Carbohydrate-Binding Module Family 70

Activities in FamilyThe hyaluronan-specific binding function of the N-terminal CBM70 module of Streptococcus pneumoniae hyaluronate lyase has been demonstrated.
3D Structure Statusβ-sandwich
NoteCreated after Suits et al. (2014) J Biol Chem 289:27264-27277 [PMID: 25100731]
Statistics GenBank accession (432); Uniprot accession (37); PDB accession (1); 3D entries (1); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 HLK66_10555   Bacillus circulans GN03 QJX62049.1    
 C2I06_04330   Bacillus circulans PK3_109 AYV66165.1    
 C2H98_05220   Bacillus circulans PK3_138 AYV71019.1    
 NCTC4824_01128   Bacillus lentus NCTC4824 SQI53822.1    
 NCTC4824_03984   Bacillus lentus NCTC4824 SQI63227.1    
 hyaluronidase (Hyl;HAase-B) (partial) 4.2.2.1 Bacillus sp. A50 AHB61202.1    
 NCTC12421_00019   Enterococcus cecorum NCTC12421 SQE53777.1    
 DOU32_08560   Enterococcus faecalis C54 QCX17614.1    
 hyaluronate lyase (BniHL)   Neobacillus niacini F8 BAO57293.1    
 PBLR_13548   Paenibacillus alvei SYX85126.1    
 PBLR_11433   Paenibacillus alvei SYX83011.1    
 PC41400_11260   Paenibacillus chitinolyticus KCCM 41400 QAV18210.1    
 A3958_01915   Paenibacillus glucanolyticus 5162 ANA78826.1    
 C7121_14620   Paenibacillus glucanolyticus W10507 AVV57259.1    
 BBD41_21650   Paenibacillus ihbetae IHBB 9852 ANY74958.1    
 D5F53_17370   Paenibacillus lautus E7593-69 AYB44936.1    
 CD191_07740   Paenibacillus odorifer CBA7130 AWV32512.1    
 IJ21_17060   Paenibacillus sp. 32O-W ALS27107.1    
 IJ21_17060   Paenibacillus sp. 32O-W ALS27107.1    
 EI981_02180   Paenibacillus sp. MBLB1234 AZS13398.1    
 GYMC10_2460   Paenibacillus sp. Y412MC10 ACX64738.1 D3E9T1  
 SAMN05661091_5261   Paenibacillus uliginis N3/975 SMF90851.1    
 NCTC11451_00695 (HylB)   Pseudomonas aeruginosa NCTC11451 VTR41759.1    
 SA111_01368 (HylB)   Streptococcus agalactiae CZT39479.1    
 BQ8897_BM110_01288 (HylB)   Streptococcus agalactiae SIW57730.1    
 HKK59_06245   Streptococcus agalactiae 01173 QJQ92957.1    
 BSA_12760   Streptococcus agalactiae 09mas018883 CCW38045.1    
 V193_05585   Streptococcus agalactiae 138P AHN30604.1    
 DN94_05585   Streptococcus agalactiae 138spar AHX75150.1    
 GBS222_1026 (HylB)   Streptococcus agalactiae 2-22 CCO74748.1    
 SAG1197   Streptococcus agalactiae 2603V/R AAN00079.1
NP_688206.1
   
 DKY66_06695   Streptococcus agalactiae 32790-3A QDI66339.1    
 hyaluronate lyase (HylB) 4.2.2.1 Streptococcus agalactiae 4755 CAA75865.1 O86478  
 GRB95_06050   Streptococcus agalactiae 515 QJC65326.1    
 CHF17_01286   Streptococcus agalactiae 874391 ASZ01543.1    
 SAK_1284 (HylB)   Streptococcus agalactiae A909 ABA45106.1    
 CCZ24_03895   Streptococcus agalactiae B105 AWZ35997.1    
 CDH84_05075   Streptococcus agalactiae B507 AWZ32146.1    
 CDH83_05005 (fragment)   Streptococcus agalactiae B508 AWZ30048.1    
 CDH85_07240   Streptococcus agalactiae B509 AWZ28445.1    
 GT95_06720   Streptococcus agalactiae C001 ASI66297.1    
 GBSCOH1_1103   Streptococcus agalactiae COH1 CDN66569.1    
 BB161_06890   Streptococcus agalactiae CUGBS591 ASA79900.1    
 CUGBS08_01230 (HylB)   Streptococcus agalactiae CU_GBS_08 AMQ14781.1    
 CUGBS98_01167 (HylB)   Streptococcus agalactiae CU_GBS_98 AMQ16773.1    
 A6J82_06845   Streptococcus agalactiae FDAARGOS_254 ARC45071.1    
 EGX82_10455   Streptococcus agalactiae FDAARGOS_512 AYZ24217.1    
 FOB77_08675   Streptococcus agalactiae FDAARGOS_669 QET35740.1    
 FOB78_02465   Streptococcus agalactiae FDAARGOS_670 QET53184.1    
 A9256_06185   Streptococcus agalactiae FWL1402 ANR97234.1    
 AOY37_06410   Streptococcus agalactiae GBS ST-1 ALP87742.1    
 DK41_06360   Streptococcus agalactiae GBS1-NY AIK71752.1    
