Glycoside Hydrolase Family 18

Activities in Familychitinase (EC 3.2.1.14); lysozyme (EC 3.2.1.17); endo-β-N-acetylglucosaminidase (EC 3.2.1.96); peptidoglycan hydrolase with endo-β-N-acetylglucosaminidase specificity (EC 3.2.1.-); Nod factor hydrolase (EC 3.2.1.-); xylanase inhibitor; concanavalin B; narbonin; dΙ-N-acetylchitobiase / reducing-end exo-hexosaminidase (EC 3.2.1.-); chitobiosidase (EC 3.2.1.200)
Mechanism Retaining
ClanGH-K
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu (experimental)
NoteContains chitinases of classes III and V. Contains non-catalytic proteins such as xylanase inhibitor; concanavalin B; narbonin
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (35967); Uniprot accession (504); PDB accession (396); 3D entries (102); cryst (2)
| 1 | 2 | 3 | 4 | 5 |
Archaea
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 chitinase (ChiN1;Chi;VNG_0816G;Vng0816g) 3.2.1.14 doi
Halobacterium salinarum NRC-1 AAG19274.1
NP_279794.1
Q9HR84  
 chitinase (Chia1;HsChiA1;OE2201F) 3.2.1.14 pubmed
Halobacterium salinarum R1 CAP13543.1 B0R478  
 HFX_5038 (ChiCHme) 3.2.1.14 pubmed
Haloferax mediterranei ATCC 33500 CGMCC 1.2087 AFK20875.1
QCQ77304.1
I3R9G5  
 HFX_5037 (ChiBHme) 3.2.1.14 pubmed
Haloferax mediterranei ATCC 33500 CGMCC 1.2087 AFK20874.1
QCQ77303.1
I3R9G4  
 HFX_5039 (ChiDHme) 3.2.1.14 pubmed
Haloferax mediterranei ATCC 33500 CGMCC 1.2087 AFK20876.1
QCQ77305.1
I3R9G6
M0JBD1
 
 HFX_5036 (ChiAHme) 3.2.1.14 pubmed
Haloferax mediterranei ATCC 33500 CGMCC 1.2087 AFK20873.1
QCQ77302.1
I3R9G3  
 chitinase (PF1234+PF1233;ChiA+ChiB) (Chi18B+Chi18A) 3.2.1.14 pubmed
pubmed
Pyrococcus furiosus DSM 3638 AAL81357.1
AAL81358.1
NP_578962.1
NP_578963.1
Q8U1H4
Q8U1H5
 
 chitinase (PF1234+PF1233;ChiA+ChiB) (Chi18B+Chi18A) 3.2.1.14 pubmed
pubmed
Pyrococcus furiosus DSM 3638 AAL81357.1
NP_578962.1
Q8U1H5 2DSK[A,B]
3A4W[A,B]
3A4X[A,B]
3AFB[A,B]
 chitinase A (ChiA;TK1765) 3.2.1.200 pubmed
Thermococcus kodakarensis KOD1 BAD85954.1
CAT70561.1
Q9UWR7  
 chitinase A (ChiA;TK1765) 3.2.1.14 pubmed
Thermococcus kodakarensis KOD1 BAD85954.1
CAT70561.1
Q9UWR7  
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 chitinase A (ChiA; Cthe_0270) (Chi18A) 3.2.1.14 pubmed
Acetivibrio thermocellus ATCC 27405 CAA93150.1
ABN51509.1
A3DC30
Q59326
Q8VVI8
 
