Activities in Family	Xylan endotransglycosylase (EC 2.4.2.-); [retaining] arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); Mixed-linkage xylan-specific endo-β-1,4-xylanase (cleaves glycosidic bond after β-1,3-linkage) (EC 3.2.1.-); Mixed-linkage xylan-specific endo-β-1,4-xylanase (cleaves glycosidic bond preceding β-1,3-linkage) (EC 3.2.1.-); Tomatinase β-galactosidase (EC 3.2.1.-); [inverting] oligosaccharide reducing-end xylanase (EC 3.2.1.156); Endo-β-1,3-xylanase (EC 3.2.1.32); Xylan β-1,4-xylosidase (EC 3.2.1.37); Endo-β-1,4-glucanase (EC 3.2.1.4); Endo-β-1,4-xylanase (EC 3.2.1.8);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	formerly known as cellulase family F.
External resources	CAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (9057); Uniprot accession (385); PDB accession (222); 3D entries (61); cryst (2)

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Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
xylanase Z / feruloyl esterase (XynZ;LX3;CtGH10)	3.2.1.8	pubmed	Acetivibrio thermocellus	AAA23286.1 AAR39815.1	P10478	1XYZ[A,B]
xylanase Y (XynY;Cthe_0912) (Xyn10B)	3.2.1.8	pubmed	Acetivibrio thermocellus ATCC 27405	ABN52146.1
xylanase C (XynC; Cthe_1838) (Xyn10C)	3.2.1.8	pubmed	Acetivibrio thermocellus ATCC 27405	ABN53059.1	A3DGI0
xylanase Z / feruloyl esterase (XynZ;Cthe_1963;E-FAERU) (Xyn10Z)	3.2.1.8	pubmed	Acetivibrio thermocellus ATCC 27405	ABN53181.1	P10478
xylan- and cellulose-specific sensor (RsgI6;Cthe_2119)	3.2.1.8	pubmed	Acetivibrio thermocellus ATCC 27405	ABN53326.1 CCF82158.1	A3DH97 H6SHY0
β-1,4-xylanase (XynD; Cthe_2590) (Xyn10D)	3.2.1.8	pubmed	Acetivibrio thermocellus ATCC 27405	ABN53790.1	A3DIL1
xylanase C (XynC) (Xyn10C)	3.2.1.8	pubmed	Acetivibrio thermocellus F1	BAA21516.2	O32374
β-1,4-xylanase (XynD) (Xyn10D)	3.2.1.8	pubmed	Acetivibrio thermocellus F7	CAE51307.1	Q70DK4
xylanase Y / feruloyl esterase (XynY;LX5) (Xyn10B)	3.2.1.8	pubmed	Acetivibrio thermocellus YS	CAA58242.1 AAR39814.1	P51584	2W5F[A,B] 2WYS[A,B] 2WZE[A,B]
xylanase (Xyn; XynA)	3.2.1.8	pubmed	Acidobacterium capsulatum 161	BAB40957.1	Q9AJR9
xylanase 10B (Acel_0180) (Xyn10B)	3.2.1.8	pubmed	Acidothermus cellulolyticus 11B	ABK51955.1	A0LR95
endo-xylanase (Acel_0372) (Xyn10A)	3.2.1.8	pubmed	Acidothermus cellulolyticus 11B	ABK52146.1	A0LRT6
xylanase E (XynE)	3.2.1.8	pubmed	Aeromonas caviae ME-1	BAA34091.1	Q9Z485