 DK42_06655   Streptococcus agalactiae GBS2-NM AIK73870.1    
 DX05_06680   Streptococcus agalactiae GBS6 AIK75919.1    
 GBS85147_1176   Streptococcus agalactiae GBS85147 AKI57601.1    
 A964_1170   Streptococcus agalactiae GD201008-001 AFS45935.1    
 GX026_05610   Streptococcus agalactiae GX026 AKU01911.1    
 GX064_06035   Streptococcus agalactiae GX064 AKU00152.1    
 SAH002_06140 (fragment)   Streptococcus agalactiae H002 AKU03714.1    
 SAHN016_06120   Streptococcus agalactiae HN016 AKT96278.1    
 SAGS_1243 (Hylb_1) (fragment)   Streptococcus agalactiae HU-GS5823 BBG32927.1    
 MSA_13200 (fragment)   Streptococcus agalactiae ILRI005 CCW40178.1    
 SAIL_13150   Streptococcus agalactiae ILRI112 CCW42329.1    
 NCTC11930_00904 (HylB)   Streptococcus agalactiae NCTC11930 SQF30737.1    
 NCTC13947_00953 (HylB)   Streptococcus agalactiae NCTC13947 VEJ27661.1    
 NCTC13949_01247 (HylB)   Streptococcus agalactiae NCTC13949 VEJ12998.1    
 NCTC8184_01208 (HylB)   Streptococcus agalactiae NCTC8184 VED65165.1    
 NCTC8187_01195 (HylB)   Streptococcus agalactiae NCTC8187 SQG26488.1    
 hyaluronate lyase (HylB;SaHyl;Gbs1270) 4.2.2.1 Streptococcus agalactiae NEM316 CAD46929.1
AAA56749.1
NP_735714.1
Q53591  
 EN72_06630   Streptococcus agalactiae NGBS061 AIF86754.1    
 AMM49_06240   Streptococcus agalactiae NGBS128 AMD32505.1    
 AMR84_06675   Streptococcus agalactiae NGBS357 AOF51244.1    
 EN73_06165   Streptococcus agalactiae NGBS572 AIF88771.1    
 C2E56_06950   Streptococcus agalactiae NJ1606 QHO95713.1    
 DLM82_06535   Streptococcus agalactiae PLGBS13 QDK30316.1    
 CUZ18_05240   Streptococcus agalactiae QMA0271 AWQ29481.1    
 BTH44_05635   Streptococcus agalactiae S13 APO41878.1    
 A9J19_05590   Streptococcus agalactiae S25 ANI27449.1    
 DSN71_06295   Streptococcus agalactiae S73 AXC17570.1    
 SaSA1_1062 (HylB)   Streptococcus agalactiae SA1 AUO87086.1    
 SaSA102_1060 (HylB)   Streptococcus agalactiae SA102 AUP03517.1    
 SaSA132_1057 (HylB)   Streptococcus agalactiae SA132 AUP05100.1    
 SaSA136_1056 (HylB)   Streptococcus agalactiae SA136 AUP06760.1    
 SaSA159_1057 (HylB)   Streptococcus agalactiae SA159 AUP08310.1    
 SaSA16_1053 (HylB)   Streptococcus agalactiae SA16 AUO92047.1    
 SaSA191_1059 (HylB)   Streptococcus agalactiae SA191 AUP11473.1    
 SaSA195_1062 (HylB)   Streptococcus agalactiae SA195 AUP13072.1    
 SaSA20_1016 (HylB)   Streptococcus agalactiae SA20-06 AFV72474.1    
 SaSA201_1058 (HylB)   Streptococcus agalactiae SA201 AUP14720.1    
 SaSA209_1058 (HylB)   Streptococcus agalactiae SA209 AUP16403.1    
 SaSA212_1056 (HylB)   Streptococcus agalactiae SA212 AUP18080.1    
 SaSA218_1057 (HylB)   Streptococcus agalactiae SA218 AUP19769.1    
 SaSA220_1055 (HylB)   Streptococcus agalactiae SA220 AUP21466.1    
 SaSA245_1053 (HylB)   Streptococcus agalactiae SA245 AUP23144.1    
 SaSA256_1055 (HylB)   Streptococcus agalactiae SA256 AUP24829.1    
 SaSA289_1057 (HylB)   Streptococcus agalactiae SA289 AUP26522.1    
 SaSA30_1059 (HylB)   Streptococcus agalactiae SA30 AUO80582.1    
 SaSA33_1058 (HylB)   Streptococcus agalactiae SA33 AUO82174.1    
 SaSA330_1059 (HylB)   Streptococcus agalactiae SA330 AUP28218.1    
 SaSA333_1056 (HylB)   Streptococcus agalactiae SA333 AUP29916.1    
 SaSA341_1058 (HylB)   Streptococcus agalactiae SA341 AUP31611.1    
 SaSA343_1053 (HylB)   Streptococcus agalactiae SA343 AUP33314.1    
 SaSA346_1051 (HylB)   Streptococcus agalactiae SA346 AUP35019.1    
 SaSA374_1057 (HylB)   Streptococcus agalactiae SA374 AUP36682.1    
 SaSA375_1057 (HylB)   Streptococcus agalactiae SA375 AUP38342.1    
 SaSA5_1060 (HylB)   Streptococcus agalactiae SA5 AUO88741.1    
 SaSA53_1053 (HylB)   Streptococcus agalactiae SA53 AUO83823.1    
