Glycoside Hydrolase Family 27

Activities in Familyα-galactosidase (EC 3.2.1.22); α-N-acetylgalactosaminidase (EC 3.2.1.49); isomalto-dextranase (EC 3.2.1.94); β-L-arabinopyranosidase (EC 3.2.1.88); galactan:galactan galactosyltransferase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
NoteMechanistic commonality with family GH36 demonstrated by Comfort et al. (2007) Biochemistry 46:3319-3330 (PMID: 17323919).
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1442); Uniprot accession (327); PDB accession (46); 3D entries (13); cryst (0)
All (1186) Archaea (1) Bacteria (847) Eukaryota (337) unclassified (1) Structure (13) Characterized (67)
| 1 | 2 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-N-acetylgalactosaminidase precursor, partial (NagA) (fragment)   Macaca mulatta AFE74309.1    
 α-N-acetylgalactosaminidase precursor, partial (NagA) (fragment)   Macaca mulatta AFE69394.1    
 MG09805.4   Magnaporthe oryzae 70-15 XP_364960.1
EAA53842.1
G4NIK9  
 MG09989.4   Magnaporthe oryzae 70-15 XP_365144.1
EAA49825.1
G4N9L9  
 MGG_11374   Magnaporthe oryzae 70-15 XP_003713653.1
EAA50899.1
XP_362213.1
   
 MGG_16425   Magnaporthe oryzae 70-15 XP_003710505.1
XP_360246.1
   
 MTYFL_FM_FN_FO1G-H-16   Medicago truncatula ACJ85800.1 B7FM17  
 unknown (fragment)   Medicago truncatula AFK36253.1    
 unknown (fragment)   Medicago truncatula AFK41337.1    
 MtrDRAFT_AC149210g12v2   Medicago truncatula ABD32283.2
ABO80215.1
Q2HU62  
 MtrDRAFT_AC164249g26v1 or MtrDRAFT_AC153004g1v1   Medicago truncatula ABE26636.1
ABE26636.2
ABE87553.1
   
 MtrDRAFT_AC138580g35v1   Medicago truncatula ABE81161.1
ABE81161.2
   
 BN887_05747   Melanopsichium pennsylvanicum 4 CDI53950.1    
 BN887_03085   Melanopsichium pennsylvanicum 4 CDI54870.1    
 BN887_03027   Melanopsichium pennsylvanicum 4 CDI55002.1    
 α-N-acetylgalactosaminidase (NagA) 3.2.1.49 Mus musculus AAC28851.1
AAH21631.1
AAL87527.1
AAL87528.1
BAC36620.1
BAE21730.1
BAE31642.1
CAA11703.1
NP_032695.2
Q9QWR8
Q9QWR8
 
 α-galactosidase A (Gls;Agl) (lysosomal) 3.2.1.22 Mus musculus AAA74453.1
AAA96749.1
AAB47244.1
AAC52583.1
AAC52584.1
AAH09021.1
BAC30508.1
BAC35819.1
BAE26260.1
BAE37692.1
BAE38627.1
BAE38657.1
CAM19136.1
CAM19137.1
NP_038491.1
P51569
Q8BGZ6
 
