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Glycoside Hydrolase Family 27

Known Activitiesα-galactosidase (EC 3.2.1.22); α-N-acetylgalactosaminidase (EC 3.2.1.49); isomalto-dextranase (EC 3.2.1.94); β-L-arabinopyranosidase (EC 3.2.1.88)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteMechanistic commonality with family GH36 demonstrated by Comfort et al. (2007) Biochemistry 46:3319-3330 (PMID: 17323919).
External resourcesCAZypedia; InterPro; PFAM; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (634); Uniprot accession (304); PDB accession (33); 3D entries (10); cryst (1)
Summary
All (459) Archaea (1) Bacteria (229) Eukaryota (228) unclassified (1) Structure (10 - 1 cryst) Characterized (66)
Bacteria
Protein Name EC#OrganismGenBankUniprotPDB/3D
 ACP_0049   Acidobacterium capsulatum ATCC 51196 ACO33663.1 C1F805  
 ACP_1583   Acidobacterium capsulatum ATCC 51196 ACO34414.1 C1F6S5  
 AciX9_1740   Acidobacterium sp. MP5ACTX9 ADW68788.1    
 AciX9_1741   Acidobacterium sp. MP5ACTX9 ADW68789.1    
 AciX9_3820   Acidobacterium sp. MP5ACTX9 ADW71106.1    
 AciX9_4314   Acidobacterium sp. MP5ACTX9 ADW71271.1    
 ACPL_3009   Actinoplanes sp. SE50/110 AEV83904.1    
 ACPL_6037   Actinoplanes sp. SE50/110 AEV86924.1    
 Amir_1044   Actinosynnema mirum DSM 43827 ACU35000.1 C6WNT1  
 Amir_1665   Actinosynnema mirum DSM 43827 ACU35614.1 C6WBP6  
 Amir_3106   Actinosynnema mirum DSM 43827 ACU37020.1 C6W7Z9  
 Amir_3796   Actinosynnema mirum DSM 43827 ACU37676.1 C6WD57  
 Amuc_1187   Akkermansia muciniphila ATCC BAA-835 ACD05012.1 B2URC7  
 RAM_17320   Amycolatopsis mediterranei S699 AEK41950.1    
 RAM_37970   Amycolatopsis mediterranei S699 AEK46061.1    
 RAM_09755   Amycolatopsis mediterranei S699 AEK40441.1    
 RAM_08870   Amycolatopsis mediterranei S699 AEK40264.1    
 RAM_40210   Amycolatopsis mediterranei S699 AEK46509.1    
 RAM_34915   Amycolatopsis mediterranei S699 AEK45456.1    
 RAM_18540   Amycolatopsis mediterranei S699 AEK42194.1    
 RAM_04355   Amycolatopsis mediterranei S699 AEK39363.1    
 RAM_46110 (fragment)   Amycolatopsis mediterranei S699 AEK47687.1    
 RAM_09420 (fragment)   Amycolatopsis mediterranei S699 AEK40374.1    
 RAM_46115 (fragment)   Amycolatopsis mediterranei S699 AEK47688.1    
 AMED_0853 (GalA)   Amycolatopsis mediterranei U32 ADJ42673.1 D8I272  
 AMED_1747 (GalA)   Amycolatopsis mediterranei U32 ADJ43558.1 D8HNK7  
 AMED_1923 (GalA)   Amycolatopsis mediterranei U32 ADJ43732.1 D8HQM1  
 AMED_3645 (GalA)   Amycolatopsis mediterranei U32 ADJ45428.1 D8I8U0  
 AMED_6804 (GalA)   Amycolatopsis mediterranei U32 ADJ48528.1 D8I1Z0  
 AMED_7386 (GalA)   Amycolatopsis mediterranei U32 ADJ49100.1 D8I9D3  
