Activities in Sub Family	[retaining] α-amylase (EC 3.2.1.1); α-glucosidase (EC 3.2.1.20);
Mechanism	Retaining a
Clan	GH-H
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Asp (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	New: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resources	CAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX;
Statistics	GenBank accession (5339); Uniprot accession (2); PDB accession (13); 3D entries (2); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
α-glucosidase Z (EO53_16270;MalZ;b0403)	3.2.1.20	Escherichia coli str. K-12 substr. MG1655	AIZ92452.1 AAA16112.1 AAB40159.1 AAC73506.1 AAC73506.2 ALI41788.1 AMC97641.1 AUG15189.1 AVI54934.1 AYG20468.1 CAA42498.1 CAY02912.1 CAZ78690.1 NP_414937.1	P21517	5BN7[A] 3.70 7VT9[A,B] 3.30	21
α-amylase I (TVA I)	3.2.1.1	Thermoactinomyces vulgaris R-47	BAA02471.1 CAY02971.1 CAZ78902.1	Q60053	1IZJ[A] 2.20 1IZK[A] 2.20 1JI1[A,B] 1.60 1UH2[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp 2.00 1UH3[A] <acarbose_derivative> <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp β-D-Glcp-(1-4)-α-D-Glcp-(1-4)-<non_carb>-(0-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp 2.60 1UH4[A] α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp 1.80 2D0F[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-6)-α-D-Glcp-(1-4)-β-D-Glcp α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp 2.08 2D0G[A] α-D-Glcp α-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-6)-β-D-Glcp-(1-4)-β-D-Glcp β-D-Glcp β-D-Glcp-(1-4)-α-D-Glcp-(1-6)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-α-D-Glcp-(1-6)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-6)-α-D-Glcp-(1-4)-α-D-Glcp β-D-Glcp-(1-4)-β-D-Glcp 2.60 2D0H[A] α-D-Glcp-(1-6)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-6)-α-D-Glcp-(1-4)-α-D-Glcp 2.10 5Z0T[A,B] 1.50 5Z0U[A] 1.37	21
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