pseudothermotoga thermarum DSM 5069 AEH50423.1 F7YVC0  
 β-glucuronidase (Rh2GUS) 3.2.1.31 pubmed
 Roseburia hominis WP_118096903.1   6MVH[A,B,C,D]
8GES[A,B,C,D]
 β-glucuronidase (ERS852391_01800; Uida_2) 3.2.1.31 pubmed
 Roseburia hominis 2789STDY5608834 CUO31707.1    
 β-glucuronidase 3.2.1.31 pubmed
 Roseburia inulinivorans WP_055167711.1 A0A173RPS8  
 β-galactosidase 3.2.1.23 pubmed
 Saccharopolyspora rectivirgula BAA34817.1 Q9ZBD1  
 β-galactosidase Z (LacZ) 3.2.1.23 pubmed
 Sinorhizobium meliloti 102F34 AAA26296.1 Q59750  
 β-glucuronidase (Gus) 3.2.1.31 pubmed
 Staphylococcus sp. RLH1 AAK29422.1
AAR75615.1
AAR75620.1
AAR75621.1
ABP04762.1		 Q9AFA2  
 β-galactosidase (LacH) 3.2.1.23 pubmed
 Staphylococcus xylosus CAA74937.1 O33815  
 β-glucuronidase (SAG0698) 3.2.1.31 pubmed
 Streptococcus agalactiae 2603V/R AAM99585.1
NP_687713.1
Q8E0N2		   4JKK[A]
4JKL[A,B]
 β-galactosidase (BgaA;SPD0562;SPD_0562) 3.2.1.23 pubmed
 Streptococcus pneumoniae D39 ABJ53768.1 A0A0H2ZMI1
Q04LN6		  
 β-galactosidase (BgaA) 3.2.1.23 pubmed
 Streptococcus pneumoniae KNR7/87 AAF97242.1 Q9KGU0  
 β-galactosidase (BgaA;spr0565; specific for β-1,4-bonds)) 3.2.1.23 pubmed
 Streptococcus pneumoniae R6 AAK99369.1
NP_358159.1		 Q8DQP4  
 β-1,4-galactosidase A (BgaA;SP0648;SP_0648) 3.2.1.23 pubmed
 Streptococcus pneumoniae TIGR4 AAK74795.1
ABA35731.1
NP_345155.1		 A0A0H2UP19
Q9KGU0		 4CU6[A]
4CU7[A]
4CU8[A]
4CUC[A]
 β-galactosidase (LacZ) 3.2.1.23 pubmed
 Streptococcus thermophilus FUA3194 CAZ66940.1 C6H180  
 β-galactosidase (STER_1366) 3.2.1.23 pubmed
 Streptococcus thermophilus LMD-9 ABJ66539.1 Q03JT3  
 exo-β-glucosaminidase (CsxA;SAV1223;SAV_1223) 3.2.1.165 pubmed
 Streptomyces avermitilis MA-4680 = NBRC 14893 BAC68933.1
NP_822398.1		 Q82NR8  
 β-galactosidase (SCO3479; SCE65.15c) 3.2.1.23 pubmed
 Streptomyces coelicolor A3(2) CAB61803.1
NP_627682.1		    
 β-D-galactofuranosidase (ORF1110) 3.2.1.146 pubmed
 Streptomyces sp. JHA19 BAS29529.1 A0A0K2SRV3  
 β-D-galactofuranosidase (ORF0643) 3.2.1.146 pubmed
 Streptomyces sp. JHA26 BAW98477.1 A0A1Q2U3E4  
 β-mannosidase (Bma;Man2S27) 3.2.1.25 pubmed
 Streptomyces sp. S27 ACCC 41168 ACN78887.1
ADK91096.1		 D2DFB5  
 β-glucuronidase (TfGUSL2;TFKS16_0857) 3.2.1.31 pubmed
 Tannerella forsythia KS16 BAR51149.1   8DHL[A,B]
 β-glucuronidase (TfGUSmL1;TFKS16_2216) 3.2.1.31 pubmed
 Tannerella forsythia KS16 BAR52418.1   8DHE[A,B,C,D]
 β-galactosidase (LacA;Teth39_0611) 3.2.1.23 pubmed
 Thermoanaerobacter pseudethanolicus ATCC 33223 CAA69850.1
ABY94275.1		 P77989  
 β-galactosidase (LacZ;LacA) 3.2.1.23 pubmed
 Thermoanaerobacterium thermosulfurigenes EM1 AAA23249.1
CAA38462.1		 P26257
Q53WT4		  
 β-mannosidase (ManB) 3.2.1.25 pubmed
 Thermobifida fusca TM51 CAD33708.1 Q8KLI9  
 β-mannosidase (ManB;Tfu_0915) 3.2.1.25 pubmed
 Thermobifida fusca YX AAZ54953.1 Q47RG4  
 β-galactosidase 2D (Bga2D; Lacz1;Cst_c02440) 3.2.1.23 pubmed
 Thermoclostridium stercorarium subsp. stercorarium DSM 8532 AGC67268.1
