Glycoside Hydrolase Family 125

Activities in Familyexo-α-1,6-mannosidase (EC 3.2.1.-)
Mechanism inverting
ClanGH-G
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseGlu
Catalytic Proton DonorAsp
NoteCreated after Gregg, Zandberg, Hehemann, Whitworth, Deng, Vocadlo & Boraston (2011) J Biol Chem 286:15586-96 [PMID:21388958]
External resourcesCAZypedia;
Statistics GenBank accession (1358); Uniprot accession (23); PDB accession (11); 3D entries (6); cryst (0)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 SDSE_1741   Streptococcus dysgalactiae subsp. equisimilis AC-2713 CCI63234.1    
 SDE12394_08300   Streptococcus dysgalactiae subsp. equisimilis ATCC 12394 ADX25100.1    
 SDEG_1590   Streptococcus dysgalactiae subsp. equisimilis GGS_124 BAH82084.1    
 NCTC5370_01560   Streptococcus dysgalactiae subsp. equisimilis NCTC5370 SQE86339.1    
 NCTC5371_01648   Streptococcus dysgalactiae subsp. equisimilis NCTC5371 SQF78802.1    
 NCTC6179_01663   Streptococcus dysgalactiae subsp. equisimilis NCTC6179 SQF67471.1    
 NCTC7136_00949   Streptococcus dysgalactiae subsp. equisimilis NCTC7136 SQG92757.1    
 NCTC9414_00717   Streptococcus dysgalactiae subsp. equisimilis NCTC9414 SQF68700.1    
 GGS_1457   Streptococcus dysgalactiae subsp. equisimilis RE378 BAM61592.1    
 SEQ_1695   Streptococcus equi subsp. equi 4047 CAW94749.1    
 SE071780_01726   Streptococcus equi subsp. equi ATCC 39506 ASB97313.1    
 SeseC_02034 (fragment)   Streptococcus equi subsp. zooepidemicus ATCC 35246 AEJ25855.1    
 Q426_01275   Streptococcus equi subsp. zooepidemicus CY AIA67199.1    
 Sez_1509   Streptococcus equi subsp. zooepidemicus MGCS10565 ACG62842.1    
 NCTC11606_01502   Streptococcus equi subsp. zooepidemicus NCTC11606 SQF54508.1    
 NCTC11824_01518   Streptococcus equi subsp. zooepidemicus NCTC11824 SQG17700.1    
 NCTC12090_01601   Streptococcus equi subsp. zooepidemicus NCTC12090 SQF06105.1    
 NCTC6176_01547   Streptococcus equi subsp. zooepidemicus NCTC6176 SQF82164.1    
 NCTC7022_01663   Streptococcus equi subsp. zooepidemicus NCTC7022 SQE96525.1    
 A6J85_05660   Streptococcus gordonii FDAARGOS_257 ARC46907.1    
 CO687_04900   Streptococcus gordonii FDAARGOS_371 ATF64828.1    
 WH25_09560   Streptococcus gordonii IE35 AOS72120.1    
 RN86_04965   Streptococcus gordonii KCOM 1506 (= ChDC B679) ALD71786.1    
 NCTC3165_01752   Streptococcus gordonii NCTC3165 SQG04764.1    
 NCTC7865_00770   Streptococcus gordonii NCTC7865 SQF27798.1    
 SGO_1769   Streptococcus gordonii str. Challis substr. CH1 ABV10762.1    
 BMF34_01740   Streptococcus iniae 89353 APD31250.1    
 CTW00_00919   Streptococcus iniae FP5228 ATX39119.1    
 DQ08_01560   Streptococcus iniae ISET0901 AHY15195.1    
 DW64_01545   Streptococcus iniae ISNO AHY17063.1    
 QMA0248_0333   Streptococcus iniae QMA0248 ASL34172.1    
 K710_0325   Streptococcus iniae SF1 AGM98127.1    
 SI82_01845   Streptococcus iniae YSFST01-82 AJG25378.1    
 SIR_1070   Streptococcus intermedius B196 AGU76431.1    
 SII_1091   Streptococcus intermedius C270 AGU78266.1    
 A6J72_02055   Streptococcus intermedius FDAARGOS_233 ARC26114.1    
 SCIM_0567   Streptococcus intermedius JTH08 BAM23221.1    
 RN88_04980   Streptococcus intermedius KCOM 1545 ALF27879.1    
 NCTC11324_00669   Streptococcus intermedius NCTC11324 SQH51652.1    
 SITYG_07060   Streptococcus intermedius TYG1620 BAW16691.1    
 smi_1999   Streptococcus mitis B6 CBJ23235.1    
 RN80_02430   Streptococcus mitis KCOM 1350 (= ChDC B183) ALD67338.1    
 AXK38_09685   Streptococcus mitis SVGS_061 AMH89502.1    
 HMPREF8579_0296   Streptococcus oralis ATCC 35037 EFE57714.1    
 HMPREF8578_0519   Streptococcus oralis ATCC 49296 ZP_07887139.1    
