Glycoside Hydrolase Family 116

Activities in Familyβ-glucosidase (EC 3.2.1.21); β-xylosidase (EC 3.2.1.37); acid β-glucosidase/β-glucosylceramidase (EC 3.2.1.45); β-N-acetylglucosaminidase (EC 3.2.1.52)
Mechanism Retaining
ClanGH-O
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorAsp (experimental)
NoteSubfamilies described in Ferrara et al. (2013) BBA 1840:367-377 (PMID:24060745)
External resourcesCAZypedia;
Statistics GenBank accession (488); Uniprot accession (131); PDB accession (9); 3D entries (1); cryst (0)
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 aryl β-glucosidase/β-xylosidase (SSO1353) 3.2.1.21
3.2.1.37
Sulfolobus solfataricus P2 AAK41589.1
NP_342799.1
Q97YG8  
 bifunctional β-glucosidase / β-N-acetylglucosaminidase (sso3039;SSO3039) 3.2.1.21
3.2.1.52
Sulfolobus solfataricus P2 AAK43141.1
NP_344351.1
Q97UH8  
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-glucosidase (TxGH116;Thexy_2211) 3.2.1.21
3.2.1.45
Thermoanaerobacterium xylanolyticum LX-11 AEF18218.1   5BVU[A]
5BX2[A]
5BX3[A]
5BX4[A]
5BX5[A]
5FJS[A,B]
5NCX[A]
5NPF[A]
5O0S[A]
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 acid β-glucosidase 2 / β-glucosylceramidase 2 (Gba2) (ER;non-lysosomal;bile) 3.2.1.45 Homo sapiens NP_065995.1
AAG44660.1
AAH11363.1
BAB13431.1
BAB55430.1
BAG59862.1
BAH12232.1
CAC83792.1
CAD38976.1
CAI10981.1
CAI10982.1
CAI10983.1
EAW58346.1
EAW58347.1
EAW58348.1
EAW58349.1
D3DRP2
Q5TCV6
Q9HCG7
 
 acid β-glucosidase 2 / glucosylceramidase 2 (Gba2;Kiaa1605) (non-lysosomal;cytosolic;bile) 3.2.1.45 Mus musculus CAM17042.1
AAH56935.1
BAC40785.1
BAD32491.1
CAM17043.1
NP_766280.1
Q69ZF3
Q6PGM3
 
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