 SaSA623_1057 (HylB)   Streptococcus agalactiae SA623 AUP40066.1    
 SaSA627_1057 (HylB)   Streptococcus agalactiae SA627 AUP41795.1    
 SaSA73_1060 (HylB)   Streptococcus agalactiae SA73 AUO85460.1    
 SaSA75_1059 (HylB)   Streptococcus agalactiae SA75 AUO93726.1    
 SaSA79_1061 (HylB)   Streptococcus agalactiae SA79 AUO95388.1    
 SaSA81_1052 (HylB)   Streptococcus agalactiae SA81 AUO97055.1    
 SaSA85_1063 (HylB)   Streptococcus agalactiae SA85 AUO98700.1    
 SaSA9_1061 (HylB)   Streptococcus agalactiae SA9 AUO90388.1    
 SaSA95_1059 (HylB)   Streptococcus agalactiae SA95 AUP00345.1    
 SaSA97_1061 (HylB)   Streptococcus agalactiae SA97 AUP01974.1    
 EXA24_06830   Streptococcus agalactiae Sag153 QIW49448.1    
 B2G84_06620 (fragment)   Streptococcus agalactiae Sag158 AQY26557.1    
 B1H24_06860   Streptococcus agalactiae Sag37 AQY24485.1    
 AMD29_06425   Streptococcus agalactiae SG-M1 ALB16210.1    
 BB194_06520   Streptococcus agalactiae SG-M158 ASA84053.1    
 BB197_06520   Streptococcus agalactiae SG-M163 ASA82000.1    
 BB164_07095 (fragment)   Streptococcus agalactiae SG-M25 ASA90294.1    
 BB268_06520   Streptococcus agalactiae SG-M29 ASA88157.1    
 BB165_06145   Streptococcus agalactiae SG-M4 ASA99110.1    
 BB313_06515   Streptococcus agalactiae SG-M50 ASA86103.1    
 BB162_06165   Streptococcus agalactiae SG-M6 ASA94416.1    
 CWQ22_06060   Streptococcus agalactiae SGEHI2015-107 ATZ83062.1    
 CWQ23_06060   Streptococcus agalactiae SGEHI2015-113 ATZ89517.1    
 CWQ20_06325   Streptococcus agalactiae SGEHI2015-25 ATZ85066.1    
 CWQ21_06595   Streptococcus agalactiae SGEHI2015-95 ATZ91585.1    
 RDF_1194   Streptococcus agalactiae SS1 AKI95609.1    
 hyaluronate lyase (fragment)   Streptococcus agalactiae SU12 BBB87116.1    
 hyaluronate lyase (fragment)   Streptococcus agalactiae SU97 BBB87173.1    
 DNK17_09455   Streptococcus agalactiae TFJ0901 AZL56540.1    
 BBP08_02765   Streptococcus agalactiae WC1535 AOQ20231.1    
 YM001_06060   Streptococcus agalactiae YM001 AKT98224.1    
 C2E46_06835   Streptococcus agalactiae YZ1605 QHO93537.1    
 G9U50_06155   Streptococcus agalactiae ZQ0910 QIM31382.1    
 SANR_1718   Streptococcus anginosus C238 AGU84133.1    
 ORF   Streptococcus anginosus MAS624 AAQ73521.1 Q6W9E0  
 ANG_0558   Streptococcus anginosus subsp. whileyi MAS624 BAN61028.1    
 hyaluronate lyase 4.2.2.1 Streptococcus constellatus subsp. constellatus ATCC 27823 AAK67165.1 Q934I5  
 ORF (partial)   Streptococcus constellatus subsp. constellatus C-19 AAQ73520.1    
 SCI_1642   Streptococcus constellatus subsp. pharyngis C1050 AGU80540.1    
 SCRE_1598   Streptococcus constellatus subsp. pharyngis C232 AGU73395.1    
 SCR2_1598   Streptococcus constellatus subsp. pharyngis C818 AGU75149.1    
 ORF   Streptococcus constellatus subsp. pharyngis MM9889A AAQ73523.1 Q6W9D8  
 FOB62_01555   Streptococcus dysgalactiae FDAARGOS_654 QET82080.1    
 FGCSD_1433 (HylB)   Streptococcus dysgalactiae Kdys0611 BBE40658.1    
 NCTC6403_00745 (HylB)   Streptococcus dysgalactiae NCTC6403 VTS99804.1    
 EBL83_03135   Streptococcus dysgalactiae SCDR-SD1 QFZ09303.1    
 EA456_04480   Streptococcus dysgalactiae subsp. dysgalactiae DB31752-13 QGG99800.1    
 NCTC4669_00818 (HylB)   Streptococcus dysgalactiae subsp. dysgalactiae NCTC4669 VDZ40044.1    
 EA458_01415   Streptococcus dysgalactiae subsp. dysgalactiae STREP97-15 QGH03286.1    
 SDSE167_0713 (HylB)   Streptococcus dysgalactiae subsp. equisimilis 167 BAN93105.1    
 SDSE_0694 (HylB)   Streptococcus dysgalactiae subsp. equisimilis AC-2713 CCI62192.1    
 SDE12394_03510   Streptococcus dysgalactiae subsp. equisimilis ATCC 12394 ADX24222.1    
