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Glycoside Hydrolase Family 18

Activities in FamilyNod factor hydrolase (EC 3.2.1.-);
Chitin exo-β-1,4-N-acetylglucosaminidase (EC 3.2.1.-);
Di-N-acetylchitobiase / reducing-end exo-hexosaminidase (EC 3.2.1.-);
Peptidoglycan endo-β-1,4-N-acetylglucosaminidase (EC 3.2.1.-);
Chitosanase (EC 3.2.1.132);
Chitinase (EC 3.2.1.14);
Chitin exo-β-1,4-N-acetylglucobiosaminidase (EC 3.2.1.200);
[reducing end] exo-chitinase (EC 3.2.1.201);
β-N-acetylhexosaminidase (EC 3.2.1.52);
Mannosyl-glycoprotein endo-β-N-acetylglucosaminidase (EC 3.2.1.96);
Mechanism Retaining e
ClanGH-K
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu (experimental)
NoteContains chitinases of classes III and V. Contains non-catalytic proteins such as xylanase inhibitor; concanavalin B; narbonin
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (41399); Uniprot accession (502); PDB accession (425); 3D entries (110); cryst (2)
Summary
Download GH18 (53976) Taxonomic display Structure (110 - 2 cryst) Characterized (431)
| 1 | 2 | 3 | 4 | 5 |
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 acidic chitinase 3.2.1.14 doi
pubmed
 Ficus pumila var. awkeotsang AAQ07267.1 Q71HN4  
 endo-β-N-acetylglucosaminidase (Endo FV;EndO) 3.2.1.96 pubmed
 Flammulina velutipes ACV60538.1 D1GA49  
 chitinase II (CHI II) 3.2.1.14 pubmed
 Glaciozyma antarctica PI12 AEH16745.1 F8UTU2  
 chitinase A 3.2.1.14 pubmed
pubmed
 Gladiolus x gandavensis   Q7M1R1
Q7M1R1		  
 chitinase 3.2.1.14 pubmed
 Glycine max BAA25015.1
ACU19618.1		 C6TCR6
O48642		  
 chitinase (Cht1;Cht) 3.2.1.14 pubmed
pubmed
 Haemaphysalis longicornis BAC06447.1 Q8MY79  
 chitinase (Cht1;Cht) 3.2.1.14 pubmed
pubmed
 Haemaphysalis longicornis BAC06447.1 Q8MY79  
 chitinase 3.2.1.14 pubmed
 Helicoverpa armigera AAQ91786.1
AAQ94193.1		 Q6VUB9  
 chitinase (Cht1;Cht-1) 3.2.1.14 pubmed
 Heterodera glycines AAN14978.1
AAN14979.1		 Q8I6X8
Q8ITJ8		  
 bifunctional chitinase / lysozyme (hevamine A) 3.2.1.-
3.2.1.14		 pubmed
pubmed
 Hevea brasiliensis CAA07608.1
AAB19633.1
ABI32402.1
ABI32402.2
ADR82196.1
CAA09110.1		 E7BQV3
P23472		 1HVQ[A]
1KQY[A]
1KQZ[A]
1KR0[A]
1KR1[A]
1LLO[A]
2HVM[A]
 chitinase 1 (ChiB;ChiC;HoChiB;HoChiC) 3.2.1.14 pubmed
 Hexagrammos otakii BAK19335.1 F2ZB48  