 AMED_7823 (GalA)   Amycolatopsis mediterranei U32 ADJ49531.1 D8HQA7  
 AMED_1856 (fragment)   Amycolatopsis mediterranei U32 ADJ43666.1 D8HPN6  
 AMED_3405   Amycolatopsis mediterranei U32 ADJ45191.1 D8I5V2  
 AMED_8989 (fragment)   Amycolatopsis mediterranei U32 ADJ50679.1 D8HKQ2  
 AMED_8990 (fragment)   Amycolatopsis mediterranei U32 ADJ50680.1 D8HKQ3  
 Achl_0056   Arthrobacter chlorophenolicus A6 ACL38059.1 B8H885  
 isomaltodextranase (ImdA) 3.2.1.94 Arthrobacter dextranolyticus T6 BAD34648.1 Q6BE01  
 isomaltodextranase (G2d;Imd) 3.2.1.94 Arthrobacter globiformis T6 BAA06424.1
BAC76886.2		 Q44052
Q7WSN5		 cryst
 Astex_1018   Asticcacaulis excentricus CB 48 CS 48 ADU12699.1 C5SFM3  
 Astex_2589   Asticcacaulis excentricus CB 48 CS 48 ADU14234.1 C5SKS3  
 Astex_3319   Asticcacaulis excentricus CB 48 CS 48 ADU14953.1 C5SLI3  
 Astex_3509   Asticcacaulis excentricus CB 48 CS 48 ADU15139.1 C5SKZ0  
 BH1870   Bacillus halodurans C-125 BAB05589.1
NP_242736.1		 Q9KBQ5 3CC1[A,B]
 BXY_38430   Bacteriodes xylanisolvens XB1A CBK68793.1 D6D2Z1  
 BF638R_1499   Bacteroides fragilis 638R CBW22036.1 E1WT83  
 BF638R_4272   Bacteroides fragilis 638R CBW24693.1 E1WQR7  
 BF638R_0283 (AgL)   Bacteroides fragilis 638R CBW20884.1 E1WM41  
 BF0227   Bacteroides fragilis NCTC 9343 CAH06003.1 Q5LIM3  
 BF1418   Bacteroides fragilis NCTC 9343 CAH07128.1 Q5LFG6  
 BF4189   Bacteroides fragilis NCTC 9343 CAH09862.1 Q5L7T7  
 BF1485   Bacteroides fragilis YCH46 BAD48236.1    
 BF4391   Bacteroides fragilis YCH46 BAD51129.1    
 BF0271   Bacteroides fragilis YCH46 BAD47020.1    
 Bache_0773   Bacteroides helcogenes P 36-108 ATCC 35417 ADV42794.1    
 Bacsa_1414   Bacteroides salanitronis DSM 18170 ADY35986.1    
 BT3065   Bacteroides thetaiotaomicron VPI-5482 AAO78171.1
NP_811977.1		    
 BT0065   Bacteroides thetaiotaomicron VPI-5482 AAO75172.1
NP_808978.1		    
 BT3592   Bacteroides thetaiotaomicron VPI-5482 AAO78697.1
NP_812503.1		    
 BT4157   Bacteroides thetaiotaomicron VPI-5482 AAO79262.1
NP_813068.1		    
 BT2662   Bacteroides thetaiotaomicron VPI-5482 AAO77769.1
NP_811575.1		    
 BVU_0640   Bacteroides vulgatus ATCC 8482 ABR38348.1 A6KY34  
 Bcav_0053   Beutenbergia cavernae DSM 12333 ACQ78319.1 C5BUU5  
 BAD_1525   Bifidobacterium adolescentis ATCC 15703 BAF40306.1 A1A3M3  
 BDP_2092 (probable fragment)   Bifidobacterium dentium Bd1 ADB10655.1 D2Q6W4  
 BLD_1538 (GalA3)   Bifidobacterium longum DJO10A ACD98983.1 B3DPC4  
 BL0177   Bifidobacterium longum NCC2705 AAN24032.1
NP_695396.1		    
 BLIF_1892 (probable fragment)   Bifidobacterium longum subsp. infantis 157F BAJ72026.1    
 BBMN68_1471 (Gala3)   Bifidobacterium longum subsp. longum BBMN68 ADQ02495.1 E4R259  
