Glycoside Hydrolase Family 112

Activities in Familylacto-N-biose phosphorylase or galacto-N-biose phosphorylase (EC 2.4.1.211); D-galactosyl-β-1,4-L-rhamnose phosphorylase (EC 2.4.1.247); galacto-N-biose/lacto-N-biose phosphorylase (EC 2.4.1.-)
Mechanism Inverting
Catalytic Proton DonorAsp (site-directed mutation)
External resourcesCAZypedia;
Statistics GenBank accession (212); Uniprot accession (43); PDB accession (6); 3D entries (1); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 AN27039_1652 (fragment)   Actinomyces naeslundii ATCC 27039 BAV84722.1    
 AN27039_1651 (fragment)   Actinomyces naeslundii ATCC 27039 BAV84721.1    
 AXE84_07345   Actinomyces oris T14V AMD99247.1    
 AXF14_12285 (fragment)   Actinomyces radicidentis CCUG 36733 AMD88216.1    
 BK816_05005   Actinomyces sp. VUL4_3 AOZ72730.1    
 β-1,3-galactosyl-N-acetylhexosamine phosphorylase / galacto-N-biose/lacto-N-biose I phosphorylase (GLNBP;Apre_1669) 2.4.1.211
2.4.1.-
Anaerococcus prevotii DSM 20548 ACV29689.1 C7RES6  
 Arch_0013   Arcanobacterium haemolyticum DSM 20595 ADH91781.1 D7BLI2  
 SAMN04489737_0539   Arcanobacterium phocae DSM 10002 SDU78599.1    
 BCAH187_A2105   Bacillus cereus AH187 ACJ78918.1 B7HNE7  
 BA202_10010   Bacillus cereus M3 ASI77552.1    
 BCN_1919   Bacillus cereus NC7401 BAL17712.1    
 BCQ_1989   Bacillus cereus Q1 ACM12417.1 B9IXZ1  
 Bsel_0456   [Bacillus] selenitireducens MLS10 ADH97994.1 D6XXD7  
 BJG91_05935   Bacillus thuringiensis SCG04-02 ARV92161.1    
 YBT020_10405   Bacillus thuringiensis serovar finitimus YBT-020 ADY21327.1    
 BBBF_0239   Bifidobacterium bifidum ATCC 29521 = JCM 1255 = DSM 20456 BAQ97446.1    
 BBBF_1042   Bifidobacterium bifidum ATCC 29521 = JCM 1255 = DSM 20456 BAQ98249.1    
 RY70_300   Bifidobacterium bifidum BF3 ALE10680.1    
 RY70_1111   Bifidobacterium bifidum BF3 ALE11464.1    
 BBB_0981   Bifidobacterium bifidum BGN4 AFL04573.1    
 BBB_0215   Bifidobacterium bifidum BGN4 AFL03811.1    
 lacto-N-biose phosphorylase (LnpA1;LnbP) 2.4.1.211 Bifidobacterium bifidum JCM 1254 BAD80752.1    
 lacto-N-biose phosphorylase 2 (LnpA2;Lnbp2)   Bifidobacterium bifidum JCM 1254 BAE95374.1    
 BBJK_03100   Bifidobacterium bifidum LMG 13195 JCM 7004 BBA49080.1    
 BBJK_01792   Bifidobacterium bifidum LMG 13195 JCM 7004 BBA48232.1    
 BBPR_0233 (LnbP)   Bifidobacterium bifidum PRL2010 ADP35361.1 E4NYY8  
 BBPR_1055 (LnbP)   Bifidobacterium bifidum PRL2010 ADP36122.1 E4NX47  
 BBIF_0256 (LnbP1)   Bifidobacterium bifidum S17 ADO52461.1 E3ELR6  
 BBIF_1000 (LnbP2)   Bifidobacterium bifidum S17 ADO53205.1 E3EQ55  
 BBTM_00549   Bifidobacterium bifidum TMC 3115 BBA55270.1    
 BBTM_02164   Bifidobacterium bifidum TMC 3115 BBA56359.1    
 galacto-N-biose/lacto-N-biose phosphorylase (Lnpa1)   Bifidobacterium bifidum TMC3108 BBA57857.1    
 B12L_1515   Bifidobacterium breve 12L AHJ16243.1    
 B689b_1616   Bifidobacterium breve 689b AHJ23603.1    
 HMPREF9228_1638 (GnpA)   Bifidobacterium breve ACS-071-V-Sch8b AEF26816.1    
