Glycoside Hydrolase Family 2

Known Activitiesβ-galactosidase (EC 3.2.1.23) ; β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); mannosylglycoprotein endo-β-mannosidase (EC 3.2.1.152); exo-β-glucosaminidase (EC 3.2.1.165)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
External resourcesCAZypedia; HOMSTRAD; InterPro; PFAM; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (3065); Uniprot accession (1572); PDB accession (83); 3D entries (13); cryst (1)
All (2468) Archaea (33) Bacteria (2264) Eukaryota (164) unclassified (7) Structure (13 - 1 cryst) Characterized (123)
Bacteria
Protein Name EC#OrganismGenBankUniprotPDB/3D
 β-galactosidase (LacZ) 3.2.1.23 Actinobacillus pleuropneumoniae CM5 AAB17954.1 P70753  
 β-galactosidase (fragment) 3.2.1.23 Alkalilactibacillus ikkense 517 ACO52514.1 C1KC07  
 exo-β-glucosaminidase / exochitosanase (CsxA) 3.2.1.165 Amycolatopsis orientalis AAX62629.1
AAX62629.2
Q56F26 2VZO[A,B]
2VZS[A,B]
2VZT[A,B]
2VZU[A,B]
2VZV[A,B]
2X05[A,B]
2X09[A,B]
 β-galactosidase (BglA) 3.2.1.23 Arthrobacter psychrolactophilus F2 BAF33372.1 Q08KN3  
 β-galactosidase (LacZ) 3.2.1.23 Arthrobacter sp. AAA69907.1 Q59140  
 β-galactosidase (BgaS) 3.2.1.23 Arthrobacter sp. 20B ACI41243.1 B6EAX7  
 β-galactosidase (LacZ) 3.2.1.23 Arthrobacter sp. C2-2 CAD29775.1 Q8KRF6 1YQ2[A,B,C,D,E,F]
 β-galactosidase (GalA) 3.2.1.23 Arthrobacter sp. ON14 ADJ18283.1 D9IU58  
 β-glucuronidase (Gus) 3.2.1.31 Arthrobacter sp. RP10 AAV91790.1 Q5MJX7  
 β-glucuronidase (Gus) 3.2.1.31 Arthrobacter sp. RP40.7 AAV91792.1 Q5MJX5  
 β-galactosidase (LacZ) 3.2.1.23 Arthrobacter sp. SB AAQ19029.1 Q7WTU5  
 β-galactosidase A / B / C / D / 91 (Bga;β-Gal-A;β-Gal-B;β-Gal-C;β-Gal-D;β-Glα-91) 3.2.1.23 Bacillus circulans ATCC 31382 BAJ61032.1    
 β-galactosidase 3.2.1.23 Bacillus megaterium 2-37-4-1 ABN13675.1 A3FFK4  
 β-galactosidase (BgaM) 3.2.1.23 Bacillus megaterium DSM 319 ADF38979.1
CAA04267.1
O52847.1  
 β-mannosidase (BT0458;BT_0458) (Man2A) 3.2.1.25 Bacteroides thetaiotaomicron VPI-5482 AAO75565.1
NP_809371.1
  2JE8[A,B]
2VJX[A,B]
2VL4[A,B]
2VMF[A,B]
2VO5[A,B]
2VOT[A,B]
2VQT[A,B]
2VQU[A,B]
2VR4[A,B]
2WBK[A,B]
 β-galactosidase (BIF1;OLGA1) 3.2.1.23 Bifidobacterium bifidum DSM 20215 CAB75342.1    
 β-galactosidase (BIF3) 3.2.1.23 Bifidobacterium bifidum DSM 20215 AAP64961.1
ABI07182.1
CAC14566.2
CAD19366.1
Q9F4D5  
 β-galactosidase (BIF2) 3.2.1.23 Bifidobacterium bifidum DSM 20215 CAC14565.1 Q9F4D6  
 lacto-N-neotetraose β-galactosidase (BbgIII) 3.2.1.23 Bifidobacterium bifidum JCM 1254 BAI94821.1    
 β-galactosidase P1 (BbgI;Bbg1) 3.2.1.23 Bifidobacterium bifidum NCIMB 41171 ABE27151.1
ABE27151.2
Q0ZI53  
 β-galactosidase S1 (BbgIII) 3.2.1.23 Bifidobacterium bifidum NCIMB 41171 ABE27152.1 A4K5H9  
 β-galactosidase K2 (BbgIV) 3.2.1.23 Bifidobacterium bifidum NCIMB 41171 ABE00939.1 Q0ZII7  
 β-galactosidase (LacZ;BL0978) 3.2.1.23 Bifidobacterium longum NCC2705 AAN24786.1
NP_696150.1
   