 BLLJ_1823 (possible fragment)   Bifidobacterium longum subsp. longum JCM 1217 BAJ67488.1    
 BLJ_1911   Bifidobacterium longum subsp. longum JDM301 ADH01334.1 D6ZWS8  
 BLNIAS_00070 (Gala3)   Bifidobacterium longum subsp. longum KACC 91563 AEI96611.1    
 BIP_16080 (fragment)   Bifidobacterium pseudocatenulatum D2CA CBK72759.1    
 Bfae_29570   Brachybacterium faecium DSM 4810 ACU86718.1 C7MA48  
 bgla_2g24110   Burkholderia gladioli BSR3 AEA64841.1    
 bglu_2g20960   Burkholderia glumae BGR1 ACR32404.1 C5AKH4  
 CIY_22650   Butyrivibrio fibrisolvens 16/4 CBK74937.1 D4IVZ4  
 bpr_I0090   Butyrivibrio proteoclasticus B316 ADL32841.1 E0RUF1  
 bpr_I0205   Butyrivibrio proteoclasticus B316 ADL32954.1 E0RW88  
 Cabther_B0051   Candidatus Chloracidobacterium thermophilum B AEP13059.1    
 Acid345_3249   Candidatus Koribacter versatilis Ellin345 ABF42250.1 Q1ILK0  
 Acid345_1677   Candidatus Koribacter versatilis Ellin345 ABF40678.1 Q1IR22  
 Caci_2554   Catenulispora acidiphila DSM 44928 ACU71472.1 C7PXL9  
 Caci_4439   Catenulispora acidiphila DSM 44928 ACU73303.1 C7PW55  
 Caci_4641   Catenulispora acidiphila DSM 44928 ACU73502.1 C7PY42  
 Caci_4912   Catenulispora acidiphila DSM 44928 ACU73772.1 C7Q336  
 Caci_6873   Catenulispora acidiphila DSM 44928 ACU75712.1 C7Q3E7  
 Caci_7918   Catenulispora acidiphila DSM 44928 ACU76741.1 C7QFG4  
 Caci_4880   Catenulispora acidiphila DSM 44928 ACU73740.1 C7Q1L1  
 Caci_5007   Catenulispora acidiphila DSM 44928 ACU73867.1 C7Q3D1  
 Caci_6252   Catenulispora acidiphila DSM 44928 ACU75106.1 C7QK32  
 Caci_6874   Catenulispora acidiphila DSM 44928 ACU75713.1 C7Q3E8  
 Caci_6974   Catenulispora acidiphila DSM 44928 ACU75804.1 C7Q3N9  
 Caci_7223   Catenulispora acidiphila DSM 44928 ACU76052.1 C7Q739  
 Cseg_1839   Caulobacter segnis ATCC 21756 ADG10312.1 D5VJA3  
 Cseg_2011   Caulobacter segnis ATCC 21756 ADG10480.1 D5VGN7  
 Caul_0313   Caulobacter sp. K31 ABZ69450.1 B0T4F0  
 Caul_2129   Caulobacter sp. K31 ABZ71257.1 B0T7R9  
 Caul_2412   Caulobacter sp. K31 ABZ71539.1 B0SVS1  
 Celf_0438   Cellulomonas fimi ATCC 484 AEE44581.1    
 Celf_3623   Cellulomonas fimi ATCC 484 AEE47731.1    
 Cfla_0456   Cellulomonas flavigena DSM 20109 ADG73371.1 D5UHU7  
 Cfla_2742   Cellulomonas flavigena DSM 20109 ADG75628.1 D5UJJ0  
 Celgi_2554   Cellvibrio gilvus ATCC 13127 AEI13053.1    
 CJA_0246 (Aga27A)   Cellvibrio japonicus Ueda107 ACE85287.1 B3PGJ1  
 α-galactosidase 27A (Aga27A) 3.2.1.22 Cellvibrio mixtus ATCC 12120 AAS19696.1 Q6QT41  
 Cpin_5740   Chitinophaga pinensis DSM 2588 ACU63161.1 C7PCU7  
 galactosidase (Ccel_1237) (Gal27A) 3.2.1.22 Clostridium cellulolyticum H10 ATCC 35319 ABG76969.1
ACL75593.1		 B8I0L8  
