Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); 6'-P-sucrose phosphorylase (EC 2.4.1.-); amino acid transporter
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (55939); Uniprot accession (7858); PDB accession (467); 3D entries (111); cryst (2)
All (51170) Archaea (370) Bacteria (47636) Eukaryota (3034) unclassified (130) Structure (111 - 2 cryst) Characterized (812)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 branching enzyme 2.4.1.18 Manihot esculenta CAA54308.1
CAA49371.1
CAA49372.1
Q08130
Q08131
  8
 α-amylase 3.2.1.1 Mus musculus AAA37221.1
AAA37219.1
AAA37220.1
AAH04698.1
AAH09121.1
BAC26543.1
CAA24097.1
CAA24099.1
CAA24100.1
NP_031472.1
P00687
Q921Y7
Q99KE6
  24
 α-amylase 3.2.1.1 Mus musculus AAA37230.1
AAA37222.1
AAA37223.1
AAA37224.1
AAA37225.1
AAA37226.1
AAA37227.1
AAA37228.1
AAA37229.1
AAA37232.1
AAA37233.1
AAH94924.1
AAI00580.1
BAC37484.1
BAE21706.1
CAA24098.1
CAA26202.1
CAA26413.1
CAA26414.1
CAA26415.1
CAA26417.1
CAA26418.1
NP_033799.1
P00688
Q61297
Q61298
Q61299
Q8C5B4
  24
 α-amylase (MAmy) 3.2.1.1 Musa acuminata AAO11776.1
AAN01149.1
AFP87138.1
Q8GUR0
Q8LJQ6
  6
 α-amylase (Amy) 3.2.1.1 Oikopleura dioica CAD43105.1 Q8I7A5  
 α-amylase (AmyI;Amy1) 3.2.1.1 Ophiostoma floccosum ABF72529.1
ABF72530.1
ABF72531.1
Q06SN2   1
 glycogen-debranching enzyme (Agl) 2.4.1.25
3.2.1.33
Oryctolagus cuniculus AAA16364.1 P35574   25
 α-amylase (Amy1.1;Amy1-1) 3.2.1.1 Oryza sativa AAA33885.1
AAN89206.1
P17654   6
 α-amylase 3.2.1.1 Oryza sativa   P27935   6
 α-amylase 3.2.1.1 Oryza sativa AAA33897.1     6
 branching-enzyme-3 (Sbe1;Rbe3;BEIIb;OsBEIIb) 2.4.1.18 Oryza sativa BAA03738.1
AAU99025.1
AAU99026.1
ABC04876.1
ACJ71361.1
ACM95322.1
ACM95323.1
Q40663   8
 isoamylase 3.2.1.68 Oryza sativa BAA29041.1 O80403   11
 α-amylase 3.2.1.1 Oryza sativa Indica Group CAA45903.1 A2YGY2
P27941
  6
 α-amylase-c (frameshift) 3.2.1.1 Oryza sativa Indica Group CAA36485.1 A2WPU3
P27940
 
 isoamylase (Isa1;OsISA1;Su1;Sugary-1;Os08g0520900) 3.2.1.68 Oryza sativa Japonica Group BAC75533.1
ACY56086.1
AII21927.1
BAF24185.1
BAT06299.1
Q84L53   11
 starch-branching enzyme 1 (Sbe1;Rbe1;BEI;OsBEI;Os06g0726400) 2.4.1.18 Oryza sativa Japonica Group BAF20543.1
AAD28284.1
AAP68993.1
AAU99032.1
AAX83629.1
ABA16988.1
ABD15942.1
ABD15943.1
ABD15944.1
ABD15945.1
ABE12599.1
ABL74557.1
ABL74558.1
ACM95329.1
ACY56114.1
ADK61026.1
ADK61027.1
AEB33747.1
AEB33748.1
AEB33749.1
AEB33750.1
AEB33751.1
AEB33752.1
AEB33753.1
AEB33754.1
AHL84201.1
AHL84202.1
AHL84212.1
