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Glycoside Hydrolase Family 18

Activities in FamilyNod factor hydrolase (EC 3.2.1.-);
Chitin exo-β-1,4-N-acetylglucosaminidase (EC 3.2.1.-);
Di-N-acetylchitobiase / reducing-end exo-hexosaminidase (EC 3.2.1.-);
Peptidoglycan endo-β-1,4-N-acetylglucosaminidase (EC 3.2.1.-);
Chitosanase (EC 3.2.1.132);
Chitinase (EC 3.2.1.14);
Chitin exo-β-1,4-N-acetylglucobiosaminidase (EC 3.2.1.200);
[reducing end] exo-chitinase (EC 3.2.1.201);
β-N-acetylhexosaminidase (EC 3.2.1.52);
Mannosyl-glycoprotein endo-β-N-acetylglucosaminidase (EC 3.2.1.96);
Mechanism Retaining e
ClanGH-K
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu (experimental)
NoteContains chitinases of classes III and V. Contains non-catalytic proteins such as xylanase inhibitor; concanavalin B; narbonin
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (41399); Uniprot accession (502); PDB accession (425); 3D entries (110); cryst (2)
Summary
Download GH18 (53976) Taxonomic display Structure (110 - 2 cryst) Characterized (431)
| 1 | 2 | 3 | 4 | 5 |
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 chitinase A (ChiA;StmChiA;Smlt0682) 3.2.1.14 pubmed
 Stenotrophomonas maltophilia K279a CAQ44264.1 B2FMT1  
 chitinase B (ChiB;StmChib;Smlt3383) 3.2.1.14 pubmed
 Stenotrophomonas maltophilia K279a CAQ46811.1 B2FN84  
 IgG-deglycosylating hydrolase (EndoSe;SEQ_0432) 3.2.1.96 pubmed
 Streptococcus equi subsp. equi 4047 CAW92602.1 C0M680  
 endo-β-N-acetylglucosaminidase S (EndoS;NdoS;Endo S) 3.2.1.96 pubmed
 Streptococcus pyogenes 40/58 AP1 AAK00850.1 Q9APG4 cryst
 endo-β-N-acetylglucosaminidase S (NdoS;EndoS;SPy1813) 3.2.1.96 pubmed
pubmed
 Streptococcus pyogenes M1 GAS SF370 AAK34539.1
NP_269818.1		 J7M8R4
Q99Y92		 6EN3[A]
8A49[B,C]
8A64[A]
 endo-β-N-acetylglucosaminidase (EndoS;M5005_Spy_1540) 3.2.1.96 pubmed
 Streptococcus pyogenes MGAS5005 AAZ52158.1   4NUY[A]
4NUZ[A]
 endo-β-1,4-N-acetylglucosamine (NdoS2;EndoS2;EndoS49;Spy49_1414c) 3.2.1.96 pubmed
 Streptococcus pyogenes NZ131 ACI61688.1 A0A0H3C1U3
B5XI26
T1WGN1		 6E58[A,B]
6MDS[A,B]
6MDV[A,B]
 chitinase H (ChiH;Chi18cH;SCO6012;SC7B7.09c) (Chi18H) 3.2.1.14 pubmed
 Streptomyces coelicolor A3(2) CAA15789.1
NP_630126.1		 O50506  
 chitinase A (ChiA;Chi18bA;SCK15.05c;SCO5003) (Chi18A) 3.2.1.14 pubmed
 Streptomyces coelicolor A3(2) CAB92596.1
BAA75642.1
NP_629155.1		 Q9KY99
Q9Z9M9		 3EBV[A]