 Ccel_1597 (P50)   Clostridium cellulolyticum H10 ATCC 35319 ACL75949.1 B8I2F6  
 Clocel_3640   Clostridium cellulovorans 743B ADL53311.1 D9SWM9  
 α-galactosidase (AgaA) (Aga27A) 3.2.1.22 Clostridium josui FERM P-9684 BAB83765.1 Q8VV86  
 Clo1100_0192   Clostridium sp. BNL1100 AEY64483.1    
 Clo1100_0917   Clostridium sp. BNL1100 AEY65174.1    
 Clo1100_1931   Clostridium sp. BNL1100 AEY66126.1    
 EUS_25330   Eubacterium siraeum 70/3 CBK97479.1 D4JWL0  
 ES1_05550   Eubacterium siraeum V10Sc8a CBL33680.1 D4MIU7  
 Fisuc_1773 / FSU_2272   Fibrobacter succinogenes subsp. succinogenes S85 ACX75366.1
ADL25866.1		 C9RS30  
 Fjoh_3110   Flavobacterium johnsoniae UW101 ABQ06127.1 A5FFA1  
 Fjoh_4436   Flavobacterium johnsoniae UW101 ABQ07440.1 A5FBH3  
 Fjoh_4947   Flavobacterium johnsoniae UW101 ABQ07946.1 A5FA25  
 FRAAL4014   Frankia alni ACN14a CAJ62656.1 Q0RIL2  
 GYMC52_1863   Geobacillus sp. Y412MC52 ADU94285.1 C3J351  
 GYMC61_2733   Geobacillus sp. Y412MC61 ACX79315.1 C9RT70  
 β-L-arabinopyranosidase (Abp) 3.2.1.88 Geobacillus stearothermophilus T-6 NCIMB 40222      
 Gbro_3450   Gordonia bronchialis DSM 43247 ACY22644.1 D0LE52  
 AciX8_2697   Granulicella mallensis MP5ACTX8 AEU37007.1    
 AciX8_2904   Granulicella mallensis MP5ACTX8 AEU37207.1    
 AciX8_3428   Granulicella mallensis MP5ACTX8 AEU37726.1    
 AciX8_3580   Granulicella mallensis MP5ACTX8 AEU37873.1    
 AciX8_4018   Granulicella mallensis MP5ACTX8 AEU38300.1    
 AciX8_4774   Granulicella mallensis MP5ACTX8 AEU39043.1    
 AciX8_2312   Granulicella mallensis MP5ACTX8 AEU36629.1    
 AciX8_2438   Granulicella mallensis MP5ACTX8 AEU36755.1    
 Halhy_3134   Haliscomenobacter hydrossis DSM 1100 AEE50996.1    
 Halhy_3136   Haliscomenobacter hydrossis DSM 1100 AEE50998.1    
 Haur_3892   Herpetosiphon aurantiacus ATCC 23779 ABX06526.1 A9AUT8  
 Isova_0802   Isoptericola variabilis 225 AEG43588.1    
 Jden_0514   Jonesia denitrificans DSM 20603 ACV08178.1 C7R0B9  
 Krad_3464   Kineococcus radiotolerans SRS30216 ABS04927.1 A6WDN8  
 Lbuc_1954   Lactobacillus buchneri NRRL B-30929 AEB74200.1    
 Mahau_1075   Mahella australiensis 50-1 BON AEE96273.1    
 Micau_3680   Micromonospora aurantiaca ATCC 27029 ADL47206.1 D9SZ70  
 ML5_4718   Micromonospora sp. L5 ADU10194.1 D3C4G9  
 MAB_4303   Mycobacterium abscessus CAM64376.1    
 Niako_0680   Niastella koreensis GR20-10 AEV97063.1    
 PP1Y_Mpl1025   Novosphingobium sp. PP1Y CCA90088.1    
 Odosp_0029   Odoribacter splanchnicus DSM 20712 ADY31144.1    
 Oter_1363   Opitutus terrae PB90-1 ACB74648.1 B1ZRW9  
 Oter_2301   Opitutus terrae PB90-1 ACB75583.1 B1ZQH4  
 Oter_3220   Opitutus terrae PB90-1 ACB76500.1 B1ZN49  
 KNP414_06099   Paenibacillus mucilaginosus KNP414 AEI44623.1    