 chitinase 2 (ChiA;HoChiA) 3.2.1.14 pubmed
 Hexagrammos otakii BAK19336.1 F2ZB49  
 chitinase (Cts1) 3.2.1.14 pubmed
 Histoplasma capsulatum AAF80370.1 Q9P4Q1  
 chitinase / chitotriosidase (Chit1; CHIT1; CHIT-1; HCHT; HsCht) 3.2.1.14 pubmed
 Homo sapiens CAC37767.1
AAC50246.1
AAE83140.1
AAE83141.1
AAG10644.1
AAH69614.1
AAI03696.1
AAI05681.1
AAI05682.1
AAI05683.1
AAY73903.1
AAY73904.1
ABE14345.1
BAG51478.1
CAC37768.1
NP_001243054.2
NP_003456.1		 Q13231 1GUV[A]
1HKI[A]
1HKJ[A]
1HKK[A]
1HKM[A]
1LG1[A]
1LG2[A]
1LQ0[A]
1WAW[A]
1WB0[A]
4WJX[A]
4WK9[A]
4WKA[A]
4WKF[A]
4WKH[A]
5HBF[A,B]
5NR8[A]
5NRA[A]
5NRF[A]
6JJR[A]
6JK6[A]
6ZE8[A,B,C,D,E,F]
 di-N-acetylchitobiase (Ctbs) 3.2.1.- pubmed
 Homo sapiens AAA35684.1
AAC35852.1
AAH24007.2
AAH96752.1
AAI26334.1
AAI26336.1
BAG37202.1
BAG52135.1
BAG60860.1
CAH70206.1
CAH70207.1
NP_004379.1		 B2RBF5
B3KQS3
B4DQ98
Q01459
Q5VX50
Q8TC97		  
 acidic chitinase / acidic mammalian chitinase (ChiA;CHIA;hAMCase) 3.2.1.14 pubmed
 Homo sapiens AAG60019.1
AAH36339.1
AAH36339.2
AAH47336.1
AAH47336.2
AAI06911.1
AAI39902.1
AAI39921.1
AAX02309.1
AAX02311.1
AAX54833.1
AAX81431.1
AAX81432.1
AAX81433.1
AAX81434.1
AAY07520.1
AAY07521.1
BAA86980.1
BAA86981.1
BAF83391.1
CAD35096.1
CAH70802.1
CAH70803.1
CAH70804.1
CAI19263.1
CAI19265.1
CAI19266.1
NP_068569.1		 A5D6V7
A8K3T7
Q1M0P3
Q1M0P4
Q2VT96
Q9BZP6		 2YBT[A,B,C,D,E,F]
2YBU[A,B,C,D,E,F]
3FXY[A,B,C,D]
3FY1[A,B]
3RM4[A,B]
3RM8[A,B]
3RM9[A,B]
3RME[A,B]
 chitinase / tRNase killer gammα-toxin (zymocin α-subunit) 3.2.1.14 pubmed
 Kluyveromyces lactis CAA25334.1
CAA25569.1
CAA30137.1		 P09805  
 chitinase (Cts1;KlCts1;KLLA0C04730g) 3.2.1.14 pubmed
 Kluyveromyces lactis NRRL Y-1140 CAH01261.1 Q6CUH9  
 endochitinase (Chit1) 3.2.1.14 doi
 Lecanicillium lecanii 432 ABD77095.1
ABD77096.1		 A6XBL0  
 basic chitinase (Ch12;Chit2) 3.2.1.14 pubmed
 Lecanicillium lecanii DAOM 175104 AAV98692.1
AAV98691.1		 Q5MNU1
Q5MNU2		  
 chitinase (Chi1) 3.2.1.14 pubmed
 Lecanicillium psalliotae ABQ57240.1 A6Y9S8  
 chitinase (Chi-1;Cht1) 3.2.1.14 pubmed
 Leishmania donovani AAC17944.1
AAS90570.1
AAS90571.1
AAS90572.1
AAS90573.1
AAS90574.1
AAS90575.1
AAS90576.1
AAS90577.1
AAS90578.1
AAS90579.1
AAS90580.1
AAS90581.1
AAS90582.1
AAS90583.1
AAS90584.1
AAS90585.1
AAS90586.1
