Glycoside Hydrolase Family 103

Activities in Familypeptidoglycan lytic transglycosylase (EC 3.2.1.-)
Mechanism Retaining
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate (inferred)
Catalytic Proton DonorGlu (experimental)
NoteCorresponds to family 3 of the peptidoglycan lytic transglycosylases described by N.T. Blackburn and A.J. Clarke (2001) J. Mol. Evol. 52, 78-84
External resourcesCAZypedia;
Statistics GenBank accession (6800); Uniprot accession (767); PDB accession (12); 3D entries (3); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 lytic murein transglycosylase B (MltB;b2701;Slt35) 4.2.2.n1 Escherichia coli str. K-12 substr. MG1655 AAB60060.1
AAC75743.1
AIZ90258.1
ALI39582.1
AMC95626.1
NP_417181.1
P41052
1D0K[A] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-α-D-GlcpNAc
β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc
2.02
1D0L[A] β-D-GlcpNAc4SO3-(1-1)-<non_carb>
1.97
1D0M[A] β-D-GlcpNAc-(1-4)-α-D-GlcpNAc
β-D-GlcpNAc4SO3-(1-1)-<non_carb>
2.47
1LTM[A] 1.70
1QDR[A] 2.10
1QDT[A] 2.10
1QUS[A] 1.70
1QUT[A] β-D-GlcpNAc
2.44
 soluble lytic transglycosylase (SltB1;PA4001)   Pseudomonas aeruginosa PAO1 AAG07388.1  
4ANR[A] 1.84
 exo-lytic transglycosylase (SltB3;PA3992) 4.2.2.n1 Pseudomonas aeruginosa PAO1 AAG07379.1  
5ANZ[A] 1.61
5AO7[A] β-D-GlcpNAc
2.09
5AO8[A] β-D-GlcpNAc
β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc-(1-1)-methyl
2.09
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