Glycoside Hydrolase Family 18

Activities in Familychitinase (EC 3.2.1.14); lysozyme (EC 3.2.1.17); endo-β-N-acetylglucosaminidase (EC 3.2.1.96); peptidoglycan hydrolase with endo-β-N-acetylglucosaminidase specificity (EC 3.2.1.-); Nod factor hydrolase (EC 3.2.1.-); xylanase inhibitor; concanavalin B; narbonin
Mechanism Retaining
ClanGH-K
3D Structure Status( β / α ) 8
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu (experimental)
NoteContains chitinases of classes III and V. Contains non-catalytic proteins such as xylanase inhibitor; concanavalin B; narbonin
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)NZYTech; PROZOMIX;
Statistics GenBank accession (14617); Uniprot accession (3282); PDB accession (301); 3D entries (77); cryst (4)
All (13074) Archaea (61) Bacteria (9464) Eukaryota (3057) Viruses (255) unclassified (237) Structure (77 - 4 cryst) Characterized (477)
| 1 | 2 | 3 | 4 | 5 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 chitinase C (ChiC) 3.2.1.14 Streptomyces lividans TK64 BAA02168.1 P36909  
 exo-chitinase (Chi01;ChiO1) 3.2.1.- Streptomyces olivaceoviridis ATCC 11238 CAA50398.1 Q05638  
 chitinase (Chi92) 3.2.1.14 Streptomyces olivaceoviridis ATCC 11238 CAB83055.1 Q9L3E8  
 chitinase C 3.2.1.14 Streptomyces peucetius AAF43629.1 Q9L8G0  
 endo-β-N-acetylglucosaminidase H (EndoH;Endo-H;Endo H) 3.2.1.96 Streptomyces plicatus AAA26738.1
AAX00996.1
AAY74563.1
ABA35708.1
P04067 1C3F[A]
1C8X[A]
1C8Y[A]
1C90[A,B]
1C91[A]
1C92[A]
1C93[A]
1EDT[A]
 chitinase-63 3.2.1.14 Streptomyces plicatus ATCC 27800 AAA26720.1 P11220  
 chitinase (Chi65) 3.2.1.14 Streptomyces sp. AJ9463 BAE47186.1 Q33CE1  
 chitinase (fragment) 3.2.1.14 Streptomyces sp. DA11 ABY83190.1 B0LS89  
 chitinase (Chi40) 3.2.1.14 Streptomyces thermoviolaceus OPC-520 BAA03404.1 Q56077 4W5U[A,B]
 chitinase (Chi30) 3.2.1.14 Streptomyces thermoviolaceus OPC-520 BAA88835.1 Q9RHU3  
 chitinase (Chi18H8;Chi) 3.2.1.14 uncultured bacterium AGN95784.1    
 chitinase B (VacB) 3.2.1.14 Vibrio alginolyticus H-8 BAB21607.1
CAC29091.1
Q99PX0  
 chitinase A (ChiA) 3.2.1.14 Vibrio cholerae AAC72236.1 Q9ZFP7  
 chitinase (ChiA2;VCA0027) 3.2.1.14 Vibrio cholerae O1 biovar El Tor str. N16961 AAF95941.1
NP_232428.1
Q9KND8  
 chitodextrinase (EndoI) 3.2.1.14 Vibrio furnissii AAC44673.1
AAE36539.1
P96156  
 chitinase A (ChiA;VhChiA) 3.2.1.14 Vibrio harveyi AAK11576.1 Q9AMP1 3ARO[A]
3ARP[A]
3ARQ[A]
3ARR[A]
3ARS[A]
3ART[A]
3ARU[A]
3ARV[A]
3ARW[A]
3ARX[A]
3ARY[A]
3ARZ[A]
3AS0[A]
3AS1[A]
3AS2[A]
3AS3[A]
3B8S[A,B]
3B9A[A]
3B9D[A]
3B9E[A]
 chitinase A (ChiA) 3.2.1.14 Vibrio harveyi BB7 AAC46383.1 P96168  
 chitinase (Vpc) 3.2.1.14 Vibrio parahaemolyticus ATCC17802 BAA78115.1 Q9WX42  
 chitinase (Chi1;Pα-Chi) 3.2.1.14 Vibrio parahaemolyticus KN1699 BAF91600.1
ABY50231.1
A8QZK0  
 chitinase A (ChiA) 3.2.1.14 Vibrio proteolyticus 442 BAF76068.1 A7M6A0  
 chitinase (ChiA) 3.2.1.14 Vibrio sp. Fi:7 AAG12973.1 Q9EY54  
 endo-β-N-acetylglucosaminidase (NixF;XCC2889) 3.2.1.- Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42161.1    
 chitinase A (ChiA) 3.2.1.14 Xanthomonas sp. AK BAA36460.1 Q9Z493  
 chitinase A (ChiA;PD_1826;PD1826) 3.2.1.14 Xylella fastidiosa Temecula1 AAO29659.1 Q87AJ8  
 chitinase (Chi1) (Yen-Tc subunit) 3.2.1.14 Yersinia sp. MH-1 / Yersinia entomophaga MH96 ABG33870.1 B6A876 3OA5[A,B]
4A5Q[A,B,C,D,E]
 chitinase (Chi2) (Yen-Tc subunit) 3.2.1.14 Yersinia sp. MH-1 / Yersinia entomophaga MH96 ABG33867.1   4DWS[A,B,C,D]
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 chitinase I 3.2.1.14 Acanthocheilonema viteae AAB68959.1
AAA87227.1
AAC47022.1
ABK42000.1
Q17100
Q27919
 
