Glycoside Hydrolase Family 13

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); 6'-P-sucrose phosphorylase (EC 2.4.1.-); amino acid transporter
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (55939); Uniprot accession (7858); PDB accession (467); 3D entries (111); cryst (2)
All (51170) Archaea (370) Bacteria (47636) Eukaryota (3034) unclassified (130) Structure (111 - 2 cryst) Characterized (812)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 α-amylase (proximal) (Amy) 3.2.1.1 Drosophila erecta BAA04582.1 Q23932   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai BAB91509.1 Q8MM52   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai CJB202 BAB91542.1 Q8MM40   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai CJB216 BAB91520.1 Q8MM99   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai CJB216 BAB91543.1 Q8N0Q0   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai HNL122 BAB91514.1 Q8N0Q6   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai HNL122 BAB91536.1 Q8MM80   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai HNL124 BAB91515.1 Q8N0Q5   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai HNL124 BAB91537.1 Q8MM80   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai HNL126 BAB91516.1 Q8MM52   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai HNL126 BAB91538.1 Q8MM40   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai HNL202 BAB91517.1 Q8N0Q4   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai HNL202 BAB91539.1 Q8N0Q2   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai HYD101 BAB91518.1 Q8MLY6   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai HYD101 BAB91540.1 Q8N0Q1   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai HYD102 BAB91519.1 Q8MM99   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai HYD102 BAB91541.1 Q8MM40   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai MDL172 BAB91508.1 Q8MM99   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai MDL172 BAB91530.1 Q8MM80   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai MDL173 BAB91531.1 Q8N0Q3   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai MDL178 BAB91510.1 Q8MM52   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai MDL178 BAB91532.1 Q8MLX9   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai MIYAKO-2 BAB91506.1 Q8MM52   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai MIYAKO-2 BAB91528.1 Q8MM40   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai MIYAKO-4 BAB91507.1 Q8MM52   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai MIYAKO-4 BAB91529.1 Q9NKZ4   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai NAGO-1 BAB91502.1 Q8N0R0   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai NAGO-1 BAB91524.1 Q8MM40   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai