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Glycoside Hydrolase Family 18

Activities in FamilyNod factor hydrolase (EC 3.2.1.-);
Chitin exo-β-1,4-N-acetylglucosaminidase (EC 3.2.1.-);
Di-N-acetylchitobiase / reducing-end exo-hexosaminidase (EC 3.2.1.-);
Peptidoglycan endo-β-1,4-N-acetylglucosaminidase (EC 3.2.1.-);
Chitosanase (EC 3.2.1.132);
Chitinase (EC 3.2.1.14);
Chitin exo-β-1,4-N-acetylglucobiosaminidase (EC 3.2.1.200);
[reducing end] exo-chitinase (EC 3.2.1.201);
β-N-acetylhexosaminidase (EC 3.2.1.52);
Mannosyl-glycoprotein endo-β-N-acetylglucosaminidase (EC 3.2.1.96);
Mechanism Retaining e
ClanGH-K
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu (experimental)
NoteContains chitinases of classes III and V. Contains non-catalytic proteins such as xylanase inhibitor; concanavalin B; narbonin
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (41399); Uniprot accession (502); PDB accession (425); 3D entries (110); cryst (2)
Summary
Download GH18 (53976) Taxonomic display Structure (110 - 2 cryst) Characterized (431)
| 1 | 2 |
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 xylanase and α-amylase inhibitor isoform II   Scadoxus multiflorus AIIMSBP-002 ADJ78351.1  
3MU7[A] 1.29
 signal processing protein (Spp-40)   Sus scrofa AAV30548.1  
1XHG[A] 2.90
1XRV[A] 2.10
1ZB5[A] 2.45
1ZBC[A] 2.29
 Chi-lectin (TCLL;TACC-III) (partial)   Tamarindus indica    
4B15[A] 1.49
4B16[A] β-D-GlcpNAc
 1.61
 chitinase (Chit33) 3.2.1.14 Trichoderma harzianum CECT 2413 CAA56315.1 Q12713
7ZY9[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 1.60
7ZYA[A] 1.12
 endochitinase (Chit-HAR1) 3.2.1.14 Trichoderma harzianum TMI-60638 BAB40589.1 P48827
Q9C1T8
6EPB[A] 1.75
6YLJ[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 1.75
6YN4[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 1.82
7AKQ[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.32
 mannosyl-glycoprotein endo-β-N-acetylglucosaminidase T (EndoT;Endo T;ENGase;Eng18A) 3.2.1.96 Trichoderma reesei RUT-C30 CAZ16624.1
CAL49862.1
CAL49863.1		 C4RA89
4AC1[X] 1.30
 Chitinase   Trichuris suis    
6G9E[A,B,C,D,E,F] 2.69
6G9C[A] 1.74
 xylanase inhibitor protein I (XipI;XIP-I;Xip)   Triticum aestivum CAD19479.1
ADB81849.1
AGN71004.1		  
1OM0[A] 1.80
1TA3[A] 1.70
1TE1[A] 2.50
 narbonin   Vicia narbonensis CAA80983.1
CAA80979.1
CAA80980.1		  
1NAR[A] 1.80
Viruses
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 Ac-ChiA   Autographa californica nucleopolyhedrovirus E2 AIU56979.1
CAD79454.1		  
5DEZ[A,B] β-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
 2.30
5DF0[A,B] β-D-GlcpNAc
 3.25
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