Glycoside Hydrolase Family 20

Activities in Familyβ-hexosaminidase (EC 3.2.1.52); lacto-N-biosidase (EC 3.2.1.140); β-1,6-N-acetylglucosaminidase) (EC 3.2.1.-); β-6-SO3-N-acetylglucosaminidase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-K
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu
External resourcesCAZypedia; HOMSTRAD; PRINTS; Tay-Sachs Disease;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (4615); Uniprot accession (779); PDB accession (79); 3D entries (18); cryst (1)
All (4333) Archaea (4) Bacteria (4008) Eukaryota (310) Viruses (1) unclassified (10) Structure (18 - 1 cryst) Characterized (124)
| 1 | 2 | 3 | 4 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 secreted protein   Achlya hypogyna ATCC 48635 AIG55828.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55828.1    
 β-N-acetylglucosaminidase   Agrotis ipsilon ADF56765.1 D6PX67  
 ORF   Amblyomma maculatum AEO33892.1    
 ORF (fragment)   Amblyomma maculatum AEO32586.1    
 ORF (fragment)   Amblyomma maculatum AEO32651.1    
 ORF (fragment)   Amblyomma maculatum AEO33277.1    
 ORF   Ampulex compressa ARK19923.1    
 β-hexosaminidase (HexB) (fragment)   Anopheles gambiae G3 AAG15372.1 Q9GT47  
 ACCB06931   Apis cerana AEY60037.1    
 processing β-N-acetylglucosaminidase / α-subunit (Fdl;AmFDL) (partial) 3.2.1.52 Apis mellifera AIZ97749.1    
 β-N-acetylhexosaminidase 2 (Hexo2;AtHex1;At1g05590) (plasma membrane) 3.2.1.52 Arabidopsis thaliana AAD30612.1
AEE27861.1
ANM60833.1
ANM60834.1
NP_172050.1
Q9SYK0  
 β-N-acetylhexosaminidase (Hexo3;AtHex3;At1g65590) (plasma membrane) 3.2.1.52 Arabidopsis thaliana AAM91092.1
AAB60911.1
AAN33206.1
AEE34399.1
NP_176737.2
O04477
Q8L7S6
 
 β-N-acetylhexosaminidase 1 (Hexo1;AtHex2;At3g55260) (vacuolar) 3.2.1.52 Arabidopsis thaliana BAE99290.1
AAM61367.1
AAN41320.1
AEE79360.1
CAB75760.1
CAM35467.1
NP_191086.1
NP_567017.1
A7WM73
Q0WUA8
Q8LFK0
Q9M3C5
 
 EGX48657.1   Arthrobotrys oligospora ATCC 24927 EGX48657.1    
 ORF   Ascaris suum ADY40724.1    
 ORF   Ascaris suum ADY42456.1    
 ORF   Ascaris suum ADY41926.1    
 ORF (fragment)   Ascaris suum ADY48924.1    
 AN2424.2   Aspergillus nidulans FGSC A4 EAA64130.1 C8VNY9
Q5BAK6
 
 N-acetylglucosaminidase (NagA;AN1502.2) 3.2.1.52 Aspergillus nidulans FGSC A4 EAA63815.1
BAB13330.1
C8VMN3
G5EB27
 
 An01g01920   Aspergillus niger CBS 513.88 CAK43562.1 A2Q7T9  
 An03g02960   Aspergillus niger CBS 513.88 CAK44595.1 A2QGF3  
 An09g02240 (NagA)   Aspergillus niger CBS 513.88 CAK40161.1 A2QTI6  
 β-N-acetylhexosaminidase (HexA) 3.2.1.52 Aspergillus oryzae CCF 1066 AAM13977.1 Q8J2T0 cryst
 β-N-acetylglucosaminidase (NagA;HexA;AO090005000639) 3.2.1.52 Aspergillus oryzae RIB40 BAC41255.1
BAE55679.1
Q2URY6
Q8J2T0
 
