Glycoside Hydrolase Family 12

Activities in Familyendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
Mechanism Retaining
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (929); Uniprot accession (212); PDB accession (46); 3D entries (16); cryst (1)
All (737) Archaea (81) Bacteria (514) Eukaryota (141) unclassified (1) Structure (16 - 1 cryst) Characterized (68)
| 1 | 2 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 EGX46152.1   Arthrobotrys oligospora ATCC 24927 EGX46152.1    
 xyloglucanase 2 (XEG2) (fragment)   Aspergillus aculeatus AAO20340.1 O94218  
 endo-β-1,4-glucanase I (EndI)   Aspergillus aculeatus AFD53250.1    
 endo-β-1,4-glucanase 1 (Cmc1;Cmc-1;FI CM-cellulase;FI-CMCase) 3.2.1.4 Aspergillus aculeatus F-50 BAA00435.1
AAR63632.1
AAR67685.1
ABJ29216.1
ACP76235.1
CAA36757.1
P22669 5GM3[A,B]
5GM4[A,B,C,D,E,F,G]
5GM5[A,B,C,D,E,F,G]
 endo-β-1,4-glucanase (xyloglucan-specific) (XEG1) 3.2.1.151 Aspergillus aculeatus KSM 510 AAD02275.1 O94218 3VL8[A]
3VL9[A,B]
3VLB[B,D]
 endo-xyloglucanase (XegA;AclaXegA;ACLA_029940) 3.2.1.151 Aspergillus clavatus NRRL 1 EAW08261.1 A1CRJ0  
 GH12 β-1, 4-endoglucanase   Aspergillus fischeri CGMCC 3.15369 APQ48493.1    
 endoglucanase (AfCel12A;Afu7g06150;AFUA_7G06150) (Cel12A) 3.2.1.4 Aspergillus fumigatus Af293 EAL86857.1    
 endoglucanase (Cel12B)   Aspergillus kawachii IFO 4308 AAM77715.1
AAR63634.1
AAR67687.1
ABJ29218.1
ACP76237.1
Q8NJY2  
 endo-β-1,4-glucanase (CekA) 3.2.1.4 Aspergillus kawachii IFO 4308 AAR63633.1
AAR67686.1
ABJ29217.1
ACP76236.1
BAA02297.1
Q12679  
 endo-β-1,4-glucanase (xyloglucan-specific) (AN0452.2) 3.2.1.151 Aspergillus nidulans FGSC A4 EAA66551.1
ABF50842.1
Q5BG78  
 endoglucanase (EglA)   Aspergillus niger ATCC 10574 ADC84000.1 D3YNY2  
 endo-β-1,4-glucanase (EglA;AnEglA) 3.2.1.4 Aspergillus niger CBS 120.49 / N400 AAE60101.1
AAE84291.1
CAA03652.1
CAA03657.1
CAA11964.1
CAG17891.1
O74705 1KS4[A]
1KS5[A]
 An03g05530   Aspergillus niger CBS 513.88 CAG17892.1
CAK38314.1
A2QH44  
 An01g03340   Aspergillus niger CBS 513.88 CAK36874.1 A2Q877  
 An03g05380   Aspergillus niger CBS 513.88 CAK38300.1 A2QH30  
 endo-β-1,4-glucanase (EglA;An14g02760) 3.2.1.4 Aspergillus niger CBS 513.88 CAK46524.1 A2R322  
 endoglucanase 3.2.1.4 Aspergillus niger HO AIX97359.1    
 xyloglucan-specific endo-β-1,4-glucanase (Xeg12A) 3.2.1.151 Aspergillus niger N402 ABF46829.1 A1XP58  
 endoglucanase A (EglA) (partial) 3.2.1.4 Aspergillus niger VTCC F-021 / VTCC-F021 ADD12042.1 D3YC02  
 xyloglucan-specific endo-β-1,4-glucanase (XegA) 3.2.1.151 Aspergillus niveus PR-2 AEV23011.1   4NPR[A,B]
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Aspergillus oryzae KBN616 BAA22588.1
AAR63635.1
AAR67688.1
ABJ29219.1
ACP76238.1
   
