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Glycoside Hydrolase Family 116

Activities in Familyβ-D-arabinofuranosidase (EC 3.2.1.-);
β-glucosidase (EC 3.2.1.21);
Xylan β-1,4-xylosidase (EC 3.2.1.37);
β-glucosylceramidase (EC 3.2.1.45);
β-N-acetylhexosaminidase (EC 3.2.1.52);
Mechanism Retaining e
ClanGH-O
3D Structure Status( α / α ) 6 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorAsp (experimental)
NoteSubfamilies described in Ferrara et al. (2013) BBA 1840:367-377 (PMID:24060745)
External resourcesCAZypedia;
Statistics GenBank accession (1310); Uniprot accession (10); PDB accession (33); 3D entries (2); cryst (0)
Summary
Download GH116 (1227) Taxonomic display Structure (2) Characterized (6)
| 1 | 2 | 3 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Dmel_CG33090 (CG33090)   Drosophila melanogaster AAO41192.2
AAL13692.1
ABC86280.1
ACH92150.1
ADC53514.1
AHN54440.1
AHN54441.1
AHN54442.1
NP_788055.2		    
 467817   Emiliania huxleyi (Emihu1)      
 M5689_000980   Euphorbia peplus WCJ18646.1    
 M5689_000982   Euphorbia peplus WCJ18648.1    
 M5689_016121   Euphorbia peplus WCJ34837.1    
 M5689_012328 (fragment)   Euphorbia peplus WCJ30796.1    
 M5689_006213   Euphorbia peplus WCJ24239.1    
 249567   Fragilariopsis cylindrus CCMP 1102 (Fracy1)      
 FPE_LOCUS9065 (fragment)   Fraxinus pennsylvanica CAI9761635.1    
 FPE_LOCUS9063 (fragment)   Fraxinus pennsylvanica CAI9761633.1    
 FPE_LOCUS25682   Fraxinus pennsylvanica CAI9778252.1    
 FPE_LOCUS17789   Fraxinus pennsylvanica CAI9770156.1    
 145081   Guillardia theta CCMP2712 (Guith1)      
 177051   Helobdella robusta (Helro1)      
 HERILL_LOCUS9170   Hermetia illucens CAD7086391.1    
 HERILL_LOCUS9170   Hermetia illucens CAD7086392.1    
 HAMR1_LOCUS6796   Heterobilharzia americana CAH8559416.1    
 HAMR2_LOCUS6170   Heterobilharzia americana CAH8588056.1    
 acid β-glucosidase 2 / β-glucosylceramidase 2 (Gba2) (ER;non-lysosomal;bile) 3.2.1.21
3.2.1.45		 Homo sapiens NP_065995.1
AAG44660.1
AAH11363.1
BAB13431.1
BAB55430.1
BAG59862.1
BAH12232.1
CAC83792.1
CAD38976.1
CAI10981.1
CAI10982.1
CAI10983.1
EAW58346.1
EAW58347.1
EAW58348.1
EAW58349.1		 B4DMF0
B7Z3J6
D3DRP2
Q5TCV6
Q9HCG7		  
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAJ97391.1    
 5992   Hyphochytrium catenoides ATCC 18719 (Hypcat1)      
 11536   Hyphochytrium catenoides ATCC 18719 (Hypcat1)      
 ORF (Gba2)   Ictalurus punctatus AHH37418.1    
 IPOD504_ LOCUS 17355   Iphiclides podalirius CAH2076649.1    
 LSAL_LOCUS11675   Lactuca saligna CAB4083311.1    
 LSAL_LOCUS33200   Lactuca saligna CAB4106120.1    
 LSAL_LOCUS966   Lactuca saligna CAB4072022.1    
 LSAL_LOCUS1751   Lactuca saligna CAB4072841.1    
 LATHSAT_LOCUS17824   Lathyrus sativus CAK8564525.1    
 LATHSAT_LOCUS24577   Lathyrus sativus CAK8571965.1    
 LATHSAT_LOCUS24577   Lathyrus sativus CAK8571966.1    
 LSAA_12762 (fragment)   Lepeophtheirus salmonis IoA-00 CAF3001293.1
CAB4068086.1		    
 LSINAPIS_LOCUS7274 (fragment)   Leptidea sinapis VUY95629.1    
 LSINAPIS_LOCUS7275 (fragment)   Leptidea sinapis VUY95630.1    
 ORF (fragment)   Lolium perenne AFA26156.1    
 non-lysosomal glucosylceramidase (Gba2)   Macaca mulatta AFE66625.1
AFI35128.1		    
 Mp_4g03610 (fragment)   Marchantia polymorpha subsp. ruderalis Tak-1 BBN07406.1    
 MPTK1_4g03610 (fragment)   Marchantia polymorpha subsp. ruderalis Takaragaike-1 BFI11965.1    
 MPTK1_4g03610   Marchantia polymorpha subsp. ruderalis Takaragaike-1 BFI11966.1    
 MPTK2_4g03610   Marchantia polymorpha subsp. ruderalis Takaragaike-2 BFI32194.1    
 MPTK2_4g03610 (fragment)   Marchantia polymorpha subsp. ruderalis Takaragaike-2 BFI32193.1    
 1629   Micromonas commoda NOUM17 (RCC 299) (MicpuN3v2)      
 MICPUN_55788   Micromonas commoda sp. RCC299 ACO61507.1    
 MICPUCDRAFT_48400   Micromonas pusilla CCMP1545 EEH53657.1    
 1712   Micromonas pusilla CCMP1545 (MicpuC3v2)      
 5536   Mortierella sp. AD094 (MospAD094_1)      
 acid β-glucosidase 2 / glucosylceramidase 2 (Gba2;Kiaa1605) (non-lysosomal;cytosolic;bile) 3.2.1.45 Mus musculus CAM17042.1