 β-galactosidase 2A (Blon_2334) (Bga2A) 3.2.1.23 Bifidobacterium longum subsp. infantis ATCC 15697 ACJ53392.1 B7GNN6  
 β-galactosidase I (β-GalI) 3.2.1.23 Bifidobacterium longum subsp. infantis HL96 AAL02052.1 Q93GI6  
 β-galactosidase (LacZ) 3.2.1.23 Bifidobacterium longum subsp. longum MB219 CAB44428.1 Q9X6Y5  
 β-galactosidase (Lac) 3.2.1.23 Caldicellulosiruptor lactoaceticus CAC50563.1 Q93KF0  
 β-mannosidase 2A (Man2A) 3.2.1.25 Cellulomonas fimi ATCC 484 AAD42775.1
AEE46894.1
Q9XCV4  
 β-galactosidase 3.2.1.23 Clostridium acetobutylicum AAA23216.1 P24131.2  
 β-galactosidase (Bga;BgaB5) 3.2.1.23 Enterobacter cloacae B5 ABB73039.1 Q2XQU3  
 β-galactosidase (LacZ) 3.2.1.23 Enterobacter cloacae GAO BAA07673.1 Q47077  
 β-glucuronidase (UidA) 3.2.1.31 Escherichia coli 493BI AAK15468.1 Q9AHJ4  
 β-galactosidase Z (LacZ;b0344) 3.2.1.23 Escherichia coli K-12 MG1655 AAA24053.1
AAB18068.1
AAC73447.1
AAW06767.1
AAY73171.1
ABN72582.1
AEL16982.1
CAA23573.1
NP_414878.1
B8LFD6
P00722.2
1BGL[A]
1BGM[I]
1DP0[A]
1F49[A]
1F4A[A]
1F4H[A]
1GHN
1GHO[I]
1HN1[A]
1JYN[A]
1JYV[A]
1JYW[A]
1JYX[A]
1JYY[A]
1JYZ[I]
1JZ0[A]
1JZ1[I]
1JZ2[A]
1JZ3[A]
1JZ4[A]
1JZ5[A]
1JZ6[A]
1JZ7[A]
1JZ8[A]
1PX3[A,B,C,D]
1PX4[A,B,C,D]
3CZJ[A,B,C,D]
3DYM[A,B,C,D]
3DYO[A,B,C,D]
3E1F[1,2,3,4]
3I3B[A,B,C,D]
3I3D[A,B,C,D]
3I3E[A,B,C,D]
3IAP[A,B,C,D]
3IAQ[A,B,C,D]
3MUY[1,2,3,4]
3MUZ[1,2,3,4]
3MV0[1,2,3,4]
3MV1[1,2,3,4]
3SEP[A,B,C,D]
3T08[A,B,C,D]
3T09[A,B,C,D]
3T0A[A,B,C,D]
3T0B[A,B,C,D]
3T0D[A,B,C,D]
3T2O[A,B,C,D]
3T2P[A,B,C,D]
3T2Q[A,B,C,D]
 β-glucuronidase (UidA;GusA;GurA;b1617) 3.2.1.31 Escherichia coli K-12 MG1655 AAA68923.1
AAB30197.1
AAC74689.1
AAR75623.1
ABE20937.1
ACR88323.1
BAA15368.1
CAJ55495.1
CAJ55496.1
CAJ55497.1
CAJ55498.1
CAJ55499.1
CAJ55500.1
NP_416134.1
P05804.2 1KZ3
1UL8
1YDQ
3K46[A,B]
3K4A[A,B]
3K4D[A,B]
3LPF[A,B]
3LPG[A,B]
 evolved β-galactosidase (EbgA;b3076) 3.2.1.23 Escherichia coli K-12 MG1655 AAA57877.1
AAA61971.1
AAC76111.1
AAT48164.1
CAA36274.1
NP_417547.2
P06864.4  
 β-galactosidase (LacZ) 3.2.1.23 Escherichia coli str. K-12 substr. W3110 BAE76126.1    
 β-galactosidase (Gal4214-1) 3.2.1.23 Flavobacterium sp. 4214 AAX48919.1 Q2VT50  
 β-galactosidase Z (LacZ) 3.2.1.23 Klebsiella pneumoniae AAA25082.1 P06219.1  
 β-galactosidase large subunit (LacL) 3.2.1.23 Lactobacillus acidophilus ATCC 4356 ACC38286.1 B2LWG2  
 β-galactosidase (LacL) 3.2.1.23 Lactobacillus acidophilus JCM 1229 BAA20536.1 A0SWS3
O07684.2
 