 PPE_02216   Paenibacillus polymyxa E681 ADM70049.1 E0RJT0  
 PPM_2208 (M1_2499)   Paenibacillus polymyxa M1 CCC85145.1    
 PPSC2_c2450   Paenibacillus polymyxa SC2 ADO56422.1 E3EJD5  
 Pjdr2_3202   Paenibacillus sp. JDR-2 ACT01843.1 C6D1H9  
 Pjdr2_3562   Paenibacillus sp. JDR-2 ACT02195.1 C6D3K2  
 Pjdr2_4264   Paenibacillus sp. JDR-2 ACT02888.1 C6D785  
 Pjdr2_4104   Paenibacillus sp. JDR-2 ACT02733.1 C6D6G0  
 HPL003_22715   Paenibacillus terrae HPL-003 AET61267.1    
 Palpr_1630   Paludibacter propionicigenes WB4 ADQ79771.1 E4T4X7  
 Palpr_1653   Paludibacter propionicigenes WB4 ADQ79794.1 E4T500  
 Palpr_1815   Paludibacter propionicigenes WB4 ADQ79954.1 E4T5G0  
 Palpr_1626   Paludibacter propionicigenes WB4 ADQ79767.1 E4T4X3  
 Phep_0715   Pedobacter heparinus DSM 2366 ACU02937.1 C6Y1G1  
 Phep_1839   Pedobacter heparinus DSM 2366 ACU04047.1 C6XVI1  
 Phep_2885   Pedobacter heparinus DSM 2366 ACU05083.1 C6Y1U1  
 Phep_2887   Pedobacter heparinus DSM 2366 ACU05085.1 C6Y1U3  
 Pedsa_2573   Pedobacter saltans DSM 12145 ADY53117.1    
 Pedsa_3616   Pedobacter saltans DSM 12145 ADY54145.1    
 PGN_2032   Porphyromonas gingivalis ATCC 33277 BAG34550.1 B2RMF5  
 PGTDC60_0363   Porphyromonas gingivalis TDC60 BAK24532.1    
 PG0085   Porphyromonas gingivalis W83 AAQ65333.1
NP_904434.1		    
 HMPREF9137_0438   Prevotella denticola F0289 AEA20682.1    
 HMPREF0659_A6322   Prevotella melaninogenica ATCC 25845 ADK96067.1 D9RSZ1  
 PRU_2377   Prevotella ruminicola 23 ADE82935.1 D5EVX6  
 Rmar_2597   Rhodothermus marinus DSM 4252 ACY49470.1 D0MFY1  
 Rhom172_2613   Rhodothermus marinus SG0.5JP17-172 AEN74501.1    
 RHOM_06015   Roseburia hominis A2-183 AEN96322.1    
 ROI_10050   Roseburia intestinalis M50/1 CBL08208.1 D4KMV6  
 RO1_22250   Roseburia intestinalis XB6B4 CBL12733.1 D4KZE3  
 Rumal_1055   Ruminococcus albus 7 ADU21581.1 E0L9A8  
 Rumal_1567   Ruminococcus albus 7 ADU22068.1 E0L9E5  
 RUM_10930   Ruminococcus sp. 18P13 CBL17246.1 D4LCA1  
 Runsl_4212   Runella slithyformis DSM 19594 AEI50556.1    
 Sde_1593 (Agl27A)   Saccharophagus degradans 2-40 ABD80855.1 Q21KC4  
 α-galactosidase (MelA;AgaB2;SACE_3139) 3.2.1.22 Saccharopolyspora erythraea NRRL 2338 AAC99325.1
CAM02417.1		 Q9Z4N5  
 SACE_7065   Saccharopolyspora erythraea NRRL 2338 CAM06226.1 A4FQA1  
 Sked_02790   Sanguibacter keddieii DSM 10542 ACZ20248.1 D1BJJ2  
 Srot_2765   Segniliparus rotundus DSM 44985 ADG99197.1 D6ZD10  
 Acid_0705   Solibacter usitatus Ellin6076 ABJ81706.1 Q02B60  
 Acid_1472   Solibacter usitatus Ellin6076 ABJ82464.1 Q028T8  
 Acid_1588   Solibacter usitatus Ellin6076 ABJ82579.1 Q028H3  
 Acid_2820   Solibacter usitatus Ellin6076 ABJ83806.1 Q023N4  