AAS90587.1
AAS90591.1
AAS90592.1
AAS90593.1
AAS90594.1
AAS90595.1		 O60994
Q6R2L4
Q6R2M9
Q6R2N1
Q6R2N2
Q6R2N7
Q6R2N8		  
 chitinase 3.2.1.14 pubmed
 Mamestra brassicae AEV22116.1
ACL30984.1		 B8XSK6
G9I1Y7		  
 chitinase (Chi535;MsCHT5) 3.2.1.14 pubmed
 Manduca sexta AAB53952.1
AAC04924.1		 P36362  
 Nod factor hydrolase 1 (Nfh1;MtNFH1) 3.2.1.- pubmed
 Medicago truncatula AGX84980.1 U5N4E3  
 chitinase (Chit42) 3.2.1.14 pubmed
 Metarhizium anisopliae HN1 / CY-1 AAY32603.1
AEL89294.1		 Q4U4M9  
 chitinase (Chit30;Chi3) (fragment) 3.2.1.14 doi
 Metarhizium anisopliae var. anisopliae E6 AAS55554.1 Q6QDR4  
 chitinase (Chit1;Chit42) 3.2.1.14 pubmed
 Metarhizium anisopliae var. anisopliae E6 AAB81998.1
AAB81999.1		 O14456  
 endochitinase (Chi2) 3.2.1.14 pubmed
 Metarhizium anisopliae var. anisopliae E6 AAY34347.1 Q4U4T0  
 chitinase 1 (chi1) 3.2.1.14 doi
 Metarhizium flavoviride CAB44709.1 Q9Y841  
 chitinase (Chi1) 3.2.1.14 pubmed
 Metschnikowia fructicola AP47 ADV90768.1 E9LKM2  
 acidic mammalian chitinase (ChiA;YNL;AMCase) 3.2.1.14 pubmed
 Mus musculus AAG60018.1
AAF31644.1
AAH11134.1
AAH34548.1
AAY07518.1
AAY07519.1
ABC86699.1
ABK78778.1
BAB25795.1
BAB25878.1
BAE35672.1
NP_075675.2		 B8K282
Q91XA9		 8FG5[A]
8FG7[A]
8FR9[A,B]
8FRA[A,B,C,D]
8FRB[A,B,C,D]
8FRC[A,B]
8FRD[A,B]
8FRG[A,B]
8GCA[A,B]
 chitotriosidase (Chit1) 3.2.1.14 pubmed
 Mus musculus AAR14312.1
AAS47832.1
BAB26025.1
EDL39627.1		 B2RS82
Q9D7Q1
Q9D7Q1		  
 di-N-acetylchitobiase (Ctbs) 3.2.1.- pubmed
pubmed
 Mus musculus ABC33736.1
AAH22594.1
ABC33737.1
BAB25896.1
NP_083112.1		 Q102J0
Q8R242		  
 class III chitinase (NaCHIT3;NaChitIII) 3.2.1.14 pubmed
 Nepenthes alata BAM28610.1 I7HCY7  
 acidic endochitinase (Chit1;NrChit1) 3.2.1.14 pubmed
 Nepenthes rafflesiana ACU31856.1 C7F822  
 chitinase (ChiV;Chi-V;NtChiV;ChiC1) 3.2.1.14 pubmed
 Nicotiana tabacum CAA54374.1
CAB58462.1		 Q43576 3ALF[A]
3ALG[A]
 chitinase/lysozyme (Chi-V;Pz) 3.2.1.-
3.2.1.14		 pubmed
pubmed
 Nicotiana tabacum CAA55128.1
CAA54373.1		 Q43591
Q7DM11		  
 chitinase (Chi1;Chi-1;Cht1;OvCHT1) 3.2.1.14 pubmed
 Onchocerca volvulus AAB68960.1 Q25615  
 chitinase (Chit;OuChit) 3.2.1.14 doi
 Ophiocordyceps unilateralis AEC16039.1 G3ESW5  
 chitin exo-α-1,4-N-acetylglucobiosaminidase (Oschib1;Os10g0416500) 3.2.1.200 pubmed
