Activities in Family	α-N-acetylgalactosaminidase (EC 3.2.1.49); β-N-acetylhexosaminidase (EC 3.2.1.52);
Mechanism	Other a,e
3D Structure Status	Rossmann fold
Catalytic Nucleophile/Base	Not applicable
Catalytic Proton Donor	None
Note	Created following Liu et al. (2007) Nature Biotechnol 25:454-64 (PMID: 17401360); the enzymes in this family display an unusual mechanism involving NAD+
External resources	CAZypedia;
Statistics	GenBank accession (2380); Uniprot accession (9); PDB accession (3); 3D entries (2); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
a/β-N-acetylgalactosaminidase (AmGH109A;Amuc_0920)	3.2.1.49 3.2.1.52	Akkermansia muciniphila ATCC BAA-835	ACD04752.1 QTD81538.1	B2UQL7	6T2B[A,B,C,D] α-D-GalpNAc 2.13
α-N-acetylgalactosaminidase (NagA)	3.2.1.49	Elizabethkingia meningoseptica ATCC 33958	CAJ01376.1	A4Q8F7	2IXA[A] 2.3 2IXB[A] α-D-GalpNAc 2.4
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