 SDEG_0654 (HylB)   Streptococcus dysgalactiae subsp. equisimilis GGS_124 BAH81156.1 C5WFJ1  
 NCTC11554_00787 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC11554 VTT14358.1    
 NCTC11556_00722 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC11556 VTT20590.1    
 NCTC5370_00706 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC5370 SQE85503.1    
 NCTC5371_00739 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC5371 SQF77647.1    
 NCTC6179_00813 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC6179 SQF66648.1    
 NCTC6181_02151 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC6181 VEF08302.1    
 NCTC7136_00741 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC7136 SQG92562.1    
 NCTC8546_00701 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC8546 VTS21365.1    
 NCTC9413_00701 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC9413 VTT00236.1    
 NCTC9414_01622 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC9414 SQF69583.1    
 GGS_0628 (HylB)   Streptococcus dysgalactiae subsp. equisimilis RE378 BAM60784.1    
 HG697_03665   Streptococcus dysgalactiae subsp. equisimilis TPCH-A19 QJD61596.1    
 HHM65_03695   Streptococcus dysgalactiae subsp. equisimilis TPCH-A74 QJD63506.1    
 HHM66_03360   Streptococcus dysgalactiae subsp. equisimilis TPCH-A88 QJR38909.1    
 SE071780_01514 (fragment)   Streptococcus equi subsp. equi ATCC 39506 ASB97105.1    
 NCTC12091_01309 (HylB)   Streptococcus equi subsp. equi NCTC12091 VED85854.1    
 NCTC9682_01573 (Hylb_2) (fragment)   Streptococcus equi subsp. equi NCTC9682 VEH34212.1    
 GJS33_06510   Streptococcus equi subsp. zooepidemicus AZ-45470 QGM23791.1    
 SZO_06680   Streptococcus equi subsp. zooepidemicus H70 CAW98747.1    
 Sez_1299   Streptococcus equi subsp. zooepidemicus MGCS10565 ACG62635.1 B4U3R8  
 NCTC11606_01304 (HylB)   Streptococcus equi subsp. zooepidemicus NCTC11606 SQF54316.1    
 NCTC11824_01293 (HylB)   Streptococcus equi subsp. zooepidemicus NCTC11824 SQG17479.1    
 NCTC11854_02014 (HylB)   Streptococcus equi subsp. zooepidemicus NCTC11854 VTP94435.1    
 NCTC12090_01400 (HylB)   Streptococcus equi subsp. zooepidemicus NCTC12090 SQF05908.1    
 NCTC4675_01333 (HylB)   Streptococcus equi subsp. zooepidemicus NCTC4675 VTS30303.1    
 NCTC6176_01339 (HylB)   Streptococcus equi subsp. zooepidemicus NCTC6176 SQF81960.1    
 NCTC6180_00474 (HylB)   Streptococcus equi subsp. zooepidemicus NCTC6180 VEF05717.1    
 NCTC7022_01369 (HylB)   Streptococcus equi subsp. zooepidemicus NCTC7022 SQE96238.1    
 BMF34_01220   Streptococcus iniae 89353 APD31157.1    
 CTW00_00807 (HylB)   Streptococcus iniae FP5228 ATX39008.1    
 D5R92_06735   Streptococcus iniae GX005 AYB02088.1    
 DQ08_01045   Streptococcus iniae ISET0901 AHY15097.1    
 DW64_01040   Streptococcus iniae ISNO AHY16967.1    
 QMA0248_0228 (HylB)   Streptococcus iniae QMA0248 ASL34076.1    
 K710_0217   Streptococcus iniae SF1 AGM98022.1    
 D5R90_06770   Streptococcus iniae YM011 AYB03955.1    
 SI82_01295   Streptococcus iniae YSFST01-82 AJG25283.1    
 hyaluronate lyase 4.2.2.1 Streptococcus intermedius ATCC 27335 AAK67167.1 Q934I4  
 SIR_1547   Streptococcus intermedius B196 AGU76898.1    
 SII_1533   Streptococcus intermedius C270 AGU78697.1    
 A6J72_07395   Streptococcus intermedius FDAARGOS_233 ARC27012.1    
 FOC71_09605   Streptococcus intermedius FDAARGOS_769 QKH78711.1    
 SCIM_1362   Streptococcus intermedius JTH08 BAM24016.1    
 RN88_07180   Streptococcus intermedius KCOM 1545 ALF28283.1    
 NCTC11324_01543   Streptococcus intermedius NCTC11324 SQH52493.1    
 SITYG_16360   Streptococcus intermedius TYG1620 BAW17615.1    
 NCTC10708_01510 (fragment)   Streptococcus milleri NCTC10708 VEE83406.1    
