Glycoside Hydrolase Family 130

Activities in Familyβ-1,4-mannosylglucose phosphorylase (EC 2.4.1.281); β-1,4-mannooligosaccharide phosphorylase (EC 2.4.1.319); β-1,4-mannosyl-N-acetyl-glucosamine phosphorylase (EC 2.4.1.320); β-1,2-mannobiose phosphorylase (EC 2.4.1.-); β-1,2-oligomannan phosphorylase (EC 2.4.1.-); β-1,2-mannosidase (EC 3.2.1.-)
Mechanism inverting
3D Structure Status5-fold β-propeller
NoteCreated after Senoura et al. (2011) BBRC 408, 701-706 [PMID: 21539815]
External resourcesCAZypedia;
Statistics GenBank accession (1432); Uniprot accession (32); PDB accession (22); 3D entries (11); cryst (0)
All (1400) Archaea (107) Bacteria (1275) Eukaryota (10) unclassified (8) Structure (11) Characterized (14)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 β-1,4-mannosylglucose phosphorylase (MGP;BF0772) 2.4.1.281 Bacteroides fragilis NCTC 9343 CAH06518.1 Q5LH68
3WAS[A,B] β-D-Manp-(1-4)-β-D-Glcp
1.50
3WAT[A,B] β-D-Glcp
β-D-Manp
1.60
3WAU[A,B] α-D-Manp
1.70
4KMI[A,B] 1.80
 β-1,2-mannosidase (BACOVA_03624) 3.2.1.- Bacteroides ovatus ATCC 8483 EDO10988.1  
3QC2[A,B] 2.30
 BACOVA_02161   Bacteroides ovatus ATCC 8483 EDO12271.1  
4ONZ[A] 1.85
 BT4094 / BT_4094   Bacteroides thetaiotaomicron VPI-5482 AAO79199.1  
3R67[A,B,C,D] 2.30
 β-1,2-mannosidase (BT3780;BT_3780) 3.2.1.- Bacteroides thetaiotaomicron VPI-5482 AAO78885.1  
5A7V[A,B] α-D-Manp
β-D-Manp
1.35
 β-1,2-mannobiose phosphorylase (Lin0857) 2.4.1.- Listeria innocua Clip11262 CAC96089.1
NP_470199.1
Q92DF6
5B0P[A,B] 1.90
5B0Q[A,B] α-D-Manp
2.30
5B0R[A,B] β-D-Manp-(1-2)-β-D-Manp
1.80
5B0S[A,B] β-D-Manp-(1-2)-β-D-Manp-(1-2)-α-D-Manp
2.10
 BDI_3141   Parabacteroides distasonis ATCC 8503 ABR44847.1  
3TAW[A] 1.70
 β-1,4-mannosylglucose phosphorylase (RaMP1;RaMGP;Rumal_0852) 2.4.1.281 Ruminococcus albus 7 = DSM 20455 ADU21379.1 E6UIS7
5AY9[A] 2.50
5AYC[A] β-D-Manp-(1-4)-β-D-Glcp
1.90
 β-1,4-mannooligosaccharide phosphorylase (MOP;RaMP2;Rumal_0099) 2.4.1.319 Ruminococcus albus 7 = DSM 20455 ADU20661.1 E6UBR9
5AYD[A,B,C,D,E,F] 2.30
5AYE[A,B,C,D,E,F] β-D-Manp-(1-4)-β-D-Manp
2.20
 TM1225   Thermotoga maritima MSB8 AAD36300.1
AGL50156.1
AHD18868.1
AKE29001.1
NP_229030.1
Q9X0V2
1VKD[A,B,C,D,E,F] 2.10
unclassified
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 β-1,4-mannopyranosyl-[N-glycan] phosphorylase / β-1,4-mannopyranosyl-chitobiose phosphorylase (UhgbMP;Uhgb_MP) 2.4.1.319
2.4.1.320
uncultured organism ADD61463.1  
4UDG[A,B,C,D,E,F] α-D-GlcpNAc
1.60
4UDI[A,B,C,D,E,F] 1.80
4UDJ[A,B,C,D,E,F] β-D-Manp
1.94
4UDK[A,B,C,D,E,F] α-D-GlcpNAc
β-D-Manp
1.76
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