 AO090023000131 (probable fragment)   Aspergillus oryzae RIB40 BAE58709.1 Q2UIA6  
 AO090701000314   Aspergillus oryzae RIB40 BAE62043.1 Q2U8S2  
 Bathy14g02430   Bathycoccus prasinos RCC1105 CCO19597.1    
 hexosaminidase   Beauveria bassiana ABG77528.1 Q0PV90  
 hexosaminidase allergen (Blo t) (fragment)   Blomia tropicalis AAQ24551.1 A1KXJ0  
 β-N-acetylglucosaminidase 3.2.1.52 Bombyx mandarina AAG48701.1 Q9GPG8  
 [N-glycan specific] processing β-N-acetylglucosaminidase (Fdl;BmFDL) 3.2.1.52 Bombyx mori ACV89846.1
ACV89847.1
BAJ20189.1
D3GGI8  
 β-N-acetylglucosaminidase 3 / A (GlcNAcase3;BmGlcNAcase3) 3.2.1.52 Bombyx mori AAT99455.1 Q3L6N4  
 β-N-acetylglucosaminidase 4 / B (GlcNAcase4;BmGlcNAcase4)   Bombyx mori AAT99456.1 Q3L6N3  
 chitooligosaccharidolytic β-N-acetylglucosaminidase (BmChiGlcNAcase) 3.2.1.52 Bombyx mori AAC60521.1 P49010  
 β-N-acetylglucosaminidase 1 (GlcNAcase1;BmGlcNAcase1;BmHex3) 3.2.1.52 Bombyx mori W1-PND BAF52531.1 A4PHN6  
 β-N-acetylglucosaminidase 2 (GlcNAcase2;BmGlcNAcase2) 3.2.1.52 Bombyx mori W1-PND BAF52532.1 A4PHN7  
 Unknown (protein for MGC:139178) (fragment)   Bos taurus AAI18142.1    
 hexosaminidase A preproprotein (HexA)   Bos taurus ABG66991.1 Q0V8R6  
 glycoside hydrolase family 20 protein (Bofut4_p137670.1)   Botrytis cinerea T4 CCD52843.1    
 processing β-N-acetylhexosaminidase (Hex-1;T14F9.3) 3.2.1.52 Caenorhabditis elegans Bristol N2 AAA91263.1
CAO72174.1
CCD68941.1
NP_508409.1
Q22492  
 processing β-N-acetylhexosaminidase (Hex-2;CeHEX-2;C14C11.3) 3.2.1.52 Caenorhabditis elegans Bristol N2 AAA96105.3
CAO72175.1
CAO72175.2
CCD64497.1
G5EFL1
Q17977
 
 processing β-N-acetylhexosaminidase (Hex-4;CeHEX-4;Y51F10.5) 3.2.1.52 Caenorhabditis elegans Bristol N2 CCD73477.2
AAL35732.2
CAO72177.1
A7DY68  
 processing β-N-acetylhexosaminidase (Hex-5;CeHEX-5;Y70D2A.2) 3.2.1.52 Caenorhabditis elegans Bristol N2 CAA22078.2
CAO72178.1
G5EEC8
Q9XW90
 
 processing β-N-acetylhexosaminidase (Hex-3;CeHEX-3;Y39A1C.4) 3.2.1.52 Caenorhabditis elegans Bristol N2 CAA19506.3
CAA19506.2
CAI06053.1
CAI06053.2
CAO72176.1
Q9XXE8  
 HEXB-like (fragment)   Callithrix jacchus ABQ22431.1 A6MK40  
 β-hexosaminidase beta chain   Callorhinchus milii AFM85656.1    
 β-hexosaminidase beta chain   Callorhinchus milii AFK11359.1    
 ORF   Callorhinchus milii AFO98958.1    
 ORF   Callorhinchus milii AFO99888.1    
 ORF (fragment)   Callorhinchus milii AFP01238.1    
 ORF (fragment)   Callorhinchus milii AFP02452.1    
 β-N-acetylglucosaminidase (Hex1) 3.2.1.52 Candida albicans A72 AAA34346.2 P43077  
 CAALFM_C503610WA (Hex1)   Candida albicans SC5314 AOW29773.1    
 N-acetyl β-glucosaminidase (fragment)   Candida dubliniensis AAD39984.1 Q9Y8B0  
 CD36_53360 (Hex1)   Candida dubliniensis CD36 CAX41713.1 B9WHR9  
 SAMEA4029010_CIC11G00000003313   [Candida] intermedia CBS 141442 SGZ51673.1    
 SAMEA4029009_CIC11G00000002337   [Candida] intermedia PYCC 4715 SGZ52265.1    
 CORT_0E06530   Candida orthopsilosis Co 90-125 CCG24234.1    
 CPAR2_304330   Candida parapsilosis CDC317 CCE41444.1    
 β-N-acetylhexosaminidase beta subunit (HexB) (fragment)   Canis lupus familiaris BAM48827.1
BAM48826.1
   