 STP_1167   Streptococcus parauberis KCTC 11537 AEF25615.1    
 SAMEA104035599_00332   Streptococcus pneumoniae VGM78639.1    
 Sequence 4843 from patent US 6800744   Streptococcus pneumoniae AAW09447.1
ABI03997.1
ABI09038.1
ABJ32554.1
ABJ50167.1
ABL17910.1
   
 BUM80_10710   Streptococcus pneumoniae 11A AUC46739.1    
 CWI64_08655   Streptococcus pneumoniae 19F AUB33652.1    
 SAMEA2148390_00319   Streptococcus pneumoniae 2245STDY5562351 VFH52701.1    
 SAMEA2147627_00349   Streptococcus pneumoniae 2245STDY5562369 VFH39652.1    
 SAMEA2150192_00280   Streptococcus pneumoniae 2245STDY5562412 VFH63301.1    
 SAMEA2145720_00259   Streptococcus pneumoniae 2245STDY5562562 VFH56913.1    
 SAMEA2162916_00336   Streptococcus pneumoniae 2245STDY5562600 VFH54667.1    
 SAMEA2157525_00322   Streptococcus pneumoniae 2245STDY5562629 VFH38729.1    
 SAMEA2203271_00394   Streptococcus pneumoniae 2245STDY5605535 VFH43289.1    
 SAMEA2203380_00301   Streptococcus pneumoniae 2245STDY5605669 VFH39829.1    
 SAMEA2203393_00420   Streptococcus pneumoniae 2245STDY5605682 VFH41045.1    
 SAMEA2204055_00313   Streptococcus pneumoniae 2245STDY5609197 VFH38267.1    
 SAMEA2204095_00301   Streptococcus pneumoniae 2245STDY5609237 VFH44106.1    
 SAMEA2336038_00432   Streptococcus pneumoniae 2245STDY5699131 VFH56851.1    
 SAMEA2341150_00372   Streptococcus pneumoniae 2245STDY5699394 VFH57270.1    
 SAMEA2341240_00373   Streptococcus pneumoniae 2245STDY5699475 VGM69976.1    
 SAMEA2434444_00324   Streptococcus pneumoniae 2245STDY5775485 VFH60204.1    
 SAMEA2434479_00391   Streptococcus pneumoniae 2245STDY5775520 VFH63924.1    
 SAMEA2434504_00356   Streptococcus pneumoniae 2245STDY5775545 VFH71583.1    
 SAMEA2434511_00394   Streptococcus pneumoniae 2245STDY5775553 VGM72086.1    
 SAMEA2434561_00300   Streptococcus pneumoniae 2245STDY5775603 VFH80899.1    
 SAMEA2434568_00358 (fragment)   Streptococcus pneumoniae 2245STDY5775610 VFH82368.1    
 SAMEA2434623_00342   Streptococcus pneumoniae 2245STDY5775666 VFH80195.1    
 SAMEA2434829_00293   Streptococcus pneumoniae 2245STDY5775874 VFH75298.1    
 SAMEA2627289_00334   Streptococcus pneumoniae 2245STDY5868782 VFH77767.1    
 SAMEA2796698_00285   Streptococcus pneumoniae 2245STDY5982722 VFH75739.1    
 SAMEA2797120_00278   Streptococcus pneumoniae 2245STDY5983173 VFH78257.1    
 SAMEA3175698_00327   Streptococcus pneumoniae 2245STDY6020210 VFH96377.1    
 SAMEA3175709_00287   Streptococcus pneumoniae 2245STDY6020221 VFI00432.1    
 SAMEA3175728_00357   Streptococcus pneumoniae 2245STDY6020240 VGM74205.1    
 SAMEA3233211_00350 (fragment)   Streptococcus pneumoniae 2245STDY6030848 VFH93871.1    
 SAMEA3233395_00365   Streptococcus pneumoniae 2245STDY6031034 VFI01133.1    
 SAMEA3233409_00345   Streptococcus pneumoniae 2245STDY6031048 VFH95894.1    
 SAMEA3354333_00394 (fragment)   Streptococcus pneumoniae 2245STDY6092581 VFH97722.1    
 SAMEA3354357_00441   Streptococcus pneumoniae 2245STDY6092613 VFI00818.1    
 SAMEA3381325_00327   Streptococcus pneumoniae 2245STDY6092834 VFI00133.1    
 SAMEA3381439_00302   Streptococcus pneumoniae 2245STDY6092949 VFI20845.1    
 SAMEA3381491_00388   Streptococcus pneumoniae 2245STDY6093044 VFI12656.1    
 SAMEA3389228_00312   Streptococcus pneumoniae 2245STDY6105839 VFI36742.1    
 SAMEA3389261_00286   Streptococcus pneumoniae 2245STDY6105855 VGM79655.1    
 SAMEA3390054_00336   Streptococcus pneumoniae 2245STDY6106337 VFI15354.1    
 SAMEA3389940_00260   Streptococcus pneumoniae 2245STDY6106372 VFI19816.1    
 SAMEA3389963_00343   Streptococcus pneumoniae 2245STDY6106384 VFI20883.1    
 SAMEA3431348_00385   Streptococcus pneumoniae 2245STDY6106635 VGM75940.1    
 SAMEA3431351_00337   Streptococcus pneumoniae 2245STDY6106637 VFI20736.1    