 ORF (fragment)   Musca domestica ALHF AFP62361.1    
 α-galactosidase (partial)   Mustela putorius furo AER99093.1    
 ORF   Mustela putorius furo AES02586.1    
 NGATSA_2059200 (fragment)   Nannochloropsis gaditana CCMP526 AFJ69054.1    
 NCLIV_054050   Neospora caninum Liverpool CBZ54978.1    
 NCLIV_009150   Neospora caninum Liverpool CBZ50446.1    
 ORF   Nepenthes mirabilis AMN14859.1    
 ORF   Nepenthes mirabilis AMN14860.1    
 α-galactosidase   Nicotiana tabacum AEB98600.1    
 α-galactosidase   Nicotiana tabacum AEB98601.1    
 α-N-acetylgalactosaminidase   Nilaparvata lugens ANJ04640.1    
 Os01g0518500   Oryza sativa Japonica Group BAD73696.1
BAB91950.1
BAF05117.1
BAG90573.1
BAS72430.1
Q5QLK3  
 α-galactosidase II (Os07g0452100) 3.2.1.22 Oryza sativa Japonica Group BAF21463.1
BAC55816.1
BAC84411.1
BAT01318.1
Q0D6R0  
 α-galactosidase III (Os07g0679300) 3.2.1.22 Oryza sativa Japonica Group BAC79549.1
BAD31216.1
BAF22553.1
BAG94006.1
BAT03227.1
Q7XIV4  
 α-galactosidase I (Os10g0493600) 3.2.1.22 Oryza sativa Japonica Group BAB12570.1
AAM92832.1
AAO85428.1
AAP54412.1
ABB47819.1
BAF26853.1
BAT11449.1
BAT11450.1
BAT11451.1
BAT11452.1
NP_922125.1
F4MGX5
Q9FXT4
Q9FXT4
1UAS[A]
 Os10g0492900   Oryza sativa Japonica Group AAG13536.1
AAP54408.1
BAF26849.1
BAT11444.1
NP_922121.1
Q9FWV8  
 α-N-acetylgalactosaminidase (fragment)   Oryzias melastigma AEA51135.1    
 α-N-acetylgalactosaminidase (NagA)   Ovis aries ACB87536.1 B2LSM7  
 ORF   Papilio xuthus BAM17755.1    
 Pc21g14820   Penicillium rubens Wisconsin 54-1255 CAP96379.1 B6HIL7  
 α-galactosidase I (Agl1;AglI) 3.2.1.22 Penicillium simplicissimum VTT-D-78090 CAA08915.1 O94221  
 α-galactosidase (fragment)   Petunia x hybrida AAQ82455.1 Q6UAY5  
 α-galactosidase (AgalB) 3.2.1.22 Phanerochaete chrysosporium ME446 AAG24511.1 Q9HFZ9  
 α-galactosidase (AgalA) 3.2.1.22 Phanerochaete chrysosporium ME446 AAG24510.1 Q9HG00  
 α-galactosidase 3.2.1.22 Phaseolus vulgaris AAA73964.1
AAR65334.1
Q41100  
 BE285   Phaseolus vulgaris AHA84202.1    
 WS0285_J03   Picea sitchensis ABR17992.1 B8LQR2  
 WS02719_G07 (fragment)   Picea sitchensis ABR16121.1 B8LKE1  
 unknown   Picea sitchensis ADE77708.1 D5ADT9  
 unknown (WS02810_D08)   Picea sitchensis ABK24468.1 A9NV07  
 unknown (WS02910_M11)   Picea sitchensis ABK24922.1 A9NWB1  
 unknown (WS0294_N01)   Picea sitchensis ABK25009.1
ABR17777.1
A9NWJ8  
 α-galactosidase 1 (Gal1) 3.2.1.22 Pisum sativum CAF34023.1 Q5ZP79  
 Pa_5_6680   Podospora anserina S mat+ CAP65080.1
CDP29829.1
B2AM92  
 unnamed protein product   Podospora anserina S mat+ CAP71790.1
CDP31181.1
B2B3V4  
 V501_01477   Pseudogymnoascus sp. VKM F-4519 (FW-2642) KFZ17922.1    
 α-galactosidase (Gal1) 3.2.1.22 Rasamsonia emersonii ABU94728.1 A7XZT2  
 Unknown (protein for MGC:95262)   Rattus norvegicus AAH82084.1 Q66H12  
 ORF (fragment)   Rimicaris exoculata ACR78680.1 C5HTY1  
 ORF   Riptortus pedestris BAN20212.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces arboricola AS 2.3318 CUW00885.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces arboricola AS 2.3319 CUW00887.1    
 α-galactosidase (Mel) (fragment)   Saccharomyces bayanus CBS 380 AAQ17217.1 Q6WN36  
 α-galactosidase (Mel1)   Saccharomyces bayanus NRRL Y-1551 CBY84987.1    
 α-galactosidase (Mel1)   Saccharomyces bayanus type strain: CBS 380 CBY84985.1    
 galactosidase / melibiase   Saccharomyces carlsbergensis AAA34770.1    
 α-galactosidase (MEL) 3.2.1.22 Saccharomyces carlsbergensis NCYC396 AAA34769.1 Q03647  
 α-galactosidase 1 (Mel1;ScMel1) 3.2.1.22 Saccharomyces cerevisiae CAA26888.1
AAE69557.1
CBY84983.1
CBY84984.1
CUW00903.1
CUW00905.1
CUW00906.1
F4N9N8
P04824
3LRK[A]
3LRL[A]
3LRM[A,B,C,D]
 α-galactosidase 2 (Mel2) 3.2.1.22 Saccharomyces cerevisiae CAA85737.1 P41945  
 α-galactosidase 5 (Mel5) 3.2.1.22 Saccharomyces cerevisiae CAA85740.1 P41946  
 α-galactosidase 6 (Mel6) 3.2.1.22 Saccharomyces cerevisiae CAA85739.1 P41947  
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae CBS 2444 CUW00896.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae CBS 4734 CUW00898.1    
 α-galactosidase (MEL)   Saccharomyces cerevisiae NCYC686 AAL07760.1 E9P8G8
Q96UV4
 
