Glycoside Hydrolase Family 12

Activities in Familyendoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); β-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207)
Mechanism Retaining
ClanGH-C
3D Structure Statusβ-jelly roll
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
Noteformerly known as cellulase family H.
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (1507); Uniprot accession (212); PDB accession (53); 3D entries (19); cryst (1)
All (1312) Archaea (117) Bacteria (963) Eukaryota (229) unclassified (3) Structure (19 - 1 cryst) Characterized (69)
| 1 | 2 | 3 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Endoglucanase-like protein (ACRE_041060)   Acremonium chrysogenum ATCC 11550     5M2D[B]
5M2D[A]
 EGX46152.1   Arthrobotrys oligospora ATCC 24927 EGX46152.1    
 xyloglucanase 2 (XEG2) (fragment)   Aspergillus aculeatus AAO20340.1 O94218  
 endo-β-1,4-glucanase I (EndI)   Aspergillus aculeatus AFD53250.1    
 endo-β-1,4-glucanase 1 (Cmc1;Cmc-1;FI CM-cellulase;FI-CMCase) 3.2.1.4 Aspergillus aculeatus F-50 BAA00435.1
AAR63632.1
AAR67685.1
ABJ29216.1
ACP76235.1
CAA36757.1
P22669 5GM3[A,B]
5GM4[A,B,C,D,E,F,G]
5GM5[A,B,C,D,E,F,G]
 endo-β-1,4-glucanase (xyloglucan-specific) (XEG1) 3.2.1.151 Aspergillus aculeatus KSM 510 AAD02275.1 O94218 3VL8[A]
3VL9[A,B]
3VLB[B,D]
 endo-β-1,3-1,4-glucanase   Aspergillus awamori CAU33 AYH63706.1    
 xyloglucanase GH12 (Gh12B)   Aspergillus cervinus VKPM F-612 AWN00461.1    
 β-glucanase (Gh12A)   Aspergillus cervinus VKPM F-612 AYM46706.1    
 ORF   Aspergillus chevalieri VKPM F-834 AYM46707.1    
 endo-xyloglucanase (XegA;AclaXegA;ACLA_029940) 3.2.1.151 Aspergillus clavatus NRRL 1 EAW08261.1 A1CRJ0  
 xyloglucan-specific endo-β-1,4-glucanase (Xyg12A)   Aspergillus fischeri QBH72468.1    
 GH12 β-1, 4-endoglucanase   Aspergillus fischeri CGMCC 3.15369 APQ48493.1   6K98[A]
6K9D[A]
 endoglucanase (AfCel12A;Afu7g06150;AFUA_7G06150) (Cel12A) 3.2.1.4 Aspergillus fumigatus Af293 EAL86857.1    
 endoglucanase (Cel12B)   Aspergillus kawachii IFO 4308 AAM77715.1
AAR63634.1
AAR67687.1
ABJ29218.1
ACP76237.1
Q8NJY2  
 endo-β-1,4-glucanase (CekA) 3.2.1.4 Aspergillus kawachii IFO 4308 AAR63633.1
AAR67686.1
ABJ29217.1
ACP76236.1
BAA02297.1
Q12679  
 endo-β-1,4-glucanase (xyloglucan-specific) (AN0452.2) 3.2.1.151 Aspergillus nidulans FGSC A4 EAA66551.1
ABF50842.1
Q5BG78  
 endoglucanase (EgL)   Aspergillus niger QEQ56120.1    
 endoglucanase (EglA)   Aspergillus niger ATCC 10574 ADC84000.1 D3YNY2  
 endo-β-1,4-glucanase (EglA;AnEglA) 3.2.1.4 Aspergillus niger CBS 120.49 / N400 AAE60101.1
AAE84291.1
CAA03652.1
CAA03657.1
CAA11964.1
CAG17891.1
O74705 1KS4[A]
1KS5[A]
 An03g05530   Aspergillus niger CBS 513.88 CAG17892.1
CAK38314.1
A2QH44  
 An01g03340   Aspergillus niger CBS 513.88 CAK36874.1 A2Q877  
 An03g05380   Aspergillus niger CBS 513.88 CAK38300.1 A2QH30  
 endo-β-1,4-glucanase (EglA;An14g02760) 3.2.1.4 Aspergillus niger CBS 513.88 CAK46524.1 A2R322  
 endoglucanase 3.2.1.4 Aspergillus niger HO AIX97359.1    
 xyloglucan-specific endo-β-1,4-glucanase (Xeg12A) 3.2.1.151 Aspergillus niger N402 ABF46829.1 A1XP58  
 endoglucanase A (EglA) (partial) 3.2.1.4 Aspergillus niger VTCC F-021 / VTCC-F021 ADD12042.1 D3YC02  
 xyloglucan-specific endo-β-1,4-glucanase (XegA) 3.2.1.151 Aspergillus niveus PR-2 AEV23011.1   4NPR[A,B]
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Aspergillus oryzae KBN616 BAA22588.1
AAR63635.1
AAR67688.1
ABJ29219.1
ACP76238.1
   