xylanase X (XynX)	3.2.1.8	pubmed	Aeromonas caviae ME-1	BAA31551.2 BAA31551.1	O83007	cryst
xylanase (XynA4)	3.2.1.8	pubmed	Alicyclobacillus sp. A4	ACY69980.1	D3VWB5
endo-β-1,4-xylanase (XynA4-2)	3.2.1.8	doi	Alicyclobacillus sp. A4 CGMCC 3147	ADK91076.1	E2EAK3
β-1,4-xylanase (XynT)	3.2.1.8	doi	Alkalihalobacillus alcalophilus AX2000	AAQ99279.1	Q6TDT4
xylanase (XynE2)	3.2.1.8	doi	Anoxybacillus sp. E2(2009)	ACY69979.1	D7NNK8
endo-β-1,4-glucanase (AlCMCase;DJ013_18025)	3.2.1.4	pubmed	Arcticibacterium luteifluviistationis SM1504	AWV99964.1	A0A2Z4GG46
β-1,4-xylanase (XynK)	3.2.1.8	doi	Bacillus pumilus TX703	AAM21605.1	Q8L2X3
arabinoxylan-specific endo-β-1,4-xylanase (XynA; Xyn10A)	3.2.1.-	pubmed	Bacillus sp. (in: firmicutes) KW1	QCO69162.1	A0A4P8ESF9	7D88[A] 7D89[A]
xylanase A (XyaA)	3.2.1.8	pubmed	Bacillus sp. (in: firmicutes) N137	CAA84631.1	Q45518
endoxylanase (XynA;XynAHJ14)	3.2.1.8	pubmed	Bacillus sp. HJ14	AHH02587.1	A0A0C4JZH7
endo-β-1,4-xylanase (XynA;XynAHJ2)	3.2.1.8	pubmed	Bacillus sp. HJ2	AFE82288.1	I6PB27
xylanase (Xyn10)	3.2.1.8	pubmed	Bacillus sp. N16-5	ADI24221.1	D7RA44
xylanase (BSX)	3.2.1.8	pubmed	Bacillus sp. NG-27	AAB70918.1	O30700	2F8Q[A,B] 2FGL[A,B] 4QCE[A,B] 4QCF[A] 4QDM[A,B] 5EB8[A,B] 5EBA[A] 5EFD[A,B] 5EFF[A,B] 5XC0[A,B] 5XC1[A,B]
xylanase (Xyn10A)	3.2.1.8	pubmed	Bacillus sp. SN5	AGA16736.1	L0CL88
endo-β-1,4-xylanase (Xyn3F) (partial)	3.2.1.8	pubmed	bacterium enrichment culture clone MC3F	AFU34339.1	K0H4D9
endo-β-1,4-xylanase (BiXyn10C;BACINT_04197) (Xyn10C)	3.2.1.8	pubmed pubmed	Bacteroides intestinalis DSM 17393	EDV05054.1	B3CER6
endo-β-1,4-xylanase (BiXyn10C;BACINT_04197) (Xyn10C)	3.2.1.8	pubmed pubmed	Bacteroides intestinalis DSM 17393	EDV05054.1	B3CER6
bifunctional endo-β-1,4-xylanase / α-L-arabinofuranosidase (BiXyn10B/BiAra43A;BACINT_04202) (Xyn10B/Ara43A)	3.2.1.8	pubmed	Bacteroides intestinalis DSM 17393	EDV05059.1	B3CES1
endo-β-1,4-xylanase (BiXyn10A, BACINT_04215) (Xyn10A)	3.2.1.8	pubmed pubmed	Bacteroides intestinalis DSM 17393	EDV05072.1	B3CET4
endo-β-1,4-xylanase (BiXyn10A, BACINT_04215) (Xyn10A)	3.2.1.8	pubmed pubmed	Bacteroides intestinalis DSM 17393	EDV05072.1	B3CET4
xylanase A (XylI)	3.2.1.8	pubmed	Bacteroides ovatus V975	AAB08023.1 ACA34972.1	B2KZK5 P49942
xylanase 10A (pseudogene BXY_46600) (Xyn10A)	3.2.1.8	pubmed	Bacteroides xylanisolvens XB1A	CBH32823.1	D6CGY9