 SAMEA3431383_00289   Streptococcus pneumoniae 2245STDY6106751 VFI16701.1    
 SAMEA3713867_00332   Streptococcus pneumoniae 2245STDY6178787 VFI34008.1    
 SAMEA3713960_00438   Streptococcus pneumoniae 2245STDY6178826 VFI36025.1    
 SAMEA3713964_00398   Streptococcus pneumoniae 2245STDY6178828 VFI51205.1    
 SAMEA3714019_00346 (fragment)   Streptococcus pneumoniae 2245STDY6178854 VGM78610.1    
 C4N11_01535   Streptococcus pneumoniae 335 AVD74319.1    
 SP670_0382   Streptococcus pneumoniae 670-6B ADM90457.1 E0TRJ4  
 HKM25_335 (HylB)   Streptococcus pneumoniae 6A-10 QJS36047.1    
 SP70585_0379   Streptococcus pneumoniae 70585 ACO16655.1 C1CB94  
 T308_01575   Streptococcus pneumoniae A026 AGZ47134.1    
 A66_00307   Streptococcus pneumoniae A66 CRI61018.1    
 SPAP_0347   Streptococcus pneumoniae AP200 ADM83940.1 E0SVG1  
 ASP0581_03190 (HysA)   Streptococcus pneumoniae ASP0581 BBG80841.1    
 SPN23F02890   Streptococcus pneumoniae ATCC 700669 CAR68147.1 B8ZL35  
 GJE16_01530   Streptococcus pneumoniae AUSMDU00010538 QGK03206.1    
 SPCG_0322   Streptococcus pneumoniae CGSP14 ACB89574.1 B2ISN7  
 SPND122_00329 (fragment)   Streptococcus pneumoniae D122 AOG55280.1    
 SPND141_00331 (fragment)   Streptococcus pneumoniae D141 AOG57361.1    
 SPD_0287   Streptococcus pneumoniae D39 ABJ54273.1 Q04ME3  
 SPV_0287 (SpnhL)   Streptococcus pneumoniae D39V AVN85461.1    
 C3Y86_01500   Streptococcus pneumoniae EF3030 AXK90819.1
QBF68327.1
   
 SPG_0285 (HyL)   Streptococcus pneumoniae G54 ACF54992.1 B5E6X4  
 HMPREF1038_00364 (HysA)   Streptococcus pneumoniae gamPNI0373 AFS42440.1    
 SPOH_0280 (fragment)   Streptococcus pneumoniae HU-OH BBG36312.1    
 SPOH_0281 (fragment)   Streptococcus pneumoniae HU-OH BBG36313.1    
 SPNHU15_00387   Streptococcus pneumoniae Hu15 ARD36199.1    
 SPNHU17_00385   Streptococcus pneumoniae Hu17 ARD33999.1    
 SPH_0426   Streptococcus pneumoniae Hungary19A-6 ACA36441.1 B1I936  
 SPNINV200_02820   Streptococcus pneumoniae INV200 CBW33916.1 E1XHX5  
 SPJ_0310   Streptococcus pneumoniae JJA ACO18875.1 C1CC91  
 KK0381_20060 (fragment)   Streptococcus pneumoniae KK0381 BAX32126.1    
 KK0381_20050 (HyL) (fragment)   Streptococcus pneumoniae KK0381 BAX32125.1    
 KK0981_23420 (fragment)   Streptococcus pneumoniae KK0981 BAW83838.1    
 KK0981_23410 (HyL) (fragment)   Streptococcus pneumoniae KK0981 BAW83837.1    
 KK1157_21240 (fragment)   Streptococcus pneumoniae KK1157 BAX34421.1    
 MDRSPN_00289 (HysA)   Streptococcus pneumoniae MDRSPN001 BBA58495.1    
 NCTC11902_00321   Streptococcus pneumoniae NCTC11902 SQG97959.1    
 NCTC12977_02029   Streptococcus pneumoniae NCTC12977 VEE31504.1    
 NCTC13276_00295   Streptococcus pneumoniae NCTC13276 SQG33576.1    
 ERS445053_00184   Streptococcus pneumoniae NCTC7465 COT00131.1    
 NCTC7466_00296   Streptococcus pneumoniae NCTC7466 SQG01354.1    
 SpnNT_00308 (fragment)   Streptococcus pneumoniae NT_110_58 AJD71249.1    
 SPNU_0306   Streptococcus pneumoniae NU83127 BBG34197.1    
 SPP_0350   Streptococcus pneumoniae P1031 ACO21275.1 C1CII1  
 HA248_01595   Streptococcus pneumoniae PZ900701590 QIP99183.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP004 AGI41259.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP008 AGI41260.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP010 AGI41261.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP014 AGI41262.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP015 AGI41263.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP017 AGI41264.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP028 AGI41265.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP031 AGI41266.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP034 AGI41267.