 chitinase (Chi1) 3.2.1.14 pubmed
Aeromonas caviae CB101 CAD58828.1 Q8GHI4  
 chitinase A (ChiA;AcD1ChiA) 3.2.1.14 pubmed
Aeromonas caviae K1 / D1 AAA93130.1 Q43919  
 chitinase (ChiA) 3.2.1.14 doi
Aeromonas hydrophila JMP636 AAF70180.1
AAE36542.1
Q9L5D5  
 chitinase 92 (Chi92) 3.2.1.14 pubmed
Aeromonas hydrophila JP101 AAG09437.1 Q9F9Q8  
 chitinase (Chi-A;AHA_0977) 3.2.1.14 pubmed
Aeromonas hydrophila subsp. hydrophila ATCC 7966 ABK39408.1 A0KGX3  
 chitinase (ChiA) 3.2.1.14 pubmed
Aeromonas hydrophila SUWA-9 BAE87051.1 Q25BN2  
 hexaoligochitin-producing chitinase (ASCHI61) (partial) 3.2.1.14 pubmed
Aeromonas schubertii ABF29701.1 D2CFK8  
 chitinase II 3.2.1.14 doi
Aeromonas sp. 10S-24 BAA06605.1 Q59145  
 chitinase (pCA8) 3.2.1.14 doi
Aeromonas sp. 10S-24 BAA36459.1 Q9ZNJ2  
 chitinase (ChiCD3) 3.2.1.14 doi
Aeromonas sp. CD3 / Aeromonas veronii CD3 ACR33067.1 D2DJ38  
 chitinase (ChiB565;B565_0857) 3.2.1.14 pubmed
Aeromonas veronii B565 AEB48892.1    
 endochitinase A (AsChi18A; VSAL_I0757) 3.2.1.14 pubmed
Aliivibrio salmonicida LFI1238 CAQ78442.1 B6EH15  
 chitinase (ChiC) 3.2.1.14 pubmed
Arthrobacter sp. TAD20 CAD43215.1 Q6A4C3  
 chitinase (ChitiA) 3.2.1.14 pubmed
Arthrobacter sp. TAD20 CAB62382.1 Q9RMB8  
 chitinase (ChitiB) 3.2.1.14 pubmed
Arthrobacter sp. TAD20 CAB62499.1 Q9REI6 1KFW[A]
 N-acetylglucosaminidase / spore cortex-lytic enzyme (SleL;YaaH;BAS3402) 3.2.1.- pubmed
Bacillus anthracis str. Sterne AAT55709.1
AJH43466.1
P0DPJ9  
 chitinase CW (ChiCW) 3.2.1.14 pubmed
Bacillus cereus 28-9 AAM48520.2 Q8KVU8  
 chitinase CH (ChiCH) 3.2.1.14 pubmed
Bacillus cereus 28-9 AAP47142.1 Q7X4L4  
 exochitinase (BC3725) 3.2.1.14 pubmed
Bacillus cereus ATCC 14579 AAP10651.1
NP_833450.1
A0A5B7VMB4
Q81A65
 
 chitinase B (ChiB) 3.2.1.14 pubmed
Bacillus cereus CH BAB16891.1 Q9FAC8  
 chitinase A (ChiA) 3.2.1.14 pubmed
Bacillus cereus CH BAB16890.1 Q9FAC9  
 cortical lytic enzyme / N-acetylglucosaminidase (CFLE;SleL) 3.2.1.- pubmed
Bacillus cereus IFO13579 BAA92376.1 Q9K3E4  
 chitinase (ChiNCTU2) 3.2.1.14 pubmed
Bacillus cereus NCTU2 / 42 ACY39278.1 D0VV09 3N11[A]
3N12[A]
3N13[A]
3N15[A]
3N17[A]
3N18[A]
3N1A[A]
 chitinase (ChiL) 3.2.1.14 pubmed
Bacillus cf. pumilus SG2 ABF50676.1
ABI15083.1
Q0MRC2
Q1HFN7
 
 bifunctional chitinase / lysozyme (ChiS) 3.2.1.14
3.2.1.17
pubmed
Bacillus cf. pumilus SG2 ABI15082.1
ABC86581.1
Q0MRC3
Q2I0I7
 
 chitinase 1 (Chi;Chi1;YvbX;BliCHI;BLi00338;BL01685) 3.2.1.14 doi
Bacillus licheniformis DSM 13 = ATCC 14580 AAU21943.2
AAU21943.1
AAU39296.1
ACR87900.1
ACW83016.1
CAF05579.1
CAV28467.1
A5A699
D0EW66
Q65NR8
 
