Glycoside Hydrolase Family 2

Activities in Familyβ-galactosidase (EC 3.2.1.23) ; β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); α-L-arabinofuranosidase (EC 3.2.1.55); mannosylglycoprotein endo-β-mannosidase (EC 3.2.1.152); exo-β-glucosaminidase (EC 3.2.1.165)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (11600); Uniprot accession (1662); PDB accession (119); 3D entries (27); cryst (2)
All (10350) Archaea (46) Bacteria (9994) Eukaryota (291) unclassified (19) Structure (27 - 2 cryst) Characterized (147)
| 1 | 2 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-galactosidase (BgalB) 3.2.1.23 Thermotoga neapolitana AAC24219.1 O85250  
 β-mannosidase (Man2) 3.2.1.25 Thermotoga neapolitana 5068 AAK52304.1 Q93M25  
 β-glucosidase (Gh2;TaGH2) 3.2.1.21 Thermus antranikianii CDO50493.1    
 β-glucosidase (Gh2;TbGH2) 3.2.1.21 Thermus brockianus CDO50494.1    
 β-galactosidase (β-gal;BgaA) 3.2.1.23 Thermus thermophilus HJ6 ABW87309.1 A8WAD1  
 β-glucuronidase (H11G11-BG) 3.2.1.31 uncultured bacterium CBJ55484.1 D5GU71  
 β-glucuronidase (C7D2-BG) 3.2.1.31 uncultured bacterium CBJ55485.1 D5GU72  
 β-galactosidase (LacZ) 3.2.1.23 Vibrio vulnificus AAK15465.1
AAK29750.1
Q8D4H3
Q9AEQ8
Q9AHK2
 
 β-galactosidase (Gal02II;GalB) 3.2.1.23 Xanthomonas campestris pv. campestris AAP86765.1 Q6X1E3  
 β-galactosidase (Gal02I;GalA) 3.2.1.23 Xanthomonas campestris pv. campestris AAP86764.1 H9L3X3
Q8PB68
 
 XC_2985 3.2.1.23 Xanthomonas campestris pv. campestris str. 8004 AAY50033.1 Q4USE0  
 β-galactosidase (BgA;XCC1256) 3.2.1.23 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM40554.1
NP_636630.1
Q8PB68  
 [N-glycan] β-1,4-mannosidase (NixH;XCC2891) 3.2.1.25 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42163.1
NP_638239.1
Q8P6S4  
 β-galactosidase (XCC4116) 3.2.1.23 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM43337.1
NP_639455.1
Q8P3F5  
 β-galactosidase (LacZ;YPO1654) 3.2.1.23 Yersinia pestis CO92 CAC90476.1
CAL20299.1
NP_405234.1
Q8ZFP0  
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-mannosidase (AkMnsD) 3.2.1.25 Aplysia kurodai BAL43431.1    
 At1g09010/F7G19.12 (mannosylglycoprotein endo-β-mannosidase; AtEBM) 3.2.1.152 Arabidopsis thaliana BAD15284.1
AAB70407.1
AAK76608.1
AAM14288.1
AEE28382.1
NP_172375.1
NP_563833.1
O04029
Q75W54
 
 β-mannosidase (ManB) (probable frameshift) 3.2.1.25 Aspergillus aculeatus F-50 BAA29029.1 O74168  
 β-mannosidase (AN3368.2) 3.2.1.25 Aspergillus nidulans FGSC A4 ABF50864.1
EAA63336.1
Q5B7W2  
 intracellular β-galactosidase (BgaD) 3.2.1.23 Aspergillus nidulans WG355 ADM36015.1    
 β-mannosidase (MndA) (Mnd2A) 3.2.1.25 Aspergillus niger CBS 120.49 / N400 CAB63902.1 Q9UUZ3  
 β-mannosidase (MndA;AnigerBM2;An11g06540) 3.2.1.25 Aspergillus niger CBS 513.88 CAK96951.1
XP_001394632.2
XP_001394632.2
A2QWU9 cryst
 exo-β-glucosaminidase (Csx;AorCsxA) 3.2.1.165 Aspergillus oryzae FL402 AHJ61328.1    
 β-glucuronidase (PGUS;GUS) 3.2.1.31 Aspergillus oryzae Li-3 ABU68712.1 A7XS03 5C70[A,B]
5C71[A,B,C,D]
 exo-β-glucosaminidase (Csx;ChiA) 3.2.1.165 Aspergillus sp. CJ22-326 ACO94980.1 C3U4R9  
 β-glucuronidase (AtGUS) 3.2.1.31 Aspergillus terreus Li-20 AEP39213.1    
 β-glucuronidase (AuGUS) 3.2.1.31 Aspergillus ustus Li-62 AEK69352.1    
 β-mannosidase 3.2.1.25 Bos taurus AAC48460.1
AAD39352.1
AAE16437.1
AAI47901.1
NP_776812.1
Q29444
Q9TTG6
 