 RY69_196   Bifidobacterium breve BR3 ALE12469.1    
 BBBR_1586   Bifidobacterium breve DSM 20213 = JCM 1192 BAR00625.1    
 B7017_1782   Bifidobacterium breve JCM 7017 AHJ18016.1    
 B7019_1756   Bifidobacterium breve JCM 7019 AHJ19923.1    
 BBL520_08870   Bifidobacterium breve LMC520 AQM43636.1    
 B2258_1601   Bifidobacterium breve NCFB 2258 AHJ21779.1    
 BS27_1569 (LnbP)   Bifidobacterium breve S27 AHJ25340.1    
 Bbr_1587 (LnbP)   Bifidobacterium breve UCC2003 ABE96256.1    
 BL105A_1601   Bifidobacterium longum 105-A BAP84218.1    
 B624_1505   Bifidobacterium longum 35624 AOL10950.1    
 BBG7_1734   Bifidobacterium longum BG7 ALE36921.1    
 GS08_08740   Bifidobacterium longum BXY01 AIF91182.1    
 BLD_1765   Bifidobacterium longum DJO10A ACD99210.1 B3DQH2  
 BL1641   Bifidobacterium longum NCC2705 AAN25428.1
NP_696792.1
Q8G3W2  
 SAMN04489749_0482   Bifidobacterium longum Su859 SDO37556.1    
 BLIF_1691   Bifidobacterium longum subsp. infantis 157F BAJ71828.1    
 Blon_2174   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ53235.1 B7GN79  
 BLIJ_2251   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 BAJ69828.1    
 RY67_268   Bifidobacterium longum subsp. infantis BT1 ALE08343.1    
 BL1206_1764   Bifidobacterium longum subsp. longum AH1206 AOP01799.1    
 BBMN68_1673   Bifidobacterium longum subsp. longum BBMN68 ADQ02714.1 E4R3E2  
 BBL306_1620   Bifidobacterium longum subsp. longum CCUG30698 ALO75149.1    
 BIL_03770   Bifidobacterium longum subsp. longum F8 CBK70037.1 D6DC16  
 BLGT_08670   Bifidobacterium longum subsp. longum GT15 AIW44228.1    
 galacto-N-biose / lacto-N-biose phosphorylase (LnpA1;LnbP;GLNBP;BLLJ_1623) 2.4.1.211 Bifidobacterium longum subsp. longum JCM 1217 BAD80751.1
BAF73924.1
BAJ67290.1
E8MF13 2ZUS[A,B,C,D]
2ZUT[A,B,C,D]
2ZUU[A,B,C,D]
2ZUV[A,B]
2ZUW[A,B,C,D]
3WFZ[A,B,C,D]
 BLJ_1683   Bifidobacterium longum subsp. longum JDM301 ADH01117.1 D6ZW61  
 BLNIAS_00368   Bifidobacterium longum subsp. longum KACC 91563 AEI96816.1    
 B8809_1506   Bifidobacterium longum subsp. longum NCIMB8809 ALO73177.1    
 BBSC_1789   Bifidobacterium scardovii JCM 12489 = DSM 13734 BAQ31869.1    
 ADH70_009855 (GnpA)   Blautia coccoides YL58 ASU31702.1    
 CGC63_12325 (GnpA)   Blautia hansenii DSM 20583 ASM70203.1    
 A4V09_11390   Blautia sp. YL58 ANU76318.1    
 bhn_I2549   Butyrivibrio hungatei MB2003 AOZ97581.1    
 bpr_I0232   Butyrivibrio proteoclasticus B316 ADL32981.1 E0RXE3  
 CGC65_29075 (GnpA) (fragment)   [Clostridium] bolteae ATCC BAA-613 ASN98382.1    
 NPD4_3445 (GnpA)   Clostridium butyricum CDC_51208 APF24856.1    
 ATD26_02010   Clostridium butyricum JKY6D1 ALS15693.1    
 ATN24_03440   Clostridium butyricum KNU-L09 ALP89229.1    
 BBB49_02025   Clostridium butyricum TK520 AOR92912.1    
 AZ909_01895   Clostridium butyricum TOA ANF12843.1    
 BTM20_01515   Clostridium chauvoei 12S0467 ATD54005.1    
 BTM21_12935   Clostridium chauvoei DSM 7528 ATD58541.1    
