Glycoside Hydrolase Family 18

Activities in Familychitinase (EC 3.2.1.14); lysozyme (EC 3.2.1.17); endo-β-N-acetylglucosaminidase (EC 3.2.1.96); peptidoglycan hydrolase with endo-β-N-acetylglucosaminidase specificity (EC 3.2.1.-); Nod factor hydrolase (EC 3.2.1.-); xylanase inhibitor; concanavalin B; narbonin
Mechanism Retaining
ClanGH-K
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu (experimental)
NoteContains chitinases of classes III and V. Contains non-catalytic proteins such as xylanase inhibitor; concanavalin B; narbonin
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)NZYTech; PROZOMIX;
Statistics GenBank accession (14617); Uniprot accession (3282); PDB accession (301); 3D entries (77); cryst (4)
All (13074) Archaea (61) Bacteria (9464) Eukaryota (3057) Viruses (255) unclassified (237) Structure (77 - 4 cryst) Characterized (477)
| 1 | 2 | 3 | 4 | 5 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 chitinase 3 (Chi3;Chit3;EiChit3) 3.2.1.14 Entamoeba invadens IP-1 ABC59331.1 Q2LEA7  
 chitinase A (EaChiA) 3.2.1.14 Equisetum arvense BAI22848.1 C7G3I3  
 chitotriosidase (Chit1) 3.2.1.14 Equus caballus ABV53445.1
ABX82529.1
B7S833  
 chitinase III (ELC) (fragment) 3.2.1.14 Euphorbia characias AGX26690.2
AGX26690.1
   
 chitinase 3 (Chi3;FcChi-3) 3.2.1.14 Fenneropenaeus chinensis AAY44300.1 Q1L837  
 acidic chitinase 3.2.1.14 Ficus pumila var. awkeotsang AAQ07267.1 Q71HN4  
 endo-β-N-acetylglucosaminidase (Endo FV;EndO) 3.2.1.96 Flammulina velutipes ACV60538.1 D1GA49  
 chitinase 3 (Chi3) 3.2.1.14 Fragaria x ananassa AAD22114.1 Q9XF93  
 endochitinase 3.2.1.14 Fusarium venenatum AAP01160.1    
 chitinase II (CHI II) 3.2.1.14 Glaciozyma antarctica PI12 AEH16745.1    
 chitinase A 3.2.1.14 Gladiolus x gandavensis   Q7M1R1
Q7M1R1
 
 chitinase 3.2.1.14 Glycine max BAA25015.1
ACU19618.1
O48642  
 acidic chitinase Chib1-a 3.2.1.14 Glycine max BAA77676.1
ACU21507.1
ACU24254.1
Q9SXM5  
 acidic chitinase Chib1-b 3.2.1.14 Glycine max BAA77675.1
BAA77677.1
Q9S7G9  
 chitinase (Cht1;Cht) 3.2.1.14 Haemaphysalis longicornis BAC06447.1 Q8MY79  
 chitinase (Cht1;Cht) 3.2.1.14 Haemaphysalis longicornis BAC06447.1 Q8MY79  
 chitinase 3.2.1.14 Helicoverpa armigera AAQ91786.1
AAQ94193.1
Q6VUB9  
 chitinase (Cht1;Cht-1) 3.2.1.14 Heterodera glycines AAN14978.1
AAN14979.1
Q8I6X8
Q8ITJ8
 
 bifunctional chitinase / lysozyme (hevamine A) 3.2.1.14
3.2.1.17
Hevea brasiliensis CAA07608.1
AAB19633.1
ABI32402.1
ABI32402.2
ADR82196.1
CAA09110.1
P23472 1HVQ[A]
1KQY[A]
1KQZ[A]
1KR0[A]
1KR1[A]
1LLO[A]
2HVM[A]
 chitinase (hevamine) (fragment) 3.2.1.14 Hevea brasiliensis CAC19408.1 Q9FEY6  
 chitinase 1 (ChiB;ChiC;HoChiB;HoChiC) 3.2.1.14 Hexagrammos otakii BAK19335.1    
 chitinase 2 (ChiA;HoChiA) 3.2.1.14 Hexagrammos otakii BAK19336.1    
 chitinase (Cts1) 3.2.1.14 Histoplasma capsulatum AAF80370.1 Q9P4Q1  
 chitinase (Cts2) 3.2.1.14 Histoplasma capsulatum AAG41982.1 Q9HEW6  
 chitinase / chitotriosidase (Chit1;CHIT1;CHIT-1;HCHT;HsCht) 3.2.1.14 Homo sapiens CAC37767.1
AAC50246.1
AAE83140.1
AAE83141.1
AAG10644.1
AAH69614.1
AAI03696.1
AAI05681.1
AAI05682.1
AAI05683.1
AAY73903.1
AAY73904.1
ABE14345.1
BAG51478.1
CAC37768.1
NP_003456.1
Q13231 1GUV[A]
1HKI[A]
1HKJ[A]
1HKK[A]
1HKM[A]
1LG1[A]
1LG2[A]
1LQ0[A]
1WAW[A]
1WB0[A]
4WJX[A]
4WK9[A]
4WKA[A]
4WKF[A]
4WKH[A]
5HBF[A,B]
 di-N-acetylchitobiase (Ctbs) 3.2.1.- Homo sapiens AAA35684.1
AAC35852.1
AAH24007.2
AAH96752.1
AAI26334.1
AAI26336.1
BAG37202.1
BAG52135.1
BAG60860.1
CAH70206.1
CAH70207.1
NP_004379.1
Q01459
Q5VX50
 
