Glycoside Hydrolase Family 145

Activities in FamilyL-Rhα-α-1,4-GlcA α-L-rhamnohydrolase (EC 3.2.1.-)
Mechanism Retaining
3D Structure Statusseven-bladed β-propeller
Catalytic Nucleophile/BaseHis
NoteCreated after Munoz-Munoz et al., Proc. Natl. Acad. Sci. USA (2017) (PMID=28396425); these enzymes hydrolyze a-L-rhamnose residues linked to position 4 of a glucuronic acid using an unusual catalytic machinery comprising a histidine residue. The active site of these a-L-rhamnosidases is located on the opposite side of CAZymes with similar b-propeller folds. Surprisingly, the "normal" side of the b-propeller bears the highest residue conservation in the family and may well have another function. The latter is unknown but strong ressemblance to family PL25 suggests a polysaccharide lyase activity.
External resourcesCAZypedia;
Statistics GenBank accession (262); Uniprot accession (1); PDB accession (5); 3D entries (4); cryst (0)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 neuraminidase   Massilia umbonata DSMZ 26121 QCP10739.1    
 MROS_0979   Melioribacter roseus P3M-2 AFN74220.1    
 F7D14_09020   Methylocystis parvus BRCS2 QGM97586.1    
 CQW49_07015   Methylosinus trichosporium OB3b ATQ67665.1    
 CQW49_23070   Methylosinus trichosporium OB3b ATQ70845.1    
 DXT68_02925   Microbacterium foliorum NRRL B-24224 AXL11201.1    
 C6C15_15090   Microbacterium sp. str. China AVL98316.1    
 CSX12_16590   Microbacterium sp. Y-01 AZH79949.1    
 MILUP08_44594   Micromonospora lupini str. Lupac 08 CCH19719.1    
 neuraminidase   Mucilaginibacter ginsenosidivorax KHI28 QEC76455.1    
 neuraminidase   Mucilaginibacter gossypii P4 QEM15375.1    
 neuraminidase   Mucilaginibacter rubeus P1 QEM11342.1    
 neuraminidase   Mucilaginibacter rubeus P2 QEM02756.1    
 neuraminidase   Muribaculum sp. TLL-A4 QCD37093.1    
 Niako_0094   Niastella koreensis GR20-10 AEV96495.1    
 EXE57_02480   Nocardioides sp. MMS17-SY117 QBR91261.1    
 neuraminidase   Olivibacter sp. LS-1 QEK99377.1    
 OPIT5_15820 (fragment)   Opitutaceae bacterium TAV5 AHF91469.1    
 OPIT5_06860   Opitutaceae bacterium TAV5 AHF89982.1    
 OPIT5_12240   Opitutaceae bacterium TAV5 AHF90862.1    
 OPIT5_28600   Opitutaceae bacterium TAV5 AHF93563.1    
 Oter_1376   Opitutus terrae PB90-1 ACB74661.1 B1ZRY5  
 E6C60_3333   Paenibacillus sp. HB172198 QCT04044.1    
 neuraminidase   Paraflavitalea soli 5GH32-13 AXY77893.1    
 GAGA_0128   Paraglaciecola agarilytica NO2 GAC02993.1    
 GCHA_4714   Paraglaciecola chathamensis S18K6 GAC12631.1    
 Phep_0953   Pedobacter heparinus DSM 2366 ACU03175.1    
 neuraminidase   Pedobacter sp. CJ43 QEK51395.1    
 neuraminidase   Pedobacter sp. HDW13 QIL41433.1    
 neuraminidase   Pedobacter sp. KBS0701 QDW25600.1    
 neuraminidase   Pedobacter steynii DX4 AOM80927.1    
 Psuf_005730   Phytohabitans suffuscus NBRC 105367 BCB83260.1    
 Psuf_033710   Phytohabitans suffuscus NBRC 105367 BCB86058.1    
 PLANPX_0435   Planctomycetales bacterium PX69 BBO30823.1    
 Enr13x_39200   Planctomycetes bacterium Enr13 QDV44059.1    
 K2D_06720   Planctomycetes bacterium K2D QDV77085.1    
 MalM25_16610   Planctomycetes bacterium MalM25 QDT68736.1    
 MalM25_16520   Planctomycetes bacterium MalM25 QDT68727.1    
 Pan181_31490   Planctomycetes bacterium Pan181 QDU56937.1    
 Pan181_12980   Planctomycetes bacterium Pan181 QDU55112.1    
 Pan265_13080   Planctomycetes bacterium Pan265 QDU71458.1    
 Pla163_03170   Planctomycetes bacterium Pla163 QDU83219.1    
 Spa11_06910   Planctomycetes bacterium Spa11 QDV72513.1    
 C6W10_03295   Plantactinospora sp. BB1 AVT35643.1    