 chitinase 1 (Cht1) 3.2.1.14 Aedes aegypti AAB81849.1 O17411  
 chitinase 2 (Cht2) 3.2.1.14 Aedes aegypti AAB81850.1 O17412  
 chitinase 2 (Cht2) 3.2.1.14 Aedes aegypti AAB81850.1 O17412  
 chitinase 2 (Cht2) 3.2.1.14 Aedes aegypti AAB81850.1 O17412  
 chitinase A (ChiA;PlChiA) 3.2.1.14 Ananas comosus BAG38685.1 B3A042  
 chitinase 1 (AgChi-1) 3.2.1.14 Anopheles gambiae AAB87764.1 O44079  
 chitinase 1 (Chi1) 3.2.1.14 Aphanocladium album CAA45468.1
AAB21333.1
AAE59708.1
P32470  
 chitinase 3.2.1.14 Arabidopsis halleri subsp. gemmifera BAA21875.1 O22074  
 chitinase 3.2.1.14 Arabidopsis kamchatica subsp. kawasakiana BAA21877.1 O22076  
 chitinase A (ChiB1;At5g24090) (acidic) 3.2.1.14 Arabidopsis thaliana AAA32768.1
AAW49295.1
AAX49380.1
AED93255.1
BAB08732.1
NP_197797.1
P19172  
 chitinase (ChiC;AtChiC;At4g19810) 3.2.1.14 Arabidopsis thaliana CAA19698.1
ABL66795.1
AEE84228.1
ANM66365.1
BAE99745.1
CAB78983.1
NP_193716.1
O81862 3AQU[A,B,C,D]
 chitinase (AvChit1) 3.2.1.14 Araneus ventricosus AAN39100.1 Q8ISH5  
 chitinase 5 (Chi5;Afu3g07110) 3.2.1.14 Aspergillus fumigatus Af293 EAL92857.2    
 chitinase A1 / 1 (Chi1;ChiA1;Afu5g03760) 3.2.1.14 Aspergillus fumigatus Af293 EAL85930.1    
 chitinase 4 (Chi4;Afu5g03530) (fragment) 3.2.1.14 Aspergillus fumigatus Af293 EAL85953.1    
 chitinase 3 (Chi3;Afu7g05140) 3.2.1.14 Aspergillus fumigatus Af293 EAL86957.1    
 chitinase A2 / 2 (Chi2;ChiA2;Afu8g00700) 3.2.1.14 Aspergillus fumigatus Af293 EAL85097.1    
 chitinase B1 (ChiB1) 3.2.1.14 Aspergillus fumigatus ATCC 13073 AAO61686.1 Q873X9 1W9P[A,B]
1W9U[A,B]
1W9V[A,B]
2A3A[A,B]
2A3B[A,B]
2A3C[A,B]
2A3E[A,B]
2IUZ[A,B]
3CH9[A,B]
3CHC[A,B]
3CHD[A,B]
3CHE[A,B]
3CHF[A,B]
 chitinase (ChiB) 3.2.1.14 Aspergillus fumigatus YJ-407 AAP23218.1 Q870C0 1WNO[A,B]
 chitinase B (ChiB;AN4871.2) 3.2.1.14 Aspergillus nidulans FGSC A4 EAA60949.1 C8V9U9
G5EAZ3
 
