Glycoside Hydrolase Family 2

Activities in Familyβ-galactosidase (EC 3.2.1.23) ; β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); α-L-arabinofuranosidase (EC 3.2.1.55); mannosylglycoprotein endo-β-mannosidase (EC 3.2.1.152); exo-β-glucosaminidase (EC 3.2.1.165)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (11711); Uniprot accession (1662); PDB accession (120); 3D entries (28); cryst (2)
All (10460) Archaea (46) Bacteria (10105) Eukaryota (290) unclassified (19) Structure (28 - 2 cryst) Characterized (147)
| 1 | 2 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-galactosidase (LacZ) 3.2.1.23 Actinobacillus pleuropneumoniae CM5 AAB17954.1 P70753  
 β-galactosidase (partial) 3.2.1.23 Alkalilactibacillus ikkensis 517 ACO52514.1 C1KC07  
 exo-β-glucosaminidase / exochitosanase (CsxA) 3.2.1.165 Amycolatopsis orientalis AAX62629.2
AAX62629.1
Q56F26 2VZO[A,B]
2VZS[A,B]
2VZT[A,B]
2VZU[A,B]
2VZV[A,B]
2X05[A,B]
2X09[A,B]
 β-galactosidase (BglA) 3.2.1.23 Arthrobacter psychrolactophilus F2 BAF33372.1 Q08KN3  
 β-galactosidase (LacZ) 3.2.1.23 Arthrobacter sp. AAA69907.1 Q59140  
 β-galactosidase (BgaS) 3.2.1.23 Arthrobacter sp. 20B ACI41243.1 B6EAX7  
 β-galactosidase (LacZ) 3.2.1.23 Arthrobacter sp. C2-2 CAD29775.1 Q8KRF6 1YQ2[A,B,C,D,E,F]
 β-galactosidase (GalA) 3.2.1.23 Arthrobacter sp. ON14 ADJ18283.1 D9IU58  
 β-glucuronidase (Gus) 3.2.1.31 Arthrobacter sp. RP10 AAV91790.1 Q5MJX7  
 β-glucuronidase (Gus) 3.2.1.31 Arthrobacter sp. RP40.7 AAV91792.1 Q5MJX5  
 β-galactosidase (LacZ) 3.2.1.23 Arthrobacter sp. SB AAQ19029.1 Q7WTU5  
 β-galactosidase A / B / C / D / 91 (Bga;BgaD;β-Gal-A;β-Gal-B;β-Gal-C;β-Gal-D;β-Glα-91) 3.2.1.23 Bacillus circulans ATCC 31382 BAJ61032.1   4YPJ[A,B]
 β-galactosidase 3.2.1.23 Bacillus megaterium 2-37-4-1 ABN13675.1 A3FFK4  
 β-galactosidase (BgaM) 3.2.1.23 Bacillus megaterium DSM 319 CAA04267.1
ADF38979.1
O52847  
 β-galactosidase (Lacz_13;BoGH2A;BACOVA_02645;Bovatus_03065) 3.2.1.23 Bacteroides ovatus ATCC 8483 ALJ47673.1    
 β-mannosidase (BT0458;BT_0458) (Man2A) 3.2.1.25 Bacteroides thetaiotaomicron VPI-5482 AAO75565.1
NP_809371.1
Q8AAK6 2JE8[A,B]
2VJX[A,B]
2VL4[A,B]
2VMF[A,B]
2VO5[A,B]
2VOT[A,B]
2VQT[A,B]
2VQU[A,B]
2VR4[A,B]
2WBK[A,B]
 bimodular β-L-arabinofuranosidase / β-glucuronidase (BT0996;BT_0996) 3.2.1.31
3.2.1.185
Bacteroides thetaiotaomicron VPI-5482 AAO76103.1
NP_809909.1