endo-β-1,4-glucanase (BbCMCase; A2066_15670)	3.2.1.4	pubmed	Bacteroidetes bacterium GWB2_41_8	OFX60056.1	A0A1F3EZY1
xylanase A	3.2.1.8	pubmed	Butyrivibrio fibrisolvens 49		P23551
xylanase B (XynB)	3.2.1.8	pubmed	Butyrivibrio fibrisolvens H17C	CAA43712.1	P26223
β-1,4-xylanase (ORF2504) (Xyn10A)	3.2.1.8	pubmed	Caldanaerobius polysaccharolyticus KMCJ	AFQ62797.1	J7JXS8
xylanase (XynA)	3.2.1.8	pubmed	Caldibacillus cellulovorans	AAF61649.1	Q9L8L8
multimodular xylanase-glucuronoyl esterase (CkXyn10C-GE15A; Calkr_2245)	3.2.1.37	pubmed	Caldicellulosiruptor acetigenus I77R1B	ADQ41707.1
xylanase (Cb193;CbXyn10A;Athe_0183)	3.2.1.8	pubmed	Caldicellulosiruptor bescii DSM 6725	ACM59335.1	B9MMA3
xylanase (Cb195;CbXyn10A;CbXyn10B;Athe_0185) (Xyn10A=Xyn10B)	3.2.1.8	pubmed	Caldicellulosiruptor bescii DSM 6725	ACM59337.1	B9MMA5	4L4O[A] 4L4P[A] 4PMD[A]
xylanase / cellobiohydrolase (CelF;Athe_1857;Cbes_1857) (Xyn10C/Cel48B)	3.2.1.-	pubmed	Caldicellulosiruptor bescii DSM 6725	ACM60945.1	B9MKT7	5OFJ[A] 5OFK[A] 5OFL[A]
exo-xylanase (Calkro_0402)	3.2.1.37	pubmed	Caldicellulosiruptor kronotskyensis 2002	ADQ45302.1	E4SE15
xylanase (CoXynA;Calow_0124)	3.2.1.8	pubmed	Caldicellulosiruptor owensensis OL	ADQ03732.1	E4Q2A4	5Y3X[A,B,C,D,E,F]
xylanase A (XynA;Orf1)	3.2.1.8	pubmed	Caldicellulosiruptor saccharolyticus	AAA23059.1 AAB87374.1	P23556
xylanase E (XynE)	3.2.1.8	pubmed	Caldicellulosiruptor saccharolyticus	AAB87372.1	O30427
Csac_2408 (XynA)	3.2.1.8	pubmed	Caldicellulosiruptor saccharolyticus DSM 8903	ABP67985.1	A4XM50
xylanase (XynE;Csac_2410)	3.2.1.8	pubmed	Caldicellulosiruptor saccharolyticus DSM 8903	ABP67987.1	A4XM52
xylanase (XynB;Ca_GH10)	3.2.1.8	pubmed	Caldicellulosiruptor sp. F32	AFO70073.1	I7D8W6
xylanase B (XynB)	3.2.1.8	pubmed	Caldicellulosiruptor sp. Rt69B.1	AAB95325.1 CAA03086.1 CAE84530.1	O52373
xylanase C (XynC) (multidomain protein)	3.2.1.8	pubmed	Caldicellulosiruptor sp. Rt69B.1	AAB95326.1 CAA03087.1 CAE84531.1	O52374
xylanase A (XynA)	3.2.1.8	pubmed	Caldicellulosiruptor sp. Rt8B.4	AAB42044.1	P40944
bifunctional β-1,4-xylanase / α-L-arabinosidase (XynA)	3.2.1.8	pubmed	Caldicellulosiruptor sp. Tok7B.1	AAD30363.1	Q9X3P5
xylanase B / 10A (Cex;Exg;XynB;Celf_1271) (Xyn10A)	3.2.1.8	pubmed	Cellulomonas fimi ATCC 484	AEA30147.1 AAA56791.1 AAA56792.1 AEE45406.1	F2XFS7 F4H454 P07986 Q59277	1EXP[A] 1FH7[A] 1FH8[A] 1FH9[A] 1FHD[A] 1J01[A] 2EXO[A] 2HIS[A] 2XYL[A] 3CUF[A] 3CUG[A] 3CUH[A] 3CUI[A] 3CUJ[A]