AII21924.1
BAA01584.1
BAA01616.1
BAA01855.1
BAD61712.1
BAD61713.1
BAD61804.1
BAD61805.1
BAG89369.1
BAS99598.1
BAS99599.1
BAS99600.1
Q01401
Q0D9D0
Q7XZP9
3AMK[A]
3AML[A]
3VU2[A,B]
8
 α-amylase 1A / I-1 (α-Amy7;RAmy1A;Amy1.1;AmyI-1;Os02g0765600) 3.2.1.1 Oryza sativa Japonica Group BAF10134.1
ACA50496.1
BAD17125.1
BAD17313.1
BAG95208.1
BAS81060.1
CAA34516.1
P17654
Q0DXA4
3WN6[A,B,C,D] 6
 α-amylase (RAmy3A;Os09g0457400) 3.2.1.1 Oryza sativa Japonica Group CAA39776.1
BAD38366.1
BAF25281.1
BAG94071.1
BAT08441.1
P27932
Q0J184
  6
 α-amylase 2A (RAmy2A;Amy2A;Os06g0713800) 3.2.1.1 Oryza sativa Japonica Group BAD54103.1
AAA33894.1
BAF20482.1
BAG94883.1
BAS99475.1
B7E3X5
Q0D9J1
  6
 α-amylase 3B/3C / II-5/6 (α-Amy6;AmyII-5;AmyII-6;RAmy3B/Ramy3C;Amy1.7;Os09g0457800) 3.2.1.1 Oryza sativa Japonica Group BAD38369.1
ALC78410.1
BAF25283.1
BAT08444.1
CAA39778.1
P27939
P27939
Q0J182
  6
 branching enzyme (Sbe4;BEIIa;OsBEIIa) 2.4.1.18 Oryza sativa Japonica Group ACY56142.1
AHM26601.1
BAA82828.1
D0TZK6
Q9SXI9
  8
 pullulanase (OsPul;R-enzyme;Os04g0164900) 3.2.1.41 Oryza sativa Japonica Group BAA28632.1
ACY56100.1
ACY56102.1
BAA09167.1
BAF14043.1
BAS87864.1
CAD39560.1
CAE02111.2
O64454
P93416
  13
 α-amylase (partial) 3.2.1.1 Oryzias latipes     3VM5[A] 24
 starch branching enzyme II (BE-II;ChlBE) 2.4.1.18 Parachlorella kessleri 11 H (= IAM C-531) BAF98234.1 A9ZPD1   8
 cell-wall active enzyme / α-amylase (Amy1;PbrAmy1) 2.4.1.-
3.2.1.1
Paracoccidioides brasiliensis IVIC Pb73 / ATCC 3207 ABS11196.1 A7L832   5
 α-1,3-glucan synthase (Ags1;AGS1) 2.4.1.183 Paracoccidioides brasiliensis Pb01 / ATCC-MYA-826 AAV52833.1 Q5S3X6   22
 α-amylase 3.2.1.1 Pecten maximus CAA68065.1 P91778   24
 PDE_01201 (Amy13A) 3.2.1.1 Penicillium oxalicum 114-2 EPS26265.1     1
 α-amylase 3.2.1.1 Phaedon cochleariae CAA76926.1 O97396   15
 α-amylase (Amy1) 3.2.1.1 Phanerochaete chrysosporium BKM-F-1767 / ATCC 24725 ABO42285.1 A5Y589   1
 α-amylase 3.2.1.1 Phaseolus vulgaris BAA33879.1 Q9ZP43   6
 branching enzyme (PvSbe2) 2.4.1.18 Phaseolus vulgaris BAA82348.2 Q9XIS5   8
 branching enzyme (PvSbe1;Kbe3) 2.4.1.18 Phaseolus vulgaris BAA82349.1 Q9XIS4   8
 α-glucosidase (MAL1) 3.2.1.20 Pichia angusta CBS4732 AAF69018.1
CBF79216.1
Q9P8G8   40
 α-amylase 3.2.1.1 Pichia burtonii 15-1 BAF98616.1 A9ZPM0   1
 branching enzyme I (SBE1;SBEI) 2.4.1.18 Pisum sativum CAA56319.1
AAU99027.1
ABC04872.1
ABE12597.1
ABE12605.1
ACM95324.1
Q41058   8
 branching enzyme II (SBEII) 2.4.1.18 Pisum sativum CAA56320.1
