Glycoside Hydrolase Family 25

Known Activities	lysozyme (EC 3.2.1.17)
Mechanism	Retaining (inferred)
3D Structure Status	( β / α ) ₅ ( β ) ₃ TIM-like
Catalytic Nucleophile/Base	Asp
Catalytic Proton Donor	Glu
External resources	CAZypedia; InterPro; PFAM; PROSITE;
Statistics	GenBank accession (1376); Uniprot accession (760); PDB accession (15); 3D entries (9); cryst (1)

Summary

All (1227) Archaea (1) Bacteria (1126) Eukaryota (15) Viruses (83) unclassified (2) Structure (9 - 1 cryst) Characterized (29)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
lysozyme (BA3501;BaGH25c)	3.2.1.17	Bacillus anthracis str. Ames	AAP27267.1 NP_845781.1	Q81YN8	2WAG[A]
bacteriolytic enzyme (PlyPH;BA2805)	3.2.1.17	Bacillus anthracis str. Ames	AAP26640.1 NP_845154.1	Q81PJ7
lysozyme CH (CAC0554)	3.2.1.17	Clostridium acetobutylicum ATCC 824	AAA23250.1 AAK78533.1 NP_347193.1	P34020.1
lysozyme (CPE1314)	3.2.1.17	Clostridium perfringens str. 13	BAB81020.1 NP_562230.1	O06496
N-acetylmuramidase (AtlC;EF1992)	3.2.1.17	Enterococcus faecalis V583	AAO81737.1 AAR58131.1 NP_815667.1
N-acetylmuramidase (AtlB;EF0355)	3.2.1.17	Enterococcus faecalis V583	AAO80218.1 NP_814147.1
cell wall lytic enzyme (LysA)	3.2.1.17	Lactobacillus fermentum BR11	AAS57574.1	Q64J93
lysozyme (LysL)	3.2.1.17	Lactococcus lactis subsp. lactis	CAA10710.1	Q9ZEK6
autolysin (AmL)	3.2.1.17	Streptococcus mutans C67-1	BAF03559.1	Q0KK88
1,4-β-N-acetylmuramidase (LytC)	3.2.1.17	Streptococcus pneumoniae M31	AAQ38109.1 AAY71755.1 CAA08765.1	Q9Z4J8
autolytic lysozyme (LytC;spr1431)	3.2.1.17	Streptococcus pneumoniae R6	AAL00235.1	Q8DP07	2WW5[A] 2WWC[A] 2WWD[A]
lysozyme (Cellosyl)	3.2.1.17	Streptomyces coelicolor MULLER			1JFX[A]
lysozyme CH / M1	3.2.1.17	Streptomyces globisporus	AAA26687.1	P25310.1
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
lysozyme (AN6470.2)	3.2.1.17	Aspergillus nidulans FGSC A4	ABF50879.1 EAA58492.1	C8V058
lysozyme CH	3.2.1.17	Chalara sp.		P00721
lysozyme	3.2.1.17	Trametes cinnabarina CBS 114004
Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
muramidase (Psm;CPR_C0050)	3.2.1.17	Clostridium perfringens SM101	ABG87925.1	Q0SPG7
endolysin (Mur-LH)	3.2.1.17	Lactobacillus helveticus phage f-0303	AAQ06663.1	Q71JA9
lysozyme	3.2.1.17	Lactobacillus phage LL-H	AAC00558.1	Q04765
endolysin (Mur)	3.2.1.17	Lactobacillus phage LL-H	AAC00557.1	Q38359
lysozyme CH	3.2.1.17	Lactobacillus phage mv1	AAA32264.1	P33486.3
lysin (Lys)	3.2.1.17	Lactobacillus phage phiadh	CAB52540.1 NP_050170.1	Q38317
endolysin (Lyb5)	3.2.1.17	Lactobacillus phage phiPYB5	ABP88927.1	A5A5E0
lysozyme	3.2.1.17	Leuconostoc phage 10MC	AAD02486.1	Q9ZXB5
peptidoglycan endolysin	3.2.1.-	Streptococcus phage B30	AAN28166.2	Q8HA43
lysozyme (Cpl1;Cpl-1)	3.2.1.17	Streptococcus phage Cp-1	AAA32204.1 CAA87744.1 NP_044837.1	P15057.2	1H09[A] 1OBA[A] 2IXU[A] 2IXV[A] 2J8F[A] 2J8G[A]
lysozyme (Cpl-7)	3.2.1.17	Streptococcus phage CP-7	AAA72844.1	P19385.1
lysozyme	3.2.1.17	Streptococcus phage CP-9	AAA72845.1	P19386.1
lysin (PlyB)	3.2.1.17	unidentified phage BcpI			2NW0[A,B]

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.