xylanase C (XynC;XylC)	3.2.1.8	pubmed	Cellulomonas fimi ATCC 484	CAA90745.1	Q59278
β-1,4-xylanase (Cfx)	3.2.1.8	pubmed	Cellulomonas fimi ATCC 484	AAZ76373.1	Q3YAW6
xylanase (CGSCsYakCAS_10610) (Xyn10A)	3.2.1.8	pubmed	Cellulosilyticum ruminicola CGMCC 1.5065	ACZ98596.1	D2KFJ4
endo-β-1,4-xylanase	3.2.1.8	doi	Cellulosimicrobium cellulans CKMX1	CDG66213.1	T2M1V1
xylanase (XylA)	3.2.1.8	pubmed	Cellulosimicrobium sp. HY-12	ABX88978.1	B2BZ80
xylanase (XylK1;XylK-1)	3.2.1.8	pubmed	Cellulosimicrobium sp. HY-13	ACY75514.1	D1GET5
xylanase B /10B (XynB;XylB;CJA_3280) (Xyn10B)	3.2.1.8	pubmed	Cellvibrio japonicus Ueda107	ACE84499.1 CAA38389.1	B3PEH8 P23030
xylanase F / 10C (Xyl10C;CJA_3066) (Xyn10C)	3.2.1.8	pubmed	Cellvibrio japonicus Ueda107	ACE84815.1 CAA88764.2	B3PDA8 Q59675	1US2[A] 1US3[A]
xylanase G /10D (CJA_2888) (Xyn10D)	3.2.1.8	pubmed	Cellvibrio japonicus Ueda107	ACE84280.1 AAD47087.1	B3PC74 Q9RBZ5
xylanase A / 10A (XynA; XylA; Xyl10A; CjXyn10A; CJA_2471) (Xyn10A)	3.2.1.8	pubmed	Cellvibrio japonicus Ueda107	ACE85439.1 CAA33469.1	B3PKK3 P14768	1CLX[A] 1E5N[A] 1W2P[A,B] 1W2V[A,B] 1W32[A,B] 1W3H[A,B] 1XYS[A]
xylanase B (XylB)	3.2.1.8	pubmed	Cellvibrio mixtus	CAA88762.1	Q59301
xylanase C / 10B (XylC; XynC; Xyl10B; CmXyn10B) (Xyn10B)	3.2.1.8	pubmed	Cellvibrio mixtus ATCC 12120	AAD09439.3	O68541	1UQY[A] 1UQZ[A] 1UR1[A] 1UR2[A] 2CNC[A]
xylanase 10B (CAP0116) (Xyn10B)	3.2.1.8	pubmed	Clostridium acetobutylicum ATCC 824	AAK76861.1 NP_149279.1	Q97TI5
xylanase (CAP0053) (Xyn10A)	3.2.1.8	pubmed	Clostridium acetobutylicum ATCC 824	AAK76799.1 NP_149217.1	Q97TP5
xylanase B (XynB)	3.2.1.8	pubmed	Clostridium cellulovorans ATCC 35296	AAT37531.1	Q6J286
xylanase (iXylC)	3.2.1.8	pubmed	Cohnella laeviribosi HY-21	ADE08352.1	D5KTJ5
endo-β-1,4-glucanase (CqCMCase;ADICYQ_4013)	3.2.1.4	pubmed	Cyclobacterium qasimii M12-11B	EPR66937.1	S7VBJ2
xylanase 10A (Xyn10A)	3.2.1.8	pubmed	Cytobacillus firmus	AAQ83581.1	Q6U892
endo-β-1,4-xylanase (Mxyn10)	3.2.1.8	pubmed	Demequina sp. JK4	ACM41799.1	B9VSZ3
xylanase (XynA)	3.2.1.8	pubmed	Dictyoglomus thermophilum RT46B.1	AAA96979.1	Q12603
xylanase (LX6;Dtur_1647) (partial)	3.2.1.8	pubmed	Dictyoglomus turgidum DSM 6724	ACK42920.1	B8E346
endo-β-1,4-xylanase (XylR)	3.2.1.8	pubmed	Duganella sp. DK-1	UAK14976.1
xylanase	3.2.1.8	doi	Eubacterium ruminantium	BAA09971.1	Q47871