AAU99033.1
ACM95330.1
Q41059   8
 α-amylase (Amy2A) 3.2.1.1 Pseudopleuronectes americanus AAF65827.1 Q9I9H6   24
 α-amylase (Amy1) 3.2.1.1 Rattus norvegicus AAA40725.1
AAA40731.1
NP_113690.1
P00689   24
 α-amylase (Amy1) 3.2.1.1 Rattus norvegicus AAH88228.1
BAB39466.1
Q5I0L0
Q99N59
  24
 glycogen branching enzyme 2.4.1.18 Rhizomucor miehei AGV00788.1     8
 α-amylase (RA) 3.2.1.1 Rhizomucor pusillus CAH04003.1
CAX51637.1
    1
 α-amylase (Amy;RpAmy) 3.2.1.1 Rhizomucor pusillus GX-3 AGJ52081.1     1
 α-amylase (Amy;RoAmy) 3.2.1.1 Rhizopus oryzae CICIM F0071 ADL28123.1 E2G4G0   1
 α-glucosidase (Mal6S;Mal62) 3.2.1.20 Saccharomyces carlsbergensis CB11 AAA34757.1
AAQ53125.1
CBF79232.1
P07265   40
 oligo-α-1,6-glucosidase 3.2.1.10 Saccharomyces cerevisiae D-346 BAD00094.1 E1AFY6
P53051
Q76CZ0
  40
 α-glucosidase (Ima4;Fsp2;YJL221C) 3.2.1.20 Saccharomyces cerevisiae S288c CAA83990.1
ADK27713.1
CAA89517.1
CBF79245.1
NP_012314.1
E1AFY9
P0CW40
P0CW41
P40439
  40
 α-glucosidase (Ima2;IMA2;YOL157c) 3.2.1.20 Saccharomyces cerevisiae S288c CAA99179.1
AAQ53126.1
ADK27711.1
NP_014485.1
E1AFY7
Q08295
  40
 oligo-α-1,6-glucosidase / isomaltase (Ima1;IMA1;Fsp2;YGR287c) 3.2.1.10 Saccharomyces cerevisiae S288c BAA07818.1
ADK27710.1
CAA97319.1
CAA97321.1
CBF79247.1
NP_011803.1
E1AFY6
P53051
3A47[A]
3A4A[A]
3AJ7[A]
3AXH[A]
3AXI[A]
40
 α-glucosidase (Mal1S;Mal12;YGR292W) 3.2.1.20 Saccharomyces cerevisiae S288c CAA97325.1
ADK27712.1
NP_011808.1
E1AFY8
P53341
  40
 α-glucosidase (AGL;Mal3S;Mal32;YBR299W;YBR2117) 3.2.1.20 Saccharomyces cerevisiae S288c CAA85264.1
CAA00532.1
NP_009858.1
P38158   40
 α-glucosidase (Ima3;IMA3;YIL172C) 3.2.1.20 Saccharomyces cerevisiae S288c CAA87020.1
NP_012096.1
E1AFY9
P0CW40
P0CW41
P40439
  40
 α-glucosidase (Ima5;IMA5;YJL216c) 3.2.1.20 Saccharomyces cerevisiae S288c CAA83995.1
CAA89513.1
CBF79243.1
NP_012319.1
P40884   40
 branching-enzyme (Glc3;Gha1;SacBE;YEL011W) 2.4.1.18 Saccharomyces cerevisiae S288c AAB64488.1
AAA34632.1
NP_010905.1
D3DLN8
P32775
  8
 glycogen-debranching enzyme (YPR184W;Gdb1) 2.4.1.25
3.2.1.33
Saccharomyces cerevisiae S288c AAB68117.1
BAA34996.1
NP_015510.1
Q06625
Q06625
  25
 α-amylase (Alp1) 3.2.1.1 Saccharomycopsis fibuligera CAA29233.1
ADU24597.1
P21567   1
 α-amylase (SfAmy KZ) 3.2.1.1 Saccharomycopsis fibuligera KZ ADD80242.1 D4P4Y7   1
 α-amylase (Amy1) 3.2.1.1 Saitozyma flava ABS76467.1 A7LGW4   1
 SPAC4A8.01 (Meu30) 3.2.1.1 Schizosaccharomyces pombe 972h- CAB11471.1
BAB60880.1
CAD62442.2
O14154   1