AAH56935.1
BAC40785.1
BAD32491.1
CAM17043.1
NP_766280.1		 Q69ZF3
Q6PGM3		  
 mCG_19285 (Gba2) (fragment)   Mus musculus mixed EDL02463.1    
 mCG_19285 (Gba2)   Mus musculus mixed EDL02461.1    
 mCG_19285 (Gba2) (fragment)   Mus musculus mixed EDL02462.1    
 GSMUA_226230.1   Musa acuminata subsp. malaccensis Doubled-haploid Pahang (DH-Pahang) CAG1834518.1    
 GSMUA_165730.1   Musa acuminata subsp. malaccensis Doubled-haploid Pahang (DH-Pahang) CAG1846778.1    
 GSMUA_176840.1   Musa acuminata subsp. malaccensis Doubled-haploid Pahang (DH-Pahang) CAG1847889.1    
 GSMUA_142680.1   Musa acuminata subsp. malaccensis Doubled-haploid Pahang (DH-Pahang) CAG1844473.1    
 GSMUA_139080.1   Musa acuminata subsp. malaccensis Doubled-haploid Pahang (DH-Pahang) CAG1844113.1    
 ORF (fragment)   Musca domestica ALHF AFP63561.1    
 glucosidase, beta 2, partial (fragment)   Mustela putorius furo AER98955.1    
 β-glucosidase 2, partial (fragment)   Mustela putorius furo AER98954.1    
 β-glucosidase 2, partial (fragment)   Mustela putorius furo AER98956.1    
 MAR_025136   Mya arenaria isolate MELC-2E11 WAR00764.1    
 66851   Naegleria gruberi (Naegr1)      
 4335   Nannochloropsis gaditana B-31 (Nangad1)      
 NTJ_03480   Nesidiocoris tenuis Japan BES90672.1    
 ORF (fragment)   Neslia paniculata ADG37976.1    
 ORF (fragment)   Neslia paniculata ADG38508.1    
 NEZAVI_ LOCUS 4776 (fragment)   Nezara viridula CAH1394245.1    
 Q1695_002058   Nippostrongylus brasiliensis MIMR WKY09391.1    
 NMOB1V02_LOCUS9003   Notodromas monacha CAD7281356.1    
 NMOB1V02_LOCUS11456 (fragment)   Notodromas monacha CAD7283846.1    
 OCTVUL_1B016718   Octopus vulgaris CAI9730886.1    
 OLC1_LOCUS11095   Oldenlandia corymbosa var. corymbosa CAI9101520.1    
 OLC1_LOCUS23800 (fragment)   Oldenlandia corymbosa var. corymbosa CAI9117798.1    
 OLC1_LOCUS23800 (fragment)   Oldenlandia corymbosa var. corymbosa CAI9117799.1    
 OsI_25831   Oryza sativa Indica Group EEC81952.1    
 OsI_34005   Oryza sativa Indica Group EEC67156.1    
 OsI_024930 (fragments)   Oryza sativa Indica Group EAZ03698.1    
 OsI_032861   Oryza sativa Indica Group EAY78902.1    
 OsI_034437   Oryza sativa Indica Group EAY80478.1    
 OsI_026592 (fragment)   Oryza sativa Indica Group EAZ05360.1    
 Os08g0111200   Oryza sativa Japonica Group BAF22739.1
BAD09496.1
BAD09542.1
BAG92914.1
BAT03507.1
BAT03508.1
EAZ41282.1
NP_001060825.1		    
 Os07g0444000 (fragment)   Oryza sativa Japonica Group BAF21443.1
NP_001059529.1		    
 Os10g0473400   Oryza sativa Japonica Group AAP54244.2
AAG16864.1
AAL31035.1
BAF26747.1
BAG90602.1
BAT11271.1
BAT11272.1
EAZ16400.1
EEE51125.1
NP_001064833.1		    
 Os11g0242100   Oryza sativa Japonica Group BAF27951.1
AAX95400.1
ABA92328.1
BAG93831.1
BAT13385.1
EAZ17950.1
NP_001067588.1		    
 OsJ_023125 (fragments)   Oryza sativa Japonica Group EEE67087.1
BAT01281.1
EAZ39642.1		    
 Gba2   Pan troglodytes XP_001167923.1
BAK63646.1
XP_520565.1		    
 U9M48_004291 (fragment)   Paspalum notatum var. saurae isolate R1 WVZ53328.1    
 U9M48_009440   Paspalum notatum var. saurae isolate R1 WVZ59272.1    
 U9M48_012622   Paspalum notatum var. saurae isolate R1 WVZ62932.1    
 U9M48_004301   Paspalum notatum var. saurae isolate R1 WVZ53341.1    
 U9M48_041237   Paspalum notatum var. saurae isolate R1 WVZ95477.1    
 U9M48_041237   Paspalum notatum var. saurae isolate R1 WVZ95476.1    
 PECUL_23A034645   Pelobates cultripes CAH2297430.1    
 PECUL_23A034645   Pelobates cultripes CAH2297431.1    
 PHAECO_ LOCUS 8379   Phaedon cochleariae CAG9821274.1    
 non-lysosomal glucosylceramidase (Gba2)   Phallusia mammillata CAB3248405.1    
 ORF (fragment)   Phaseolus vulgaris AGV54567.1    
 PHYEVI_ LOCUS 735   Phyllotreta striolata CAG9854271.1    
 PHYPADRAFT_122471   Physcomitrella patens subsp. patens EDQ75122.1    
 PHYPADRAFT_189506   Physcomitrella patens subsp. patens EDQ64036.1    
 MPIPNATIZW_LOCUS2144   Pipistrellus nathusii CAK6433838.1    
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