Glycoside Hydrolase Family 125

Activities in Familyexo-α-1,6-mannosidase (EC 3.2.1.-)
Mechanism inverting
ClanGH-G
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseGlu
Catalytic Proton DonorAsp
NoteCreated after Gregg, Zandberg, Hehemann, Whitworth, Deng, Vocadlo & Boraston (2011) J Biol Chem 286:15586-96 [PMID:21388958]
External resourcesCAZypedia;
Statistics GenBank accession (1077); Uniprot accession (23); PDB accession (11); 3D entries (6); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 HMPREF8578_0519   Streptococcus oralis ATCC 49296 ZP_07887139.1    
 CO686_08745   Streptococcus oralis FDAARGOS_367 ATF57523.1    
 BWR56_0092   Streptococcus oralis S.MIT/ORALIS-351 AQA07348.1    
 STO1_000960   Streptococcus oralis subsp. tigurinus osk_001 BBA07700.1    
 SOR_1903   Streptococcus oralis Uo5 CBZ01550.1    
 HMPREF0833_11627   Streptococcus parasanguinis ATCC 15912 AEH56658.1 D5S9S2  
 Spaf_0256   Streptococcus parasanguinis FW213 AFJ25279.1    
 STP_1216   Streptococcus parauberis KCTC 11537 AEF25664.1    
 SGPB_1530 (YpdC)   Streptococcus pasteurianus ATCC 43144 BAK30558.1    
 SP670_2290   Streptococcus pneumoniae 670-6B ADM92340.1    
 SP70585_2272   Streptococcus pneumoniae 70585 ACO16562.1    
 T308_10275   Streptococcus pneumoniae A026 AGZ48634.1    
 A66_01951   Streptococcus pneumoniae A66 CRI62662.1    
 SPAP_2194   Streptococcus pneumoniae AP200 ADM85725.1    
 SPN23F_21770   Streptococcus pneumoniae ATCC 700669 YP_002512007.1 B8ZPY4  
 CGSSpBS455_10485   Streptococcus pneumoniae BS455 ZP_07341947.1 E1H4H6  
 SP28804_2009   Streptococcus pneumoniae CDC0288-04 ZP_02715818.1 B2DUL0  
 SP108700_2144   Streptococcus pneumoniae CDC1087-00 ZP_02710758.1 B2DHT3  
 SPCG_2114   Streptococcus pneumoniae CGSP14 YP_001836831.1 B2ING5  
 SPND122_02080   Streptococcus pneumoniae D122 AOG56925.1    
 SPND141_02093   Streptococcus pneumoniae D141 AOG59111.1    
 SPND219_02184   Streptococcus pneumoniae D219 ANO37920.1    
 SPD_1972   Streptococcus pneumoniae D39 ABJ55325.1
YP_817360.1
Q04I28  
 YP_002038734.1   Streptococcus pneumoniae G54 YP_002038734.1 B5E3F3  
 HMPREF1038_02155   Streptococcus pneumoniae gamPNI0373 AFS44119.1    
 SPNHU15_02176   Streptococcus pneumoniae Hu15 ARD37920.1    
 SPNHU17_02202   Streptococcus pneumoniae Hu17 ARD35727.1    
 SPH_2337   Streptococcus pneumoniae Hungary19A-6 YP_001695502.1 B1I9V7  
 INV104_18510   Streptococcus pneumoniae INV104 CBW37532.1 E1XNG6  
 SPNINV200_19560   Streptococcus pneumoniae INV200 CBW35589.1    
 SPJ_2170   Streptococcus pneumoniae JJA ACO18135.1    
 KK0381_16180   Streptococcus pneumoniae KK0381 BAX31747.1    
 KK0981_41650   Streptococcus pneumoniae KK0981 BAW85600.1    
 KK1157_16700   Streptococcus pneumoniae KK1157 BAX33989.1    
 ERS445053_00621   Streptococcus pneumoniae NCTC7465 COT09794.1    
 SpnNT_02231 (fragment)   Streptococcus pneumoniae NT_110_58 AJD73110.1    
 SpnNT_02232 (fragment)   Streptococcus pneumoniae NT_110_58 AJD73111.1    
 SpnNT_02233 (fragment)   Streptococcus pneumoniae NT_110_58 AJD73112.1    
 SPNOXC_18910   Streptococcus pneumoniae OXC141 CBW33543.1    
 SPP_2195   Streptococcus pneumoniae P1031 ACO20374.1    
 spr1952   Streptococcus pneumoniae R6 NP_359543.1 Q8DN33  
 CGSSp11BS70_05635   Streptococcus pneumoniae SP11-BS70 ZP_01825569.1 A5M1X0  
 CGSSp14BS69_00650   Streptococcus pneumoniae SP14-BS69 ZP_01827900.1 A5M8K1  
 CGSSp19BS75_03083   Streptococcus pneumoniae SP19-BS75 ZP_01833155.1 A5MNK6  
 CGSSp3BS71_10313   Streptococcus pneumoniae SP3-BS71 ZP_01817728.1 A5LBN2  
 BMJ42_02221   Streptococcus pneumoniae SP49 APJ31443.1    