Q8A921  
 β-galactosidase (BIF1;OLGA1) 3.2.1.23 Bifidobacterium bifidum DSM 20215 CAB75342.1    
 β-galactosidase (BIF3) 3.2.1.23 Bifidobacterium bifidum DSM 20215 CAC14566.2
AAP64961.1
ABI07182.1
CAD19366.1
Q9F4D5  
 β-galactosidase (BIF2) 3.2.1.23 Bifidobacterium bifidum DSM 20215 CAC14565.1 Q9F4D6  
 lacto-N-neotetraose β-galactosidase (BbgIII) 3.2.1.23 Bifidobacterium bifidum JCM 1254 BAI94821.1   5DMY[A,B,C]
 β-galactosidase P1 (BbgI;Bbg1) 3.2.1.23 Bifidobacterium bifidum NCIMB 41171 ABE27151.1
ABE27151.2
Q0ZI53  
 β-galactosidase S1 (BbgIII) 3.2.1.23 Bifidobacterium bifidum NCIMB 41171 ABE27152.1 A4K5H9  
 β-galactosidase K2 (BbgIV) 3.2.1.23 Bifidobacterium bifidum NCIMB 41171 ABE00939.1 Q0ZII7  
 β-galactosidase (LacZ;Lacz6;Bbr_1552_lacZ;Bbr_1552 3.2.1.23 Bifidobacterium breve UCC2003 ABE96223.1    
 β-galactosidase (LacZ;BL0978) 3.2.1.23 Bifidobacterium longum NCC2705 AAN24786.1
NP_696150.1
Q8G5N0  
 β-galactosidase 2A (Blon_2334) (Bga2A) 3.2.1.23 Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ53392.1 B7GNN6  
 β-galactosidase (Blon_0268) 3.2.1.23 Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ51396.1 B7GTV5  
 β-galactosidase I (β-GalI) 3.2.1.23 Bifidobacterium longum subsp. infantis HL96 AAL02052.1 Q93GI6  
 β-galactosidase (LacZ) 3.2.1.23 Bifidobacterium longum subsp. longum MB219 CAB44428.1 Q9X6Y5  
 galactomannan-binding β-1,4-mannosidase (CbMan2A;Athe_0227) (Man2A) 3.2.1.25 Caldicellulosiruptor bescii DSM 6725 ACM59377.1 B9MME5  
 β-galactosidase (Lac;OLGA313) 3.2.1.23 Caldicellulosiruptor lactoaceticus CAC50563.1 Q93KF0  
 β-mannosidase 2A (CfMan2A) (Man2A) 3.2.1.25 Cellulomonas fimi ATCC 484 AAD42775.1
AEE46894.1
Q9XCV4  
 β-galactosidase 3.2.1.23 Clostridium acetobutylicum AAA23216.1 P24131  
 β-mannosidase (DtMan;DICTH_1692) 3.2.1.25 Dictyoglomus thermophilum H-6-12 ACI19676.1 B5YAN4 5N6U[A,B,C,D]
 β-galactosidase (Bga;BgaB5) 3.2.1.23 Enterobacter cloacae B5 ABB73039.1 Q2XQU3  
 β-galactosidase (LacZ) 3.2.1.23 Enterobacter cloacae GAO BAA07673.1 Q47077  
 β-galactosidase (LacZ) 3.2.1.23 Escherichia coli CAC87491.1 Q8VNN2 4TTG[A,B,C,D]
 β-galactosidase (LacZ;EcDH1_3262) 3.2.1.23 Escherichia coli DH1 ACX40886.1
BAJ42187.1
C9QQT4  
 β-galactosidase Z (LacZ;Lac-Z;b0344;EO53_16565) 3.2.1.23 Escherichia coli str. K-12 substr. MG1655 AAA24053.1
AAB18068.1
AAC73447.1
AAW06767.1
AAY73171.1
ABN72582.1