 chitinase A (ChiA;AN8241.2) 3.2.1.14 Aspergillus nidulans FGSC A4 EAA58979.1 C8V7G5
G5EB30
 
 chitinase C (ChiC;AN9390.2) 3.2.1.14 Aspergillus nidulans FGSC A4 EAA66457.1
AAG34171.1
C8VRJ3
Q5AQP0
 
 chitinase A (ChiA) 3.2.1.14 Aspergillus nidulans FGSC89 BAA36223.1 Q92223  
 chitinase B (ChiB) 3.2.1.14 Aspergillus nidulans FGSC89 BAA35140.2 Q92222  
 chitinase (starvation-induced) (ChiB;CfcA;An02g07020) 3.2.1.14 Aspergillus niger CBS 513.88 CAK44246.1 A5AA94  
 exo-chitinase (CfcI;An02g13580) 3.2.1.- Aspergillus niger CBS 513.88 CAK47771.1 A2QF78  
 An09g06400 3.2.1.14 Aspergillus niger CBS 513.88 CAK40432.1 A2QUQ2  
 class III chitinase (Chi3-1;BoCHI3-1) 3.2.1.14 Bambusa oldhamii ABW75909.1 C6ZCS9  
 endochitinase (Chit2) 3.2.1.14 Beauveria bassiana AAN41260.1
AAN41261.1
ADM64636.1
ADM64637.1
Q8J042  
 chitinase (Chit1;BbChit1) 3.2.1.14 Beauveria bassiana Bb0062 AAN41259.1
AEG21075.1
Q8J1Y3  
 chitinase (Chit1;BbChit1) 3.2.1.14 Beauveria bassiana NCIM1216 ACF32998.1 Q8J1Y3  
 chitinase (Chib1) 3.2.1.14 Benincasa hispida AAD56239.1 Q9SP41  
 chitinase (SE2) 3.2.1.14 Beta vulgaris AAB28479.1
CAA01678.1
P36910  
 chitinase (Cts1) 3.2.1.14 Blastomyces dermatitidis AAF80371.1 Q9P4Q0  
 chitinase (Chi;ChiB;ChiB4) 3.2.1.14 Bombyx mori AAB47538.1
AAG37105.1
AAL51080.1
BAB13481.1
BAB20017.1
P90710
Q8WR52
Q9GQC4
Q9GR93
Q9GV05
 
 chitinase (BmChi-h) 3.2.1.14 Bombyx mori P50T BAC67246.1 Q869E2  
 chitinase / chitotriosidase (ChTl;BjChTl) 3.2.1.14 Branchiostoma japonicum AEI59134.1    
 chitinase 3.2.1.14 Brugia malayi AAA27854.1 P29030  
 chitinase (fragment) 3.2.1.14 Brugia pahangi AAC47324.1 Q27457  
 toad pancreatic chitinase (TPCase) 3.2.1.14 Bufo japonicus CAC87888.1 Q90W34  
 chitinase 1 (Cht1) 3.2.1.14 Candida albicans AAC49409.2 P46876  
 chitinase 2 (Cht2) 3.2.1.14 Candida albicans AAA68015.1
AAS66201.1
P40953  
 chitinase 3 (Cht3; CAALFM_CR10110WA) 3.2.1.14 Candida albicans SC5314 AOW31663.1
AAA68016.1
AAV05306.1
EAL00460.1
P40954  
 chitinase (Chi3-P1) 3.2.1.14 Capsicum annuum AAN37389.1
AAN37390.1
AAN37391.1
AAN37392.1
AAN37393.1
Q8GRR2
Q8H6X6
Q8H6X7
 
