Glycoside Hydrolase Family 116

Activities in Familyβ-glucosidase (EC 3.2.1.21); β-xylosidase (EC 3.2.1.37); acid β-glucosidase/β-glucosylceramidase (EC 3.2.1.45); β-N-acetylglucosaminidase (EC 3.2.1.52)
Mechanism Retaining
ClanGH-O
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorAsp (experimental)
NoteSubfamilies described in Ferrara et al. (2013) BBA 1840:367-377 (PMID:24060745)
External resourcesCAZypedia;
Statistics GenBank accession (488); Uniprot accession (131); PDB accession (9); 3D entries (1); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 AaeL_AAEL001478   Aedes aegypti LIVERPOOL EAT47379.1 Q17L47  
 At3g24180   Arabidopsis thaliana BAE99039.1
AAL38843.1
AEE76868.1
AEE76869.1
BAB01359.1
NP_001030757.1
NP_189060.2
Q8VZ08  
 At5g49900   Arabidopsis thaliana AAQ65174.1
AAO00842.1
AED95869.1
ANM69564.1
ANM69565.1
BAA97011.1
BAE99037.1
BAH19567.1
NP_199801.2
Q8GUI9  
 At4g10060/T5L19.190   Arabidopsis thaliana NP_192744.3
AAN46866.1
AEE82834.1
ANM67377.1
CAB39630.1
CAB78129.1
F4JLJ2  
 At1g33700   Arabidopsis thaliana NP_174631.2
AAF97289.1
AAO42222.1
AEE31614.1
AEE31615.1
ANM58169.1
ANM58170.1
NP_001031135.1
F4HR96  
 ORF   Ascaris suum ADY40283.1    
 ORF (fragment)   Ascaris suum ADY41606.1    
 ORF (fragment)   Ascaris suum ADY41918.1    
 CBG08749   Caenorhabditis briggsae CAE64133.1 A8X7A9  
 CBG10433   Caenorhabditis briggsae CAE65467.1    
 Y105E8A.10a / Y105E8A.10b / Y105E8A.10c   Caenorhabditis elegans Bristol N2 CAD21661.1
CAC48128.1
CAH04764.1
NP_001021680.1
NP_001021681.1
NP_001021682.1
Q8WQB2  
 R08F11.1 (frameshift)   Caenorhabditis elegans Bristol N2 AAB54243.1
CCD72306.1
CCD72306.2
NP_504047.1
O01893  
 ORF   Callorhinchus milii AFO96150.1    
 ORF (fragment)   Capsella grandiflora ADG37970.1 D6PNN8  
 ORF (fragment)   Capsella grandiflora ADG37971.1 D6PNN9  
 ORF (fragment)   Capsella grandiflora ADG37974.1 D6PNP2  
 ORF (fragment)   Capsella grandiflora ADG38504.1 D6PQ72  
 ORF (fragment)   Capsella grandiflora AEN83322.1    
 ORF (fragment)   Capsella rubella AEN81036.1    
 ORF (fragment)   Capsella rubella AEN81041.1    
 ORF (fragment)   Capsella rubella AEN82035.1    
 ORF (fragment)   Capsella rubella AEN83325.1    
 LOC100187229   Ciona intestinalis XP_002127036.1    
 bile acid β-glucosidase (fragment)   Ctenopharyngodon idella ACF57667.1 B5AFK6  
 ORF (fragment)   Dendrobium nobile ADC68237.1 D3Y115  
 DDB_G0292446   Dictyostelium discoideum AX4 EAL61202.1    
 Dbus_chr2Lg2029   Drosophila busckii ALC39944.1    
 Dmel_CG33090 (CG33090)   Drosophila melanogaster AAO41192.2
AAL13692.1
ABC86280.1
ACH92150.1
ADC53514.1
AHN54440.1
AHN54441.1
AHN54442.1
NP_788055.2
B5RIG1
Q7KT91
 
 acid β-glucosidase 2 / β-glucosylceramidase 2 (Gba2) (ER;non-lysosomal;bile) 3.2.1.45 Homo sapiens NP_065995.1
AAG44660.1
AAH11363.1
BAB13431.1
BAB55430.1
BAG59862.1
BAH12232.1
CAC83792.1
CAD38976.1
CAI10981.1
CAI10982.1
CAI10983.1
EAW58346.1
EAW58347.1
EAW58348.1
EAW58349.1
D3DRP2
Q5TCV6
Q9HCG7
 
 predicted protein (fragment)   Hordeum vulgare subsp. vulgare BAJ97391.1    
 ORF (Gba2)   Ictalurus punctatus AHH37418.1    
 ORF (fragment)   Lolium perenne AFA26156.1    
 non-lysosomal glucosylceramidase (Gba2)   Macaca mulatta AFE66625.1
AFI35128.1
   