AEL16982.1
AIZ92504.1
ALI41840.1
AMC97588.1
CAA23573.1
NP_414878.1
B8LFD6
P00722
1BGL[A]
1BGM[I]
1DP0[A]
1F49[A]
1F4A[A]
1F4H[A]
1GHO[I]
1HN1[A]
1JYN[A]
1JYV[A]
1JYW[A]
1JYX[A]
1JYY[A]
1JYZ[I]
1JZ0[A]
1JZ1[I]
1JZ2[A]
1JZ3[A]
1JZ4[A]
1JZ5[A]
1JZ6[A]
1JZ7[A]
1JZ8[A]
1PX3[A,B,C,D]
1PX4[A,B,C,D]
3CZJ[A,B,C,D]
3DYM[A,B,C,D]
3DYO[A,B,C,D]
3E1F[1,2,3,4]
3I3B[A,B,C,D]
3I3D[A,B,C,D]
3I3E[A,B,C,D]
3IAP[A,B,C,D]
3IAQ[A,B,C,D]
3J7H[A,B,C,D]
3MUY[1,2,3,4]
3MUZ[1,2,3,4]
3MV0[1,2,3,4]
3MV1[1,2,3,4]
3SEP[A,B,C,D]
3T08[A,B,C,D]
3T09[A,B,C,D]
3T0A[A,B,C,D]
3T0B[A,B,C,D]
3T0D[A,B,C,D]
3T2O[A,B,C,D]
3T2P[A,B,C,D]
3T2Q[A,B,C,D]
3VD3[A,B,C,D]
3VD4[A,B,C,D]
3VD5[A,B,C,D]
3VD7[A,B,C,D]
3VD9[A,B,C,D]
3VDA[A,B,C,D]
3VDB[A,B,C,D]
3VDC[A,B,C,D]
4CKD[A,B,C,D]
4DUV[A,B,C,D]
4DUW[A,B,C,D]
4DUX[A,B,C,D]
5A1A[A,B,C,D]
 β-glucuronidase (UidA;GusA;GurA;b1617) 3.2.1.31 Escherichia coli str. K-12 substr. MG1655 AAC74689.1
AAA68923.1
AAB30197.1
AAR75623.1
ABE20937.1
ACR88323.1
AIZ91278.1
ALI40610.1
AMC98822.1
CAJ55495.1
CAJ55496.1
CAJ55497.1
CAJ55498.1
CAJ55499.1
CAJ55500.1
NP_416134.1
P05804 3K46[A,B]
3K4A[A,B]
3K4D[A,B]
3LPF[A,B]
3LPG[A,B]
4JHZ[A,B]
5CZK[A,B]
 evolved β-galactosidase (EbgA;b3076) 3.2.1.23 Escherichia coli str. K-12 substr. MG1655 AAA61971.1
AAA57877.1
AAC76111.1
AAT48164.1
AIZ89904.1
ALI39224.1
AMC95983.1
CAA36274.1
NP_417547.2
P06864  
 β-galactosidase (LacZ) 3.2.1.23 Escherichia coli str. K-12 substr. W3110 BAE76126.1    
 β-galactosidase (Gal4214-1) 3.2.1.23 Flavobacterium sp. 4214 AAX48919.1 Q2VT50  
 β-galactosidase (BglP) 3.2.1.23 gamma proteobacterium NT2-2 AMK07416.1    
 β-galactosidase Z (LacZ) 3.2.1.23 Klebsiella pneumoniae AAA25082.1 P06219  
 β-galactosidase (LacZ) 3.2.1.23 Klebsiella pneumoniae 285 AEA30145.1    
 β-galactosidase (GalB) 3.2.1.23 Klebsiella sp. T17-2 AMK07522.1    
 β-galactosidase large subunit (LacL) 3.2.1.23 Lactobacillus acidophilus ATCC 4356 ACC38286.1 B2LWG2  
 β-galactosidase (LacL) 3.2.1.23 Lactobacillus acidophilus JCM 1229 BAA20536.1 A0SWS3
O07684
 
 LVIS_2259 + LVIS_2258 3.2.1.23 Lactobacillus brevis ATCC 367 ABJ65308.1    
 β-glucuronidase (Gus) 3.2.1.31 Lactobacillus brevis RO1 ACU21612.1 D2DMF3  
 β-galactosidase Z 3.2.1.23 Lactobacillus delbrueckii AAA25240.1
AAA25244.1
AAY08349.1
ACW22137.1
CAC07488.1
   
 β-galactosidase Z (LacZ;Lbul?gal;Ldb1201) 3.2.1.23 Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002 CAI98003.1