 BOC71_02036   Streptococcus pneumoniae SP61 APJ33463.1    
 BOC72_02038   Streptococcus pneumoniae SP64 APJ35488.1    
 CGSSp9BS68_10975   Streptococcus pneumoniae SP9-BS68 ZP_01821778.1 A5LR29  
 SPN034156_09720   Streptococcus pneumoniae SPN034156 SNP034156 CCP36641.1    
 SPN034183_18950   Streptococcus pneumoniae SPN034183 SNP034183 CCP33605.1    
 SPN994038_18840   Streptococcus pneumoniae SPN994038 SNP994038 CCP31620.1    
 SPN994039_18850   Streptococcus pneumoniae SPN994039 SNP994039 CCP35579.1    
 SPNA45_00065   Streptococcus pneumoniae SPNA45 CCM07355.1    
 MYY_2064   Streptococcus pneumoniae ST556 AFC95716.1    
 SPT_2157   Streptococcus pneumoniae Taiwan19F-14 ACO23347.1    
 HMPREF0837_10146   Streptococcus pneumoniae TCH8431/19A ADI68374.1    
 exo-α-1,6-mannosidase (SpGH125;SP_2144) 3.2.1.- Streptococcus pneumoniae TIGR4 AAK76201.1   3QPF[A,B]
3QRY[A,B]
3QSP[A,B]
 SPPN_11010   Streptococcus pseudopneumoniae IS7493 AEL11606.1    
 STAB904_07040   Streptococcus pyogenes 1E1 AIW12142.1    
 SP5448_03005   Streptococcus pyogenes 5448 AKK70037.1    
 STAB1101_05810   Streptococcus pyogenes 7F7 AIT77820.1    
 A20_1350   Streptococcus pyogenes A20 AFV38430.1    
 SPYALAB49_001294   Streptococcus pyogenes Alab49 AEQ24887.1    
 SPAP1_02915   Streptococcus pyogenes AP1 AKG27573.1    
 AUQ45_1303 (Hypo17)   Streptococcus pyogenes AP53 AMY97857.1    
 DP15_384   Streptococcus pyogenes ATCC 19615 AIL11893.1    
 SpyM6D471_06020   Streptococcus pyogenes D471 AKI78168.1    
 AL510_06470   Streptococcus pyogenes FDAARGOS_149 AMH03487.1    
 B2G65_03305   Streptococcus pyogenes GUR ASO73772.1    
 CFA72_03305   Streptococcus pyogenes GURSA1 ASO68056.1    
 SPYH293_01195   Streptococcus pyogenes H293 CDJ55443.1    
 HKU360_01355   Streptococcus pyogenes HKU360 AIW25158.1    
 HKU488_01254   Streptococcus pyogenes HKU488 AKP82183.1    
 L897_06545   Streptococcus pyogenes HSC5 AGQ27955.1    
 JMUB1235_1226   Streptococcus pyogenes JMUB1235 BAV55480.1    
 SPYJRS4_1262   Streptococcus pyogenes JRS4 BAR44762.1
AKI76497.1
   
 M1GAS476_1383   Streptococcus pyogenes M1 476 BAM30712.2    
 SPy_1603   Streptococcus pyogenes M1 GAS AAK34380.1    
 FE90_1015   Streptococcus pyogenes M23ND AIQ01778.1    
 ABO05_02680   Streptococcus pyogenes M28PF1 AKJ92193.1    
 M3B_0650   Streptococcus pyogenes M3-b BAU60020.1    
 AWM59_02720   Streptococcus pyogenes MEW123 AMA70171.1    
 AWM58_06375   Streptococcus pyogenes MEW427 AMA69269.1    
 MGAS10270_Spy1432   Streptococcus pyogenes MGAS10270 ABF34497.1    
 M6_Spy1334   Streptococcus pyogenes MGAS10394 AAT87469.1    
 MGAS10750_Spy1425 (fragment)   Streptococcus pyogenes MGAS10750 ABF38375.1    
 MGAS11027_1271   Streptococcus pyogenes MGAS11027 ANC24261.1    
 MGAS15252_1201   Streptococcus pyogenes MGAS15252 AFC66537.1    
 MGAS1882_1262   Streptococcus pyogenes MGAS1882 AFC68467.1    
 MGAS2096_Spy1337   Streptococcus pyogenes MGAS2096 ABF36389.1    
 MGAS23530_1180   Streptococcus pyogenes MGAS23530 ANC25856.1    
 MGAS27061_1216   Streptococcus pyogenes MGAS27061 ANC27485.1    
 SpyM3_1296 (fragment)   Streptococcus pyogenes MGAS315 AAM79903.1    
 M5005_Spy1316   Streptococcus pyogenes MGAS5005 AAZ51934.1    
 M28_Spy1357   Streptococcus pyogenes MGAS6180 AAX72467.1    
 spyM18_1610   Streptococcus pyogenes MGAS8232 AAL98165.1    
 MGAS9429_Spy1310   Streptococcus pyogenes MGAS9429 ABF32497.1    
 MTB313_1333   Streptococcus pyogenes MTB313 BAQ51740.1    
 MTB314_1252   Streptococcus pyogenes MTB314 BAQ53415.1    
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