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae UWOPS 03.461.4 CUW00899.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae UWOPS 05.217.3 CUW00900.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae UWOPS 05.227.2 CUW00901.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae x Saccharomyces eubayanus CBS 1260 SBT28030.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae x Saccharomyces eubayanus CBS 2156 SBT28031.1    
 melibiase (α-galactosidase), partial (Mel1) (fragment)   Saccharomyces cerevisiae x Saccharomyces eubayanus CBS 8834 SBT28032.1    
 melibiase (α-galactosidase), partial (Mel1) (fragment)   Saccharomyces cerevisiae x Saccharomyces eubayanus x Saccharomyces uvarum NCAIM00676 SBT28034.1    
 melibiase (α-galactosidase), partial (Mel1) (fragment)   Saccharomyces cerevisiae x Saccharomyces eubayanus x Saccharomyces uvarum NCAIM00677 SBT28035.1    
 melibiase (α-galactosidase) (Mel1)   Saccharomyces cerevisiae x Saccharomyces kudriavzevii x Saccharomyces uvarum CBS 8614 (CID1) SBT28033.1    
 α-galactosidase (Mel1)   Saccharomyces eubayanus CBS 12357 CCG27770.1    
 α-galactosidase (MELj) 3.2.1.22 Saccharomyces mikatae IFO 1816 CAA64760.1 Q11129  
 melibiase (α-galactosidase) (Mel1)   Saccharomyces mikatae NBRC 1816 CUW00891.1    
 α-galactosidase (MELp) 3.2.1.22 Saccharomyces paradoxus 61-248 CAA64759.1 Q09187  
 α-galactosidase (Mel1)   Saccharomyces pastorianus CBS 1503 CCG27771.1    
 α-galactosidase (Mel) (fragment)   Saccharomyces pastorianus CBS 1538 AAQ17218.1 Q6WN35  
 melibiase (α-galactosidase) (Mel1)   Saccharomyces uvarum CBS 14186 (VN-5A) SBT28037.1    
 α-galactosidase (Mel1)   Saccharomyces uvarum CBS 1545 CBY84990.1    
 α-galactosidase (Mel1)   Saccharomyces uvarum CBS 2946 CBY84988.1
CBY84989.1
CCA89532.1
   