 Oryza sativa Japonica Group AAM08773.1
AAG02504.1
AAP53767.1
BAF26521.1
BAG96413.1
BAT10856.1
CAZ91449.1		    
 chitin exo-α-1,4-N-acetylglucobiosaminidase (Oschib2;Os10g0416800) 3.2.1.200 pubmed
 Oryza sativa Japonica Group AAM08776.1
AAP53770.1
BAF26522.1
BAG96519.1
BAT10858.1		   7XMH[A]
 chitinase (Rcb4;Os10g0416100) 3.2.1.14 pubmed
 Oryza sativa Japonica Group AAK26395.1
AAO15366.1
AAP53763.1
BAF26519.1
BAG92504.1
BAT10852.1
BAT10853.1		 A0A0P0XUN5
A3C4R6
Q8GZT6
Q9AT30		  
 chitinase (OsChib1b;OsChib3b;Os01g0860500) 3.2.1.14 doi
 Oryza sativa Japonica Group BAA23809.1
BAA22266.1
BAB90566.1
BAB91759.1
BAD82025.1
BAD82632.1
BAF06786.1
BAG96431.1
BAS75333.1		 O04139
O49827
Q0JHJ2
Q5N920		  
 chitinase (OsChib1a;OsChib3a;Os01g0660200) 3.2.1.14 doi
 Oryza sativa Japonica Group BAA21743.2
BAA23811.1
BAA77605.1
BAB85276.1
BAC06302.1
BAF05686.1
BAG94860.1
BAS73527.1		 O22080
Q7F4M8		  
 group II chitinase 3.2.1.14 pubmed
pubmed
 Ostrinia furnacalis ASO66823.1 A0A221ZS22 5Y29[A]
5Y2B[A]
6JAV[A]
6JAW[A]
6JAX[A]
6JAY[A]
 group II chitinase 3.2.1.14 pubmed
pubmed
 Ostrinia furnacalis ASO66823.1 A0A221ZS22 5Y2A[A,B]
5Y2C[A,B]
 chitinase (ChtIV) 3.2.1.14 pubmed
 Ostrinia furnacalis QBQ65803.1 A0A482LWB1 6JM7[A]
6JM8[A]
6JMB[A]
 exochitinase-h (Chi-H; OfChi-H) 3.2.1.14 pubmed
 Ostrinia furnacalis BAE16587.1
AGZ20170.1		 Q4AE59
U5U6I0		 5GPR[A]
5GQB[A]
6JMN[A]
7VRG[A,B]
 exochitinase (Cht5; OfChtI; OfCHT5) 3.2.1.200 pubmed
 Ostrinia furnacalis ABB97081.2
AAW50396.1
ABB97081.1
ABI81757.1		 Q06GI9
Q2TPA6
Q2V6H4		 3W4R[A]
3WKZ[A]
3WL0[A]
3WL1[A]
3WQV[A]
3WQW[A]
 chitinase (OfChtIII) 3.2.1.14 pubmed
pubmed
 Ostrinia furnacalis AGX32025.1 U5LUV7 5WUP[A]
5WV8[A]
5WV9[A]
5WVB[A]
 chitinase (OfChtIII) 3.2.1.14 pubmed
pubmed
 Ostrinia furnacalis AGX32025.1 U5LUV7 5WUS[A]
5WVF[A]
5WVG[A]
5WVH[A]
 chitinase (ChiA;PtChiA) 3.2.1.14 pubmed
 Paecilomyces sp. thermophila AEO50762.1 I6N3H2  
 chitinase (Cts1;PbCTS1) 3.2.1.14 pubmed
 Paracoccidioides brasiliensis ATCC-MYA-826 / Pb01 AAQ75798.3 Q5YLC0  
 chitinase 1 (ChiA;Chi-1;PtChiA;PtChi-1) 3.2.1.14 doi
 Parapristipoma trilineatum BAK43286.1 F7J9X2  
 chitinase 2 (ChiB;Chi-2;PtChiB;PtChi-2) 3.2.1.14 doi
 Parapristipoma trilineatum BAK43287.1 F7J9X3  
 endochitinase (Ppl2) 3.2.1.14 pubmed