 β-D-N-acetylhexosaminidase 1 (β-Hex) 3.2.1.52 Capsicum annuum ADU20405.1    
 β-N-acetylhexosaminidase 1 (Hexo1) (fragment)   Ceratitis capitata XP_004519044.1    
 β-N-acetylhexosaminidase 2 (Hexo2) (fragment)   Ceratitis capitata XP_004535045.1    
 β-N-acetylglucosaminidase, partial (fragment)   Cherax quadricarinatus ALC79577.1    
 β-N-acetylglucosaminidase 3.2.1.52 Choristoneura fumiferana AAX94571.1 Q52H16  
 N-acetyl-β-D-glucosaminidase (Nag1;Cr-Nag1) 3.2.1.52 Clonostachys rosea IK726 IBT 9371 ABC73393.1 A2SW08  
 β-L-N-acetylhexosaminidase, partial (fragment)   Cnaphalocrocis medinalis AJG44546.1    
 β-N-acetylhexosaminidase / chitobiase (Hex1;CpHEX1) 3.2.1.52 Coccidioides posadasii SILVEIRA ABB18373.1 Q309C3  
 β-N-acetylhexosaminidase / chitobiase 2 (Hex2;CpHEX2)   Coccidioides posadasii SILVEIRA ABU87865.1 A7XUU4  
 chitooligosaccharidolytic β-N-acetylglucosaminidase   Cotesia chilonis APD15623.1    
 ORF (probable fragment)   Crotalus adamanteus AFJ50290.1    
 CGB_F1600C   Cryptococcus gattii WM276 ADV22857.1    
 CNAG_06659   Cryptococcus neoformans var. grubii H99 AFR95944.1    
 CNF03620   Cryptococcus neoformans var. neoformans JEC21 AAW44323.1 Q5KEZ9  
 Unknown (protein for MGC:113333)   Danio rerio AAH90449.1 Q5BLG5  
 Unknown (protein for MGC:112084)   Danio rerio AAH93192.1
AAI52604.1
AAI64861.1
Q567F4  
 Unknown (protein for MGC:152869)   Danio rerio AAI24161.1 Q08CN8  
 DKEY-35I22.2-001   Danio rerio CAM16012.1
AAI34041.1
A2BHD8  
 DKEY-35I22.2-002 (fragment)   Danio rerio CAM16013.1 A2BHD9  
 DEHA2F18920g   Debaryomyces hansenii CBS767 CAR66369.1
CAG89553.1
   
 unknown   Dendroctonus ponderosae AEE61398.1    
 unknown   Dendroctonus ponderosae AEE62494.1    
 hexosaminidase   Dermatophagoides farinae AIO08858.1    
 DLA_Ib00130   Dicentrarchus labrax CBN81171.1    
 N-acetyl β-glucosaminidase (α-chain) (NagA) 3.2.1.52 Dictyostelium discoideum AAA33230.1 P13723  
 dd_01409 (β-hexosaminidase A)   Dictyostelium discoideum AX4 AAM09357.1    
 GA14705 (fragment)   Drosophila affinis 0141.2 ADJ12628.1 D9MUB7  
 ORF (short fragment)   Drosophila arizonae SC0307-60 AEE61337.1    
 Dbus_chr2Rg275   Drosophila busckii ALC40696.1    
 Dbus_chr3Rg1523   Drosophila busckii ALC46773.1    
 Dbus_chr3Lg687   Drosophila busckii ALC43521.1    
 Dbus_chrXg560   Drosophila busckii ALC48704.1    
 CG7985   Drosophila melanogaster AAF55509.2
AGB96079.1
Q9VEB8  
 β-N-acetylhexosaminidase 2 / b(2)-subunit (Hexo2;Hex2;CG1787) 3.2.1.52 Drosophila melanogaster AAF46406.1
AAM48390.1
NP_525081.1
Q9W3C4  
 β-N-acetylhexosaminidase 1 / b(1)-subunit (Hexo1;Hex1;CG1318) 3.2.1.52 Drosophila melanogaster AAF47881.1
AAG22248.1
AAG22248.2
AAL28566.1
AAM49995.1
AAN11596.1
AAN11597.1
AAN11597.2
ACU43551.1
NP_523924.1
NP_728974.1
NP_728975.1
NP_728976.1
Q0E8H9
Q8IRB6
Q8MSS9
Q95S03
Q9VZE3
 
 processing β-N-acetylglucosaminidase / α-subunit (Fdl;DmFDL;CG8824;Dmel_CG8824) 3.2.1.52 Drosophila melanogaster AAM29423.1
AAF58500.2
AAL55992.1
AAM68691.1
AAM68691.2
AAM68692.1
AAM68693.1
ABY20426.1
AFC17499.1
AHN56148.1
AHN56149.1
NP_610790.1
NP_725178.2
NP_725179.1
NP_725180.1
Q8WSF3  
 GA14705 (fragment)   Drosophila miranda 0101.3 ADJ12629.1 D9MUB8  
 GA14705 (fragment)   Drosophila miranda SP295 ADJ12636.1 D9MUC5  
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