 α-galactosidase (Mel1)   Saccharomyces uvarum CBS 425 CCG27777.1    
 melibiase (α-galactosidase), partial (Mel1) (fragment)   Saccharomyces uvarum NCAIM00789 SBT28036.1    
 α-galactosidase (Mel1)   Saccharomyces uvarum type strain: CBS 395 CBY84986.1    
 α-N-acetylgalactosaminidase (NagaB) (fragment)   Salmo salar ACI33826.1 B5X3E5  
 AgaL   Salmo salar ACN10914.1 C0HA45  
 NagaB   Salmo salar ACN10976.1 C0HAA7  
 BT072612 (fragment)   Salmo salar ACN60308.1 C0PUN5  
 ORF   Salvia miltiorrhiza AAU86897.1 Q5XTZ3  
 α-N-acetylgalactosaminidase (NagA)   Schistosoma japonicum CAX70042.1
AAW26732.1
CAX70041.1
CAX70043.1
Q5DBS4  
 unknown (fragment)   Schistosoma japonicum AAX25755.1
AAX25755.2
Q5C3M0  
 SJCHGC03011 (fragment)   Schistosoma japonicum AAX25683.2 Q5C3U2  
 Smp_089290   Schistosoma mansoni Puerto Rico CAY17477.1
CCD80298.1
C1M0A5  
 Smp_170830 (fragment)   Schistosoma mansoni Puerto Rico CAY17473.1
CCD80294.1
C1M097  
 Smp_089270 (fragment)   Schistosoma mansoni Puerto Rico CAY17474.1
CCD80295.1
C1M098  
 Smp_170840 (fragment)   Schistosoma mansoni Puerto Rico CAY17475.1
CCD80296.1
C1M099  
 Smp_179260 (partial)   Schistosoma mansoni Puerto Rico CAZ37305.1
CCD80291.1
C4QPB8  
 Smp_179260 (partial)   Schistosoma mansoni Puerto Rico CAZ37305.1
CCD80291.1
C4QPB8  
 Smp_179250   Schistosoma mansoni Puerto Rico CAZ37304.1
CCD80292.1
C4QPB7  
 Smp_186710 (fragment)   Schistosoma mansoni Puerto Rico CAZ38188.1
CCD80293.1
C4QRV1  
 α-galactosidase (Mel1;SPAC869.07c) 3.2.1.22 Schizosaccharomyces pombe 972h- CAB60017.1
NP_595012.1
Q9URZ0  
 sscle_03g025620   Sclerotinia sclerotiorum 1980 UF-70 APA07792.1    
 sscle_02g015110   Sclerotinia sclerotiorum 1980 UF-70 APA06741.1    
 sscle_01g005950   Sclerotinia sclerotiorum 1980 UF-70 APA05825.1    
 sscle_07g056960   Sclerotinia sclerotiorum 1980 UF-70 APA10926.1    
 ORF (fragment)   Secale cereale ACJ06604.1 B6VCK1  
 unnamed protein product   Senna occidentalis CAA03733.1    
 PIIN_05502   Serendipita indica DSM 11827 CCA71565.1    
 PIIN_08399   Serendipita indica DSM 11827 CCA74446.1    
 PIIN_08905   Serendipita indica DSM 11827 CCA74935.1    
 α-galactosidase (LeaGal) 3.2.1.22 Solanum lycopersicum AAF04591.1
AAG16693.1
Q9FUR8
Q9SP05
 