AEN14565.1
Q1G9Z4  
 β-galactosidase (BgaL3) 3.2.1.23 Lactobacillus delbrueckii subsp. bulgaricus L3 ACE06986.1 B3GS90  
 β-galactosidase (LacLM;LacL+LacM) 3.2.1.23 Lactobacillus fermentum K4 AEJ32720.1    
 β-glucuronidase (GusA) 3.2.1.31 Lactobacillus gasseri ADH AAK07836.1
AAS22718.1
Q9AHJ8  
 β-galactosidase large subunit (LacL;WANG_0293) 3.2.1.23 Lactobacillus kefiranofaciens ZW3 AEG39988.1    
 β-galactosidase (LacL+LacM) 3.2.1.23 Lactobacillus plantarum ATCC 8014 AAL09167.1 Q938Q6  
 β-galactosidase (LacL+LacM) 3.2.1.23 Lactobacillus plantarum FUA3112 CAZ66936.1    
 β-galactosidase (LacL+LacM,lp_3483+lp_3484) 3.2.1.23 Lactobacillus plantarum WCFS1 CAD65569.1
CCC80451.1
NP_786691.1
   
 β-galactosidase (Lreu?gal) (LacL + LacM) 3.2.1.23 Lactobacillus reuteri L103 ABF72116.1    
 β-galactosidase L+S (LacL+LacS) (heterodimer) 3.2.1.23 Lactobacillus sakei subsp. sakei DSM 20017 CAA57730.1 Q48846  
 β-galactosidase (LacZ) 3.2.1.23 Lactococcus lactis ATCC 7962 AAD11504.1
AAC63020.1
CAA56341.1
O87523
Q48727
 
 β-galactosidase (LacZ;L0025) 3.2.1.23 Lactococcus lactis subsp. lactis Il1403 AAK06078.1
NP_268137.2
Q48727  
 β-galactosidase L+M (LacL+LacM) 3.2.1.23 Leuconostoc lactis AAA25267.1
CAL48858.1
Q02603  
 β-galactosidase (BgaA;MsBgaA;MS0806) 3.2.1.23 Mannheimia succiniciproducens MBEL55E AAU37413.1 Q65UE7  
 β-glycosidase (Bgp2) 3.2.1.- Microbacterium esteraromaticum GS514 AFC90218.1    
 β-mannosidase (ManB;MANB) (partial) 3.2.1.25 Paenibacillus polymyxa A-8 / A8 AGX85875.1    
 β-galactosidase 3.2.1.23 Pantoea agglomerans B1 ABN42680.1 A3FEW8  
 β-galactosidase (BgaL;(Par?DG) 3.2.1.23 Paracoccus sp. 32d ACY69080.1 D1LZK0 5EUV[A,B]
5LDR[A,B]
 β-galactosidase (LacZ) 3.2.1.23 Pseudoalteromonas haloplanktis TAE 79 CAA10470.1
AAU97746.1
P81650  
 β-galactosidase (LacZ) 3.2.1.23 Pseudoalteromonas sp. 22b AAR92204.1 Q6RGS1  
 α-L-arabinofuranosidase (TtAFase;Theth_0328) 3.2.1.55 Pseudothermotoga thermarum DSM 5069 AEH50423.1    
 β-galactosidase Z (LacZ) 3.2.1.23 Psychromonas marina BAA76741.1 Q9WXJ2  
 β-glucuronidase (UidA) 3.2.1.31 Ruminococcus gnavus E1 AAQ76046.1 Q6W7J7  
 β-galactosidase 3.2.1.23 Saccharopolyspora rectivirgula BAA34817.1 Q9ZBD1  
 β-1,4-galactosidase 3.2.1.23 Serratia sp. D04 AAZ81660.1 Q3YJ54  
 β-galactosidase Z (LacZ) 3.2.1.23 Sinorhizobium meliloti 102F34 AAA26296.1 Q59750  