NAGO-2 BAB91503.1 Q8N0Q9   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai NAGO-2 BAB91525.1 Q8MM80   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai NAGO-3 BAB91504.1 Q8N0Q8   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai NAGO-3 BAB91526.1 Q8MM80   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai NAGO-4 BAB91505.1 Q8MM52   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai NAGO-4 BAB91527.1 Q9NKZ4   15
 α-amylase (Amy4) 3.2.1.1 Drosophila kikkawai NAHA-1 BAA95432.1 Q9N651   15
 α-amylase (Amy3) 3.2.1.1 Drosophila kikkawai NAHA-1 BAA95431.1 Q9N651   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai NAHA-1 BAA95430.1 Q9NKZ4   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai NAHA-1 BAA95429.1 Q9NKZ5   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai NAHA-2 BAB91501.1 Q8MM99   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai NAHA-2 BAB91521.1 Q9NKZ4   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai NAHA-3 BAB91522.1 Q8MM40   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai NAHA-4 BAB91523.1 Q8MM40   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai RGN31 BAB91513.1 Q8N0Q7   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai RGN31 BAB91535.1 Q8MM40   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai SWB174 BAB91511.1 Q8MLY6   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai SWB174 BAB91533.1 Q8MLX9   15
 α-amylase (Amy1) 3.2.1.1 Drosophila kikkawai SWB184 BAB91512.1 Q8MLY6   15
 α-amylase (Amy2) 3.2.1.1 Drosophila kikkawai SWB184 BAB91534.1 Q8MM40   15
 α-amylase (Amy4) 3.2.1.1 Drosophila leontia RGN210-8 BAA95440.1 Q9NKY6   15
 α-amylase (Amy3) 3.2.1.1 Drosophila leontia RGN210-8 BAA95439.1 Q9NKY7   15
 α-amylase (Amy2) 3.2.1.1 Drosophila leontia RGN210-8 BAA95438.1 Q9NKY8   15
 α-amylase (Amy1) 3.2.1.1 Drosophila leontia RGN210-8 BAA95437.1 Q9NKY9   15
 α-amylase (Amy3) 3.2.1.1 Drosophila lini 14028-0581.0 BAA95443.1
AAM69526.1
AAM69527.1
AAM69528.1
Q8MX60
Q8MX61
Q8MX62
Q9NKY5
  15
 α-amylase (Amy2) 3.2.1.1 Drosophila lini 14028-0581.0 BAA95442.1 Q9N6Q7   15
 α-amylase (Amy1) 3.2.1.1 Drosophila lini 14028-0581.0 BAA95441.1 Q9N6Q7   15
 α-amylase A 3.2.1.1 Drosophila mauritiana BAA04583.1
BAA04584.1
P54215   15
 α-amylase (AmyD;AmyP;Amy-p;DMA;CG18730) 3.2.1.1 Drosophila melanogaster AAA92226.1
AAA92227.1
AAA92228.1
AAA92229.1
AAA92230.1
AAA92231.1
AAA92232.1
AAA92233.1
AAA92234.1
AAA92235.1
AAA92236.1
AAA92237.1
AAA92238.1
AAA92239.1
AAA92240.1
AAA92241.1
AAA92242.1
AAA92243.1
AAF57894.1
AAQ94115.1
AAQ94116.1
AAQ94117.1
BAB32503.1
BAB32504.1
BAB32505.1
BAB32506.1
BAB32507.1
BAB32508.1
BAB32509.1
BAB32510.1
BAB32511.1
BAB32512.1
BAB32513.1
BAB32514.1
BAB32515.1
BAB32516.1
BAB32517.1
BAB32518.1
BAB32519.1
BAB32520.1
BAB32521.1
BAB32522.1
BAB32523.1
BAB32524.1