 acidic chitinase / acidic mammalian chitinase (ChiA;CHIA;hAMCase) 3.2.1.14 Homo sapiens AAG60019.1
AAH36339.1
AAH36339.2
AAH47336.1
AAH47336.2
AAI06911.1
AAI39902.1
AAI39921.1
AAX02309.1
AAX02311.1
AAX54833.1
AAX81431.1
AAX81432.1
AAX81433.1
AAX81434.1
AAY07520.1
AAY07521.1
BAA86980.1
BAA86981.1
BAF83391.1
CAD35096.1
CAH70802.1
CAH70803.1
CAH70804.1
CAI19263.1
CAI19265.1
CAI19266.1
NP_068569.1
Q9BZP6 2YBT[A,B,C,D,E,F]
2YBU[A,B,C,D,E,F]
3FXY[A,B,C,D]
3FY1[A,B]
3RM4[A,B]
3RM8[A,B]
3RM9[A,B]
3RME[A,B]
 chitinase 3.2.1.14 Hyphantria cunea AAB47539.1 P91731  
 chitinase 3.2.1.14 Hypocrea rufa AAF19616.1
AAV91517.1
Q9UV45  
 chitinase 3.2.1.14 Hypocrea rufa GJS 89-142 AAF19617.1 Q9UV44  
 chitinase 3.2.1.14 Hypocrea rufa HY9 AAF19626.1 Q9UV35  
 chitinase 3.2.1.14 Hypocrea vinosa AAF19625.1 Q9UV36  
 chitinase (Chit2;Ifu-Chit2) 3.2.1.14 Isaria fumosorosea RCEF3304 AKM77638.1
ADR77504.1
E5KZV1  
 Chi-1 (fragment) 3.2.1.14 Isaria javanica AAZ83728.1 Q3YLC5  
 chitinase / tRNase killer gammα-toxin (zymocin α-subunit) 3.2.1.14 Kluyveromyces lactis CAA25334.1
CAA25569.1
CAA30137.1
P09805  
 chitinase (Cts1;KlCts1;KLLA0C04730g) 3.2.1.14 Kluyveromyces lactis NRRL Y-1140 CAH01261.1 Q6CUH9  
 acidic chitinase (LcChi) 3.2.1.14 Latimeria chalumnae BAP90826.1    
 endochitinase (Chit1) 3.2.1.14 Lecanicillium lecanii 432 ABD77095.1
ABD77096.1
A6XBL0  
 basic chitinase (Ch12;Chit2) 3.2.1.14 Lecanicillium lecanii DAOM 175104 AAV98692.1
AAV98691.1
Q5MNU1  
 chitinase (Chi1) 3.2.1.14 Lecanicillium psalliotae ABQ57240.1 A6Y9S8  
 chitinase (Chi-1;Cht1) 3.2.1.14 Leishmania donovani AAC17944.1
AAS90570.1
AAS90571.1
AAS90572.1
AAS90573.1
AAS90574.1
AAS90575.1
AAS90576.1
AAS90577.1
AAS90578.1
AAS90579.1
AAS90580.1
AAS90581.1
AAS90582.1
AAS90583.1
AAS90584.1
AAS90585.1
AAS90586.1
AAS90587.1
AAS90591.1
AAS90592.1
AAS90593.1
AAS90594.1
AAS90595.1
O60994  
 chitinase 3.2.1.14 Lupinus albus CAA76203.1 O49876  
 chitinase (Chi1) 3.2.1.14 Malus domestica AAG25709.1 Q9FUD7  
 chitinase (Chi535;MsCHT5) 3.2.1.14 Manduca sexta AAB53952.1
AAC04924.1
P36362  
 chitinase 1 (Chi1;PjChi-1) 3.2.1.14 Marsupenaeus japonicus BAA12287.1 Q26042  
 chitinase 2 (Chi2;PjChi-2) 3.2.1.14 Marsupenaeus japonicus BAA14014.1 P91773  
 chitinase 3 (Chi3;PjChi-3) 3.2.1.14 Marsupenaeus japonicus BAA22854.1 O15993  
 Nod factor hydrolase 1 (Nfh1;MtNFH1) 3.2.1.- Medicago truncatula AGX84980.1    
 chitinase 3.2.1.14 Mesembryanthemum crystallinum AAD11423.1 Q9ZSR4  
 chitinase (Chit42) 3.2.1.14 Metarhizium anisopliae HN1 / CY-1 AAY32603.1
AEL89294.1
Q4U4M9  
 chitinase (Chit30;Chi3) (fragment) 3.2.1.14 Metarhizium anisopliae var. anisopliae E6 AAS55554.1 Q6QDR4  
 chitinase (Chit1;Chit42) 3.2.1.14 Metarhizium anisopliae var. anisopliae E6 AAB81998.1
AAB81999.1
O14456  
 endochitinase (Chi2) 3.2.1.14 Metarhizium anisopliae var. anisopliae E6 AAY34347.1 Q4U4T0  
 chitinase 1 (chi1) 3.2.1.14 Metarhizium flavoviride CAB44709.1 Q9Y841  
 chitinase (Chi1) 3.2.1.14 Metschnikowia fructicola AP47 ADV90768.1    
 acidic mammalian chitinase (ChiA;YNL;AMCase) 3.2.1.14 Mus musculus AAG60018.1
AAF31644.1
AAH11134.1
AAH34548.1
AAY07518.1
AAY07519.1
ABC86699.1
ABK78778.1
BAB25795.1
BAB25878.1
BAE35672.1
NP_075675.2
B8K282
Q91XA9
 