 AO090003000905   Aspergillus oryzae RIB40 BAE58022.1 Q2UK93  
 endo-β-1,4-glucanase (CelA;AO090026000102) 3.2.1.4 Aspergillus oryzae RIB40 BAE59597.1 Q2UFR8  
 AO090701000185   Aspergillus oryzae RIB40 BAE61926.1 Q2U939  
 AO090038000175   Aspergillus oryzae RIB40 BAE64005.1 Q2U360  
 endoglucanase (EglD;AtEglD;AtGH12;ATEG_09894) 3.2.1.4 Aspergillus terreus NIH2624 EAU30085.1
XP_001218516.1
  cryst
 endo-β-1,4-glucanase (AuCel12A) (Cel12A) 3.2.1.4 Aspergillus usamii E001 AEL12376.1    
 mixed β-1,3-1,4-glucanase (Mlg2) 3.2.1.73 Bipolaris zeicola AAF65311.1 Q9P8N6  
 glycoside hydrolase family 12 protein (Bofut4_p031650.1)   Botrytis cinerea T4 CCD49289.1    
 glycoside hydrolase family 12 protein (Bofut4_p021270.1)   Botrytis cinerea T4 CCD51821.1    
 glycoside hydrolase family 12 protein (Bofut4_p008250.1)   Botrytis cinerea T4 CCD45108.1    
 Bofut4_p039820.1   Botrytis cinerea T4 CCD47080.1    
 glycoside hydrolase family 12 protein (Bofut4_p124780.1) (fragment)   Botrytis cinerea T4 CCD54430.1    
 endoglucanase (Cel12A)   Chaetomium brasiliense CBS 140.50 AAM77701.1
AAR63638.1
AAR67691.1
ABJ29222.1
ACP76241.1
Q8NJZ6  
 Cbh12 (fragment)   Chaetomium thermophilum CT2 AGY80099.1    
 endoglucanase (EG3; EG III) 3.2.1.4 Chrysosporium lucknowense AAQ38148.1
ACH15006.1
   
 endo-β-1,4-glucanase (EGIII) 3.2.1.4 Clonostachys rosea AAR67695.1
AAR63642.1
ABJ29226.1
ACP76245.1
   
 endoglucanase (Cel12A)   Clonostachys rosea 1003 AAM77706.1 Q8NJZ1  
 endoglucanase (Cel12B)   Clonostachys rosea 1003 AAM77707.1
AAR63643.1
AAR67696.1
ABJ29227.1
ACP76246.1
Q8NJZ0  
 endoglucanase (Cel12C)   Clonostachys rosea 1003 AAM77708.1
AAR63644.1
AAR67697.1
ABJ29228.1
ACP76247.1
Q8NJY9  
 endoglucanase (Cel12D)   Clonostachys rosea 1003 AAM77709.1
AAR63645.1
AAR67698.1
ABJ29229.1
ACP76248.1
Q8NJY8  
 endoglucanase 1B   Colletotrichum gloeosporioides AND80748.1    
 orf   Diaphorina citri ABG82005.1 Q0PXV4  
 endoglucanase (Cel12A)   Emericella desertorum CBS 653.73 AAM77702.1
AAR63647.1
AAR67700.1
ABJ29231.1
ACP76250.1
Q8NJZ5  
 endoglucanase II (EG-II;Eg2;EG35) (Cel12) 3.2.1.4 Fomitopsis palustris FFPRI 0507 BAF49602.1 A4PID1  
 endoglucanase (Cel12A)   Fusarium equiseti CBS 185.34 AAM77703.1
AAR63639.1
AAR67692.1
ABJ29223.1
ACP76242.1
Q8NJZ4  
 FFUJ_14533   Fusarium fujikuroi IMI 58289 CCT67597.1    
 FFUJ_00072   Fusarium fujikuroi IMI 58289 CCT63295.1    
 FFUJ_13006   Fusarium fujikuroi IMI 58289 CCT66840.1    
 FFUJ_11983   Fusarium fujikuroi IMI 58289 CCT75931.1    
 xyloglucanase (fg05851;FGSG_05851) (6993) 3.2.1.151 Fusarium graminearum PH-1 XP_386027.1    
 endo-β-glucanase (fg11037;FGSG_11037) (7138)   Fusarium graminearum PH-1 XP_391213.1    
 endo-β-glucanase (FGRAMPH1_01T25915; fg07892;FGSG_07892) (7048)   Fusarium graminearum PH-1 SCB65334.1
XP_388068.1
   
