Glycoside Hydrolase Family 145

Activities in FamilyL-Rhα-α-1,4-GlcA α-L-rhamnohydrolase (EC 3.2.1.-)
Mechanism Retaining
3D Structure Statusseven-bladed β-propeller
Catalytic Nucleophile/BaseHis
NoteCreated after Munoz-Munoz et al., Proc. Natl. Acad. Sci. USA (2017) (PMID=28396425); these enzymes hydrolyze a-L-rhamnose residues linked to position 4 of a glucuronic acid using an unusual catalytic machinery comprising a histidine residue. The active site of these a-L-rhamnosidases is located on the opposite side of CAZymes with similar b-propeller folds. Surprisingly, the "normal" side of the b-propeller bears the highest residue conservation in the family and may well have another function. The latter is unknown but strong ressemblance to family PL25 suggests a polysaccharide lyase activity.
External resourcesCAZypedia;
Statistics GenBank accession (262); Uniprot accession (1); PDB accession (5); 3D entries (4); cryst (0)
| 1 | 2 | 3 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 DVK44_34825   Streptomyces sp. GSSD-12 AXG82054.1    
 F9278_43055   Streptomyces sp. GY16 QFR01841.1    
 G7Z13_31970   Streptomyces sp. JB150 QIJ66113.1    
 CFP59_01977   Streptomyces sp. M56 AUA09887.1    
 EJ357_03640   Streptomyces sp. MK-45 AZQ32648.1    
 C6376_25320   Streptomyces sp. P3 AVV44267.1    
 QR97_35310   Streptomyces sp. PBH53 AKN74302.1    
 FNV59_47370   Streptomyces sp. RLB1-8 QDO64728.1    
 FNV58_48315   Streptomyces sp. RLB1-9 QDO02725.1    
 FNV62_46715   Streptomyces sp. RLB3-17 QDO44595.1    
 FNV60_45115   Streptomyces sp. RLB3-5 QDO54483.1    
 FNV61_47905   Streptomyces sp. RLB3-6 QDN92214.1    
 FNV63_46920   Streptomyces sp. S1A1-3 QDO34581.1    
 FNV64_48335   Streptomyces sp. S1A1-7 QDN82328.1    
 FNV65_46900   Streptomyces sp. S1A1-8 QDO24460.1    
 FNV66_46635   Streptomyces sp. S1D4-14 QDN72025.1    
 FNV67_47785   Streptomyces sp. S1D4-20 QDN61973.1    
 FNV68_48975   Streptomyces sp. S1D4-23 QDO13039.1    
 D7Y56_26145   Streptomyces sp. S501 QBR09101.1    
 CAG99_02725   Streptomyces sp. SCSIO 03032 ARQ67894.1    
 DLM49_02270   Streptomyces sp. WAC 01438 AZM58535.1    
 DMB38_02170   Streptomyces sp. WAC 06738 AZM44779.1    
 DMB38_30870   Streptomyces sp. WAC 06738 AZM49594.1    
 SSPO_021070   Streptomyces sporoclivatus NBRC 100767 BBJ39389.1    
 THTE_3910   Thermogutta terrifontis R1 ASV76511.1    
 UNDKW_4121   Undibacterium sp. KW1 BBB62394.1    
 neuraminidase   Verrucomicrobia bacterium HZ-65 ATC65312.1    
 IMCC26134_01360   Verrucomicrobia bacterium IMCC26134 AKC81760.1    
 ZPR_0909   Zunongwangia profunda SM-A87 ADF51256.1
YP_003583452.1
   
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