 chitotriosidase (Chit1) 3.2.1.14 Mus musculus AAR14312.1
AAS47832.1
BAB26025.1
EDL39627.1
B2RS82
Q9D7Q1
Q9D7Q1
 
 class III chitinase (NaCHIT3;NaChitIII) 3.2.1.14 Nepenthes alata BAM28610.1    
 acidic endochitinase (Chit1;NrChit1) 3.2.1.14 Nepenthes rafflesiana ACU31856.1 C7F822  
 chitinase (ChiV;Chi-V;NtChiV;ChiC1) 3.2.1.14 Nicotiana tabacum CAA54374.1
CAB58462.1
Q43576 3ALF[A]
3ALG[A]
 chitinase/lysozyme (Chi-V;Pz) 3.2.1.14
3.2.1.17
Nicotiana tabacum CAA55128.1
CAA54373.1
Q43591  
 chitinase A 3.2.1.14 Nicotiana tabacum CAA77656.1 P29060  
 chitinase B 3.2.1.14 Nicotiana tabacum CAA77657.1 P29061  
 chitinase (Chi1;Chi-1;Cht1;OvCHT1) 3.2.1.14 Onchocerca volvulus AAB68960.1 Q25615  
 chitinase (Chit;OuChit) 3.2.1.14 Ophiocordyceps unilateralis AEC16039.1    
 chitinase (Rcb4;Os10g0416100) 3.2.1.14 Oryza sativa Japonica Group AAK26395.1
AAO15366.1
AAP53763.1
BAF26519.1
BAG92504.1
BAT10852.1
BAT10853.1
Q8GZT6
Q9AT30
 
 chitinase (OsChib1b;OsChib3b;Os01g0860500) 3.2.1.14 Oryza sativa Japonica Group BAA23809.1
BAA22266.1
BAB90566.1
BAB91759.1
BAD82025.1
BAD82632.1
BAF06786.1
BAG96431.1
BAS75333.1
O04139
O49827
 