 β-glucuronidase (GusA) 3.2.1.31 Sphingomonas elodea ACE13470.1    
 β-glucuronidase (Gus) 3.2.1.31 Staphylococcus sp. RLH1 AAK29422.1
AAR75615.1
AAR75620.1
AAR75621.1
ABP04762.1
Q9AFA2  
 β-galactosidase (LacH) 3.2.1.23 Staphylococcus xylosus CAA74937.1 O33815  
 β-galactosidase (BgaA;SPD0562;SPD_0562) 3.2.1.23 Streptococcus pneumoniae D39 ABJ53768.1 Q04LN6  
 β-galactosidase (BgaA) 3.2.1.23 Streptococcus pneumoniae KNR7/87 AAF97242.1 Q9KGU0  
 β-galactosidase (BgaA;spr0565) 3.2.1.23 Streptococcus pneumoniae R6 AAK99369.1
NP_358159.1
Q8DQP4  
 β-1,4-galactosidase A (BgaA;SP0648;SP_0648) 3.2.1.23 Streptococcus pneumoniae TIGR4 AAK74795.1
ABA35731.1
NP_345155.1
Q9KGU0 4CU6[A]
4CU7[A]
4CU8[A]
4CUC[A]
 β-galactosidase Z (LacZ) 3.2.1.23 Streptococcus thermophilus A054 AAA26913.1
AAA63532.1
AAA63533.1
P23989  
 β-galactosidase (LacZ) 3.2.1.23 Streptococcus thermophilus FUA3194 CAZ66940.1 C6H180  
 β-galactosidase (STER_1366) 3.2.1.23 Streptococcus thermophilus LMD-9 ABJ66539.1 Q03JT3  
 exo-β-glucosaminidase (CsxA;SAV1223;SAV_1223) 3.2.1.165 Streptomyces avermitilis MA-4680 = NBRC 14893 BAC68933.1
NP_822398.1
Q82NR8  
 β-mannosidase (Bma;Man2S27) 3.2.1.25 Streptomyces sp. S27 ACCC 41168 ACN78887.1
ADK91096.1
D2DFB5  
 β-galactosidase (Lac) 3.2.1.23 Thermoanaerobacter mathranii CAC50570.1 Q93IM0  
 β-galactosidase (Lac) 3.2.1.23 Thermoanaerobacter mathranii CAC50569.1 Q93IM1  
 β-galactosidase (LacA;Teth39_0611) 3.2.1.23 Thermoanaerobacter pseudethanolicus ATCC 33223 CAA69850.1
ABY94275.1
P77989  
 β-galactosidase (LacZ;LacA) 3.2.1.23 Thermoanaerobacterium thermosulfurigenes EM1 AAA23249.1
CAA38462.1
P26257
Q53WT4
 
 β-mannosidase (ManB) 3.2.1.25 Thermobifida fusca TM51 CAD33708.1 Q8KLI9  
 β-mannosidase (ManB;Tfu_0915) 3.2.1.25 Thermobifida fusca YX AAZ54953.1 Q47RG4  
 β-galactosidase Z (LacZ;TmLac;TM1193) 3.2.1.23 Thermotoga maritima MSB8 AAD36268.1
AAA50597.1
AGL50124.1
AHD18900.1
AKE28970.1
CAA04513.1
NP_228998.1
G4FEF3
Q56307
 
 β-glucuronidase (Gus;TmGUS;TM1062;Tmari_1066) 3.2.1.31 Thermotoga maritima MSB8 AAD36143.1
AAR75619.1
AAR75627.1
AGL49990.1
AHD19030.1
AKE28838.1
NP_228868.1
Q9X0F2  
 β-mannosidase (TM1624;ManA) (Man2) 3.2.1.25 Thermotoga maritima MSB8 AAD36691.1
AAM56797.1
AGL50557.1
AHD18479.1
AKE29383.1
CAB56855.1
NP_229424.1
Q9RIK8
Q9X1V9
 
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