Glycoside Hydrolase Family 128

Activities in Familyβ-1,3-glucanase (EC 3.2.1.39); β-1,3-glucosidase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu
Catalytic Proton DonorGlu
NoteCreated following a paper by Sakamoto and colleagues (PMID:21965406); distantly related to clan GH-A; Mechanism, Fold and catalytic aminoacids have been determinated by Santos and al. (10.1038/s41589-020-0554-5)
Statistics GenBank accession (481); Uniprot accession (35); PDB accession (25); 3D entries (9); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 endo-β-1,3-glucanase (AmGH128_I;RAM_19160) 3.2.1.39 Amycolatopsis mediterranei S699 AEK42318.1
AFO77254.1
 
6UAQ[A] 1.15
6UAR[A] β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp
1.40
6UAS[A] β-D-Glcp
β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-α-D-Glcp
1.91
6UAT[A] β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp
1.90
6UAU[A] β-D-Glcp-(1-3)-β-D-Glcp
β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp
1.90
6UFL[A] β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp
1.61
6UFZ[A] 1.90
 endo-β-1,3-glucanase (PvGH128_II;CFBP1590__2373) 3.2.1.39 Pseudomonas viridiflava CFBP 1590 SMS09959.1  
6UAV[A] 1.50
6UAW[A] β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp
1.50
 endo-β-1,3-glucanase (ScGH128_II;sce3275) 3.2.1.39 Sorangium cellulosum So ce56 CAN93434.1 A9GMG4
6UAX[A,B] 1.30
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 AnGH128_VI (M436DRAFT_66913) 3.2.1.- Aureobasidium namibiae CBS 147.97 KEQ69643.1  
6UB8[A,B,C,D,E,F,G,H,I,J] 1.90
6UBA[A,B,C,D,E,F,G,H,I,J] β-D-Glcp-(1-3)-β-D-Glcp
β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp
2.40
6UBB[A,B,C,D,E,F,G,H,I,J] β-D-Glcp-(1-3)-β-D-Glcp
2.35
 BgGH128_III (BDBG_03339) 3.2.1.39
3.2.1.-
Blastomyces gilchristii SLH14081 OAT07255.1  
6UAY[A,B] 1.80
6UAZ[A,B] β-D-Glcp
1.85
6UB0[A] β-D-Glcp-(1-3)-α-D-Glcp
1.75
6UB1[A,B,C,D] β-D-Glcp
β-D-Glcp-(1-3)-β-D-Glcp
1.60
 CnGH128_VII (CNAG_04963)   Cryptococcus neoformans var. grubii H99 AFR94229.1
AGV14217.1
 
6UBC[A] 1.65
 CnGH128_V (CNAG_02661) 3.2.1.- Cryptococcus neoformans var. grubii H99 AFR94030.1  
6UB7[A] 1.80
 endo-β-1,3-glucanase (LeGH128_IV;GLU1) 3.2.1.39 Lentinula edodes H600 BAL27560.1  
6UB2[A,B,C,D] 1.80
6UB3[A,B] β-D-Glcp-(1-3)-β-D-Glcp
1.85
6UB4[A,B] β-D-Glcp-(1-3)-β-D-Glcp
β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp
1.60
6UB5[A] β-D-Glcp-(1-3)-β-D-Glcp
β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp
1.30
6UB6[A] β-D-Glcp-(1-3)-β-D-Glcp
β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp-(1-3)-β-D-Glcp
1.25
 TgGH128_VII (TGAMA5MH_01007)   Trichoderma gamsii A5MH PNP47955.1  
6UBD[A] 1.25
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