 AO090003000905   Aspergillus oryzae RIB40 BAE58022.1 Q2UK93  
 endo-β-1,4-glucanase (CelA;AO090026000102) 3.2.1.4 Aspergillus oryzae RIB40 BAE59597.1 Q2UFR8  
 AO090701000185   Aspergillus oryzae RIB40 BAE61926.1 Q2U939  
 AO090038000175   Aspergillus oryzae RIB40 BAE64005.1 Q2U360  
 endoglucanase (EglD;AtEglD;AtGH12;ATEG_09894) 3.2.1.4 Aspergillus terreus NIH2624 EAU30085.1
XP_001218516.1
  cryst
 endo-β-1,4-glucanase (AuCel12A) (Cel12A) 3.2.1.4 Aspergillus usamii E001 AEL12376.1    
 mixed β-1,3-1,4-glucanase (Mlg2) 3.2.1.73 Bipolaris zeicola AAF65311.1 Q9P8N6  
 BCIN_04g06050   Botrytis cinerea B05.10 ATZ49459.1    
 BCIN_06g00490   Botrytis cinerea B05.10 ATZ50552.1    
 BCIN_13g02320   Botrytis cinerea B05.10 ATZ56393.1    
 BCIN_13g03350   Botrytis cinerea B05.10 ATZ56497.1    
 BCIN_03g03630   Botrytis cinerea B05.10 ATZ48116.1    
 glycoside hydrolase family 12 protein (Bofut4_p031650.1)   Botrytis cinerea T4 CCD49289.1    
 glycoside hydrolase family 12 protein (Bofut4_p021270.1)   Botrytis cinerea T4 CCD51821.1    
 glycoside hydrolase family 12 protein (Bofut4_p008250.1)   Botrytis cinerea T4 CCD45108.1    
 Bofut4_p039820.1   Botrytis cinerea T4 CCD47080.1    
 glycoside hydrolase family 12 protein (Bofut4_p124780.1) (fragment)   Botrytis cinerea T4 CCD54430.1    
 endoglucanase (Cel12A)   Chaetomium brasiliense CBS 140.50 AAM77701.1
AAR63638.1
AAR67691.1
ABJ29222.1
ACP76241.1
Q8NJZ6  
 Cbh12 (fragment)   Chaetomium thermophilum CT2 AGY80099.1    
 endoglucanase (EG3; EG III) 3.2.1.4 Chrysosporium lucknowense AAQ38148.1
ACH15006.1
   
 endo-β-1,4-glucanase (EGIII) 3.2.1.4 Clonostachys rosea AAR67695.1
AAR63642.1
ABJ29226.1
ACP76245.1
   