 dextranase (Dex1)   Sphingobacterium sp. V-54 BAE92747.1 Q1XGE4  
 SJA_C2-02330 (GalA)   Sphingobium japonicum UT26S UT26S (= NBRC 101211) BAI98596.1 D4Z7X7  
 SAV1077   Streptomyces avermitilis MA-4680 BAC68787.1
NP_822252.1		    
 β-L-arabinopyranosidase (AgaA2;SaArap27A;SAV_2186) (Arap27A) 3.2.1.88 Streptomyces avermitilis MA-4680 BAC69897.1
NP_823362.1		   3A21[A,B]
3A22[A,B]
3A23[A,B]
 SAV628 (AgaA1)   Streptomyces avermitilis MA-4680 BAC68338.1
NP_821803.1		    
 SAV1475 (AgaB2)   Streptomyces avermitilis MA-4680 BAC69185.1
NP_822650.1		    
 SBI_01330   Streptomyces bingchenggensis BCW-1 ADI04451.1 D7CBV6  
 SBI_02019   Streptomyces bingchenggensis BCW-1 ADI05140.1 D7BRH7  
 SBI_02098   Streptomyces bingchenggensis BCW-1 ADI05219.1 D7BT04  
 SBI_02205   Streptomyces bingchenggensis BCW-1 ADI05326.1 D7BTB1  
 SBI_09936   Streptomyces bingchenggensis BCW-1 ADI13054.1 D7CDL2  
 SCATT_56350   Streptomyces cattleya DSM 46488 AEW98006.1    
 SCAT_5636 (AgaA)   Streptomyces cattleya NRRL 8057 CCB78324.1    
 SCO0284 or SCF85.12   Streptomyces coelicolor A3(2) CAB54169.1
NP_624613.1		 Q9S2C9  
 α-galactosidase I (α-GalI) (peptide fragment) 3.2.1.22 Streptomyces griseoloalbus      
 SHJG_0110   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY85392.1    
 SHJG_1048   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY86325.1    
 SHJG_1806   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY87081.1    
 SHJG_2134   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY87409.1    
 SHJG_2526   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY87801.1    
 SHJG_8422   Streptomyces hygroscopicus subsp. jinggangensis 5008 AEY93687.1    
 SCAB_3891   Streptomyces scabiei 87.22 CBG67596.1 C9YSS1  
 SCAB_44311   Streptomyces scabiei 87.22 CBG71494.1 C9Z7A0  
 SACTE_6011   Streptomyces sp. SirexAA-E AEN13791.1    
 Strvi_2248   Streptomyces violaceusniger Tu 4113 AEM81975.1    
 Strvi_3740   Streptomyces violaceusniger Tu 4113 AEM83404.1    
 Strvi_4333   Streptomyces violaceusniger Tu 4113 AEM83982.1    
 Strvi_5822   Streptomyces violaceusniger Tu 4113 AEM85332.1    
 Strvi_7924   Streptomyces violaceusniger Tu 4113 AEM87247.1    
 TERTU_4091   Teredinibacter turnerae T7901 ACR13989.1 C5BUE6  
 AciPR4_1545   Terriglobus saanensis SP1PR4 ADV82366.1 E1N696  
 AciPR4_1700   Terriglobus saanensis SP1PR4 ADV82507.1 E1MXY3  
 AciPR4_4094   Terriglobus saanensis SP1PR4 ADV84842.1 E1MZ30  
 GHF27 protein   uncultured bacterium G2_7 AEW47968.1    
 VAB18032_19530   Verrucosispora maris AB-18-032 AEB45008.1    
 XALc_1947   Xanthomonas albilineans GPE PC73 CBA16433.1    
 zobellia_3523   Zobellia galactanivorans DsiJT CAZ97661.1    




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