 α-1,3-glucan synthase (Mok12;Pi011;SPBC32H8.13C) 2.4.1.183 Schizosaccharomyces pombe 972h- CAC37503.1
BAA21388.1
BAA76558.1
NP_595619.1
Q9UUL4   22
 α-1,3-glucan synthase (Mok13;SPBC16D10.05) 2.4.1.183 Schizosaccharomyces pombe 972h- BAA76559.1
CAB38509.1
NP_596500.1
Q9Y719   22
 cell-wall active enzyme (Aah3;SPCC63.02c) 2.4.1.- Schizosaccharomyces pombe 972h- CAB40006.1
NP_587976.1
Q9Y7S9   1
 α-1,3-/α-1,4-glucan synthase (Ags1;Mok1;SPCC1281.01;SPCC338.01C;SPCC17A7.01) 2.4.1.-
2.4.1.183
Schizosaccharomyces pombe 972h- AAC31430.1
BAA34054.1
CAA19332.1
CAA19332.2
NP_588165.1
Q9USK8   22
 α-amylase (Amy1;Amy) 3.2.1.1 Schwanniomyces occidentalis ATCC 26077 CAA34162.1
AAB22383.2
P19269   1
 α-amylase (Swa2) 3.2.1.1 Schwanniomyces occidentalis ATCC 26077 CAA51912.1 Q08806   1
 α-amylase (Amy54;Amy43) 3.2.1.1
3.2.1.116
Sclerotinia sclerotiorum ACN82436.1 C0LW29   1
 α-amylase (Amy1) 3.2.1.1 Solanum tuberosum AAA91884.1
ACV30014.1
ACZ26470.1
CAA01542.1
CAA01546.1
Q41442   6
 branching enzyme (Sbe1;Sbe) 2.4.1.18 Solanum tuberosum CAA49463.1
AAB20554.1
AAU99028.1
ABE12603.1
ACM95325.1
ATD50215.1
CAA70038.1
CAD79842.1
O04864
P30924
  8
 branching enzyme II (Sbe) 2.4.1.18 Solanum tuberosum CAB40748.1
AAN95805.1
AAW18508.1
ABC04871.1
ABE12595.1
ABE12602.1
ABE12604.1
CAB40743.1
CAB40744.1
CAB40745.1
CAB40746.1
CAB40747.1
CAB40749.1
Q9T0N2
Q9T0N3
Q9XGA5
Q9XGA6
Q9XGA7
Q9XGA8
Q9XGA9
  8
 branching enzyme II (Sbe-II) 2.4.1.18 Solanum tuberosum ABE12606.1
CAA03846.1
CAD79840.1
O49953   8
 starch branching enzyme IIb (SbeIIb) 2.4.1.18 Sorghum bicolor AAP72267.1
ABK80522.1
ABK80523.1
ABK80524.1
ABK80525.1
ABK80526.1
ABK80527.1
ABK80528.1
ABK80529.1
ABK80530.1
ABK80531.1
ABK80532.1
ABK80533.1
ABK80534.1
ABK80535.1
ABK80536.1
ABK80537.1
ABK80538.1
ABK80539.1
ABK80540.1
ABK80541.1
ABK80542.1
ABK80543.1
ABK80544.1
ABK80545.1
Q7XZK7   8
 branching enzyme 2.4.1.18 Sorghum bicolor AAD50279.2
ABK78850.1
ABK78851.1
ABK78852.1
ABK78853.1
ABK78854.1
ABK78855.1
ABK78856.1
ABK78857.1
ABK78858.1
ABK78859.1
ABK78860.1
ABK78861.1
ABK78862.1
ABK78863.1
ABK78864.1
ABK78865.1
ABK78866.1
ABK78867.1
ABK78868.1
ABK78869.1
ABK78870.1
ABK78871.1
ABK78872.1
Q9M6P8   8
 limit dextrinase / pullulanase (PULSPO) 3.2.1.41 Spinacia oleracea AAN26412.1
AAR67499.1
AAT24831.1
CAA03391.1
CAA58803.1
Q41386   13
 α-amylase (PA) (pancreatic) 3.2.1.1 Struthio camelus   P83053   24
 α-amylase (Ppa;PPA) (pancreatic) 3.2.1.1 Sus scrofa AAF02828.1 P00690 1BVN[P]
1DHK[A]
1HX0[A]
1JFH[A]
1KXQ[A]
1KXT[A]
1KXV[A]
1OSE[A]