BAB32525.1
BAB32526.1
BAB32527.1
BAB32528.1
BAB32529.1
BAB32530.1
BAB32531.1
BAB32532.1
BAB32533.1
BAB32534.1
BAB32535.1
BAB32537.1
BAB32538.1
BAB32539.1
BAB32540.1
BAB32541.1
BAB32542.1
BAB32543.1
BAB32544.1
BAB32545.1
CAA28238.1
CAA59126.1
NP_523768.1
NP_536346.1
P08144
Q9BPT3
  15
 α-glucosidase D (LvpD) 3.2.1.20 Drosophila melanogaster AAF59088.1
AAL49188.1
CAA23492.1
NP_476625.2
P07191
P07191
  17
 α-glucosidase H (LvpH; RE72980p) 3.2.1.20 Drosophila melanogaster AAF59089.3
AAF59089.2
AAL48097.2
CAA23491.1
NP_476627.1
P07190   17
 α-glucosidase L (LvpL) 3.2.1.20 Drosophila melanogaster AAM50308.1
AAF59087.2
CAA23493.1
NP_476628.2
P07192
P07192
  17
 α-amylase 3.2.1.1 Drosophila pseudoobscura AAC46839.1
AAA73568.1
AAA73569.1
AAA73570.1
AAA73571.1
AAC46840.1
AAC46841.1
AAC46842.1
AEM77093.1
CAA53819.1
CAA53820.1
CAA53821.1
O46116
Q24609
Q24613
Q27609
Q27610
Q27611
Q27612
Q27863
Q27891
  15
 α-amylase (Amy) 3.2.1.1 Drosophila sechellia BAA04585.1 Q24642   15
 α-amylase 3.2.1.1 Drosophila virilis AAC46463.1 Q24737   15
 α-glucosidase 1 (Mav1) 3.2.1.20 Drosophila virilis AAB82327.1
CAZ78900.1
CBF79236.1
O16098   17
 α-glucosidase 2 (Mav2) 3.2.1.20 Drosophila virilis AAB82328.1
CBF79239.1
O16099   17
 α-amylase A 3.2.1.1 Drosophila yakuba AAG60011.1
AAG60012.1
AAG60013.1
AAG60014.1
BAA04590.1
BAA04591.1
P51548
Q9BN01
  15
 α-amylase (Eur m 4) (allergen) 3.2.1.1 Euroglyphus maynei AAD38943.1 Q9Y196   24
 glycogen branching enzyme (GBE1) 2.4.1.18 Felis catus AAR13899.1
ABI97859.1
Q6T308   8
 α-amylase (AmyA) 3.2.1.1 Fusicoccum sp. BCC4124 ABG48762.1 Q0Z8K1   1
 α-amylase (Amy) 3.2.1.1 Gallus gallus AAC60246.1 Q98942   24
 branching-enzyme 1 2.4.1.18 Gracilaria gracilis AAB97471.1 O49185   8
 α-amylase 1 (AmyI;HdAmyI) 3.2.1.1 Haliotis discus discus ABO26610.1 B6RB08   24
 α-amylase (HdAmy58) 3.2.1.1 Haliotis discus hannai BAM74656.1     24
 α-amylase (HdAmy82) 3.2.1.1 Haliotis discus hannai BAM74657.1    
 α-1,3-glucan synthase (Ags1;HCBG_04272) 2.4.1.183 Histoplasma capsulatum G186AR EEH07393.1     22
 α-amylase (Amy2A) (pancreatic) 3.2.1.1 Homo sapiens AAA51724.1
AAA51723.1
AAA51725.1
AAA52280.1
AAH07060.1
AAI46998.1
BAD97183.1
CAA30099.1
CAA30100.1
CAN87444.1
NP_000690.1
P04746
P04746
1B2Y[A]
1BSI[A]
1CPU[A]
1HNY[A]
1KB3[A]
1KBB[A]
1KBK[A]
1KGU[A]
1KGW[A]
1KGX[A]
1U2Y[A]
1U30[A]
1U33[A]
1XCW[A]
1XCX[A]
1XD0[A]
1XD1[A]
1XGZ[A]
1XH0[A]
1XH1[A]
1XH2[A]
2CPU[A]
2QMK[A]
2QV4[A]
3BAI[A]
3BAJ[A]
3BAK[A]
3BAW[A]
3BAX[A]
3BAY[A]
3CPU[A]
3IJ7[A]
3IJ8[A]
3IJ9[A]
3OLD[A]
3OLE[A]
3OLG[A]
3OLI[A]
4GQQ[A]
4GQR[A]
4W93[A]
4X9Y[A]
5E0F[A]
5EMY[A]
5KEZ[A]
5TD4[A]
24
 α-amylase (salivary) (Amy1A;Amy1;HSA) 3.2.1.1 Homo sapiens AAH63129.1
AAA16183.1
AAA52279.1
AAA57345.1
AAA58368.1
AAH69347.1
AAH69463.1
AAH70302.1
AAH92444.1
AAI32986.1
AAI32988.1
AAI32996.1
AAI32998.1
AAI44453.1
BAF85030.1