 β-glucuronidase (Gus) 3.2.1.31 Lactobacillus brevis RO1 ACU21612.1 D2DMF3  
 β-galactosidase Z 3.2.1.23 Lactobacillus delbrueckii AAA25240.1
AAA25244.1
AAY08349.1
ACW22137.1
CAC07488.1
P20043  
 β-galactosidase Z (LacZ;Ldb1201) 3.2.1.23 Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 CAI98003.1 Q1G9Z4  
 β-galactosidase 3.2.1.23 Lactobacillus delbrueckii subsp. bulgaricus L3 ACE06986.1 B3GS90  
 β-galactosidase (LacLM;LacL+LacM) 3.2.1.23 Lactobacillus fermentum K4 AEJ32720.1    
 β-glucuronidase (GusA) 3.2.1.31 Lactobacillus gasseri ADH AAK07836.1
AAS22718.1
Q9AHJ8  
 β-galactosidase (LacL+LacM) 3.2.1.23 Lactobacillus plantarum ATCC 8014 AAL09167.1 Q938Q6  
 β-galactosidase (LacL+LacM) 3.2.1.23 Lactobacillus plantarum FUA3112 CAZ66936.1    
 β-galactosidase (LacL+LacM,lp_3483+lp_3484) 3.2.1.23 Lactobacillus plantarum WCFS1 CAD65569.1
CCC80451.1
NP_786691.1
   
 β-galactosidase (LacL + LacM) 3.2.1.23 Lactobacillus reuteri L103 ABF72116.1    
 β-galactosidase L+S (LacL+LacS) (heterodimer) 3.2.1.23 Lactobacillus sakei subsp. sakei DSM 20017 CAA57730.1 Q48846  
 β-galactosidase (LacZ) 3.2.1.23 Lactococcus lactis ATCC 7962 AAC63020.1
AAD11504.1
CAA56341.1
O87523
Q48727.3
 
 β-galactosidase (LacZ;L0025) 3.2.1.23 Lactococcus lactis subsp. lactis Il1403 AAK06078.1
NP_268137.2
   
 β-galactosidase L+M (LacL+LacM) 3.2.1.23 Leuconostoc lactis AAA25267.1
CAL48858.1
Q02603  
 β-galactosidase (BgaA;MsBgaA;MS0806) 3.2.1.23 Mannheimia succiniciproducens MBEL55E AAU37413.1 Q65UE7  
 β-galactosidase 3.2.1.23 Pantoea agglomerans B1 ABN42680.1 A3FEW8  
 β-galactosidase (BgaL) 3.2.1.23 Paracoccus sp. 32d ACY69080.1 D1LZK0  
 β-galactosidase (LacZ) 3.2.1.23 Pseudoalteromonas haloplanktis TAE 79 AAU97746.1
CAA10470.1
P81650  
 β-galactosidase (LacZ) 3.2.1.23 Pseudoalteromonas sp. 22b AAR92204.1 Q6RGS1  
 β-galactosidase Z (LacZ) 3.2.1.23 Psychromonas marina BAA76741.1 Q9WXJ2  
 β-glucuronidase (UidA) 3.2.1.31 Ruminococcus gnavus E1 AAQ76046.1 Q6W7J7  
 β-galactosidase 3.2.1.23 Saccharopolyspora rectivirgula BAA34817.1 Q9ZBD1  
 β-1,4-galactosidase 3.2.1.23 Serratia sp. D04 AAZ81660.1 Q3YJ54  
 β-galactosidase Z (LacZ) 3.2.1.23 Sinorhizobium meliloti 102F34 AAA26296.1 Q59750  
 β-glucuronidase (GusA) 3.2.1.31 Sphingomonas elodea ACE13470.1    
 β-glucuronidase (Gus) 3.2.1.31 Staphylococcus sp. RLH1 AAK29422.1 Q9AFA2  
 β-galactosidase (LacH) 3.2.1.23 Staphylococcus xylosus CAA74937.1 O33815.1  
 β-galactosidase (BgaA;SPD0562;SPD_0562) 3.2.1.23 Streptococcus pneumoniae D39 ABJ53768.1 Q04LN6  
 β-galactosidase (BgaA) 3.2.1.23 Streptococcus pneumoniae KNR7/87 AAF97242.1 Q9KGU0  
 β-galactosidase (BgaA) 3.2.1.23 Streptococcus pneumoniae R6 AAK99369.1
NP_358159.1
Q8DQP4  
 β-galactosidase A (BgaA;SP0648;SP_0648) 3.2.1.23 Streptococcus pneumoniae TIGR4 AAK74795.1
ABA35731.1
NP_345155.1
Q9KGU0  
 β-galactosidase Z (LacZ) 3.2.1.23 Streptococcus thermophilus A054 AAA26913.1
AAA63532.1
AAA63533.1
P23989.1  
 β-galactosidase (LacZ) 3.2.1.23 Streptococcus thermophilus FUA3194 CAZ66940.1 C6H180  
 β-galactosidase (STER_1366) 3.2.1.23 Streptococcus thermophilus LMD-9 ABJ66539.1 Q03JT3  
 exo-β-glucosaminidase (CsxA;SAV1223;SAV_1223) 3.2.1.165 Streptomyces avermitilis MA-4680 BAC68933.1
NP_822398.1
   
