Glycoside Hydrolase Family 125

Activities in Familyexo-α-1,6-mannosidase (EC 3.2.1.-)
Mechanism inverting
ClanGH-G
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseGlu
Catalytic Proton DonorAsp
NoteCreated after Gregg, Zandberg, Hehemann, Whitworth, Deng, Vocadlo & Boraston (2011) J Biol Chem 286:15586-96 [PMID:21388958]
External resourcesCAZypedia;
Statistics GenBank accession (1089); Uniprot accession (23); PDB accession (11); 3D entries (6); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 BACOVA_03626   Bacteroides ovatus ATCC 8483 ZP_02066626.1  
3ON6[A,B] 1.70
 BACOVA_03347   Bacteroides ovatus ATCC 8483 ZP_02066351.1  
3P2C[A,B] 1.60
 exo-α-1,6-mannosidase (BT3781) 3.2.1.- Bacteroides thetaiotaomicron VPI-5482 AAO78886.1  
2P0V[A,B] 2.10
 CPF_0428   Clostridium perfringens ATCC 13124 ABG84485.1  
2NVP[A] 2.20
 exo-α-1,6-mannosidase (CpGH125;CPE0426) 3.2.1.- Clostridium perfringens str. 13 BAB80132.1  
3QT3[A] 2.35
3QT9[A] α-D-Manp-(1-6)-α-D-Manp6SH
2.05
5M7I[A] α-D-Manp-(1-6)-β-D-Manp
2.10
5M7Y[A] α-D-Manp-(1-6)-α-D-Manp-(1-6)-α-D-Manp
1.55
 exo-α-1,6-mannosidase (SpGH125;SP_2144) 3.2.1.- Streptococcus pneumoniae TIGR4 AAK76201.1  
3QPF[A,B] 2.15
3QRY[A,B] <carb_like_DMJ>
1.75
3QSP[A,B] α-D-Manp-(1-6)-β-D-Manp
2.10
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