NP_004029.2
P04745 1C8Q[A]
1JXJ[A]
1JXK[A]
1MFU[A]
1MFV[A]
1NM9[A]
1Q4N[X]
1SMD[A]
1XV8[A,B]
1Z32[X]
3BLK[A]
3BLP[X]
3DHP[A]
24
 α-amylase 2B (AMY2B) 3.2.1.1 Homo sapiens AAA35525.1
AAH11179.1
AAH20861.1
BAA14130.1
BAG53093.1
BAG54429.1
NP_066188.1
B3KXB7
D3DT76
P19961
P19961
  24
 branching-enzyme (Gbe1;HosBE) 2.4.1.18 Homo sapiens AAA58642.1
AAH12098.1
ABE12601.1
BAD92968.1
BAG54265.1
BAG60255.1
BAG62313.1
NP_000149.1
Q04446
Q04446
4BZY[A,B,C]
5CLT[A,B,C]
5CLW[A,B,C]
8
 glycogen-debranching enzyme 1 (AGL) 2.4.1.25
3.2.1.33
Homo sapiens AAB48466.1
AAB41040.1
AAB48467.1
AAB48468.1
AAB48469.1
AAB48470.1
AAH78663.1
ALC78881.1
ALN12516.1
BAA88405.1
BAD92104.1
BAK64140.1
NP_000019.1
NP_000633.1
NP_000634.1
NP_000635.1
NP_000636.1
NP_000637.1
D3DT51
P35573
  25
 starch branching enzyme I (SbeI) 2.4.1.18 Hordeum vulgare AAP72268.1 Q7XZK6   8
 α-amylase (Amy1;Amy32b) 3.2.1.1 Hordeum vulgare CAA28803.1
AAA32935.1
AAY44169.1
AAY44170.1
Q42504   6
 α-amylase 1 (Amy1;Amy1.1) 3.2.1.1 Hordeum vulgare AAA32929.1
AAA32927.1
P00693
Q40017
1HT6[A]
1P6W[A]
1RP8[A]
1RP9[A]
1RPK[A]
2QPS[A]
2QPU[A,B,C]
3BSG[A]
3BSH[A]
6
 α-amylase 2 (Amy2) 3.2.1.1 Hordeum vulgare CAA33298.1
AAA32925.1
AAA98790.1
P04063
Q40015
1AMY[A]
1AVA[A,B]
1BG9[A]
6
 α-amylase 6 3.2.1.1 Hordeum vulgare CAA33299.1
AAA32932.1
AAA98615.1
P04750
Q03651
  6
 isoamylase 1 (fragment) 3.2.1.68 Hordeum vulgare AAD33889.1 Q9XFG6   11
 limit dextrinase (HvLD99) 3.2.1.41 Hordeum vulgare AAD04189.1
AAD34347.1
AAD34348.1
AAF98802.1
O48541
Q9FYY0
Q9S7S8
2X4B[A]
2X4C[A]
2Y4S[A]
2Y5E[A]
4AIO[A]
4CVW[A,B]
4J3S[A]
4J3T[A]
4J3U[A,B]
4J3V[A]
4J3W[A]
4J3X[A]
13
 starch branching enzyme IIa 2.4.1.18 Hordeum vulgare AAC69753.1
ABE23221.1
Q9ZTB7   8
 starch branching enzyme IIb 2.4.1.18 Hordeum vulgare AAC69754.1 Q9ZTB6   8
 α-amylase (Amy1;Amy) 3.2.1.1 Hordeum vulgare subsp. vulgare CAA72143.1 O04964   6
 starch branching enzyme (IBE;Sbe ii) 2.4.1.18 Ipomoea batatas BAB64912.1
BAB40334.1
Q948N7
Q9AVL7
  8
 α-glucosidase (maltase mal22) 3.2.1.20 Kluyveromyces lactis CAB46746.1
CBF79221.1
Q9Y844   40
 α-amylase (LKA2) 3.2.1.1 Lipomyces kononenkoae SPENCER-MARTINSIAE IGC4052B AAO12212.1 Q8J1E4   1
 α-amylase (Lka1) 3.2.1.1 Lipomyces spencermartinsiae IGC4052B AAC49622.1 Q01117   1
 α-amylase 3.2.1.1 Lipomyces starkeyi KSM 22M AAN75021.1 Q6YF33   1
 α-amylase 1 3.2.1.1 Litopenaeus vannamei CAA54524.1
AAR19061.1
Q26193   24
 α-amylase (Amy) 3.2.1.1 Litopenaeus vannamei CAB65553.1
AAR19062.1
CAD43060.1
Q9U0F6   24
 α-amylase (Amy) 3.2.1.1 Litopenaeus vannamei CAB65552.2 Q9U0F9   24
 α-1,3-glucan synthase (Ags1;MgAGS1;MG09639;MGG_09639) 2.4.1.183 Magnaporthe oryzae 70-15 EAA48102.1
XP_003721444.1
XP_364794.1
    22
 α-amylase (AmyA;McAmyA) 3.2.1.1 Malbranchea cinnamomea AFD54462.1   3VM7[A] 1
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