 chitinase C (ChiC;Chi18aC;ScChiC;2SC6G5.20c;SCO5376) (Chi18C) 3.2.1.14 pubmed
 Streptomyces coelicolor A3(2) CAB94547.1
AAD16453.1
BAA75644.1
NP_629515.1		 Q7AKG2
Q9S675
Q9Z9M8		  
 chitinase D (ChiD;Chi18aD;SCO1429) (Chi18D) 3.2.1.14 pubmed
 Streptomyces coelicolor A3(2) CAB61662.1
BAA75645.1
NP_625711.1		 Q7AKQ9
Q9Z9M7		  
 chitinase I (Chi I) 3.2.1.14   Streptomyces griseus HUT 6037 BAB86375.1 Q8RQP8  
 chitinase II (Chi II) 3.2.1.14 pubmed
 Streptomyces griseus HUT 6037 BAB86376.1 Q8RQP7  
 chitinase III (ChiIII;Chi III) 3.2.1.14 pubmed
 Streptomyces griseus HUT 6037 BAB86377.1 Q8RQP6  
 chitinase B (ChiB) 3.2.1.14 doi
 Streptomyces lividans 1326 BAA25139.1 O69311  
 chitinase A (ChiA) 3.2.1.14 doi
 Streptomyces lividans TK64 BAA02918.1    
 chitinase C (ChiC) 3.2.1.14 pubmed
 Streptomyces lividans TK64 BAA02168.1 P36909  
 exo-chitinase (Chi01;ChiO1) 3.2.1.200 pubmed
 Streptomyces olivaceoviridis ATCC 11238 CAA50398.1 Q05638  
 chitinase (Chi92) 3.2.1.14 doi
 Streptomyces olivaceoviridis ATCC 11238 CAB83055.1 Q9L3E8  
 chitinase C 3.2.1.14 pubmed
 Streptomyces peucetius AAF43629.1 Q9L8G0  
 endo-β-N-acetylglucosaminidase H (EndoH;Endo-H;Endo H) 3.2.1.96 pubmed
 Streptomyces plicatus AAA26738.1
AAX00996.1
AAY74563.1
ABA35708.1		 P04067 1C3F[A]
1C8X[A]
1C8Y[A]
1C90[A,B]
1C91[A]
1C92[A]
1C93[A]
1EDT[A]
6VE1[A,B,C,D]
 chitinase-63 3.2.1.14 pubmed
 Streptomyces plicatus ATCC 27800 AAA26720.1 P11220  
 chitinase (fragment) 3.2.1.14 pubmed
 Streptomyces sp. DA11 ABY83190.1 B0LS89  
 chitinase (Chi40) 3.2.1.14 pubmed
 Streptomyces thermoviolaceus OPC-520 BAA03404.1 Q56077 4W5U[A,B]
 chitinase (Chi30) 3.2.1.14 pubmed
 Streptomyces thermoviolaceus OPC-520 BAA88835.1 Q9RHU3  
 endochitinase (Tfu_0580) 3.2.1.14 doi
 Thermobifida fusca YX AAZ54618.1 Q47SE9  
 chitinase (Chi18H8;Chi) 3.2.1.14 pubmed
 uncultured bacterium AGN95784.1 R9WA37  
 chitinase B (VacB) 3.2.1.14 pubmed
 Vibrio alginolyticus H-8 BAB21607.1
CAC29091.1		 Q99PX0  
 chitinase A (ChiA) 3.2.1.14 pubmed
 Vibrio cholerae AAC72236.1 Q9ZFP7  
 chitinase (ChiA2;VCA0027) 3.2.1.14 pubmed
 Vibrio cholerae O1 biovar El Tor str. N16961 AAF95941.1
NP_232428.1		 Q9KND8  
 chitodextrinase (EndoI) 3.2.1.200 pubmed
 Vibrio furnissii AAC44673.1
AAE36539.1		 P96156  
 chitinase A (ChiA;VhChiA) 3.2.1.14 pubmed
 Vibrio harveyi AAK11576.1 Q9AMP1 3ARO[A]
3ARP[A]
3ARQ[A]
3ARR[A]
3ARS[A]
3ART[A]
3ARU[A]
3ARV[A]
3ARW[A]
3ARX[A]
3ARY[A]
3ARZ[A]
3AS0[A]
3AS1[A]
3AS2[A]
3AS3[A]
