Glycoside Hydrolase Family 20

Activities in Familyβ-hexosaminidase (EC 3.2.1.52); lacto-N-biosidase (EC 3.2.1.140); β-1,6-N-acetylglucosaminidase) (EC 3.2.1.-); β-6-SO3-N-acetylglucosaminidase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-K
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu
External resourcesCAZypedia; HOMSTRAD; PRINTS; Tay-Sachs Disease;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (4682); Uniprot accession (779); PDB accession (79); 3D entries (18); cryst (1)
All (4400) Archaea (4) Bacteria (4073) Eukaryota (312) Viruses (1) unclassified (10) Structure (18 - 1 cryst) Characterized (124)
| 1 | 2 | 3 | 4 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 GI16594 (short fragment)   Drosophila mojavensis ANZA402.17 AEE61329.1    
 GA14705 (fragment)   Drosophila pseudoobscura MV1 ADJ12645.1 D9MUD4  
 β-N-acetylglucosaminidase B / β-subunit / hexosaminidase 1 (HexB;Hex1)   Entamoeba histolytica HM-1:IMSS CAD10500.3 Q86M34  
 β-N-acetylglucosaminidase A / α-subunit (HexA;Hex-A;Bex-1;EHI_148130) 3.2.1.52 Entamoeba histolytica HM-1:IMSS CAE46968.1
AAA80165.1
CAG23943.1
EAL52144.2
P49009  
 N-acetyl β-glucosaminidase (β-chain) 3.2.1.52 Felis catus AAB30707.2
AAB67612.1
AEP60131.1
O18795
P49614
 
 β-N-acetylhexosaminidase alpha subunit (HexA)   Felis catus AEP60130.1    
 β-N-acetylglucosaminidase   Fenneropenaeus chinensis ABB86961.1 A0S0Q2  
 FFUJ_01479   Fusarium fujikuroi IMI 58289 CCT62012.1    
 FFUJ_05368   Fusarium fujikuroi IMI 58289 CCT69480.1    
 FFUJ_08236   Fusarium fujikuroi IMI 58289 CCT71670.1    
 FFUJ_02081 (fragment)   Fusarium fujikuroi IMI 58289 CCT61443.1    
 FGRAMPH1_01T03177   Fusarium graminearum PH-1 SCB64211.1    
 unnamed protein product (fragment)   Fusarium graminearum PH-1 CEF72482.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF87217.1    
 exochitinase   Fusarium venenatum AAP01161.1
AAP01156.1
   
 RCJMB04_30g17   Gallus gallus CAG32597.1 Q5ZI46  
 β-N-acetylhexosaminidase   Glossina morsitans morsitans ADD20246.1 D3TRB8  
 β-hexosaminidase β-subunit   Heterocephalus glaber AIZ09005.1    
 hexosaminidase D (HexDC)   Homo sapiens CAR57925.1 B7UUP6
Q8WVB3
 