 β-mannosidase (Bma;Man2S27) 3.2.1.25 Streptomyces sp. S27 ACCC 41168 ACN78887.1
ADK91096.1
D2DFB5  
 β-galactosidase (Lac) 3.2.1.23 Thermoanaerobacter mathranii CAC50570.1 Q93IM0  
 β-galactosidase (Lac) 3.2.1.23 Thermoanaerobacter mathranii CAC50569.1 Q93IM1  
 β-galactosidase (LacA; Teth39_0611) 3.2.1.23 Thermoanaerobacter pseudethanolicus ATCC 33223 39E ABY94275.1
CAA69850.1
P77989  
 β-galactosidase (LacZ;LacA) 3.2.1.23 Thermoanaerobacterium thermosulfurigenes EM1 AAA23249.1
CAA38462.1
P26257.1
Q53WT4
 
 β-mannosidase (ManB) 3.2.1.25 Thermobifida fusca TM51 CAD33708.1 Q8KLI9  
 β-mannosidase (ManB;Tfu_0915) 3.2.1.25 Thermobifida fusca YX AAZ54953.1 Q47RG4  
 β-galactosidase Z (LacZ;TM1193) 3.2.1.23 Thermotoga maritima MSB8 AAA50597.1
AAD36268.1
CAA04513.1
NP_228998.1
Q56307.2  
 β-glucuronidase (TM1062) 3.2.1.31 Thermotoga maritima MSB8 AAD36143.1
AAR75619.1
AAR75627.1
NP_228868.1
Q9X0F2  
 β-mannosidase (TM1624;ManA) (Man2) 3.2.1.25 Thermotoga maritima MSB8 AAD36691.1
AAM56797.1
CAB56855.1
NP_229424.1
Q9RIK8
Q9X1V9
 
 β-galactosidase (BgalB) 3.2.1.23 Thermotoga neapolitana AAC24219.1 O85250  
 β-mannosidase (Man2) 3.2.1.25 Thermotoga neapolitana 5068 AAK52304.1 Q93M25  
 β-glucuronidase (H11G11-BG) 3.2.1.31 uncultured bacterium CBJ55484.1 D5GU71  
 β-glucuronidase (C7D2-BG) 3.2.1.31 uncultured bacterium CBJ55485.1 D5GU72  
 β-galactosidase (LacZ) 3.2.1.23 Vibrio vulnificus AAK15465.1
AAK29750.1
Q8D4H3
Q9AEQ8
Q9AHK2
 
 β-galactosidase (Gal02II;GalB) 3.2.1.23 Xanthomonas campestris pv. campestris AAP86765.1 Q6X1E3  
 β-galactosidase (Gal02I;GalA) 3.2.1.23 Xanthomonas campestris pv. campestris AAP86764.1 Q8PB68  
 XC_2985 3.2.1.23 Xanthomonas campestris pv. campestris str. 8004 AAY50033.1 Q4USE0  
 β-galactosidase (BgA;XCC1256) 3.2.1.23 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM40554.1
NP_636630.1
   
 β-galactosidase (XCC4116) 3.2.1.23 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM43337.1
NP_639455.1
   
 β-galactosidase (LacZ;YPO1654) 3.2.1.23 Yersinia pestis CO92 Biovar Orientalis CAC90476.1
CAL20299.1
NP_405234.1
Q8ZFP0  
Eukaryota
Protein Name EC#OrganismGenBankUniprotPDB/3D
 At1g09010/F7G19.12 (mannosylglycoprotein endo-β-mannosidase; AtEBM) 3.2.1.152 Arabidopsis thaliana AAB70407.1
AAK76608.1
AAM14288.1
AEE28382.1
BAD15284.1
NP_172375.1
NP_563833.1
O04029
Q75W54
 