3B8S[A,B]
3B9A[A]
3B9D[A]
3B9E[A]
 chitinase A (ChiA) 3.2.1.14 pubmed
 Vibrio harveyi BB7 AAC46383.1 P96168  
 chitinase (Vpc) 3.2.1.14 pubmed
 Vibrio parahaemolyticus ATCC17802 BAA78115.1 Q9WX42  
 chitinase (Chi1;Pα-Chi) 3.2.1.14 pubmed
 Vibrio parahaemolyticus KN1699 BAF91600.1
ABY50231.1		 A8QZK0
B0F618		 8HRF[A,B]
 chitinase A (ChiA) 3.2.1.14 pubmed
 Vibrio proteolyticus 442 BAF76068.1 A7M6A0  
 chitinase (ChiA) 3.2.1.14 pubmed
 Vibrio sp. Fi:7 AAG12973.1 Q9EY54  
 endo-β-N-acetylglucosaminidase (NixF;XCC2889) 3.2.1.14 pubmed
 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42161.1 Q8P6S6  
 chitinase A (ChiA) 3.2.1.14 doi
 Xanthomonas sp. AK BAA36460.1 Q9Z493  
 chitinase A (ChiA;PD_1826;PD1826) 3.2.1.14 pubmed
 Xylella fastidiosa Temecula1 AAO29659.1 Q87AJ8  
 chitinase (Chi1) (Yen-Tc subunit) 3.2.1.14 pubmed
 Yersinia sp. MH-1 / Yersinia entomophaga MH96 ABG33870.1 B6A876 3OA5[A,B]
4A5Q[A,B,C,D,E]
 chitinase (Chi2) (Yen-Tc subunit) 3.2.1.14 doi
 Yersinia sp. MH-1 / Yersinia entomophaga MH96 ABG33867.1 B6A879 4DWS[A,B,C,D]
6OGD[C,F,I,L,O]
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 chitinase I (L3) 3.2.1.14 pubmed
 Acanthocheilonema viteae AAB68959.1
AAA87227.1
AAC47022.1
ABK42000.1		 A0MWE0
Q17100
Q27919
Q7JQ23		  
 chitinase A (ChiA;PlChiA) 3.2.1.14 doi
 Ananas comosus BAG38685.1 B3A042  
 chitinase 1 (Chi1) 3.2.1.14 pubmed
 Aphanocladium album CAA45468.1
AAB21333.1
AAE59708.1		 P32470  
 chitinase A (ChiB1;At5g24090) (acidic) 3.2.1.14 pubmed
 Arabidopsis thaliana AAA32768.1
AAW49295.1
AAX49380.1
AED93255.1
BAB08732.1
NP_197797.1		 A0A178UN65
P19172		  
 chitinase (ChiC;AtChiC;At4g19810) 3.2.1.14 pubmed
 Arabidopsis thaliana CAA19698.1
ABL66795.1
AEE84228.1
ANM66365.1
BAE99745.1
CAB78983.1
NP_193716.1		 O81862 3AQU[A,B,C,D]
 chitinase (AvChit1) 3.2.1.14 pubmed
 Araneus ventricosus AAN39100.1 Q8ISH5  
 chitinase B1 (ChiB1) 3.2.1.14 pubmed
 Aspergillus fumigatus ATCC 13073 AAO61686.1 Q873X9 1W9P[A,B]
1W9U[A,B]
1W9V[A,B]
2A3A[A,B]
2A3B[A,B]
2A3C[A,B]
2A3E[A,B]
2IUZ[A,B]
3CH9[A,B]
3CHC[A,B]
3CHD[A,B]
3CHE[A,B]
3CHF[A,B]
 chitinase A1 (ChiA1) 3.2.1.200 pubmed
 Aspergillus fumigatus ATCC 13073 AAO61685.1 Q873Y0 2XTK[A,B]
2XUC[A,B,C]
2XVN[A,B,C]
2XVP[A,B]
4TX6[A,B]
 chitinase (ChiB) 3.2.1.14 pubmed
 Aspergillus fumigatus YJ-407 AAP23218.1 Q870C0
Q873X9		 1WNO[A,B]
 chitinase B (ChiB; AN4871.2) 3.2.1.14 pubmed
 Aspergillus nidulans FGSC A4 EAA60949.1 C8V9U9