 β-N-acetylglucosaminidase / β-hexosaminidase A (α-chain) (HexA) 3.2.1.52 Homo sapiens AAB00965.1
AAA51827.1
AAD13932.1
AAH01138.2
AAH18927.1
AAH21030.1
AAH84537.1
AAQ70000.1
ACM85216.1
ALQ33567.1
ALQ33569.1
ALQ33570.1
BAD96222.1
BAG59159.1
BAG60039.1
BAG62619.1
BAG62730.1
CAH10482.1
NP_000511.1
P06865
Q9BVJ8
2GJX[A,D,E,H]
2GK1[A,C,E,G]
 β-N-acetylglucosaminidase B (β-chain) (HexB) 3.2.1.52 Homo sapiens AAA52645.1
AAA51828.1
AAA51829.1
AAA68620.1
AAH17378.1
AAM46114.1
AAP88921.1
AAV48875.1
ACI46028.1
ACV87197.1
NP_000512.1
P07686 1NOU[A,B]
1NOW[A,B]
1NP0[A,B]
1O7A[A,B,C,D,E,F]
2GJX[B,C,F,G]
2GK1[B,D,F,H]
3LMY[A,B]
5BRO[A]
 predicted protein   Hordeum vulgare subsp. vulgare BAK05351.1    
 N-acetylhexosaminidase (fragment)   Hypholoma fasciculare AAT37495.1 Q6IX33  
 ORF   Hypocrella siamensis MTCC 10142 ANH56414.1    
 ORF (HexB)   Ictalurus punctatus AHH42608.1    
 ORF (HexdC)   Ictalurus punctatus AHH42765.1    
 glycoside hydrolase 20   Lagenidium giganteum ARSEF 373 AOW41676.1    
 β-hexosaminidase (short fragment) 3.2.1.52 Lagenorhynchus acutus AAF98707.1
AAF98706.1
Q9GJW3  
 β-hexosaminidase (short fragment) 3.2.1.52 Lagenorhynchus obliquidens AAF98696.1
AAF98688.1
AAF98689.1
AAF98690.1
AAF98691.1
AAF98692.1
AAF98693.1
AAF98694.1
AAF98695.1
Q9GJW1  
 β-hexosaminidase (short fragment) 3.2.1.52 Lagenorhynchus obscurus AAF98705.1
AAF98697.1
AAF98698.1
AAF98699.1
AAF98700.1
AAF98701.1
AAF98702.1
AAF98703.1
AAF98704.1
Q9GJW2  
 β-N-acetylhexosaminidase (LeHex20B) 3.2.1.52 Lentinula edodes BAQ21906.1    
 N-acetylhexosaminidase (LeHex20A) (Hex20A) 3.2.1.52 Lentinula edodes H600 BAM42836.1    
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX95932.1 E4ZWF6  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX98249.1 E5A3N6  
 LRAMOSA07546   Lichtheimia ramosa CDS05016.1    
 LRAMOSA08168   Lichtheimia ramosa CDS05640.1    
 LRAMOSA01937   Lichtheimia ramosa CDS07988.1    
 LRAMOSA10940   Lichtheimia ramosa CDS09580.1    
 β-N-acetylglucosaminidase 3.2.1.52 Litopenaeus vannamei ACR23316.1 C4P6W6  
 β-N-acetylglucosaminidase (Nag1;LmNAG1) 3.2.1.52 Locusta migratoria AFZ76982.1    
 ORF   Macaca fascicularis BAE01310.1
BAE87202.1
Q4R6G5  
 ORF   Macaca fascicularis BAE02244.1 Q4R3S2  
 β-hexosaminidase subunit alpha preproprotein (HexA)   Macaca mulatta AFE66324.1
AFI36970.1
   
 β-hexosaminidase subunit beta preproprotein (HexB)   Macaca mulatta AFE77998.1
AFH32165.1
AFI36971.1
   
 hexosaminidase D, partial (HexdC) (fragment)   Macaca mulatta AFE67440.1    
 β-hexosaminidase subunit beta preproprotein (HexB)   Macaca mulatta AFJ70442.1    
 N-acetyl-β-D-glucosaminidase   Macrobrachium nipponense ANV82809.1    
 MG07601.4   Magnaporthe oryzae 70-15 XP_367690.1 G4N2K3  
 MG09922.4   Magnaporthe oryzae 70-15 XP_365077.1 G4MR77  
 MGG_12291   Magnaporthe oryzae 70-15 XP_003715093.1    
 β-N-acetylglucosaminidase   Mamestra brassicae AKR06190.1    
 β-N-acetylglucosaminidase (NAG;McNAG) (partial)   Mamestra configurata AJF93429.1    
 β-N-acetylglucosaminidase 3.2.1.52 Manduca sexta AAQ97603.1 Q6UJX7  
 unknown   Medicago truncatula AFK39607.1    
 MtrDRAFT_AC135798g19v1   Medicago truncatula ABE82127.1 G7IQQ5  
 BN887_03509   Melanopsichium pennsylvanicum 4 CDI51629.1    
 BN887_00906   Melanopsichium pennsylvanicum 4 CDI54330.1    
 β-N-acetylglucosaminidase (Nag1)   Metarhizium anisopliae AAY17951.1 Q52JJ1  
 β-N-acetylglucosaminidase (α-chain) / β-hexosaminidase A (HexA) 3.2.1.52 Mus musculus AAC53246.1
AAA18775.1
AAA18777.1
AAH10755.1
BAC36036.1
BAC36049.1
BAC38018.1
BAE25744.1
BAE29566.1
BAE30831.1
BAE34808.1
BAE35394.1
BAE35457.1
BAE35636.1
BAE39189.1
BAE40146.1
CAA45615.1
NP_034551.1
P29416
Q8BNS6
Q91XG3
 
 β-N-acetylglucosaminidase (β-chain) / β-hexosaminidase B (HexB) 3.2.1.52 Mus musculus AAA18776.1
AAA74738.1
AAB60667.1
BAE30155.1
BAE34846.1
BAE34877.1
BAE35874.1
BAE40652.1
CAA68781.1
NP_034552.1
P20060
Q3TXR9
 
 unnamed protein product   Mus musculus NOD BAE32455.1
CAM21737.1
CAM21738.1
CAO78073.1
CAO78074.1
CAR57923.1
CAR57924.1
B7UUP4
Q3U4H6
 