 CCH01_26270   Clostridium chauvoei JF4335 SLK22936.1    
 A7L45_08570   Clostridium estertheticum subsp. estertheticum DSM 8809 APC40118.1    
 ADH65_21270 (GnpA)   [Clostridium] innocuum I46 ASU20826.1    
 ADH65_10115 (GnpA)   [Clostridium] innocuum I46 ASU18840.1    
 galacto-N-biose phosphorylase (CPF_0553) 2.4.1.211 Clostridium perfringens ATCC 13124 ABG83511.1 Q0TTN3  
 BXT91_03000   Clostridium perfringens CP15 AQW22912.1    
 BXT94_03475   Clostridium perfringens Del1 AQW25866.1    
 BG908_03020   Clostridium perfringens EHE-NE18 ASY50669.1    
 FORC3_0569   Clostridium perfringens FORC_003 ALG47946.1    
 FORC25_0545   Clostridium perfringens FORC_025 AOY52965.1    
 JFP55_03115   Clostridium perfringens JP55 AMN31952.1    
 JFP838_03255   Clostridium perfringens JP838 AMN34809.1    
 CMR01_12355 (GnpA)   Clostridium perfringens LLY_N11 ATD49541.1    
 CPR_0537   Clostridium perfringens SM101 ABG86710.1 Q0SVI5  
 CPE0573   Clostridium perfringens str. 13 BAB80279.1    
 Closa_2404   [Clostridium] saccharolyticum WM1 ADL04976.1 D9R4A6  
 SAMN02745906_2015   [Clostridium] sphenoides JCM 1415 ATCC 19403 SET79962.1    
 CSTERLE_00100   [Clostridium] stercorarium subsp. leptospartum DSM 9219 ANX00107.1    
 Cst_c00210   [Clostridium] stercorarium subsp. stercorarium DSM 8532 AGC67054.1
AGI38140.1
AGI38140.2
   
 CSTERTH_00100   [Clostridium] stercorarium subsp. thermolacticum DSM 2910 ANW97547.1    
 VO62_00390   Cutibacterium acnes A1-14 ALU22662.1    
 β-1,3-galactosyl-N-acetylhexosamine phosphorylase (GnpA) 2.4.1.211 Cutibacterium acnes JCM 6425 BAH10636.1 B7XEJ1  
 GnpA   Cutibacterium acnes JCM 6473 BAH10635.1 B7XEJ0  
 RN83_00825   Cutibacterium acnes KCOM 1861 (= ChDC B594) ALD68855.1    
 ALW29_00420   Cutibacterium acnes PA_12_1_L1 ALT41271.1    
 ALW27_00420   Cutibacterium acnes PA_12_1_R1 ALT39029.1    
 ALW33_00415   Cutibacterium acnes PA_15_1_R1 ALT43531.1    
 ALW23_00415   Cutibacterium acnes PA_15_2_L1 ALT36724.1    
 ALW21_00410   Cutibacterium acnes PA_21_1_L1 ALT34444.1    
 ALW22_00415   Cutibacterium acnes PA_30_2_L1 ALT32181.1    
 PALO_05900   Cutibacterium avidum 44067 AGJ77788.1    
 BFS79_01890   Cutibacterium avidum DPC 6544 AOG27493.1    
 β-1,3-galactosyl-N-acetylhexosamine phosphorylase / galacto-N-biose phosphorylase (GNBP;HMPREF0357_1319) 2.4.1.211 Erysipelothrix rhusiopathiae ATCC 19414 ZP_05748149.1    
 A4V01_17980   Erysipelotrichaceae bacterium I46 ANU70689.1    
 A4V01_07185   Erysipelotrichaceae bacterium I46 ANU68732.1    
 EUBREC_0138   [Eubacterium] rectale ATCC 33656 ACR73943.1 C4Z9U5  
 EUR_30710   [Eubacterium] rectale DSM 17629 CBK91983.1 D6DZH0  
 ERE_03140   [Eubacterium] rectale M104/1 CBK92425.1 D4JN71  
 CRH10_04060 (GnpA)   Faecalibacterium prausnitzii Indica ATL89539.1    
 FP2_19420   Faecalibacterium prausnitzii L2-6 L2/6 CBK99351.1 D4JZA2  
 FPR_27530   Faecalibacterium prausnitzii SL3/3 CBL02866.1 D4K5K7  
 EC1_19680 (fragment)   Faecalitalea cylindroides T2-87 CBK89181.1 D4JG59  