G5EAZ3		  
 chitinase A (ChiA; AN8241.2) 3.2.1.14 pubmed
 Aspergillus nidulans FGSC A4 EAA58979.1 C8V7G5
G5EB30		  
 chitinase B (ChiB) 3.2.1.14 pubmed
 Aspergillus nidulans FGSC89 BAA35140.2 Q92222  
 chitinase (starvation-induced) (ChiB;CfcA;An02g07020) 3.2.1.14 pubmed
 Aspergillus niger CBS 513.88 CAK44246.1 A5AA94  
 exo-chitinase (CfcI;An02g13580) 3.2.1.201 pubmed
 Aspergillus niger CBS 513.88 CAK47771.1 A2QF78  
 chitinase (AnChiB; An08g09030) 3.2.1.14 pubmed
 Aspergillus niger CBS 513.88 CAK96682.1   6IGY[A]
 class III chitinase (Chi3-1;BoCHI3-1) 3.2.1.14 pubmed
 Bambusa oldhamii ABW75909.1 C6ZCS9  
 chitinase (Chit1;BbChit1) 3.2.1.14 pubmed
 Beauveria bassiana Bb0062 AAN41259.1
AEG21075.1		 F6MIV5
Q8J1Y3		  
 chitinase (Chit1;BbChit1) 3.2.1.14 pubmed
 Beauveria bassiana NCIM1216 ACF32998.1 Q8J1Y3  
 chitinase (Chib1) 3.2.1.14 pubmed
 Benincasa hispida AAD56239.1 Q9SP41  
 chitinase (SE2) 3.2.1.14 pubmed
 Beta vulgaris AAB28479.1
CAA01678.1		 P36910  
 chitinase (Chi;ChiB;ChiB4) 3.2.1.14 doi
 Bombyx mori AAB47538.1
AAG37105.1
AAL51080.1
BAB13481.1
BAB20017.1		 P90710
Q8WR52
Q9GQC4
Q9GR93
Q9GV05		  
 exochitinase (BmChi-h) 3.2.1.200 pubmed
 Bombyx mori P50T BAC67246.1 Q869E2  
 chitinase / chitotriosidase (ChTl;BjChTl) 3.2.1.14 pubmed
 Branchiostoma japonicum AEI59134.1 F8UWD4  
 chitinase 3.2.1.14 pubmed
 Brugia malayi AAA27854.1 P29030  
 toad pancreatic chitinase (TPCase) 3.2.1.14 doi
 Bufo japonicus CAC87888.1 Q90W34  
 chitinase (CeCht1;C04F6.3/cht-1) 3.2.1.14 pubmed
 Caenorhabditis elegans Bristol N2 CCD63028.1
AAA83586.1
NP_508588.1		 Q11174 6LDU[A]
6LE7[A]
6LE8[A]
 chitinase 1 (Cht1) 3.2.1.14 pubmed
 Candida albicans AAC49409.2 P46876  
 chitinase 2 (Cht2) 3.2.1.14 pubmed
 Candida albicans AAA68015.1
AAS66201.1		 P40953
Q6SYY8		  
 chitinase 3 (Cht3; CAALFM_CR10110WA) 3.2.1.14 pubmed
 Candida albicans SC5314 AOW31663.1
AAA68016.1
AAV05306.1
EAL00460.1		 P40954  
 chitinase (Chi58) 3.2.1.14 pubmed
 Chaetomium cupreum ABK27625.2
ABI48362.2		 Q0GA12  
 endochitinase (Chi46) 3.2.1.14 pubmed
 Chaetomium globosum ABI95486.1
ABI95487.1		 Q06HA3  
 chitinase 3.2.1.14 pubmed
 Chelonus sp. near curvimaculatus AAA61639.1 Q23737  
 chitinase (Chit) 3.2.1.14 pubmed
 Choristoneura fumiferana AAM43792.1 Q8MTK0  
 chitinase class III (CpCC-III) 3.2.1.14 doi
pubmed
 Cicer arietinum CAA49998.1 P36908  
 chitinase (CrChi1) 3.2.1.14 pubmed
 Clonostachys rosea CGMCC 0806 ABV57861.1 A9LI60 3G6L[A]
