Glycoside Hydrolase Family 1

Activities in Familyβ-glucosidase (EC 3.2.1.21); β-galactosidase (EC 3.2.1.23); β-mannosidase (EC 3.2.1.25); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-D-fucosidase (EC 3.2.1.38); phlorizin hydrolase (EC 3.2.1.62); exo-β-1,4-glucanase (EC 3.2.1.74); 6-phospho-β-galactosidase (EC 3.2.1.85); 6-phospho-β-glucosidase (EC 3.2.1.86); strictosidine β-glucosidase (EC 3.2.1.105); lactase (EC 3.2.1.108); amygdalin β-glucosidase (EC 3.2.1.117); prunasin β-glucosidase (EC 3.2.1.118); vicianin hydrolase (EC 3.2.1.119); raucaffricine β-glucosidase (EC 3.2.1.125); thioglucosidase (EC 3.2.1.147); β-primeverosidase (EC 3.2.1.149); isoflavonoid 7-O-β-apiosyl-β-glucosidase (EC 3.2.1.161); ABA-specific β-glucosidase (EC 3.2.1.175); DIMBOA β-glucosidase (EC 3.2.1.182); β-glycosidase (EC 3.2.1.-); hydroxyisourate hydrolase (EC 3.-.-.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental); absent in plant myrosinases
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (24212); Uniprot accession (2276); PDB accession (252); 3D entries (60); cryst (0)
All (22152) Archaea (147) Bacteria (20711) Eukaryota (1244) Viruses (2) unclassified (48) Structure (60) Characterized (338)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 13 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 unnamed protein product   Glycine max CAW48604.1
CBC08429.1
CBD31946.1
   