 chitinase (OsChib1a;OsChib3a;Os01g0660200) 3.2.1.14 Oryza sativa Japonica Group BAA21743.2
BAA23811.1
BAA77605.1
BAB85276.1
BAC06302.1
BAF05686.1
BAG94860.1
BAS73527.1
O22080  
 chitinase-h (Chi-H;OfChi-H) 3.2.1.14 Ostrinia furnacalis BAE16587.1
AGZ20170.1
Q4AE59 5GPR[A]
5GQB[A]
 chitinase (Cht5;OfChtI;OfCHT5) 3.2.1.14 Ostrinia furnacalis ABB97081.2
AAW50396.1
ABB97081.1
ABI81757.1
Q2V6H4 3W4R[A]
3WKZ[A]
3WL0[A]
3WL1[A]
3WQV[A]
3WQW[A]
 chitinase (ChiA;PtChiA) 3.2.1.14 Paecilomyces sp. J18 AEO50762.1    
 chitinase (Cts1;PbCTS1) 3.2.1.14 Paracoccidioides brasiliensis ATCC-MYA-826 / Pb01 AAQ75798.3 Q5YLC0  
 chitinase 1 (ChiA;Chi-1;PtChiA;PtChi-1) 3.2.1.14 Parapristipoma trilineatum BAK43286.1    
 chitinase 2 (ChiB;Chi-2;PtChiB;PtChi-2) 3.2.1.14 Parapristipoma trilineatum BAK43287.1    
 endochitinase (Ppl2) 3.2.1.14 Parkia platycephala CAO78600.1 A6ZJJ1 2GSJ[A]
 chitinase (peptide fragment) 3.2.1.14 Parthenocissus quinquefolia   P23473  
 chitinase 3 (Chi3;PmChi3) (partial) 3.2.1.14 Penaeus monodon ADG22163.1 D6N9T3  
 chitinase 1 (Chi-1;Chi1;PmChi1) 3.2.1.14 Penaeus monodon AAD40313.1
ADG22162.1
Q9Y0D4  
 chitinase 1 3.2.1.14 Pennahia argentata BAJ51753.1    
 chitinase 3.2.1.14 Phaedon cochleariae CAA77014.1 O97403  
 chitinase B 3.2.1.14 Phytolacca americana BAB92957.1
AAB34670.1
Q8LST3  
 chitinase (PfChit1) 3.2.1.14 Plasmodium falciparum K1 AAF16902.1 Q9U4I9  
 chitinase 3.2.1.14 Plasmodium gallinaceum AAF63208.1
AAW12822.1
Q9NJX9  
 chitinase (PvCht1) 3.2.1.14 Plasmodium vivax SALI BAC98930.1 Q76EB5  
 chitinase 3.2.1.14 Psophocarpus tetragonolobus BAA08708.1 Q43098  
 chitinase A (ChiA;PrChiA) 3.2.1.14 Pteris ryukyuensis BAE98134.1 Q0WYK2 4RL3[A,B]
 class III chitinase (Psc) 3.2.1.14 Punica granatum BAK68869.1   4TOQ[A,B,C,D]
 di-N-acetylchitobiase (Ctbs) 3.2.1.- Rattus norvegicus AAA40924.1
AAH88129.1
NP_112285.1
Q01460  
 chitotriosidase (ChtBD2) 3.2.1.14 Rattus norvegicus ABB89471.1
ABL06995.1
ABL06996.1
ABL06997.1
ABL06998.1
ABL06999.1
A0S5V8  
 acidic class III chitinase 3.2.1.14 Rehmannia glutinosa AAO47731.1 Q84U85  
 chitinase I (Chi1) 3.2.1.14 Rhizopus microsporus var. oligosporus IFO 8631 BAA01021.1 P29026  
 chitinase II (Chi2) 3.2.1.14 Rhizopus microsporus var. oligosporus IFO 8631 BAA01022.1 P29027  
 chitinase III (Chi3) 3.2.1.14 Rhizopus microsporus var. oligosporus IFO 8631 BAA13489.1 Q92270  
 chitinase (Chi1) 3.2.1.14 Rhizopus niveus IFO4810 BAA01018.1 P29025  
 chitinase (Cts1;YLR286C) 3.2.1.14 Saccharomyces cerevisiae S288c AAT93059.1
AAB67331.1
ABC16985.1
NP_013388.1
P29029 2UY2[A]
2UY3[A]
2UY4[A]
2UY5[A]
4TXE[A]
 chitinase 1 (Chi;SjChi) 3.2.1.14 Scomber japonicus BAL40979.1    
 chitinase 1 (SmChi-1;SmChiA;SmChiB) 3.2.1.14 Sebastiscus marmoratus BAL40980.1    
 chitinase 2 (SmChi-2; SmChiC ) 3.2.1.14 Sebastiscus marmoratus BAL40981.1    
 chitinase Chit 3.2.1.14 Sphenostylis stenocarpa AAD27874.1
AAD27874.2
Q9XHC3  
 chitinase (Chi;SlChi;Sl-Chi) 3.2.1.14 Spodoptera litura BAB12678.1
AAQ91787.1
AAQ94194.1
Q9GV44  
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