Glycoside Hydrolase Family 109

Activities in Familyα-N-acetylgalactosaminidase (EC 3.2.1.49); β-N-acetylhexosaminidase (EC 3.2.1.52)
Mechanism Retaining
3D Structure StatusRossmann fold
Catalytic Nucleophile/BaseNot applicable
Catalytic Proton DonorNone
NoteCreated following Liu et al. (2007) Nature Biotechnol 25:454-64 (PMID: 17401360); the enzymes in this family display an unusual mechanism involving NAD+
External resourcesCAZypedia;
Statistics GenBank accession (1724); Uniprot accession (7); PDB accession (3); 3D entries (2); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 a/β-N-acetylgalactosaminidase (AmGH109A;Amuc_0920) 3.2.1.49
3.2.1.52
Akkermansia muciniphila ATCC BAA-835 ACD04752.1
QTD81538.1
B2UQL7
6T2B[A,B,C,D] α-D-GalpNAc
2.13
 α-N-acetylgalactosaminidase (NagA) 3.2.1.49 Elizabethkingia meningoseptica ATCC 33958 CAJ01376.1 A4Q8F7
2IXA[A] 2.3
2IXB[A] α-D-GalpNAc
2.4
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