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP035 AGI41268.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP036 AGI41269.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP037 AGI41270.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP038 AGI41271.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP039 AGI41272.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP041 AGI41273.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP043 AGI41274.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP044 AGI41275.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP066 AGI41276.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP074 AGI41278.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP089 AGI41279.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP090 AGI41280.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP091 AGI41281.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP092 AGI41282.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP094 AGI41283.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP096 AGI41284.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP098 AGI41285.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP100 AGI41286.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP102 AGI41287.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP103 AGI41288.1    
 BMJ42_00426   Streptococcus pneumoniae SP49 APJ29761.1    
 BOC71_00314 (fragment)   Streptococcus pneumoniae SP61 APJ31834.1    
 BOC71_00313 (fragment)   Streptococcus pneumoniae SP61 APJ31833.1    
 BOC72_00314 (fragment)   Streptococcus pneumoniae SP64 APJ33859.1    
 BOC72_00313 (fragment)   Streptococcus pneumoniae SP64 APJ33858.1    
 C1H54_01650   Streptococcus pneumoniae SPN XDR SMC1710-32 AXJ87751.1    
 SPNA45_01722   Streptococcus pneumoniae SPNA45 CCM09007.1    
 MYY_0397   Streptococcus pneumoniae ST556 AFC94059.1    
 SPT_0364   Streptococcus pneumoniae Taiwan19F-14 ACO22630.1 C1CPJ1  
 HMPREF0837_10617 (fragment)   Streptococcus pneumoniae TCH8431/19A ADI68845.1 D6ZQF6  
 hyaluronate lyase (Hyl;SpHyl;SP0314) 4.2.2.1 Streptococcus pneumoniae TIGR4 AAK74491.1
NP_344851.1
Q54873 4D0Q[A]
 CXP32_01570   Streptococcus pneumoniae Xen35 AUF84202.1    
 SR187_3375   Streptococcus ruminantium GUT187T BBA92284.1    
 BZG42_03485   Streptococcus sp. DAT741 QHF54467.1    
 EGX96_00365   Streptococcus sp. FDAARGOS_520 AYZ03772.1    
 EGX72_05860   Streptococcus sp. FDAARGOS_521 AYY68524.1    
 EGX70_01505   Streptococcus sp. FDAARGOS_522 AYY63625.1    
 A6J68_07690   Streptococcus sp. group B FDAARGOS_229 ARC25048.1    
 NCTC10228_00503 (HylB)   Streptococcus sp. NCTC 10228 VUC96290.1    
 NCTC11567_01447 (HylB)   Streptococcus sp. NCTC 11567 VUC99377.1    
 hyaluronidase (HylA)   Streptococcus suis CAG27053.1 Q6H8Y0  
 hyaluronidase (HylA)   Streptococcus suis CAG27052.1 Q6H8Y1  
 HylA (fragment)   Streptococcus suis CAC87664.1
ADF49630.1
Q8VLQ6  
 hyaluronidase (HylA) (fragment)   Streptococcus suis CAG27068.1 Q6A1P9  
 HAS68_04750   Streptococcus suis 05HAS68 AHF59038.1    
 SSU05_1215 + SSU05_1214 (fragment)   Streptococcus suis 05ZYH33 ABP90180.1
ABP90181.1
   
 hyaluronate lyase (HylA)   Streptococcus suis 1043248 AKC34794.1    
 hyaluronate lyase (HylA)   Streptococcus suis 1097205 AKC34795.1    
 ID09_06430   Streptococcus suis 6407 AIG43680.1    
 AN924_01090   Streptococcus suis 90-1330 AMU78672.1    
 hyaluronidase (HylA) (fragment)   Streptococcus suis 98015 ABD74496.1 Q8VLQ6  
 SSU98_1230 + SSU98_1229 (fragment)   Streptococcus suis 98HAH33 ABP92387.1
ABP92388.1
   
 SSUA7_1066 (fragment)   Streptococcus suis A7 AER44388.1    
 CR541_06045 (fragment)   Streptococcus suis CS100322 AUW24079.1    