 chitinase (ChiA) 3.2.1.14 pubmed
Bacillus licheniformis DSM 8785 ACK44109.1 B7UB89  
 chitinase A-BL3 (ChiA;ChiA-BL3) 3.2.1.14 pubmed
Bacillus licheniformis MS-3 ACI24006.1 B6DXA5  
 chitinase (ChiMY;ChiB) 3.2.1.14 pubmed
Bacillus licheniformis MY75 ACF40833.1 B5A7P1  
 chitinase 3.2.1.14 doi
Bacillus licheniformis N1 ACU43581.1 C8CAY2  
 chitinase B (ChiB;Chi72;Chi66;Chi58) 3.2.1.14 pubmed
pubmed
Bacillus licheniformis SK-1 ABJ74158.1 Q1EM71  
 chitinase (ChiL;ChiLm) 3.2.1.14 pubmed
Bacillus sp. AV2-9 AFK64770.1 I3UID2  
 chitinase (Chisb;Chi) (chitobiose-producing) 3.2.1.132 pubmed
Bacillus sp. DAU101 ABC66095.1 A0EQW8  
 chitinase (Chi-1;SCChi-1) 3.2.1.14 pubmed
Bacillus sp. SC081 / Bacillus atrophaeus SC081 ADJ56636.1 D8V3F2  
 chitinase (Chi113) 3.2.1.14 pubmed
Bacillus subtilis AP113 ABG57262.1 Q0Q2G5  
 chitinase (Chi) (Chi18) 3.2.1.14 pubmed
Bacillus subtilis CHU26 AAC23715.1 O85500  
 chitinase 3.2.1.14 pubmed
Bacillus thuringiensis 97243-1 ACA34287.1 B1PBV0  
 chitinase (ChiA74;Chi) 3.2.1.14 pubmed
Bacillus thuringiensis LBIT-82 AAL17867.1
AAL71886.2
ABO21095.1
A0A243G6Q6
A4GT76
Q8RSX8
Q93AD3
6BT9[A,B]
 chitinase B (ChiB) 3.2.1.14 pubmed
Bacillus thuringiensis serovar colmeri 15A3 ABF57674.1 Q1G154  
 chitinase A (ChiA) 3.2.1.14 doi
Bacillus thuringiensis serovar colmeri 15A3 ABM05818.1 A1YLR3  
 chitinase (Schi;Kchi) 3.2.1.14 doi
Bacillus thuringiensis serovar kurstaki AAO34713.1 Q84FN2  
 chitinase (Chi;BtCHI) (partial) 3.2.1.14 pubmed
Bacillus thuringiensis serovar kurstaki ACW83014.1 D0EW64  
 chitobiosidase / exochitinase (Chi255) 3.2.1.14
3.2.1.200
pubmed
pubmed
Bacillus thuringiensis serovar kurstaki BUPM255 CAG25670.1 Q3MTV5  
 chitinase (ChiA;ChiA-HD73) 3.2.1.14 pubmed
Bacillus thuringiensis serovar kurstaki HD-73 ABQ65137.2 A5YRG4  
 chitinase (Chi9602;Chi) 3.2.1.14 pubmed
Bacillus thuringiensis serovar tenebrionis 9602 AHA95666.1 V5NZX0  
 chitinase (Chi) 3.2.1.14 pubmed
Bacillus thuringiensis SUBSP. PAKISTANI AAB58579.1 O07088  
 mannosyl-glycoprotein endo-β-N-acetylglucosaminidase (BT1044) 3.2.1.96 pubmed
Bacteroides thetaiotaomicron VPI-5482 AAO76151.1
NP_809957.1
A0A0P0FQI4
Q8A8X3
6Q64[A]
 endo-β-N-acetylglucosaminidase (BT3987;BT_3987) 3.2.1.96 pubmed
pubmed
Bacteroides thetaiotaomicron VPI-5482 AAO79092.1
NP_812898.1
Q8A0N4 3POH[A]