 endo-β-mannosidase (Ebm) 3.2.1.152 Brassica oleracea BAE97370.1 Q14U56  
 β-glucuronidase (GusB) 3.2.1.31 Canis lupus familiaris AAC48809.1 O18835  
 β-mannosidase 3.2.1.25 Capra hircus (MANBA) AAC48665.1 Q95327  
 β-glucuronidase (GusB) 3.2.1.31 Felis catus AAD01498.1
AAD01499.1
O97524  
 β-glucuronidase b (GusB;GUSB) 3.2.1.31 Homo sapiens AAA52561.1
AAH14142.1
AAQ96851.1
AAR75622.1
ABH92596.1
ACH09936.1
ACM86199.1
BAD97126.1
BAG35619.1
BAG61991.1
BAG64768.1
CAC41170.1
NP_000172.1
P08236 1BHG[A,B]
3HN3[A,B,D,E]
 β-mannosidase (ManBA) 3.2.1.25 Homo sapiens AAC39573.1
AAH15743.1
ABS29701.1
BAD93083.1
BAF84287.1
BAG61830.1
O00462  
 β-galactosidase (Lac4;BgaL) 3.2.1.23 Kluyveromyces lactis CBS2359 AAA35265.1 P00723 3OB8[A,B,C,D]
3OBA[A,B,C,D]
 β-galactosidase (BglKL) 3.2.1.23 Kluyveromyces lactis F61 AHW49176.1    
 β-galactosidase (BgaL;KLLA0B14883g) 3.2.1.23 Kluyveromyces lactis NRRL Y-1140 CAH02587.1 P00723  
 β-galactosidase 3.2.1.23 Kluyveromyces marxianus DSM5418 AAS18310.1 Q6QTF4  
 mannosylglycoprotein endo-β-mannosidase (Ebm) 3.2.1.152 Lilium longiflorum BAD89079.2
BAD89079.1
Q5H7P5  
 β-glucuronidase (GusB;Gus-S) 3.2.1.31 Mus musculus AAA37696.1
AAA37697.1
AAA63307.1
AAA63308.1
AAA63309.1
AAA98623.1
AAH71226.1
AAQ41980.1
BAE23021.1
BAE29265.1
BAE34865.1
BAE35155.1
BAE35384.1
BAE36917.1
CAC41171.1
NP_034498.1
P12265  
 β-mannosidase 3.2.1.25 Mus musculus AAK18177.1
AAH31409.1
BAE24954.1
BAE38715.1
BAE41690.1
NP_081564.1
Q8K2I4
Q99MS1
 
 β-glucuronidase (Gus) 3.2.1.31 Penicillium canescens DSM1215 AAV91787.1 Q5MJY0  
 β-glucuronidase (Gus) 3.2.1.31 Penicillium canescens RPK AAV91785.1 Q5MJY2  
 β-glucuronidase (GusB;Gus) 3.2.1.31 Rattus norvegicus AAA41228.1
AAP86274.1
CAA68705.1
NP_058711.1
P06760
Q7TPJ3
 
 β-glucuronidase (Gus) 3.2.1.31 Scopulariopsis sp. RP38.3 AAV91788.1 Q5MJX9  
 β-mannosidase (Man9;bMann9) 3.2.1.25 Thermothelomyces thermophila C1 AFJ59925.1 I2C092  
 exo-β-glucosaminidase (Gls93) 3.2.1.165 Trichoderma reesei PC-3-7 BAD99604.1 Q4R1C4 cryst
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