 Parkia platycephala CAO78600.1 A6ZJJ1 2GSJ[A]
 chitinase 3 (Chi3;FcChi-3) 3.2.1.14 pubmed
 Penaeus chinensis AAY44300.1 Q1L837  
 chitinase 3 (Chi3;PjChi-3) 3.2.1.14 pubmed
 Penaeus japonicus BAA22854.1 O15993  
 chitinase 3 (Chi3;PmChi3) (partial) 3.2.1.14 pubmed
 Penaeus monodon ADG22163.1 D6N9T3  
 chitinase 1 (Chi-1;Chi1;PmChi1) 3.2.1.14 pubmed
 Penaeus monodon AAD40313.1
ADG22162.1		 D6N9T2
Q9Y0D4		  
 chitinase 1 3.2.1.14 pubmed
 Pennahia argentata BAJ51753.1 E5RWT9  
 chitinase B 3.2.1.14 pubmed
pubmed
 Phytolacca americana BAB92957.1
AAB34670.1		 Q8LST3  
 chitinase (PfChit1) 3.2.1.14 pubmed
 Plasmodium falciparum K1 AAF16902.1 Q9U4I9  
 chitinase 3.2.1.14 pubmed
 Plasmodium gallinaceum AAF63208.1
AAW12822.1		 Q9NJX9  
 chitinase (PvCht1) 3.2.1.14 pubmed
 Plasmodium vivax SALI BAC98930.1 Q76EB5  
 chitinase 3.2.1.14 pubmed
 Psophocarpus tetragonolobus BAA08708.1 Q43098  
 chitinase A (ChiA;PrChiA) 3.2.1.14 pubmed
 Pteris ryukyuensis BAE98134.1 Q0WYK2 4RL3[A,B]
 class III chitinase (Psc) 3.2.1.14 pubmed
 Punica granatum BAK68869.1 G1UH28 4TOQ[A,B,C,D]
 chitinase (VFPFJ_10438) 3.2.1.14 pubmed
 Purpureocillium lilacinum XP_018173934.1 A0A179GHR0  
 D8674_001647 3.2.1.14 pubmed
 Pyrus ussuriensis x Pyrus communis KAB2598727.1 A0A5N5F715  
 di-N-acetylchitobiase / reducing-end exo-hexosaminidase (Ctbs) 3.2.1.- pubmed
 Rattus norvegicus AAA40924.1
AAH88129.1
NP_112285.1		 Q01460  
 chitotriosidase (ChtBD2) 3.2.1.14 pubmed
 Rattus norvegicus ABB89471.1
ABL06995.1
ABL06996.1
ABL06997.1
ABL06998.1
ABL06999.1		 A0S5V8  
 chitinase (RmChi1) 3.2.1.14 pubmed
 Rhizomucor miehei   A0A3B6UEQ2 5XWQ[A]
5YUQ[A,B]
7FBT[A]
5XWF[A]
 exochitinase (Chi44; RmChi44) 3.2.1.200
3.2.1.-		 pubmed
pubmed
 Rhizomucor miehei CAU432 / CGMCC4967 AMP42675.1 A0A286JZ72  
 chitinase I (Chi1) 3.2.1.14 pubmed
 Rhizopus microsporus var. oligosporus IFO 8631 BAA01021.1 P29026  
 chitinase II (Chi2) 3.2.1.14 pubmed
 Rhizopus microsporus var. oligosporus IFO 8631 BAA01022.1 P29027  
 chitinase III (Chi3) 3.2.1.14 pubmed
 Rhizopus microsporus var. oligosporus IFO 8631 BAA13489.1 Q92270  
 chitinase (Cts1;YLR286C) 3.2.1.14 pubmed
 Saccharomyces cerevisiae S288c AAT93059.1
AAB67331.1
ABC16985.1
NP_013388.1		 P29029 2UY2[A]
2UY3[A]
2UY4[A]
2UY5[A]