6T8I[A]
6T8K[A,B]
6T8L[A]
6TCV[B]
6TCW[A]
7NWF[A]
 endo-β-N-acetylglucosaminidase (EndoBI-2;BLIF_1310) 3.2.1.96 pubmed
Bifidobacterium longum subsp. infantis 157F BAJ71450.1 E8MUK6  
 endoglycosidase (EndoBI-1; Blon_2468) 3.2.1.96 pubmed
Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ53522.1 B7GPC7  
 chitinase (ChiA) 3.2.1.14 pubmed
Brevibacillus laterosporus M64 AKN21157.1 A0A0H3YJ45  
 chitinase (ChiC) 3.2.1.14 pubmed
Brevibacillus laterosporus M9 AKN79540.1 A0A0H4CS66  
 chitinase 72A (Chi72A) 3.2.1.14 doi
Brevibacillus sp. CDY64 AKN79541.1 A0A0H4CPE0  
 chitinase A (ChiA) 3.2.1.14 pubmed
Cellulomonas uda ATCC 21399 AAG27061.2 Q9EY44  
 chitinase 18A (CjChi18A; CJA_1182) (Chi18A) 3.2.1.14 pubmed
Cellvibrio japonicus Ueda107 ACE83143.1 B3PBW8  
 chitinase 18B (CjChi18B; CJA_0988) (Chi18B) 3.2.1.14 pubmed
Cellvibrio japonicus Ueda107 ACE84354.1 B3PB16  
 chitinase 18C (CjChi18C; CJA_2993) (Chi18C) 3.2.1.14 pubmed
Cellvibrio japonicus Ueda107 ACE85832.1 B3PCT3  
 chitinase 18D (CjChi18D; CJA_2611) (Chi18D) 3.2.1.14 pubmed
Cellvibrio japonicus Ueda107 ACE85899.1 B3PLJ1  
 chitinase C (ChiC) 3.2.1.14 pubmed
Chitiniphilus shinanonensis SAY3 BAK53887.1 F8WSQ0  
 chitinase E (ChiE) 3.2.1.14 pubmed
Chitiniphilus shinanonensis SAY3 BAK53889.1 F8WSQ2  
 chitinase G (ChiG) 3.2.1.14 pubmed
Chitiniphilus shinanonensis SAY3 BAK53891.1 F8WSQ4  
 chitinase (ChiL; CsChiL) 3.2.1.14 pubmed
Chitiniphilus shinanonensis SAY3 BAK53954.1 F8WSX2 6KST[A,B]
6KXL[A,B]
6KXM[A,B]
6KXN[A,B]
 chitinase (Chi54) 3.2.1.14 pubmed
Chromobacterium sp. C-61 AAP88583.1 Q5MYT4  
 chitinase (Chi45;CvChi45;CV2935) 3.2.1.14 pubmed
Chromobacterium violaceum ATCC 12472 AAQ60603.1
NP_902605.1
Q7NTW8 4TX8[A]
 exo-chitinase X (CHI-X) 3.2.1.14 pubmed
Citrobacter freundii P AGD94964.2
AGD94964.1
L7YAM9  
 chitinase A (ChiA) (Chi18A) 3.2.1.14 pubmed
Clostridium paraputrificum M-21 BAA34922.1 Q9ZNL0  
 chitinase B (ChiB) (Chi18B) 3.2.1.14 pubmed
Clostridium paraputrificum M-21 BAA23796.1 O50076  
 chitinase C (ChiC) (Chi18C) 3.2.1.14 pubmed
Clostridium paraputrificum M-21 BAD12045.1
BAD29950.1
Q75ZW9  
 chitinase (ChiD ; CcChi1; COCOR_06744) 3.2.1.14 pubmed
Corallococcus coralloides DSM 2259 AFE08343.1 H8MZA8  
 chitinase (JSX79_03650) 3.2.1.14 pubmed
Curtobacterium sp. GD1 WP_229085214.1
MCC8906936.1
   