 C6361_06725   Plantactinospora sp. BC1 AVT29231.1    
 EAO79_03990   Plantibacter sp. PA-3-X8 AZH82150.1    
 neuraminidase   Polaribacter reichenbachii 6Alg 8T APZ45927.1    
 neuraminidase   Polaribacter reichenbachii KCTC 23969 AUC19789.1    
 GM418_02640   Prolixibacteraceae bacterium WC007 QGY42586.1    
 AL527_05800   Pseudomonas fulva FDAARGOS_167 AVF54731.1    
 NCTC13098_02598 (fragment)   Raoultella terrigena NCTC13098 VDR26257.1    
 C7V51_06805   Rathayibacter iranicus NCCPB 2253 AZZ55625.1    
 EKG83_12610   Saccharothrix syringae NRRL B-16468 QFZ18215.1    
 AW14_13375   Siansivirga zeaxanthinifaciens CC-SAMT-1 AJR04497.1    
 sce9313   Sorangium cellulosum So ce56 CAN99486.1    
 SOCE836_108110   Sorangium cellulosum So ce836 AUX38564.1    
 SOCEGT47_037240   Sorangium cellulosum So ceGT47 AUX23201.1    
 SCE1572_52500   Sorangium cellulosum So0157-2 AGP42384.1    
 CA265_06055   Sphingobacteriaceae bacterium GW460-11-11-14-LB5 ARS39259.1    
 neuraminidase   Sphingobacterium psychroaquaticum SJ-25 QBQ40808.1    
 Sph21_0793   Sphingobacterium sp. 21 ADZ77369.1    
 neuraminidase   Sphingobacterium sp. B29 APU96225.1    
 neuraminidase   Sphingobacterium sp. DR205 QIH35631.1    
 NCTC11429_01309   Sphingobacterium thalpophilum NCTC11429 VTR34304.1    
 E5554_14945   Sphingobium sp. PAMC28499 QCB39004.1    
 A6768_08740   Sphingobium yanoikuyae S72 ATI80083.1    
 BV87_15370   Sphingobium yanoikuyae SHJ ATP21553.1    
 EBF16_10890   Sphingobium yanoikuyae SJTF8 AYO77339.1    
 GS397_09100   Sphingobium yanoikuyae YC-JY1 QHD67200.1    
 NX02_05120   Sphingomonas sanxanigenens DSM 19645 = NX02 AHE52764.1    
 CVN68_10755   Sphingomonas sp. Cra20 ATY32394.1    
 BXU08_18035   Sphingomonas sp. LM7 AQR75307.1    
 EKD16_15315   Streptomonospora sp. M2 QBI54840.1    
 DMT42_34610   Streptomyces actuosus ATCC 25421 AWT46891.1    
 CD934_31805   Streptomyces asterosporus DSM 41452 QDI72772.1    
 C5746_39180   Streptomyces atratus SCSIO_ZH16 AXE81955.1    
 BV401_37085   Streptomyces autolyticus CGMCC0516 AQA15193.1    
 SAVMC3_84080   Streptomyces avermitilis MC3 BBJ55779.1    
 EJC51_41055   Streptomyces brunneus CR22 AZP21923.1    
 CP983_03380   Streptomyces chartreusis ATCC 14922 QEV65825.1    
 CP976_38850   Streptomyces coeruleorubidus ATCC 13740 QEV29484.1    
 CP966_32485   Streptomyces galilaeus ATCC 14969 QEU69464.1    
 DWG14_01012   Streptomyces griseorubiginosus 3E-1 AYC36802.1    
 ELQ87_03215   Streptomyces griseoviridis F1-27 AZS83413.1    
 ELQ87_38825   Streptomyces griseoviridis F1-27 AZS89544.1    
 CEB94_37610   Streptomyces hawaiiensis ATCC 12236 QCD59870.1    
 SHXM_02217   Streptomyces hygroscopicus XM201 AQW48754.1    
 ABB07_03375   Streptomyces incarnatus NRRL 8089 AKJ09098.1    
 SLCG_7636   Streptomyces lincolnensis LC-G AXG58791.1    
 SLINC_7649   Streptomyces lincolnensis NRRL 2936 ANS69873.1    
 SMALA_6697 (fragment)   Streptomyces malaysiensis DSM 4137 ATL86917.1
QDL69581.1
   
 CP967_01715   Streptomyces nitrosporeus ATCC 12769 QEU70842.1    
 CP972_32645   Streptomyces prasinus ATCC 13879 QEV09719.1    
 A4E84_37460   Streptomyces qaidamensis S10(2016) AMW14662.1    
 A4E84_36250   Streptomyces qaidamensis S10(2016) AMW15654.1    
 M271_09285   Streptomyces rapamycinicus NRRL 5491 AGP53470.1    
 CGL27_39655   Streptomyces sp. 11-1-2 ASQ98324.1    
 SAMN05444521_1021   Streptomyces sp. 3214.6 SHH58546.1    
 CXR04_32235   Streptomyces sp. CMB-StM0423 AUH44245.1    
 C1703_36835   Streptomyces sp. Go-475 AXE90615.1    
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