 unnamed protein product   Glycine max CAW48605.1
CBC08430.1
CBD21398.1
   
 unknown (fragment)   Glycine max ACU17400.1 C6T6G9  
 unnamed protein product   Glycine max CBD31896.1    
 unnamed protein product   Glycine max CBD31947.1    
 unnamed protein product   Glycine max CBD31950.1    
 unnamed protein product   Glycine max CBD31952.1    
 unnamed protein product   Glycine max CBD31953.1    
 unnamed protein product   Glycine max CBD31954.1    
 unnamed protein product   Glycine max CBD31897.1    
 unnamed protein product   Glycine max CBD31948.1    
 unnamed protein product   Glycine max CBD31949.1    
 unnamed protein product   Glycine max CBD31956.1    
 isoflavone conjugate-specific β-glucosidase (GmICHG) 3.2.1.161
3.2.1.21
Glycine max BAF34333.1 Q08IT7  
 Klotho (fragment)   Grampus griseus ADZ57973.1    
 ORF (fragment)   Griffithsia japonica AAM93923.1 Q7XZA1  
 β-galactosidase/β-glucosidase (BglA) 3.2.1.21
3.2.1.23
Hamamotoa singularis ATCC 24193 BAD95570.1 Q564N5  
 lactase, partial (LcT) (fragment)   Heleophryne purcelli AUD47044.1    
 seminal fluid protein HACP047 (fragment)   Heliconius erato ADJ58542.1 D9HQ54  
 glucosidase (fragment)   Helicoverpa armigera GR ADF43507.1 D5G3H8  
 ORF (fragment)   Henrardia persica AER62667.1    
 P66 protein   Hevea brasiliensis AAO49267.1
ACH11662.1
CAW42879.1
CAW48582.1
CBC08407.1
CBD21375.1
CBG21222.1
Q84L69  
 cyanogenic β-glucosidase   Hevea brasiliensis AAP51059.1
CAW42878.1
CAW48581.1
CBC08406.1
CBD21374.1
CBG21220.1
Q7Y073  
 β-glucosidase (Vsp1;HbVSP1)   Hevea brasiliensis ABL01537.1    
 Klotho (fragment)   Hippopotamus amphibius AEB78523.1    
 lactase-phlorizin hydrolase (Lct) 3.2.1.108
3.2.1.62
Homo sapiens CAA30801.1
AAA59504.1
AAP12677.1
AAQ79768.1
AAX88924.1
ACM80708.1
ACM82337.1
NP_002290.1
P09848  
 lactase-phlorizin hydrolase (Lct) 3.2.1.108
3.2.1.62
Homo sapiens CAA30801.1
AAA59504.1
AAP12677.1
AAX88924.1
ACM80708.1
ACM82337.1
NP_002290.1
P09848  
 klotho (KL)   Homo sapiens BAA23382.1
AAQ41828.1
AAQ41829.1
ACP57343.1
ACP57344.1
BAA24940.1
BAA24941.1
BAG53456.1
CAH71888.1
CAR95139.1
CAR95140.1
Q9UEF7
Q9UEF7
Q9UEI9
Q9Y4F0
5W21[A]
 klotho (KL)   Homo sapiens BAA23382.1
AAQ41828.1
AAQ41829.1
ACP57343.1
ACP57344.1
BAA24940.1
BAA24941.1
BAG53456.1
CAC94767.1
CAH71888.1
CAR95139.1
CAR95140.1
Q9UEF7
Q9UEF7
Q9UEI9
Q9Y4F0
5W21[A]
 neutral β-glycosylceramidase / β-glucosidase (Gba3;CbgCBgl1;GluC;KLrP) (cytosolic) 3.2.1.21
3.2.1.62
Homo sapiens CAC08178.1
AAG39217.1
AAH29362.1
AAI01830.1
AAI09378.1
AAL37305.1
BAB18741.1
BAD96683.1
BAF85435.1
BAG36006.1
BAH12772.1
NP_066024.1
A8K9N1
Q9H227
2E9L[A]
2E9M[A]
2JFE[X]
2ZOX[A]
3VKK[A]
 β-Klotho (KLB;G6VTS68545; klotho-like)   Homo sapiens BAC56857.1
AAH33021.1
AAI04872.1
AAI13654.1
AAI43576.1
AAQ41832.1
BAG63737.1
NP_783864.1
Q86Z14 5VAN[A]
5VAQ[A]
 β-Klotho (KLB;G6VTS68545; klotho-like)   Homo sapiens BAC56857.1
AAI04872.1
AAI13654.1
AAI43576.1
AAQ41832.1
NP_783864.1
Q86Z14 5VAK[A]
5VAN[A]
5VAQ[A]
5WI9[A,B]
 KPVW3022/UNQ3022   Homo sapiens AAQ89091.1
ABA66378.1
ABH82958.1
ABI02344.1
ABI12629.1
ABJ30855.1
ABJ38985.1
ABJ43341.1
ABN29974.1
ABN30161.1
ABX91624.1
ABX91900.1
ABX92176.1
ABX92452.1
ABX92728.1
ABX93162.1
ABX93669.1
ABX94403.1
ABX95410.1
ABX95686.1
ABX95962.1
ABY04184.1
ABY04460.1
ABY04736.1
ABY05322.1
ABY16428.1
ABY17920.1
ABY18196.1
ABY18472.1
ACC17005.1
ACC30665.1
ACC36886.1
ACE07531.1
ACE09369.1
ACE10581.1
ACJ96144.1
ACN02410.1
ACN06820.1
ACP73535.1
ACP89063.1
ACR89013.1
ACR89565.1
ACW28655.1
BAG52192.1
NP_997221.1
NP_997221.2
Q6UWM7  
 lactase, partial (LcT) (fragment)   Hoplobatrachus tigerinus AUD47077.1    
 ORF (fragment)   Hordeum marinum subsp. marinum AER62670.1    
 unnamed protein product   Hordeum vulgare CBD31906.1    
 unnamed protein product   Hordeum vulgare CBD31960.1    
 β-mannosidase / β-glucosidase (HvbMANNOS1) 3.2.1.21
3.2.1.25
Hordeum vulgare AAA87339.1
CAW42869.1
CAW48572.1
CBC08397.1
CBD21365.1
CBG21202.1
Q40025  
 NIASHv1004L05   Hordeum vulgare subsp. vulgare BAJ85274.1
CBD31959.1
   