 hyaluronidase (HylA) (fragment)   Streptococcus suis CVCC606 ABP35951.1 Q8VLQ6  
 hyaluronidase (HylA) (fragment)   Streptococcus suis CVCC607 ABP35952.1 A4ZX85  
 SSUD9_1371   Streptococcus suis D9 AER17555.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis DAT229 AKC34791.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis DAT261 AKC34790.1    
 A6M16_03715   Streptococcus suis DN13 ANC99638.1    
 BFP66_03605   Streptococcus suis GZ0565 AOM74360.1    
 SSGZ1_1071 (fragment)   Streptococcus suis GZ1 ADE31528.1 D5AI63  
 CR542_06845   Streptococcus suis HA0609 AUW26221.1    
 hyaluronidase   Streptococcus suis HA1001111 ADO66679.1 E3UN55  
 hyaluronidase   Streptococcus suis HA1001112 ADO66680.1 E3UN56  
 hyaluronidase (HylA) (fragment)   Streptococcus suis HA9801 ADC54170.1 D3K641  
 FPT06_00400   Streptococcus suis INT-01 QDS22866.1    
 DK235_05820 (fragment)   Streptococcus suis ISU1606 QLL45367.1    
 DK237_06380   Streptococcus suis ISU2614 QLL47460.1    
 hyaluronidase (HylA) (fragment)   Streptococcus suis JR0507 ADF49631.1 D5LKE5  
 SSUJS14_1182 + SSUJS14_1181 (fragment)   Streptococcus suis JS14 ADV70253.1
ADV70254.1
   
 A9494_05630 (fragment)   Streptococcus suis LSM102 ARX90495.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis MGGUS2 AKC34789.1    
 hyaluronate lyase (HylA)   Streptococcus suis MGGUS5 AKC34796.1    
 hyaluronate lyase (HylA)   Streptococcus suis MGGUS9 AKC34799.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis MNCM01 AKC34787.1    
 hyaluronate lyase (HylA)   Streptococcus suis MNCM04 AKC34797.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis MNCM16 AKC34788.1    
 hyaluronate lyase (HylA)   Streptococcus suis MNCM43 AKC34798.1    
 NCTC10234_01050 (fragment)   Streptococcus suis NCTC10234 SQH00684.1    
 NCTC10237_01202   Streptococcus suis NCTC10237 VTT03533.1    
 AA105_07005   Streptococcus suis NSUI002 ALA28993.1    
 APQ97_06125   Streptococcus suis NSUI060 AML46650.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis P1/7 AKC34785.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis P477/03P1 AKC34793.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis P517/03P4 AKC34792.1    
 YYK_05005 (HylA) (fragment)   Streptococcus suis S735 AFR00520.1
AKC34786.1
   
 NJAUSS_1123 (fragment)   Streptococcus suis SC070731 AGG64592.1    
 hyaluronidase (HylA) (fragment)   Streptococcus suis SC152 ABD74495.1 Q8VLQ6  
 hyaluronidase (HylA) (fragment)   Streptococcus suis SC17 ABD74493.1 Q8VLQ6  
 B9H01_05870 (fragment)   Streptococcus suis SC19 ARL70059.1    
 hyaluronidase (HylA) (fragment)   Streptococcus suis SC22 ABD74494.1 Q8VLQ6  
 hyaluronidase (HylA)   Streptococcus suis SEROTYPE 2 CAG27049.1
CAG27048.1
Q6H8Y3
Q6H8Y4
 
 hyaluronidase (HylA)   Streptococcus suis SEROTYPE 2 CAG27050.1 Q6H8Y2
Q6H8Y4
 
 hyaluronidase (HylA) 4.2.2.1 Streptococcus suis SEROTYPE 7 CAC87662.1 Q8VLQ8  
 A7J08_03850   Streptococcus suis SRD478 ASW49450.1    
 SSU12_1118 (fragment)   Streptococcus suis SS12 AER15299.1    
 BVD85_05705 (fragment)   Streptococcus suis SS2-1 AUW22057.1    
 hyaluronidase (HylA) (fragment)   Streptococcus suis SS2-1 ADC54171.1    
 SSUST1_0748   Streptococcus suis ST1 AER21132.1    
 SSUST3_1226   Streptococcus suis ST3 AEB81651.1    
 T15_0747   Streptococcus suis T15 AGZ22850.1    
 YB51_6050   Streptococcus suis YB51 AGW87582.1    
 ZY05719_05815 (fragment)   Streptococcus suis ZY05719 AKG40504.1    
 NCTC3858_01491 (HylB)   Streptococcus uberis NCTC3858 SQG46732.1    
 NCTC13766_00112 (Hylb_1) (fragment)   Streptococcus urinalis NCTC13766 VEF31047.1    
 Trebr_1554   Treponema brennaborense DSM 12168 AEE16977.1    
 BME96_15890   Virgibacillus halodenitrificans PDB-F2 APC49583.1    
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