| Activities in Family | β-glucosidase (EC 3.2.1.21); β-xylosidase (EC 3.2.1.37); acid β-glucosidase/β-glucosylceramidase (EC 3.2.1.45); β-N-acetylglucosaminidase (EC 3.2.1.52) |
|---|---|
| Mechanism | Retaining |
| Clan | GH-O |
| 3D Structure Status | ( α / α ) 6 |
| Catalytic Nucleophile/Base | Glu (experimental) |
| Catalytic Proton Donor | Asp (experimental) |
| Note | Subfamilies described in Ferrara et al. (2013) BBA 1840:367-377 (PMID:24060745) |
| External resources | CAZypedia; |
| Statistics | GenBank accession (505); Uniprot accession (131); PDB accession (9); 3D entries (1); cryst (0) |
| Archaea | ||||||
| Protein Name | EC# | Organism | GenBank | Uniprot | PDB/3D | |
| aryl β-glucosidase/β-xylosidase (SSO1353) | 3.2.1.21 3.2.1.37 |
Sulfolobus solfataricus P2 | AAK41589.1 NP_342799.1 |
Q97YG8 | ||
| bifunctional β-glucosidase / β-N-acetylglucosaminidase (sso3039;SSO3039) | 3.2.1.21 3.2.1.52 |
Sulfolobus solfataricus P2 | AAK43141.1 NP_344351.1 |
Q97UH8 | ||
| Bacteria | ||||||
| Protein Name | EC# | Organism | GenBank | Uniprot | PDB/3D | |
| β-glucosidase (TxGH116;Thexy_2211) | 3.2.1.21 3.2.1.45 |
Thermoanaerobacterium xylanolyticum LX-11 | AEF18218.1 | 5BVU[A] 5BX2[A] 5BX3[A] 5BX4[A] 5BX5[A] 5FJS[A,B] 5NCX[A] 5NPF[A] 5O0S[A] |
||
| Eukaryota | ||||||
| Protein Name | EC# | Organism | GenBank | Uniprot | PDB/3D | |
| acid β-glucosidase 2 / β-glucosylceramidase 2 (Gba2) (ER;non-lysosomal;bile) | 3.2.1.45 | Homo sapiens | NP_065995.1 AAG44660.1 AAH11363.1 BAB13431.1 BAB55430.1 BAG59862.1 BAH12232.1 CAC83792.1 CAD38976.1 CAI10981.1 CAI10982.1 CAI10983.1 EAW58346.1 EAW58347.1 EAW58348.1 EAW58349.1 |
D3DRP2 Q5TCV6 Q9HCG7 |
||
| acid β-glucosidase 2 / glucosylceramidase 2 (Gba2;Kiaa1605) (non-lysosomal;cytosolic;bile) | 3.2.1.45 | Mus musculus | CAM17042.1 AAH56935.1 BAC40785.1 BAD32491.1 CAM17043.1 NP_766280.1 |
Q69ZF3 Q6PGM3 |
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