 β-mannosidase (ManB) (probable frameshift) 3.2.1.25 Aspergillus aculeatus F-50 BAA29029.1 O74168  
 β-mannosidase (AN3368.2) 3.2.1.25 Aspergillus nidulans FGSC A4 ABF50864.1
EAA63336.1
   
 β-mannosidase (MndA) (Mnd2A) 3.2.1.25 Aspergillus niger CBS 120.49 / N400 CAB63902.1 Q9UUZ3  
 An11g06540 (MndA) 3.2.1.25 Aspergillus niger CBS 513.88 CAK96951.1 A2QWU9  
 exo-β-glucosaminidase (Csx) 3.2.1.165 Aspergillus sp. CJ22-326 ACO94980.1 C3U4R9  
 β-mannosidase 3.2.1.25 Bos taurus AAC48460.1
AAD39352.1
AAE16437.1
AAI47901.1
NP_776812.1
Q29444
Q9TTG6
 
 endo-β-mannosidase (Ebm) 3.2.1.152 Brassica oleracea BAE97370.1 Q14U56  
 β-glucuronidase (GusB) 3.2.1.31 Canis lupus familiaris AAC48809.1 O18835.1  
 β-mannosidase 3.2.1.25 Capra hircus (MANBA) AAC48665.1 Q95327  
 β-glucuronidase (GusB) 3.2.1.31 Chlorocebus aethiops AAC34593.1 O77695.1  
 β-glucuronidase (GusB) 3.2.1.31 Felis catus AAD01498.1
AAD01499.1
O97524.1  
 β-glucuronidase b (GusB) 3.2.1.31 Homo sapiens AAA52561.1
AAH14142.1
AAQ96851.1
AAR75622.1
ABH92596.1
ACH09936.1
ACM86199.1
BAD97126.1
BAG35619.1
BAG61991.1
BAG64768.1
CAC41170.1
NP_000172.1
P08236.2 1BHG[A,B]
3HN3[A,B,D,E]
 β-mannosidase (ManBA) 3.2.1.25 Homo sapiens AAC39573.1
AAH15743.1
ABS29701.1
BAD93083.1
BAF84287.1
BAG61830.1
O00462.3  
 exo-β-glucosaminidase (Gls93) 3.2.1.165 Hypocrea jecorina PC-3-7 BAD99604.1 Q4R1C4 cryst
 β-mannosidase (5475) 3.2.1.25 Hypocrea jecorina Z12      
 β-galactosidase (Lac4;BgaL) 3.2.1.23 Kluyveromyces lactis CBS2359 AAA35265.1 P00723.2 3OB8[A,B,C,D]
3OBA[A,B,C,D]
 β-galactosidase (BgaL;KLLA0B14883g) 3.2.1.23 Kluyveromyces lactis NRRL Y-1140 CAH02587.1    
 β-galactosidase 3.2.1.23 Kluyveromyces marxianus DSM5418 AAS18310.1 Q6QTF4  
 mannosylglycoprotein endo-β-mannosidase (Ebm) 3.2.1.152 Lilium longiflorum BAD89079.1
BAD89079.2
Q5H7P5  
 β-glucuronidase (GusB;Gus-S) 3.2.1.31 Mus musculus AAA37696.1
AAA37697.1
AAA63307.1
AAA63308.1
AAA63309.1
AAA98623.1
AAH71226.1
AAQ41980.1
BAE23021.1
BAE29265.1
BAE34865.1
BAE35155.1
BAE35384.1
BAE36917.1
CAC41171.1
NP_034498.1
P12265.1  
 β-mannosidase 3.2.1.25 Mus musculus AAH31409.1
AAK18177.1
BAE24954.1
BAE38715.1
BAE41690.1
NP_081564.1
Q8K2I4
Q99MS1
 
 β-glucuronidase (Gus) 3.2.1.31 Penicillium canescens DSM1215 AAV91787.1 Q5MJY0  
 β-glucuronidase (Gus) 3.2.1.31 Penicillium canescens RPK AAV91785.1 Q5MJY2  
 β-glucuronidase (PguS) 3.2.1.31 Penicillium purpurogenum LI-3 ABU68712.1 A7XS03  
 β-glucuronidase (GusB;Gus) 3.2.1.31 Rattus norvegicus AAA41228.1
AAP86274.1
CAA68705.1
NP_058711.1
P06760.1
Q7TPJ3
 
 β-glucuronidase (Gus) 3.2.1.31 Scopulariopsis sp. RP38.3 AAV91788.1 Q5MJX9  

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.





Last update: 2012-01-31 © Copyright 1998-2012
AFMB - CNRS - Universités Aix-Marseille I & II