AGI38337.1		 L7VP00  
 β-galactosidase 2C (Bga2C; Lacz2; Cst_c06190) 3.2.1.23 pubmed
 Thermoclostridium stercorarium subsp. stercorarium DSM 8532 AGC67637.1
AGI38685.1		 L7VLR6  
 β-galactosidase 2B (Bga2B; Lacz3; Cst_c09830) 3.2.1.23 pubmed
 Thermoclostridium stercorarium subsp. stercorarium DSM 8532 AGC67981.1
AGI39016.1		 L7VND8  
 β-glucuronidase 2A (Uid2A; Cst_c13910) 3.2.1.31
3.2.1.-		 pubmed
pubmed
 Thermoclostridium stercorarium subsp. stercorarium DSM 8532 AGI39403.1
AGC68382.1		 L7VNM6  
 β-galactosidase 2E (Bga2E; Cst_c01600) 3.2.1.23 pubmed
 Thermoclostridium stercorarium subsp. stercorarium DSM 8532 AGI38265.1
AGC67186.1		 L7VL47  
 β-galactosidase Z (LacZ;TmLac;TM1193) 3.2.1.23 pubmed
 Thermotoga maritima MSB8 AAD36268.1
AAA50597.1
AGL50124.1
AHD18900.1
AKE28970.1
CAA04513.1
NP_228998.1		 G4FEF3
Q56307		 6S6Z[A,B,C,D,E,F,G,H]
6SD0[A,B,C,D]
 β-glucuronidase (Gus;TmGUS;TM1062;Tmari_1066) 3.2.1.31 pubmed
 Thermotoga maritima MSB8 AAD36143.1
AAR75619.1
AAR75627.1
AGL49990.1
AHD19030.1
AKE28838.1
NP_228868.1		 Q9X0F2
R4NQD9		  
 β-mannosidase (ManA; TM1624) (Man2) 3.2.1.25 doi
 Thermotoga maritima MSB8 AAD36691.1
AAM56797.1
AGL50557.1
AHD18479.1
AKE29383.1
CAB56855.1
NP_229424.1		 Q9RIK8
Q9X1V9
R4P1P3		  
 β-mannosidase (TnMan2) (Man2) 3.2.1.25 pubmed
 Thermotoga neapolitana 5068 AAK52304.1 Q93M25  
 β-glucosidase (Gh2;TaGH2) 3.2.1.21 doi
 Thermus antranikianii CDO50493.1 A0A0F7RRH2  
 β-glucosidase (Gh2;TbGH2) 3.2.1.21 doi
 Thermus brockianus CDO50494.1 A0A0F7RR59  
 β-galactosidase (pTsbg; TSC_c19230) 3.2.1.23 pubmed
 Thermus scotoductus SA-01 ADW22536.1
WP_015717801.1		    
 β-N-acetylglucosaminidase (TTP0222) 3.2.1.21
3.2.1.23
3.2.1.52		 doi
doi
 Thermus thermophilus HB27 AAS82550.1 Q745T5  
 β-glucuronidase (TlGUSL1) 3.2.1.31 pubmed
 Treponema lecithinolyticum     8DHW[A,B]
8E72[A,B]
8DHV[A,B]
 β-glucuronidase (H11G11-BG) 3.2.1.31 pubmed
 uncultured bacterium CBJ55484.1 D5GU71  
 β-glucuronidase (C7D2-BG) 3.2.1.31 pubmed
 uncultured bacterium CBJ55485.1 D5GU72  
 Betα-glucuronidase (uidA_2) 3.2.1.31 pubmed
 uncultured Clostridium sp.   A0A1C5YG41 6U7J[A,B,C,D]
 agarolytic β-galactosidase (VejABG;VEJY3_09170) 3.2.1.23 pubmed
 Vibrio sp. EJY3 AEX22320.1    
 β-galactosidase (Gal02II;GalB) 3.2.1.23 pubmed
 Xanthomonas campestris pv. campestris AAP86765.1 Q6X1E3  
 β-galactosidase (XC2985; XC_2985) 3.2.1.23 pubmed
 Xanthomonas campestris pv. campestris str. 8004 AAY50033.1 A0A0H2X9M6  
 [N-glycan] β-1,4-mannosidase (NixH;XCC2891) 3.2.1.25 pubmed
 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42163.1
NP_638239.1		 Q8P6S4  
 exo-β-mannanase (XacMan2A; XAC3075) (XacMan2A) 3.2.1.25 pubmed
 Xanthomonas citri pv. citri str. 306 AAM37920.1
NP_643384.1		 Q8PI23 6BYC[A]
6BYE[A,B]
6BYG[A,B]
6BYI[A,B]
 β-galactosidase (BgaB; zobellia_3633) 3.2.1.23 pubmed
 Zobellia galactanivorans DsijT CAZ97771.1 G0L1N0  
 agarolytic β-galactosidase (BgaF; zobellia_4655) 3.2.1.23 pubmed