 endo-N-acetylglucosaminidase F1 (EndoF1;Endo F1) 3.2.1.96 pubmed
Elizabethkingia meningoseptica ATCC 33958 AAA24922.1 P36911 2EBN[A]
 endo-N-acetylglucosaminidase F2 (EndoF2;Endo F2) 3.2.1.96 pubmed
pubmed
Elizabethkingia meningoseptica ATCC 33958 AAA24923.1 P36912  
 endo-N-acetylglucosaminidase F3 (EndoF3;Endo F3) 3.2.1.96 pubmed
pubmed
Elizabethkingia meningoseptica ATCC 33958 AAA24924.1 P36913 1EOK[A]
1EOM[A]
 chitinase A (ChiA) 3.2.1.201 doi
Enterobacter sp. G-1 AAB97779.1 O54328  
 endoglycosidase (EndoE;NdoE) 3.2.1.96 pubmed
Enterococcus faecalis HER1044 AAR20477.1 Q6U890 7PUJ[A]
7PUK[A,B]
 bifunctional endo-β-N-acetylglucosaminidase / exo-β-N-acetylglucosaminidase (EndoE;OG1RF_10107) 3.2.1.96 pubmed
Enterococcus faecalis OG1RF AEA92794.1
AZV32936.1
   
 endo-N-glycosidase (EndoE;EF0114) 3.2.1.52
3.2.1.96
pubmed
pubmed
Enterococcus faecalis V583 AAO79989.1
AAR59795.1
NP_813917.1
Q839P8  
 chtinase (EfChi18A;EF0361) (Chi18A) 3.2.1.14 pubmed
Enterococcus faecalis V583 AAO80224.1
NP_814153.1
Q838S2  
 endo-β-N-acetylglucosaminidase (EfEndo18A; EF2863) (Endo18A) 3.2.1.96 pubmed
Enterococcus faecalis V583 AAO82555.1
NP_816485.1
Q830C5  
 endochitinase (ChiA;YheB;b3338) 3.2.1.14 pubmed
Escherichia coli str. K-12 substr. MG1655 AAC76363.1
AAA58135.1
AIZ89659.1
ALI38980.1
AMC96225.1
AUG18042.1
AVI53496.1
AYG17720.1
NP_417797.1
P13656  
 chitinase 3.2.1.14 doi
Ewingella americana PI98 CAA62151.1
ABD47744.1
Q27SX4
Q59341
 
 chitinase (ChiA;Fjoh_4555) 3.2.1.14 pubmed
pubmed
Flavobacterium johnsoniae UW101 ABQ07554.1 A5FB63  
 chitinase (ChiA;Fjoh_4555) 3.2.1.14 pubmed
pubmed
Flavobacterium johnsoniae UW101 ABQ07554.1 A5FB63  
 chitinase (FjChiB;Fjoh_4560) 3.2.1.14 pubmed
Flavobacterium johnsoniae UW101 ABQ07559.1 A5FB54 6XYZ[A]
 endo-β-N-acetylglucosaminidase (Endo-Fsp) 3.2.1.96 pubmed
Flavobacterium sp. SK1022 BAB20938.1
AAB20312.1
P80036
Q9F1K1
 
 FTH_0088 (ChiB) 3.2.1.14 pubmed
Francisella tularensis subsp. holarctica OSU18 ABI82135.1    
 FTH_1471 (ChiA) 3.2.1.14 pubmed
Francisella tularensis subsp. holarctica OSU18 ABI83277.1    
 FTH_1579 (ChiC) 3.2.1.14 pubmed
Francisella tularensis subsp. holarctica OSU18 ABI83369.1    
 chitinase A (ChiA;FTN_0627) 3.2.1.14 pubmed
Francisella tularensis subsp. novicida U112 ABB76136.1
ABK89520.1
AJI60891.1
A0Q5K5
Q09WI8
 
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