Glycoside Hydrolase Family 13 / Subf 10

Activities in Familyα-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-α-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); α-glucosidase (EC 3.2.1.20); maltotetraose-forming α-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming α-amylase (EC 3.2.1.98); maltotriose-forming α-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-α-glucanotransferase (EC 2.4.1.25); maltopentaose-forming α-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-α-1,6-glucosidase (EC 3.2.1.33); α-1,4-glucan: phosphate α-maltosyltransferase (EC 2.4.99.16); 6'-P-sucrose phosphorylase (EC 2.4.1.-); amino acid transporter
Activities in Sub Family
Mechanism Retaining
ClanGH-H
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorGlu (experimental)
NoteNew: many members have been assigned to subfamilies as described by Stam et al. (2006) Protein Eng Des Sel. 19, 555-562 (PMID: 17085431)
External resourcesCAZypedia; EBI Protein of the Month; HOMSTRAD; PDB Molecule of the Month; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (2488); Uniprot accession (303); PDB accession (18); 3D entries (3); cryst (0)
All (2415) Archaea (35) Bacteria (2380) Structure (3) Characterized (15)
Archaea
Protein Name EC# OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 α-amylase / maltooligosyltrehalose trehalohydrolase (GTHase) 3.2.1.1
3.2.1.141
Sulfolobus solfataricus KM1 AAR46454.1
BAA11010.1
Q55088
1EH9[A] 3.00
1EHA[A] 3.00
3VGB[A] 2.65
3VGD[A] 2.40
3VGE[A] 2.70
3VGF[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
2.30
3VGG[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-3)-α-D-Glcp
2.66
3VGH[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-1)-α-D-Glcp
2.60
10
Bacteria
Protein Name EC# OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 malto-oligosyltrehalose trehalohydrolase (DR0464) 3.2.1.141 Deinococcus radiodurans R1 AAF10042.1
ANC72786.1
NP_294187.1
Q9RX51
2BHU[A] 1.1
2BHY[A] α-D-Glcp
α-D-Glcp-(1-1)-α-D-Glcp
1.5
2BHZ[A] α-D-Glcp-(1-4)-β-D-Glcp
1.2
2BXY[A] α-D-Glcp
α-D-Glcp-(1-1)-α-D-Glcp
β-D-Glcp
1.75
2BXZ[A] α-D-Glcp
α-D-Glcp-(1-1)-α-D-Glcp
β-D-Glcp
1.75
2BY0[A] α-D-Glcp-(1-1)-α-D-Glcp
β-D-Glcp
1.55
2BY1[A] α-D-Glcp-(1-1)-α-D-Glcp
β-D-Glcp
1.55
2BY2[A] α-D-Glcp
α-D-Glcp-(1-1)-α-D-Glcp
β-D-Glcp
1.5
2BY3[A] α-D-Glcp-(1-1)-α-D-Glcp
β-D-Glcp
1.5
10
 STM1560   Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 AAL20478.1
NP_460519.1
Q8ZPF0
3M07[A] 1.40
10
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