1PIF[A]
1PIG[A]
1PPI[A]
1UA3[A]
1VAH[A]
1WO2[A]
3L2L[A]
3L2M[A]
4X0N[A]
24
 α-amylase 3.2.1.1 Tenebrio molitor   P56634 1CLV[A]
1JAE[A]
1TMQ[A]
1VIW[A]
15
 amylase-1 3.2.1.1 Tetraodon nigroviridis CAC87125.1 Q8UWE5   24
 amylase-3 3.2.1.1 Tetraodon nigroviridis CAC87127.1 Q8UWE3   24
 α-amylase 3.2.1.1 Thermomyces lanuginosus CAA03110.1
CAA03111.1
    1
 α-amylase I 3.2.1.1 Tribolium castaneum AAA03708.1
AGW27504.1
AGW27506.1
Q26854   15
 α-amylase II 3.2.1.1 Tribolium castaneum AAA03709.1 Q26855   15
 α-amylase (TRa2) 3.2.1.1 Trichoderma viride IAM 5141 / JCM22452 BAG69580.1 B5BQC3   1
 isoamylase 3 (Isa3;TaISA3) 3.2.1.68 Triticum aestivum AEV92948.1     11
 α-amylase 3.2.1.1 Triticum aestivum AAA34259.1
CAA29252.1
CAZ78894.1
P08117   6
 branching enzyme 2.4.1.18 Triticum aestivum AAB17086.1
AAQ37450.1
O24397   8
 branching enzyme I 2.4.1.18 Triticum aestivum CAB40980.1
AAG27622.1
CAB40979.1
CAB40981.1
Q9FUU8
Q9XGB2
  8
 branching enzyme I 2.4.1.18 Triticum aestivum AAU99038.1
ABN48660.1
ACM95335.1
CAA72987.1
O04074   8
 branching enzyme II 2.4.1.18 Triticum aestivum CAA72154.1
AAU99020.1
AAU99039.1
ABU93825.1
ABU93826.1
ABU93827.1
ABU93828.1
ACF32780.1
ACF32781.1
ACF32785.1
ACM95317.1
ACM95336.1
CCD41775.1
P93691   8
 isoamylase 3.2.1.68 Triticum aestivum AAL31015.1
AAL31016.1
AAY75324.1
ABA70415.1
ABA70416.1
CAC07514.1
CAC07515.1
CAC41016.2
CAC82925.1
Q8VWM3
Q8VWN0
Q8W546
Q8W547
  11
 limit dextrinase (LD1) 3.2.1.41 Triticum aestivum ABL84490.1
AAK52485.1
A1YUM8
Q93XN7
  13
 starch branching enzyme 2 (Sbe2) 2.4.1.18 Triticum aestivum CHEYENNE AAG27623.1
CAR95900.1
Q9FUU7   8
 starch branching enzyme 1 (Sbe1D) 2.4.1.18 Triticum aestivum CHEYENNE AAG27621.1 O04074   8
 α-amylase 3.2.1.1 Valsaria rubricosa CBS 848.96 CAJ21046.1
CAJ21047.1
    1
 α-amylase 3.2.1.1 Vigna angularis BAC76729.1 Q7X9T1   6
 α-amylase 3.2.1.1 Vigna mungo CAA37217.1
CAA51734.1
P17859   6
 α-amylase (AMY) 3.2.1.1 Vigna radiata 1803517A     6
 α-amylase 3.2.1.1 Zabrotes subfasciatus AAF73435.1 Q9N2P9   15
 α-amylase 3.2.1.1 Zea mays ACF88424.1
AAA50161.1
ABJ38332.1
ACW20097.1
B4G231
Q41770
  6
 branching enzyme I 2.4.1.18 Zea mays AAA82735.1
AAC36471.1
AAO20100.1
AAR75248.1
AAU99031.1
ABA16989.1
ABE12598.1
ABJ42248.1
ABQ15209.1
ABX94247.1
ACG32270.1
ACM95328.1
ACN28680.1
ALN66063.1
BAA01854.1
Q41740
Q84XW7
  8
 branching enzyme IIa 2.4.1.18 Zea mays AAB67316.1
AAR75246.1
AAU99021.1
ABJ42249.1
ACM95318.1
O24421   8
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