 unnamed protein product   Hordeum vulgare subsp. vulgare BAJ93784.1
CBD31961.1
   
 unnamed protein product   Hordeum vulgare subsp. vulgare CBD31962.1
BAJ89480.1
   
 unnamed protein product   Hordeum vulgare subsp. vulgare CBD31958.1
BAJ89678.1
   
 predicted protein   Hordeum vulgare subsp. vulgare BAJ93012.1    
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAK08154.1    
 β-mannosidase / β-glucosidase (HvBII) 3.2.1.21
3.2.1.25
3.2.1.74
Hordeum vulgare subsp. vulgare ACF07998.1 B5A496  
 β-glucosidase (Bgl4;Bglhi) 3.2.1.21 Humicola grisea var. thermoidea IFO9854 / Humicola insolens RP86 BAA74958.1 O93784 4MDO[A]
4MDP[A]
 β-glucosidase (BglhI)   Humicola insolens RP86 AII80277.1    
 β-glucosidase (fragment)   Hyacinthus orientalis AAT08711.1 Q677B3  
 lactase, partial (LcT) (fragment)   Hyla chinensis AUD47043.1    
 β-glucosidase 30 (Bglu30)   Hylocereus polyrhizus ASZ85203.1    
 lactase, partial (LcT) (fragment)   Hylomantis lemur AUD46967.1    
 lactase, partial (LcT) (fragment)   Hyloscirtus lindae AUD46992.1    
 lactase, partial (LcT) (fragment)   Hyloxalus jacobuspetersi AUD47009.1    
 lactase, partial (LcT) (fragment)   Hymenochirus sp. CAS 249965 AUD47045.1    
 lactase, partial (LcT) (fragment)   Hypodactylus brunneus AUD46989.1    
 lactase, partial (LcT) (fragment)   Hypsiboas fasciatus AUD46981.1    
 ORF LCTL   Ictalurus punctatus AHH40387.1    
 lactase, partial (LcT) (fragment)   Insuetophrynus acarpicus AUD46986.1    
 ORF   Ipomoea nil BAN58137.1    
 JHL23J11.2   Jatropha curcas Palawan BAJ53147.1    
 lactase, partial (LcT) (fragment)   Kalophrynus pleurostigma AUD47046.1    
 lactase, partial (LcT) (fragment)   Kaloula conjuncta AUD46991.1    
 lactase, partial (LcT) (fragment)   Kaloula pulchra AUD47047.1    
 Klotho (fragment)   Kogia sima ADZ57979.1    
 β-glucosidase 3.2.1.21 Lasiodiplodia theobromae CBS 247.96 CAJ81226.1    
 lactase, partial (LcT) (fragment)   Leiopelma hochstetteri AUD47014.1    
 ArbB   Leishmania infantum AAG46031.1 Q9GPU3  
 lactase, partial (LcT) (fragment)   Lepidobatrachus sp. TNHC-GDC 17421 AUD46994.1    
 lactase, partial (LcT) (fragment)   Leptobrachium chapaense AUD47049.1    
 lactase, partial (LcT) (fragment)   Leptodactylodon ovatus AUD47051.1    
 lactase, partial (LcT) (fragment)   Leptolalax alpinus AUD47048.1    
 ORF   Leptosphaeria maculans JN3 CBX97760.1 E5A243  
 ORF   Leptosphaeria maculans JN3 CBX98890.1 E5A5J2  
 ORF   Leptosphaeria maculans JN3 CBY01668.1 E5AEM9  
 hydroxynitrile glucoside-cleaving β-glucosidase (Bglu1;LlBglu1 3.2.1.21 Leucaena leucocephala ABY48758.1
ABI34907.1
ABI34907.2
ABI34907.3
ABY84677.1
B0LJR5  
 ORF (fragment)   Leucaena leucocephala ABK60303.2 A0SXU2  
 lactase, partial (LcT) (fragment)   Limnodynastes salmini AUD47052.1    
 lactase, partial (LcT) (fragment)   Limnonectes fujianensis AUD47050.1    
 unnamed protein product   Linum usitatissimum CBD31903.1    
 cell wall glycosidase (fragment)   Linum usitatissimum ABM64783.1 A2IBG8  
 lactase, partial (LcT) (fragment)   Liophryne schlaginhaufeni AUD46979.1    
 Klotho (fragment)   Lipotes vexillifer ADZ57971.1    
 lactase, partial (LcT) (fragment)   Liurana xizangensis AUD47081.1    
 β-glucosidase 31, partial (fragment)   Lolium perenne AFA36600.1    
 β-glucosidase, partial (fragment)   Lotus arenarius AGZ83062.1    
 β-glucosidase, partial (fragment)   Lotus burttii AGZ83066.1    
 β-glucosidase, partial (fragment)   Lotus conimbricensis AII26337.1    
 β-glucosidase, partial (fragment)   Lotus corniculatus AII26340.1    
 β-glucosidase, partial (fragment)   Lotus corniculatus AII26339.1    
 β-glucosidase, partial (fragment)   Lotus corniculatus AII26341.1    
 β-glucosidase, partial (fragment)   Lotus corniculatus AII26342.1    
 ORF (fragment)   Lotus drepanocarpus AGZ83063.1    
 β-glucosidase, partial (fragment)   Lotus edulis AII26338.1    
 β-glucosidase, partial (fragment)   Lotus filicaulis AGZ83061.1    
 unknown (fragment)   Lotus japonicus AFK38801.1    
 unknown (fragment)   Lotus japonicus AFK40243.1    
 unknown (fragment)   Lotus japonicus AFK43877.1    
 unknown (fragment)   Lotus japonicus AFK47660.1    
 β-glucosidase (LjBGD10)   Lotus japonicus AGS43007.1    
 β-glucosidase D7 (LjBGD7)   Lotus japonicus ACD65511.1
AFK35989.1
B2ZUU2  
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