3G6M[A]
 chitinase 1 (Cts1) 3.2.1.14 pubmed
 Coccidioides posadasii AAA92643.1
AAA96515.1
AAB06687.1
CAC29129.1
CAC29130.1		 C5P230
P0CB51
P54196
P54196		  
 chitinase 2 (Cts2) 3.2.1.14 pubmed
 Coccidioides posadasii AAA92642.1
ACC06929.1		 P54197  
 complement fixation-chitinase 3.2.1.14 pubmed
 Coccidioides posadasii SILVEIRA AAB48567.1
AAB48566.1		 P0CB51
P54196		 1D2K[A]
1LL4[A]
1LL6[A]
1LL7[A]
 chitinase (CH1) 3.2.1.14 doi
 Coniothyrium minitans CM-2 AAG00504.1 Q9HGU5  
 chitinase 2 (Chi2) 3.2.1.14 pubmed
 Coprinellus congregatus AFD19009.1 H9CWQ0  
 chitinase 1 (Chi1) 3.2.1.14 pubmed
 Coprinellus congregatus A1 = CC16 CAQ51152.1 B2G3S2  
 chitinase (ChiIII;CC1G_04407) 3.2.1.14 pubmed
 Coprinopsis cinerea okayama7#130 EAU93428.2 A8N0I6  
 chitinase (VlCHI) 3.2.1.14 pubmed
 Cordyceps confragosa CA-12 AGU42402.1
AGU42403.1		 A6XBL0  
 chitinase (Chit2;Ifu-Chit2) 3.2.1.14 pubmed
 Cordyceps fumosorosea RCEF3304 AKM77638.1
ADR77504.1		 E5KZV1  
 Chi-1 (fragment) 3.2.1.14 pubmed
 Cordyceps javanica AAZ83728.1 Q3YLC5  
 endo-β-N-acetylglucosaminidase (ENGase; CCM_08020) 3.2.1.96 pubmed
 Cordyceps militaris CM01 XP_006673222.1 G3JPF7 6KPL[A]
6KPM[A]
6KPN[A]
6KPO[A]
 chitinase (Chit;Chit1;Cg-Chit;Cg-Chit1) 3.2.1.14 pubmed
 Crassostrea gigas CAI96026.1 Q1RQ19  
 chitinase (CVC) (partial) 3.2.1.14 pubmed
 Crocus vernus   G1K3S3 3SIM[B]
3SIM[A]
 chitinase 3.2.1.14 pubmed
 Cucumis sativus AAA33120.1
AAC37395.1
ABK55716.2
ADG56718.1
ALT53700.1		 A0A0U3C3Y4
A1BQL5
D6QXZ9
P17541		  
 chitinase (PLC) 3.2.1.14 doi
 Cucurbita moschata AAD53006.1 Q9SQI0  
 chitinase A (ChiA;CrChiA;CrChi-A) 3.2.1.14 pubmed
 Cycas revoluta BAD98525.1 Q4W6L6 3WIJ[A]
4MNJ[A]
4MNK[A]
4MNL[A]
4MNM[A]
4R5E[A]
 chitinase 3.2.1.14 pubmed
 Entamoeba dispar SAW 1734 AAB52722.1 P92134  
 chitinase (EhCHT1;EHI_109890) 3.2.1.14   Entamoeba histolytica HM-1:IMSS AAB52723.1
EAL46819.1		 C4M3K8
P90546		  
 chitinase 1 (Chi1;Chit1;EiChit1) 3.2.1.14 pubmed
pubmed
 Entamoeba invadens IP-1 AAB52724.1 P90547  
 chitinase 2 (Chi2;Chit2;EiChit2) 3.2.1.14 pubmed
 Entamoeba invadens IP-1 ABC59330.2
ABC59330.1		 Q2LEA8  
 chitinase 3 (Chi3;Chit3;EiChit3) 3.2.1.14 pubmed
 Entamoeba invadens IP-1 ABC59331.1 Q2LEA7  
 chitinase A (EaChiA) 3.2.1.14 pubmed
 Equisetum arvense BAI22848.1 C7G3I3  
 chitinase III (ELC) 3.2.1.14 pubmed
 Euphorbia characias AGX26690.2
AGX26690.1		 U5LKV8  
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