 Hprae_0861   Halanaerobium praevalens DSM 2228 ADO77015.1 E3DRA9  
 IB211_02403   Intestinimonas butyriciproducens AF211 ALP94794.1    
 BW727_101347 (LnpA)   Jeotgalibaca dankookensis EX-07 AQS53714.1    
 β-1,3-galactosyl-N-acetylhexosamine phosphorylase (Cphy_3030) 2.4.1.211 Lachnoclostridium phytofermentans ISDg ABX43387.1 A9KQ75  
 β-1,3-galactosyl-N-acetylhexosamine phosphorylase (Cphy_0577) 2.4.1.211 Lachnoclostridium phytofermentans ISDg ABX40964.1 A9KIW5  
 D-galactosyl-1,4-L-rhamnose phosphorylase (Cphy_1920) 2.4.1.247 Lachnoclostridium phytofermentans ISDg ABX42289.1 A9KHK4  
 A4V08_18610   Lachnoclostridium sp. YL32 ANU47501.1    
 HMPREF0573_10220   Mobiluncus curtisii ATCC 43063 ADI66539.1 D6ZIJ0  
 D-galactosyl-β-1,4-L-rhamnose phosphorylase (GalRhaP;Oter_1377) 2.4.1.247 Opitutus terrae PB90-1 ACB74662.1 B1ZRY6  
 PBOR_04085   Paenibacillus borealis DSM 13188 AIQ56225.1    
 B9T62_36785 (GnpA)   Paenibacillus donghaensis KCTC 13049 ASA25801.1    
 B9T62_06185 (GnpA)   Paenibacillus donghaensis KCTC 13049 ASA20428.1    
 PODO_03630   Paenibacillus odorifer DSM 15391 AIQ72435.1    
 PODO_22090   Paenibacillus odorifer DSM 15391 AIQ75742.1    
 ABE82_04240   Paenibacillus peoriae HS311 ALA40787.1    
 VK72_04445   Paenibacillus polymyxa ATCC 15970 APQ58060.1    
 LK13_17405   Paenibacillus polymyxa CF05 AIY10202.1    
 X809_04085   Paenibacillus polymyxa CR1 AHC18481.1    
 PPE_00843 (fragment)   Paenibacillus polymyxa E681 ADM68693.2 E0RHV5  
 AOU00_17085   Paenibacillus polymyxa J AOK91385.1    
 PPM_0844 (M1-1040)   Paenibacillus polymyxa M1 CCC83781.1    
 RE92_07460   Paenibacillus polymyxa Sb3-1 AJE50918.1    
 PPSC2_c0917   Paenibacillus polymyxa SC2 ADO54900.1 E3EDC1  
 PPSQR21_009000   Paenibacillus polymyxa SQR-21 SQR21 AHM64560.1    
 PPYC1_19805   Paenibacillus polymyxa YC0136 APB72482.1    
 BBD42_16190   Paenibacillus sp. BIHB4019 ANY67839.1    
 H70357_03775   Paenibacillus sp. FSL H7-0357 AIQ15913.1    
 H70737_03770   Paenibacillus sp. FSL H7-0737 AIQ22048.1    
 H70737_22430   Paenibacillus sp. FSL H7-0737 AIQ25376.1    
 P40081_04395   Paenibacillus sp. FSL P4-0081 AIQ27525.1    
 R50345_05030   Paenibacillus sp. FSL R5-0345 AIQ34061.1    
 R50345_03490   Paenibacillus sp. FSL R5-0345 AIQ33793.1    
 R50912_04000   Paenibacillus sp. FSL R5-0912 AIQ39298.1    
 R70723_03420   Paenibacillus sp. FSL R7-0273 AIQ45059.1    
 R70331_03425   Paenibacillus sp. FSL R7-0331 AIQ50681.1    
 BS614_07860   Paenibacillus xylanexedens PAMC 22703 APO43933.1    
 STSP2_01316   Phycisphaerae bacterium ST-NAGAB-D1 AQT68161.1    
 PAZ_c00870   Propionibacterium acnes 266 AEE71298.1    
 TIB1ST10_00415 (fragment)   Propionibacterium acnes 6609 AEH28397.1    
 PAC1_00415 (fragment)   Propionibacterium acnes C1 AFU39863.1    
 TIA1EST1_00415 (fragment)   Propionibacterium acnes hdn-1 AID36816.1    
 PAGK_0081 (fragment)   Propionibacterium acnes HL096PA1 AGJ78950.1    
 PPA0083 (GnpA)   Propionibacterium acnes KPA171202 AAT81843.1 Q6ABP1  