 MICPUN_55788   Micromonas commoda sp. RCC299 ACO61507.1 C1DYY0  
 MICPUCDRAFT_48400   Micromonas pusilla CCMP1545 EEH53657.1 C1N2V6  
 acid β-glucosidase 2 / glucosylceramidase 2 (Gba2;Kiaa1605) (non-lysosomal;cytosolic;bile) 3.2.1.45 Mus musculus CAM17042.1
AAH56935.1
BAC40785.1
BAD32491.1
CAM17043.1
NP_766280.1
Q69ZF3
Q6PGM3
 
 mCG_19285 (Gba2) (fragment)   Mus musculus mixed EDL02463.1    
 mCG_19285 (Gba2)   Mus musculus mixed EDL02461.1    
 mCG_19285 (Gba2) (fragment)   Mus musculus mixed EDL02462.1    
 ORF (fragment)   Musca domestica ALHF AFP63561.1    
 glucosidase, beta 2, partial (fragment)   Mustela putorius furo AER98955.1    
 β-glucosidase 2, partial (fragment)   Mustela putorius furo AER98954.1    
 β-glucosidase 2, partial (fragment)   Mustela putorius furo AER98956.1    
 ORF (fragment)   Neslia paniculata ADG37976.1 D6PNP4  
 ORF (fragment)   Neslia paniculata ADG38508.1 D6PQ76  
 OsI_25831   Oryza sativa Indica Group EEC81952.1 B8B5P4  
 OsI_34005   Oryza sativa Indica Group EEC67156.1 B8BHF7  
 OsI_024930 (fragments)   Oryza sativa Indica Group EAZ03698.1    
 OsI_032861   Oryza sativa Indica Group EAY78902.1    
 OsI_034437   Oryza sativa Indica Group EAY80478.1    
 OsI_026592 (fragment)   Oryza sativa Indica Group EAZ05360.1    
 OsJ_24071   Oryza sativa Japonica Group EEE67087.1
BAT01281.1
B9FX00  
 OsJ_31868   Oryza sativa Japonica Group EEE51125.1 B9G678  
 Os08g0111200   Oryza sativa Japonica Group BAF22739.1
BAD09496.1
BAD09542.1
BAG92914.1
BAT03507.1
BAT03508.1
EAZ41282.1
NP_001060825.1
Q6ZC53  
 Os07g0444000 (fragment)   Oryza sativa Japonica Group BAF21443.1
NP_001059529.1
Q0D6T0  
 Os10g0473400   Oryza sativa Japonica Group BAF26747.1
AAG16864.1
AAL31035.1
AAP54244.2
BAG90602.1
BAT11271.1
BAT11272.1
EAZ16400.1
NP_001064833.1
Q7XDG7  
 Os11g0242100   Oryza sativa Japonica Group BAF27951.1
AAX95400.1
ABA92328.1
BAG93831.1
BAT13385.1
EAZ17950.1
NP_001067588.1
Q2R859  
 OsJ_023125 (fragments)   Oryza sativa Japonica Group EAZ39642.1 A3BJA3  
 Gba2   Pan troglodytes XP_001167923.1
BAK63646.1
XP_520565.1
   
 ORF (fragment)   Phaseolus vulgaris AGV54567.1    
 PHYPADRAFT_122471   Physcomitrella patens subsp. patens EDQ75122.1 A9S119  
 PHYPADRAFT_189506   Physcomitrella patens subsp. patens EDQ64036.1 A9SXS9  
 glucosylceramidase 2 (Gba2)   Rattus norvegicus AAH88200.1
EDL98757.1
Q5M868  
 Smp_155750.1   Schistosoma mansoni Puerto Rico CAZ33749.1
CAZ33750.1
CCD79501.1
CCD79502.1
C4QE81  
 SRAE_1000207300   Strongyloides ratti ED321 Heterogonic CEF63815.1    
 GSTEN:00035263:G:001 (fragment)   Tetraodon nigroviridis CAG12815.1 Q4RFL7  
 VIGAN_08128200 (Vigan.08g128200)   Vigna angularis var. angularis BAT94661.1    
 VIGAN_01552300 (Vigan.01g552300)   Vigna angularis var. angularis BAT77410.1    
 GSVIVT00035303001   Vitis vinifera CAO46877.1 A7QC94  
 GSVIVT00021808001   Vitis vinifera CAO16273.1 A7PPW2  
 GSVIVT00020494001   Vitis vinifera CAO71587.1 A7NXU8  
 VITISV_019326 (possible fragment)   Vitis vinifera CAN61187.1 A5BBB7  
 Loc100249401   Vitis vinifera XP_002285674.1    
 VITISV_016690 (possible fragment)   Vitis vinifera CAN61857.1 A5BW60  
 Unknown (protein for IMAGE:7678184) (fragment)   Xenopus tropicalis AAI60640.1 B1H1K5  
 unknown (fragment)   Zea mays ACG47878.1    
 unknown (probable fragment)   Zea mays B73 ACL53681.1
ACN33233.1
B8A0I2  
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