Glycoside Hydrolase Family 26

Activities in Family	Mixed-linkage xylan-specific endo-β-1,4-xylanase (cleaves glycosidic bond after β-1,3-linkage) (EC 3.2.1.-); Exo-β-1,4-mannobiohydrolase / mannobiose-producing exo-β-mannanase (EC 3.2.1.100); Endo-β-1,3-xylanase (EC 3.2.1.32); Endo-β-1,4-glucanase (EC 3.2.1.4); Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) ₈ barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	formerly known as cellulase family I.
External resources	CAZypedia; PRINTS;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (5168); Uniprot accession (85); PDB accession (44); 3D entries (21); cryst (2)


unclassified
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
Mannan endo-1,4-β-mannosidase		feces metagenome	SJX74202.1
Mannan endo-1,4-β-mannosidase (fragment)		feces metagenome	SJX74183.1
endo-β-1,4-mannanase precursor (Manem17)	3.2.1.78	insect gut metagenome	ARK08557.1
β-1,4-galactomannanase precursor (Manem6)		insect gut metagenome	ARK08556.1
endo-mannanase		metagenome			6UEH[A]
β-mannanase (LC2)		uncultured microorganism	ADB80099.1
β-mannanase (LC2)		uncultured microorganism	ADB80101.1
β-mannanase (LC2)		uncultured microorganism	ADB80106.1
mannanase		uncultured microorganism	AET14832.1
CAZy families GH26 protein, partial (fragment)		uncultured microorganism	AIA93804.1
Glyco_hydro_26, partial (fragment)		uncultured microorganism	AIA86687.1
β-mannanase (DC2-5)		uncultured microorganism	ACA61146.1
β-mannanase (DC23-2)		uncultured microorganism	ACA61159.1
β-mannanase		uncultured organism	AAT36643.1
endo-β-1,4-glucanase (SARM_0007 / 3811766_160700 / TW-10)	3.2.1.4	uncultured organism	ADX05678.1	E9NSI3
SARM_0038 / 798985_48230 / TW-11		uncultured organism	ADX05709.1
RR.01-3		unidentified microorganism	CAJ19136.1
RR.02-1 (ManB)		unidentified microorganism	CAJ19138.1
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