 endo-β-glucanase (fgd146-200;FGSG_16349) (7213)   Fusarium graminearum PH-1 XP_383205.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF87069.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF87277.1    
 FGRAMPH1_01T11887   Fusarium graminearum PH-1 SCB65736.1    
 endoglucanase (Cel12A)   Fusarium striatum CBS 203.32 AAM77704.1
AAR63640.1
AAR67693.1
ABJ29224.1
ACP76243.1
Q8NJZ3  
 endoglucanase (Cel12B)   Fusarium striatum CBS 203.32 AAM77705.1
AAR63641.1
AAR67694.1
ABJ29225.1
ACP76244.1
Q8NJZ2  
 endo-β-1,4-glucanase (Cel12g;GtCel12A) (Cel12A) 3.2.1.4 Gloeophyllum trabeum ATCC 11539 AEJ35167.1
AEM23897.1
P84196  
 endoglucanase (Cel12A) 3.2.1.4 Humicola grisea ATCC 22081 AAM77714.2
AAR63636.1
AAR63637.1
AAR67689.1
AAR67690.1
ABJ29220.1
ABJ29221.1
ACP76239.1
ACP76240.1
Q8NJY3 1OLR[A]
1UU4[A]
1UU5[A]
1UU6[A]
1W2U[A]
 endoglucanase III (EgIII)   Hypocrea orientalis EU7-22 AFD50196.1    
 endoglucanase (Cel12A) 3.2.1.4 Hypocrea schweinitzii ATCC 66965 AAM77711.1
AAE59776.1
AAN19481.1
AAO95540.1
AAQ42102.1
AAR63631.1
AAR67684.1
ABJ29215.1
ACP76234.1
Q8NJY6 1OA3[A,B,C,D]
 ORF   Hypocrella siamensis MTCC 10142 ANH56485.1    
 endoglucanase (LeCel12A) (Cel12A)   Lentinula edodes H600 BAN51847.1    
 xyloglucan-specific endoglucanase (LeCel12B) (Cel12B)   Lentinula edodes H600 BAN51848.1    
 xyloglucan-specific endoglucanase (LeCel12C) (Cel12C)   Lentinula edodes H600 BAN51849.1    
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX91934.1 E5R4G6  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX95838.1 E4ZW62  
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX99520.1 E5A7C5  
 GH12 xyloglucanase (Xeg1)   Leucoagaricus gongylophorus ANB44746.1    
 xyloglucanase (Xeg1)   Leucoagaricus gongylophorus Ae322 CDJ79826.1    
 LRAMOSA08030   Lichtheimia ramosa CDS05502.1    
 xyloglucan endotransglycosylase (XET) 2.4.1.207 Macrophomina phaseolina AAN89225.1
AAS22565.1
   
 endo-β-1,3-1,4-glucanase (MoCel12A;MG00677.4) (Cel12A) 3.2.1.73 Magnaporthe oryzae 70-15 XP_368567.1 G4NAZ1  
 endo-β-1,3-1,4-glucanase (MoCel12C;MG10972.4) (Cel12C) 3.2.1.73 Magnaporthe oryzae 70-15 XP_361895.1 G4NBX2  
 endo-β-1,3-1,4-glucanase (MoCel12B;MG08537.4) (Cel12B) 3.2.1.73 Magnaporthe oryzae 70-15 XP_362900.1 G4N5V2  
 xyloglucanase 3.2.1.151 Malbranchea cinnamomea AAO95986.1    
 endoglucanase (Cel12A)   Memnoniella echinata CBS 304.54 AAM77710.1
AAR63646.1
AAR67699.1
ABJ29230.1
ACP76249.1
Q8NJY7  
 NCU08227.1   Neurospora crassa OR74A XP_328933.1 Q7S3L6  
 Cel12 (fragment) (Cel12)   Penicillium decumbens 114-2 ACH57440.1 B5M080  
 PDE_06439 (Cel12A) 3.2.1.4 Penicillium oxalicum 114-2 EPS31484.1    
 Egl2 (fragment)   Penicillium oxalicum GZ-2 AGW24294.1    
 acid-stable endoxyloglucanase / xyloglucan-specific endo-β-1,4-glucanase (PoXeg12A) (Xeg12A) 3.2.1.151 Penicillium oxalicum HP7-1 AJA40324.1    
 Pc16g06060   Penicillium rubens Wisconsin 54-1255 CAP93276.1 B6H8I9  
 Pc16g08690   Penicillium rubens Wisconsin 54-1255 CAP93539.1 B6H7Y5  
 Pc20g07340   Penicillium rubens Wisconsin 54-1255 CAP86063.1 B6HDE0  
 endoglucanase 28 (Cel12A) 3.2.1.4 Phanerochaete chrysosporium K3 AAU12276.1 Q66NB6  
 endoglucanase (Egl12.1;Cell 12A) (Cel12A)   Phytophthora infestans ABG91065.1 Q0PQ33  
 endoglucanase (EGL12-H) (Cel12H)   Phytophthora ramorum ABB22039.1 Q30BY2  
 endoglucanase (EGL12-G) (Cel12G)   Phytophthora ramorum ABB22038.1 Q30BY3  
 endoglucanase (EGL12-F) (Cel12F)   Phytophthora ramorum ABB22037.1 Q30BY4  
 endoglucanase (EGL12-E) (Cel12E)   Phytophthora ramorum ABB22036.1 Q30BY5  
 endoglucanase (EGL12-D) (Cel12D)   Phytophthora ramorum ABB22035.1 Q30BY6  
 endoglucanase (EGL12-C) (Cel12C)   Phytophthora ramorum ABB22034.1 Q30BY7  
 endoglucanase (EGL12-B) (Cel12B)   Phytophthora ramorum ABB22033.1 Q30BY8  
 endoglucanase (EGL12-A) (Cel12A)   Phytophthora ramorum ABB22032.1 Q30BY9  
 endoglucanase (EGL12-B;Ps109281;PHYSODRAFT_355355)   Phytophthora sojae AAT66504.1
EGZ11358.1
Q6DTZ0  
 endoglucanase (EGL12-L) (fragment)   Phytophthora sojae ABB92621.1 Q2V8M9  
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