 Zobellia galactanivorans DsijT CAZ98790.1 G0L4M6  
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 β-D-galactofuranosidase (AaGH2) 3.2.1.146 pubmed
 Amesia atrobrunnea UOO01254.1    
 β-mannosidase (AkMnsD) 3.2.1.25 pubmed
 Aplysia kurodai BAL43431.1 H1AFK3  
 mannosylglycoprotein endo-β-mannosidase (AtEBM; At1g09010/F7G19.12) 3.2.1.152 pubmed
 Arabidopsis thaliana BAD15284.1
AAB70407.1
AAK76608.1
AAM14288.1
AEE28382.1
NP_172375.1
NP_563833.1		 A0A178WLW7
O04029
Q75W54		  
 β-mannosidase (ManB) (fragment) 3.2.1.25 pubmed
 Aspergillus aculeatus F-50 BAA29029.1 O74168  
 α-L-arabinofuranosidase / β-D-galactofuranosidase (Afu2g14520; AFUA_2G14520) 3.2.1.55
3.2.1.146		 pubmed
pubmed
 Aspergillus fumigatus Af293 EAL93747.2 Q4X068  
 β-D-galactofuranosidase (GfgA; AN2395) 3.2.1.146 pubmed
 Aspergillus nidulans FGSC A4 EAA64506.1 A0A1U8QH40  
 β-1,5-D-galactofuranosidase (GfgB; AN3200) 3.2.1.146 pubmed
 Aspergillus nidulans FGSC A4 EAA62925.1
AFD22629.1		 A0A1U8QGM2
H9N4D0		  
 β-mannosidase (AN3368.2; MndB) 3.2.1.25 pubmed
 Aspergillus nidulans FGSC A4 ABF50864.1
EAA63336.1		 Q5B7W2  
 intracellular β-galactosidase (BgaD) 3.2.1.23 pubmed
 Aspergillus nidulans WG355 ADM36015.1 G8Z4I7  
 β-mannosidase (MndA) (Mnd2A) 3.2.1.25 pubmed
 Aspergillus niger CBS 120.49 / N400 CAB63902.1 Q9UUZ3  
 β-mannosidase (MndA;AnigerBM2;An11g06540) 3.2.1.25 pubmed
 Aspergillus niger CBS 513.88 CAK96951.1
XP_001394632.2		 A2QWU9 cryst
 exo-β-glucosaminidase (Csx;AorCsxA) 3.2.1.165 pubmed
 Aspergillus oryzae FL402 AHJ61328.1 W8E1X9  
 β-glucuronidase (PGUS;GUS) 3.2.1.31 doi
 Aspergillus oryzae Li-3 ABU68712.1 A7XS03 5C70[A,B]
5C71[A,B,C,D]
 exo-β-glucosaminidase (Csx;ChiA) 3.2.1.165 pubmed
 Aspergillus sp. CJ22-326 ACO94980.1 C3U4R9  
 β-glucuronidase (AtGUS) 3.2.1.31 pubmed
 Aspergillus terreus Li-20 AEP39213.1 G4XPL5  
 β-glucuronidase (AuGUS) 3.2.1.31 pubmed
 Aspergillus ustus Li-62 AEK69352.1 G1FNU5  
 β-mannosidase 3.2.1.25 pubmed
pubmed
 Bos taurus AAC48460.1
AAD39352.1
AAE16437.1
AAI47901.1
NP_776812.1		 A6QLB0
Q29444
Q9TTG6		  
 endo-β-mannosidase (Ebm) 3.2.1.152 pubmed
 Brassica oleracea BAE97370.1 Q14U56  
 β-glucuronidase (GusB) 3.2.1.31 pubmed
 Canis lupus familiaris AAC48809.1 O18835  
 β-mannosidase 3.2.1.25 pubmed
 Capra hircus (MANBA) AAC48665.1 Q95327  
 glycyrrhizin β-glucuronidase (cg-GUS) 3.2.1.128 pubmed
 Chaetomium globosum QIM55348.1 A0A6G8IQN4  
 β-glucuronidase (GusB) 3.2.1.31 pubmed
 Felis catus AAD01498.1
AAD01499.1		 O97524  
 β-glucuronidase b (GusB;GUSB) 3.2.1.31 pubmed
 Homo sapiens AAA52561.1
AAH14142.1
AAQ96851.1
AAR75622.1
ABH92596.1
ACH09936.1
ACM86199.1
BAD97126.1
BAG35619.1
BAG61991.1
BAG64768.1
CAC41170.1
NP_000172.1
SJX44098.1		 B2R6X2
B4DTH9
P08236		 1BHG[A,B]
3HN3[A,B,D,E]
 β-mannosidase (ManBA) 3.2.1.25 pubmed
 Homo sapiens AAC39573.1
AAH15743.1
ABS29701.1
BAD93083.1
BAF84287.1
BAG61830.1		 A7LFP5
A8K6D3
B4DT18
O00462
Q59EG5		  
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