 ORF   Musca domestica ALHF AFP60361.1
AFP64089.1
   
 ORF   Musca domestica ALHF AFP61547.1    
 ORF (fragment)   Mustela putorius furo AER99697.1    
 ORF (fragment)   Mustela putorius furo AER99698.1    
 ORF (fragment)   Mustela putorius furo AER99699.1    
 ORF (fragment)   Mustela putorius furo AER99700.1    
 β-N-acetylglucosaminidase   Mythimna separata ASF79655.1    
 lysosomal hexosaminidase (fragment)   Mytilus galloprovincialis ABY60965.1 B0FN50  
 N-acetylglucosaminidase 3.2.1.52 Neotyphodium sp. FCB-2004 AAU29327.1 Q643Y1  
 NCU10852 (Nag-1)   Neurospora crassa OR74A EDO65100.1    
 β-hexosaminidase 3 (Hexo3)   Nicotiana benthamiana ANW86205.1    
 β-hexosaminidase 1 (Hexo1)   Nicotiana benthamiana ANW86204.1    
 seminal fluid protein, partial   Nilaparvata lugens APA33934.1    
 β-N-acetylhexosaminidase   Nilaparvata lugens AJO25051.1    
 β-N-acetylhexosaminidase   Nilaparvata lugens AJO25048.1    
 β-N-acetylhexosaminidase   Nilaparvata lugens AJO25055.1    
 β-N-acetylhexosaminidase   Nilaparvata lugens AJO25050.1    
 β-N-acetylhexosaminidase   Nilaparvata lugens AJO25054.1    
 β-N-acetylhexosaminidase   Nilaparvata lugens AJO25053.1    
 β-N-acetylhexosaminidase   Nilaparvata lugens AJO25047.1    
 β-N-acetylhexosaminidase   Nilaparvata lugens AJO25052.1    
 β-N-acetylhexosaminidase   Nilaparvata lugens AJO25046.1    
 β-N-acetylhexosaminidase   Nilaparvata lugens AJO25049.1    
 β-hexosaminidase β-subunit (HexB) (fragment)   Oryctolagus cuniculus AAV34702.1 Q5DLV8  
 β-hexosaminidase α-subunit (HexA) (fragment)   Oryctolagus cuniculus AAV34701.1 Q5DLV9  
 Os01g0891000   Oryza sativa Japonica Group BAD87534.1
BAB90183.1
BAF06966.1
BAS75659.1
Q5JLX3  
 Os07g0575500   Oryza sativa Japonica Group BAC83175.1
BAD30243.1
BAF21992.1
BAT02283.1
Q6ZL33  
 Os05g0415700   Oryza sativa Japonica Group AAV32135.1
AAT77374.1
BAF17471.1
BAG95560.1
BAS94036.1
Q5WMR0  
 Os05g0115900   Oryza sativa Japonica Group AAU44085.1
AAV44197.1
BAF16382.1
BAG91208.1
BAS91968.1
BAS91969.1
Q65XA2  
 Os03g0219400   Oryza sativa Japonica Group BAF11315.1
BAG94727.1
BAS83001.1
Q10PW1  
 β-N-acetylhexosaminidase (Fdl;OfFDL) 3.2.1.52 Ostrinia furnacalis ADF97235.1 D6PW84  
 β-N-acetylhexosaminidase (Hex1;OfHex1) 3.2.1.52 Ostrinia furnacalis ABI81756.1 Q06GJ0 3NSM[A]
3NSN[A]
3OZO[A]
3OZP[A]
3S6T[A]
3VTR[A]
3WMB[A]
3WMC[A]
 β-N-acetylhexosaminidase (Hex2;OfHEX2) 3.2.1.52 Ostrinia furnacalis ABO65045.1 A4LAF9  
 hexosaminidase 3 (Hex3;OfHex3) 3.2.1.52 Ostrinia furnacalis ABV79901.1 A8IDA5  
 hexosaminidase A (HexA)   Ovis aries ACB87535.1 B2LSM6  
 ORF (fragment)   Pan troglodytes BAK63426.1    
 β-N-acetylglucosaminidase (NaG) (fragment)   Pandalus platyceros ADD52190.1    
 ORF (fragment)   Papilio polytes BAM19250.1    
 ORF (fragment)   Papilio xuthus BAM18776.1    
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