 HMPREF0675_3084 (GnpA)   Propionibacterium acnes SK137 ADD99899.1 D4HEP2  
 TIIST44_05030 (fragment)   Propionibacterium acnes subsp. defendens ATCC 11828 AER05505.1    
 TIA2EST22_00405 (fragment)   Propionibacterium acnes TypeIA2 P.acn17 AEW80429.1    
 TIA2EST36_00415 (fragment)   Propionibacterium acnes TypeIA2 P.acn31 AEW82692.1    
 BCB70_01760   Propionibacterium sp. oral taxon 193 F0672 AOH44837.1    
 RHOM_04120   Roseburia hominis A2-183 AEN95946.1    
 ROI_24320   Roseburia intestinalis M50/1 CBL09398.1 D4KR96  
 RO1_13220   Roseburia intestinalis XB6B4 CBL11952.1 D4KX62  
 CK1_01170   Ruminococcus sp. SR1/5 CBL18493.1 D4LPJ2  
 SpiBuddy_0363   Sphaerochaeta globosa str. Buddy ADY12199.1    
 β-1,3-galactosyl-N-acetylhexosamine phosphorylase / galacto-N-biose phosphorylase (GNBP;Smon_0146) 2.4.1.211 Streptobacillus moniliformis DSM 12112 ACZ00636.1 D1AWG0  
 BW733_15430   Tessaracoccus flavescens SST-39T AQP52006.1    
 RPIT_07005 (fragment)   Tessaracoccus flavus RP1T AQP44593.1    
 BW730_07300   Tessaracoccus sp. NSG39 AQP47333.1    
 Trebr_2353   Treponema brennaborense DSM 12168 AEE17762.1    
 AN946_03315   Trueperella pyogenes 2012CQ-ZSH ALD73520.1    
 CQ11_07080   Trueperella pyogenes TP6375 AHU89776.1    
 X956_00620   Trueperella pyogenes TP8 AJC68833.1    
 lacto-N-biose phosphorylase, partial (fragment)   uncultured bacterium AMP53243.1    
 Lacto-N-biose phosphorylase, partial (fragment)   uncultured bacterium APO32646.1    
 ORF (fragment)   uncultured bacterium APO32857.1    
 ORF (fragment)   uncultured bacterium APO33019.1    
 IMCC26134_08930   Verrucomicrobia bacterium IMCC26134 AKC82867.1    
 AL543_05765   Vibrio mimicus ATCC 33654 AMG02510.1    
 VM_20595   Vibrio mimicus SCCF01 AOW85053.1    
 BA891_15435   Vibrio natriegens CCUG 16371 ANQ18608.1    
 BA893_16735   Vibrio natriegens CCUG 16373 ANQ23312.1    
 BA894_18520   Vibrio natriegens CCUG 16374 ANQ28418.1    
 PN96_15920   Vibrio natriegens NBRC 15636 = ATCC 14048 = DSM 759 ALR17480.1
ANQ14971.1
   
 VIBNI_B0675   Vibrio nigripulchritudo SFn1 CCO60475.1    
 CEQ48_01550 (GnpA)   Vibrio sp. 2521-89 ASK53518.1    
 VEJY3_24026   Vibrio sp. EJY3 AEX25214.1    
 VV93_v1c44840   Vibrio vulnificus 93U204 AIL73535.1    
 AL549_02250   Vibrio vulnificus ATL 6-1306 AMG10178.1    
 β-1,3-galactosyl-N-acetylhexosamine phosphorylase (GalGlyNAcP;VV2_1091) 2.4.1.211 Vibrio vulnificus CMCP6 AAO07997.1
NP_763007.1
   
 FORC17_4504   Vibrio vulnificus FORC_017 ANN29567.1    
 FORC36_4457   Vibrio vulnificus FORC_036 ARN68974.1    
 FORC37_4354   Vibrio vulnificus FORC_037 ASC60048.1    
 VVM_03116   Vibrio vulnificus MO6-24/O ADV89504.1    
 VVA1614   Vibrio vulnificus YJ016 BAC97640.1 Q7MBX3  
 BME96_14450   Virgibacillus halodenitrificans PDB-F2 APC50287.1    
 BKP57_16780   Virgibacillus sp. 6R API94323.1    
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 LDC_03740 (fragment)   uncultured microorganism AEI30480.1    
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