 chitinase (Chi58) 3.2.1.14 Chaetomium cupreum ABK27625.2
ABI48362.2
Q0GA12  
 endochitinase (Chi46) 3.2.1.14 Chaetomium globosum ABI95486.1
ABI95487.1
Q06HA3  
 chitinase (Chit1;CtChit1) 3.2.1.14 Chaetomium thermophilum CT2 ACD86396.1 B3GGC7  
 chitinase 3.2.1.14 Chelonus sp. near curvimaculatus AAA61639.1 Q23737  
 chitinase 3.2.1.14 Chironomus tentans CAA73685.1 O01935  
 chitinase 3.2.1.14 Chironomus tentans CAA73686.1 O01936  
 chitinase (Chit) 3.2.1.14 Choristoneura fumiferana AAM43792.1 Q8MTK0  
 chitinase class III (CpCC-III) 3.2.1.14 Cicer arietinum CAA49998.1 P36908  
 chitinase (CrChi1) 3.2.1.14 Clonostachys rosea CGMCC 0806 ABV57861.1 A9LI60 3G6L[A]
3G6M[A]
 chitinase 1 (Cts1) 3.2.1.14 Coccidioides posadasii AAA92643.1
AAA96515.1
AAB06687.1
CAC29129.1
CAC29130.1
P54196
P54196
 
 chitinase 2 (Cts2) 3.2.1.14 Coccidioides posadasii AAA92642.1
ACC06929.1
P54197  
 complement fixation-chitinase 3.2.1.14 Coccidioides posadasii SILVEIRA AAB48567.1
AAB48566.1
P0CB51
P54196
1D2K[A]
1LL4[A]
1LL6[A]
1LL7[A]
 chitinase (CH1) 3.2.1.14 Coniothyrium minitans CM-2 AAG00504.1 Q9HGU5  
 chitinase 1 (Chi1) 3.2.1.14 Coprinellus congregatus A1 = CC16 CAQ51152.1 B2G3S2  
 chitinase 2 (Chi2) 3.2.1.14 Coprinellus congregatus H99 AFD19009.1    
 chitinase (ChiIII;CC1G_04407) 3.2.1.14 Coprinopsis cinerea okayama7#130 EAU93428.2    
 chitinase (VlCHI) 3.2.1.14 Cordyceps confragosa CA-12 AGU42402.1
AGU42403.1
   
 Chit2 (fragment) 3.2.1.14 Crassostrea gigas CAI96025.1 Q1RQ20  
 Chit3 (fragment) 3.2.1.14 Crassostrea gigas CAI96027.1 Q1RQ18  
 chitinase 1 3.2.1.14 Cucumis melo AAF64474.1 Q9M544  
 chitinase 3.2.1.14 Cucumis sativus AAA33120.1
AAC37395.1
ABK55716.2
ADG56718.1
ALT53700.1
P17541  
 chitinase (PLC) 3.2.1.14 Cucurbita moschata AAD53006.1 Q9SQI0  
 chitinase A (ChiA;CrChiA;CrChi-A) 3.2.1.14 Cycas revoluta BAD98525.1 Q4W6L6 3WIJ[A]
4MNJ[A]
4MNK[A]
4MNL[A]
4MNM[A]
4R5E[A]
 chitinase 3.2.1.14 Dioscorea oppositifolia BAC77768.1 Q7XZD6  
 chitinase (Cht2;CG2054) 3.2.1.14 Drosophila melanogaster AAF47562.1
AAB81859.1
AAL13818.1
ACY46080.1
AFH04221.1
AGB93977.1
NP_477298.2
D0IQG7
Q9W092
 
 chitinase 3.2.1.14 Entamoeba dispar SAW 1734 AAB52722.1 P92134  
 chitinase (EhCHT1;EHI_109890) 3.2.1.14 Entamoeba histolytica HM-1:IMSS AAB52723.1
EAL46819.1
P90546  
 chitinase 1 (Chi1;Chit1;EiChit1) 3.2.1.14 Entamoeba invadens IP-1 AAB52724.1 P90547  
 chitinase 2 (Chi2;Chit2;EiChit2) 3.2.1.14 Entamoeba invadens IP-1 ABC59330.2
ABC59330.1
Q2LEA8  
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