 endoglucanase (Cel12A)   Clonostachys rosea 1003 AAM77706.1 Q8NJZ1  
 endoglucanase (Cel12B)   Clonostachys rosea 1003 AAM77707.1
AAR63643.1
AAR67696.1
ABJ29227.1
ACP76246.1
Q8NJZ0  
 endoglucanase (Cel12C)   Clonostachys rosea 1003 AAM77708.1
AAR63644.1
AAR67697.1
ABJ29228.1
ACP76247.1
Q8NJY9  
 endoglucanase (Cel12D)   Clonostachys rosea 1003 AAM77709.1
AAR63645.1
AAR67698.1
ABJ29229.1
ACP76248.1
Q8NJY8  
 endoglucanase 1B   Colletotrichum gloeosporioides AND80748.1    
 A9K55_002807   Cordyceps militaris ATCC 34164 ATY58637.1    
 orf   Diaphorina citri ABG82005.1
AXM42399.1
Q0PXV4  
 endoglucanase (Cel12A)   Emericella desertorum CBS 653.73 AAM77702.1
AAR63647.1
AAR67700.1
ABJ29231.1
ACP76250.1
Q8NJZ5  
 endoglucanase II (EG-II;Eg2;EG35) (Cel12) 3.2.1.4 Fomitopsis palustris FFPRI 0507 BAF49602.1 A4PID1  
 endoglucanase (Cel12A)   Fusarium equiseti CBS 185.34 AAM77703.1
AAR63639.1
AAR67692.1
ABJ29223.1
ACP76242.1
Q8NJZ4  
 CEK26_001879   Fusarium fujikuroi Augusto2 QGI90664.1    
 CEK26_007535   Fusarium fujikuroi Augusto2 QGI94466.1    
 CEK26_003521   Fusarium fujikuroi Augusto2 QGJ02077.1    
 CEK26_006835   Fusarium fujikuroi Augusto2 QGI93766.1    
 CEK27_003513   Fusarium fujikuroi CSV1 QGI71184.1    
 CEK27_006851   Fusarium fujikuroi CSV1 QGI62880.1    
 CEK27_007556   Fusarium fujikuroi CSV1 QGI63585.1    
 CEK27_001874   Fusarium fujikuroi CSV1 QGI59749.1    
 CEK25_007585   Fusarium fujikuroi I1.3 QGI80856.1    
 CEK25_006779 (fragment)   Fusarium fujikuroi I1.3 QGI80050.1    
 CEK25_001856   Fusarium fujikuroi I1.3 QGI76950.1    
 CEK25_003475   Fusarium fujikuroi I1.3 QGI88519.1    
 FFUJ_14533   Fusarium fujikuroi IMI 58289 CCT67597.1    
 FFUJ_00072   Fusarium fujikuroi IMI 58289 CCT63295.1    
 FFUJ_13006   Fusarium fujikuroi IMI 58289 CCT66840.1    
 FFUJ_11983   Fusarium fujikuroi IMI 58289 CCT75931.1    
 FGRAMCML3066_01t26003.1   Fusarium graminearum CZS73871.1    
 FGRAMCML3066_01t21163.1   Fusarium graminearum CZS85638.1    
 FGRAMCML3066_01t11967.1   Fusarium graminearum CZS81041.1    
 FGRAMCML3066_01t18999.1   Fusarium graminearum CZS84556.1    
 xyloglucanase (fg05851;FGSG_05851) (6993) 3.2.1.151 Fusarium graminearum PH-1 XP_386027.1    
 broad specificity endo-β-glucanase (fg11037;FGSG_11037) (7138)   Fusarium graminearum PH-1 XP_391213.1    
 broad specificity endo-β-glucanase (FGRAMPH1_01T25915; fg07892;FGSG_07892) (7048) 3.2.1.4 Fusarium graminearum PH-1 SCB65334.1
XP_388068.1
   
 broad specificity endo-β-glucanase (fgd146-200;FGSG_16349) (7213) 3.2.1.4 Fusarium graminearum PH-1 XP_383205.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF87069.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF87277.1    
 FGRAMPH1_01T11887   Fusarium graminearum PH-1 SCB65736.1    
 FOBC_00476   Fusarium oxysporum Fo47 QKD46501.1    
 FOBC_04281   Fusarium oxysporum Fo47 QKD50245.1    
 FOBC_03525   Fusarium oxysporum Fo47 QKD49498.1    
 FOBC_15570   Fusarium oxysporum Fo47 QKD61365.1    
 FOBC_17264   Fusarium oxysporum Fo47 QKD62991.1    
 endoglucanase (Cel12A)   Fusarium striatum CBS 203.32 AAM77704.1
AAR63640.1
AAR67693.1
ABJ29224.1
ACP76243.1
Q8NJZ3  
 endoglucanase (Cel12B)   Fusarium striatum CBS 203.32 AAM77705.1
AAR63641.1
AAR67694.1
ABJ29225.1
ACP76244.1
Q8NJZ2  
 FVRRES_12736   Fusarium venenatum A3/5 CEI40045.1    
 FVRRES_05936   Fusarium venenatum A3/5 CEI61500.1    
 FVRRES_09421   Fusarium venenatum A3/5 CEI69344.1    
 FVRRES_04132   Fusarium venenatum A3/5 CEI67620.1    
 FVRRES_10389   Fusarium venenatum A3/5 CEI70312.1    
 FVRRES_07901   Fusarium venenatum A3/5 CEI63465.1    
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