 sr15067   Sporisorium reilianum SRZ2 CBQ68784.1    
 sr15386   Sporisorium reilianum SRZ2 CBQ68925.1    
 SPSC_05590   Sporisorium scitamineum SscI8 CDR88758.1    
 SPSC_04760   Sporisorium scitamineum SscI8 CDU24927.1    
 SRAE_1000106900   Strongyloides ratti ED321 Heterogonic CEF62800.1    
 α-galactosidase A   Sus scrofa ACD67895.1
ACD67896.1
D5FGE4  
 α-N-acetylgalactosaminidase (NagA)   Sus scrofa ACA43013.1 B1PK16  
 Agal   Takifugu rubripes CAC44626.1 Q90WL7  
 α-galactosidase (Aga27A) 3.2.1.22 Talaromyces leycettanus JCM12802 AJF11712.1    
 α-galactosidase (aGal) 3.2.1.22 Talaromyces purpureogenus 618 BAA22992.1 O13295  
 α-galactopyranosidase (Gla1;GLA1)   Talaromyces purpureogenus ATCC MYA-38 AKH40275.1    
 α-galactosidase (TcGal27A) (Gal27A) 3.2.1.22 Thermoascus crustaceus JCM12803 ATO91445.1    
 MYCTH_2119446 (Aga1)   Thermothelomyces thermophila ATCC 42464 AEO59170.1    
 MYCTH_2313137 (Aga2)   Thermothelomyces thermophila ATCC 42464 AEO62124.1    
 α-galactosidase (Aga2)   Thermothelomyces thermophila C1 AFJ59927.1    
 α-galactosidase (Aga1;aGal1) 3.2.1.22 Thermothelomyces thermophila C1 AFJ59926.1    
 α-galactosidase   Thielavia terrestris CAU709 ARI48112.1    
 THITE_2124844   Thielavia terrestris NRRL 8126 AEO71949.1    
 α-galactosidase (MELt) 3.2.1.22 Torulaspora delbrueckii BAA86883.1 Q9UVD6  
 TDEL_0E00170 (Tdel0e00170) (fragment)   Torulaspora delbrueckii type strain:CBS 1146 CCE92260.1    
 α-galactosidase (Agl1) 3.2.1.22 Trichoderma reesei   Q92456 1T0O[A]
1SZN[A]
 α-galactosidase 1 (Agl1;AGLI) 3.2.1.22 Trichoderma reesei RUTC-30 CAA93244.1 Q92456  
 α-galactosidase 3 (Agl3;AGLIII) 3.2.1.22 Trichoderma reesei RUTC-30 CAA93246.1 Q92451  
 Sequence 105792 from patent US 7214786   Triticum aestivum ABT18322.1    
 Sequence 107403 from patent US 7214786   Triticum aestivum ABT19933.1    
 ORF (fragment)   Triticum monococcum ACJ06602.1 B6VCJ9  
 ORF (fragment)   Triticum urartu ACJ06601.1 B6VCJ8  
 α-galactosidase I (GalI;UvGalI) 3.2.1.22 Umbelopsis vinacea     3A5V[A]
 α-galactosidase II 3.2.1.22 Umbelopsis vinacea BAA33931.1 O93816  
 α-galactosidase 3.2.1.22 Umbelopsis vinacea AAB35252.2 Q02402  
 UBRO_06272   Ustilago bromivora UB2112 SAM83953.1    
 α-galactosidase   Vernicia fordii ARV78455.1    
 VIGAN_09002800 (Vigan.09g002800) (fragment)   Vigna angularis var. angularis BAT96745.1    
 VIGAN_11209000 (Vigan.11g209000)   Vigna angularis var. angularis BAU02541.1    
 VIGAN_01092100 (Vigan.01g092100)   Vigna angularis var. angularis BAT73439.1    
 VIGAN_04422100 (Vigan.04g422100)   Vigna angularis var. angularis BAT86554.1    
 VIGAN_02181800 (Vigan.02g181800)   Vigna angularis var. angularis BAT79025.1    
 VIGAN_04113100 (Vigan.04g113100) (fragment)   Vigna angularis var. angularis BAT83891.1    
 VIGAN_04114600 (Vigan.04g114600)   Vigna angularis var. angularis BAT83904.1    
 VITISV_043596   Vitis vinifera CAN75523.1 A5ACL5  
 VITISV_001661 (fragment)   Vitis vinifera CAN75822.1 A5AM08  
 VITISV_000962   Vitis vinifera CAN66885.1 A5ALZ9  
 VITISV_041251   Vitis vinifera CAN81856.1 A5C5Q1  
 α-galactosidase   Xanthophyllomyces dendrorhous CED85437.1    
 Unknown (protein for IMAGE:5156001)   Xenopus laevis AAH72931.1 Q6GQ17  
 Unknown (protein for MGC:81044)   Xenopus laevis AAH71089.1 Q6GR44  
 Unknown (protein for MGC:130872)   Xenopus laevis AAI06338.1 Q3KQ87  
 LOC100145767 protein   Xenopus tropicalis AAI61735.1 B1WBF4  
 Unknown (protein for IMAGE:7874727)   Xenopus tropicalis AAI54864.1
AAI22060.1
A8WGV2  
 unknown   Zea mays ACG38718.1 B6TNN5  
 unknown   Zea mays ACG27087.1 B6SQF4  
 unknown (fragment)   Zea mays ACG34083.1    
 unknown (probable fragment)   Zea mays ACG46467.1    
 unknown   Zea mays B73 ACN31209.1
ACR34399.1
C0PAL4  
 unknown (ZM_BFc0123C14) (fragment)   Zea mays B73 ACF78685.1 B4F992  
 unknown (ZM_BFc0061B12)   Zea mays B73 ACF78913.1 B4F9X0  
 unknown (ZM_BFc0036L21)   Zea mays B73 ACF78970.1
ACN34719.1
B4FA27  
 unknown (ZM_BFb0086O11)   Zea mays B73 ACF80887.1 B4FFJ4  
 unknown (ZM_BFb0345J15)   Zea mays B73 ACF83970.1 B4F9X0  
 unknown (ZM_BFc0121L19)   Zea mays B73 ACF88218.1 B4FA27  
 unknown (ZM_BFc0169O05)   Zea mays B73 ACF88364.1 B4G1X1  
 α-galactosidase (MELr) 3.2.1.22 Zygotorulaspora mrakii IFO 1835 BAA99555.1 Q9P4V4  
 ZT1A5_G992   Zymoseptoria tritici ST99CH_1A5 SMY19557.1    
 ZT1E4_G1007   Zymoseptoria tritici ST99CH_1E4 SMR42229.1    
 ZT3D1_G985   Zymoseptoria tritici ST99CH_3D1 SMR44403.1    
 ZT3D7_G1026   Zymoseptoria tritici ST99CH_3D7 SMQ45881.1    
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 MedDCM-OCT-S04-C188-cds6 / ENSANGP00000020847 (fragment)   uncultured organism MedDCM-OCT-S04-C188 ADD95732.1 D6PJ31  
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