xylanase E (XynE; Xyn10M; Fisuc_1793; FSU_2293) (Xyn10E)	3.2.1.8	pubmed	Fibrobacter succinogenes subsp. succinogenes S85	AAG36765.1 AAG02561.1 ACX75386.1 ADL27036.1	Q9F108 Q9F4K9
xylanase D (XynD; Xyn10L; Fisuc_1791; FSU_2292) (Xyn10D)	3.2.1.8	pubmed	Fibrobacter succinogenes subsp. succinogenes S85	AAG02560.1 AAG36764.1 ACX75384.1 ADL26381.1	Q9F109 Q9F4L0
xylanase B (XynB;Fisuc_1794;FSU_2294) (Xyn10B)	3.2.1.8	pubmed	Fibrobacter succinogenes subsp. succinogenes S85	ACX75387.1 AAG36763.1 ADL25544.1	C9RS51 D9S458 Q9F107
endo-β-1,4-xylanase (Fjoh_3866) (Xyn10A)	3.2.1.8	pubmed	Flavobacterium johnsoniae UW101	ABQ06877.1	A5FD49
xylanase (Xyn-FLA)	3.2.1.8	pubmed	Flavobacterium sp. LW53	ACN87363.1	C0M1B6
xylanase (XFH;Xyn10)	3.2.1.8	pubmed	Flavobacterium sp. MSY2	AAY98787.1	Q288H9
thermostable xylanase (XyzGeo71)	3.2.1.8	pubmed	Geobacillus sp. 71	AEO96821.1	G3G7L3
xylanase	3.2.1.8	pubmed	Geobacillus sp. TC-W7	ACX42569.1	D0EM78
xylanase (XynA;XylA)	3.2.1.8	pubmed	Geobacillus sp. WBI	ACH43142.1	B5M201
endo-β-1,4-xylanase (I656_02756)	3.2.1.8	pubmed	Geobacillus sp. WSUCF1	EPR27574.2	S7U0J0
endo-β-1,4-xylanase (XynA)	3.2.1.8	pubmed	Geobacillus stearothermophilus 1A05583	AGD81833.1	L7XJX2
xylanase A (XynA;LX2)	3.2.1.8	doi	Geobacillus stearothermophilus 21	BAA05668.1	P45703
endo-β-1,4-xylanase 22 (ET31_03035)	3.2.1.8	doi	Geobacillus stearothermophilus 22	KFL17026.1
xylanase	3.2.1.8	pubmed	Geobacillus stearothermophilus MT-1	AAZ74783.1	Q3YBZ9
xylanase (XynA2;IXT6;HUS_CDS61) (intracellular)	3.2.1.8	pubmed	Geobacillus stearothermophilus T-6 NCIMB 40222	AAC98123.1 ABI49937.1 ABI49937.2	Q09LY9 Q9ZFM8	1N82[A,B] 2Q8X[A,B] 3MS8[A,B] 3MSD[A,B] 3MSG[A,B] 3MUA[A,B] 3MUI[A,B]
xylanase T-6 (XynA;XT6;XynA2;HUS_CDS83)	3.2.1.8	pubmed	Geobacillus stearothermophilus T-6 NCIMB 40222	AAC98140.1 ABI49951.1 CAA82319.1	P40943	1HIZ[A] 1R85[A] 1R86[A] 1R87[A] 3MMD[A] 4PRW[A] 4PUD[A] 4PUE[A]
extracellular xylanase (GthAK53Xyl)	3.2.1.8	pubmed	Geobacillus thermodenitrificans AK53	AJD08621.1 AJD08620.1	A0A0B4UJS8 A0A0B4UJV3
xylanase (GeXyl)	3.2.1.8	pubmed	Geobacillus thermodenitrificans JK1	AEP39603.1	G5CKS2
xylanase (LX1) (thermostable)	3.2.1.8	doi	Geobacillus thermodenitrificans T-2	ACC86109.1	B2Z4E4
endoxylanase (XynA;GtXynA1;GTHT12_01347)	3.2.1.8	pubmed	Geobacillus thermodenitrificans T12	ARP42887.1 APH81401.1	G5CKS2
endoxylanase	3.2.1.8	pubmed	Geobacillus thermodenitrificans TSAA1	AFU93447.1	G5CKS2
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