4TXE[A]
 chitinase 1 (Chi;SjChi) 3.2.1.14 doi
 Scomber japonicus BAL40979.1 G9MC82  
 chitinase 1 (SmChi-1;SmChiA;SmChiB) 3.2.1.14 doi
 Sebastiscus marmoratus BAL40980.1 G9MC83  
 chitinase 2 (SmChi-2; SmChiC ) 3.2.1.14 doi
 Sebastiscus marmoratus BAL40981.1 G9MC84  
 chitinase (Chi;SlChi;Sl-Chi) 3.2.1.14 pubmed
 Spodoptera litura BAB12678.1
AAQ91787.1
AAQ94194.1
QBG82044.1		 A0A481S6W9
Q6EHZ5
Q9GV44		  
 chitinase (Chi1;TfChi1) 3.2.1.14 URL
 Talaromyces flavus ADV02754.1
ADV02753.1		 K9JS25  
 chitinase (Chi) 3.2.1.14 pubmed
 Tenebrio molitor AAP92418.1 Q7YZB9  
 endochitinase (Chit1;TaChit1) 3.2.1.14 pubmed
 Thermoascus aurantiacus var. levisporus ABS00927.1
ABI95802.1		 A6YJX1
Q06AK1		  
 chitinase (Chit1;CtChit1) 3.2.1.14 pubmed
 Thermochaetoides thermophila CT2 ACD86396.1 B3GGC7  
 chitinase 2 (Chit2) 3.2.1.14 pubmed
 Thermomyces lanuginosus SSBP AIW06012.1 A0A0A0RVU7  
 chitinase (ChiT;Chi48) 3.2.1.14 doi
 Thermomyces lanuginosus SY2 / RMB AAY99632.1
AAV58834.1		 Q4FCX2  
 chitinase (Ech42;Chit42) 3.2.1.14 pubmed
 Trichoderma asperellum AAF19623.1
AAF19620.1
AAF19624.1
AAF19627.1
AAG44827.1
AAG44828.1
AAP21814.1
AAV98503.1
ADT82645.1		 E7CYC4
Q86ZR3
Q9HDE4
Q9UV34
Q9UV37
Q9UV38
Q9UV41		  
 Chi42 3.2.1.14 pubmed
 Trichoderma asperellum TN42 ADI46582.1 D7RZT5  
 endochitinase (Chi1;Tachi1) 3.2.1.14 pubmed
 Trichoderma asperellum Tr10 ADV74846.1
ADV74845.1		 I3NN23  
 endo-β-N-acetylglucosaminidase (Eng18B;TRIATDRAFT_302173) 3.2.1.96 pubmed
 Trichoderma atroviride IMI 206040 EHK41777.1 G9P8K0  
 endo-β-N-acetylglucosamidase (Eng18A;TRIATDRAFT_217415) 3.2.1.96 pubmed
 Trichoderma atroviride IMI 206040 EHK47006.1 G9NR36  
 endochitinase (Chit36P1) 3.2.1.14 pubmed
 Trichoderma atroviride P1 AAM77132.1 Q7Z8C9  
 endochitinase (Chit42) 3.2.1.14 pubmed
 Trichoderma atroviride PTCC5220 AAY84618.1
AAY84619.1		 Q4JQJ0  
 chitinase (Ech42) 3.2.1.14 pubmed
 Trichoderma aureoviride AAW31950.1 Q5I6E0  
 chitinase (Chit42) 3.2.1.14 pubmed
 Trichoderma hamatum LU593 AAC60385.1
AAP15043.1		 O43111
Q86ZV4		  
 chitinase 37 (Chit37) 3.2.1.14 pubmed
 Trichoderma harzianum CECT 2413 AAM93195.1 Q8NJQ5  
 chitinase (Chit42) 3.2.1.14 pubmed
 Trichoderma harzianum CECT 2413 AAB34355.1 P48827  
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