 CO686_08745   Streptococcus oralis FDAARGOS_367 ATF57523.1    
 BWR56_0092   Streptococcus oralis S.MIT/ORALIS-351 AQA07348.1    
 STO1_000960   Streptococcus oralis subsp. tigurinus osk_001 BBA07700.1    
 SOR_1903   Streptococcus oralis Uo5 CBZ01550.1    
 HMPREF0833_11627   Streptococcus parasanguinis ATCC 15912 AEH56658.1 D5S9S2  
 Spaf_0256   Streptococcus parasanguinis FW213 AFJ25279.1    
 STP_1216   Streptococcus parauberis KCTC 11537 AEF25664.1    
 SGPB_1530 (YpdC)   Streptococcus pasteurianus ATCC 43144 BAK30558.1    
 NCTC13784_01744   Streptococcus pasteurianus NCTC13784 SQI09161.1    
 BUM80_08505   Streptococcus pneumoniae 11A AUC46353.1    
 CWI64_06420   Streptococcus pneumoniae 19F AUB33265.1    
 C4N11_11360   Streptococcus pneumoniae 335 AVD76019.1    
 SP670_2290   Streptococcus pneumoniae 670-6B ADM92340.1    
 SP70585_2272   Streptococcus pneumoniae 70585 ACO16562.1    
 T308_10275   Streptococcus pneumoniae A026 AGZ48634.1    
 A66_01951   Streptococcus pneumoniae A66 CRI62662.1    
 SPAP_2194   Streptococcus pneumoniae AP200 ADM85725.1    
 SPN23F_21770   Streptococcus pneumoniae ATCC 700669 YP_002512007.1 B8ZPY4  
 CGSSpBS455_10485   Streptococcus pneumoniae BS455 ZP_07341947.1 E1H4H6  
 SP28804_2009   Streptococcus pneumoniae CDC0288-04 ZP_02715818.1 B2DUL0  
 SP108700_2144   Streptococcus pneumoniae CDC1087-00 ZP_02710758.1 B2DHT3  
 SPCG_2114   Streptococcus pneumoniae CGSP14 YP_001836831.1 B2ING5  
 DA395_10915   Streptococcus pneumoniae CP2215 AVV92256.1    
 SPND122_02080   Streptococcus pneumoniae D122 AOG56925.1    
 SPND141_02093   Streptococcus pneumoniae D141 AOG59111.1    
 SPND219_02184   Streptococcus pneumoniae D219 ANO37920.1    
 SPD_1972   Streptococcus pneumoniae D39 ABJ55325.1
YP_817360.1
Q04I28  
 SPV_1972   Streptococcus pneumoniae D39V AVN86976.1    
 YP_002038734.1   Streptococcus pneumoniae G54 YP_002038734.1 B5E3F3  
 HMPREF1038_02155   Streptococcus pneumoniae gamPNI0373 AFS44119.1    
 SPNHU15_02176   Streptococcus pneumoniae Hu15 ARD37920.1    
 SPNHU17_02202   Streptococcus pneumoniae Hu17 ARD35727.1    
 SPH_2337   Streptococcus pneumoniae Hungary19A-6 YP_001695502.1 B1I9V7  
 INV104_18510   Streptococcus pneumoniae INV104 CBW37532.1 E1XNG6  
 SPNINV200_19560   Streptococcus pneumoniae INV200 CBW35589.1    
 SPJ_2170   Streptococcus pneumoniae JJA ACO18135.1    
 KK0381_16180   Streptococcus pneumoniae KK0381 BAX31747.1    
 KK0981_41650   Streptococcus pneumoniae KK0981 BAW85600.1    
 KK1157_16700   Streptococcus pneumoniae KK1157 BAX33989.1    
 MDRSPN_01956   Streptococcus pneumoniae MDRSPN001 BBA60100.1    
 NCTC11902_02067   Streptococcus pneumoniae NCTC11902 SQG99617.1    
 NCTC13276_01998   Streptococcus pneumoniae NCTC13276 SQG35190.1    
 ERS445053_00621   Streptococcus pneumoniae NCTC7465 COT09794.1    
 NCTC7466_02006   Streptococcus pneumoniae NCTC7466 SQG02975.1    
 SpnNT_02231 (fragment)   Streptococcus pneumoniae NT_110_58 AJD73110.1    
 SpnNT_02232 (fragment)   Streptococcus pneumoniae NT_110_58 AJD73111.1    
 SpnNT_02233 (fragment)   Streptococcus pneumoniae NT_110_58 AJD73112.1    
 SPNOXC_18910   Streptococcus pneumoniae OXC141 CBW33543.1    
 SPP_2195   Streptococcus pneumoniae P1031 ACO20374.1    
 spr1952   Streptococcus pneumoniae R6 NP_359543.1 Q8DN33  
 CGSSp11BS70_05635   Streptococcus pneumoniae SP11-BS70 ZP_01825569.1 A5M1X0  
 CGSSp14BS69_00650   Streptococcus pneumoniae SP14-BS69 ZP_01827900.1 A5M8K1  
 CGSSp19BS75_03083   Streptococcus pneumoniae SP19-BS75 ZP_01833155.1 A5MNK6  
 CGSSp3BS71_10313   Streptococcus pneumoniae SP3-BS71 ZP_01817728.1 A5LBN2  
 BMJ42_02221   Streptococcus pneumoniae SP49 APJ31443.1    
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