Carbohydrate-Binding Module Family 70

Activities in FamilyThe hyaluronan-specific binding function of the N-terminal CBM70 module of Streptococcus pneumoniae hyaluronate lyase has been demonstrated.
3D Structure Statusβ-sandwich
NoteCreated after Suits et al. (2014) J Biol Chem 289:27264-27277 [PMID: 25100731]
Statistics GenBank accession (226); Uniprot accession (37); PDB accession (1); 3D entries (1); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 hyaluronate lyase (BniHL)   Bacillus niacini F8 BAO57293.1    
 hyaluronidase (Hyl;HAase-B) (partial) 4.2.2.1 Bacillus sp. A50 AHB61202.1    
 A3958_01915   Paenibacillus glucanolyticus 5162 ANA78826.1    
 BBD41_21650   Paenibacillus ihbetae IHBB 9852 ANY74958.1    
 IJ21_17060   Paenibacillus sp. 32O-W ALS27107.1    
 IJ21_17060   Paenibacillus sp. 32O-W ALS27107.1    
 GYMC10_2460   Paenibacillus sp. Y412MC10 ACX64738.1 D3E9T1  
 SAMN05661091_5261   Paenibacillus uliginis N3/975 SMF90851.1    
 SZO_06680   Steptococcus equi subsp. zooepidemicus H70 CAW98747.1    
 SA111_01368 (HylB)   Streptococcus agalactiae CZT39479.1    
 BQ8897_BM110_01288 (HylB)   Streptococcus agalactiae SIW57730.1    
 BSA_12760   Streptococcus agalactiae 09mas018883 CCW38045.1    
 V193_05585   Streptococcus agalactiae 138P AHN30604.1    
 DN94_05585   Streptococcus agalactiae 138spar AHX75150.1    
 GBS222_1026 (HylB)   Streptococcus agalactiae 2-22 CCO74748.1    
 SAG1197   Streptococcus agalactiae 2603V/R AAN00079.1
NP_688206.1
   
 hyaluronate lyase (HylB) 4.2.2.1 Streptococcus agalactiae 4755 CAA75865.1 O86478  
 CHF17_01286   Streptococcus agalactiae 874391 ASZ01543.1    
 SAK_1284 (HylB)   Streptococcus agalactiae A909 ABA45106.1    
 GT95_06720   Streptococcus agalactiae C001 ASI66297.1    
 GBSCOH1_1103   Streptococcus agalactiae COH1 CDN66569.1    
 BB161_06890   Streptococcus agalactiae CUGBS591 ASA79900.1    
 CUGBS08_01230 (HylB)   Streptococcus agalactiae CU_GBS_08 AMQ14781.1    
 CUGBS98_01167 (HylB)   Streptococcus agalactiae CU_GBS_98 AMQ16773.1    
 A6J82_06845   Streptococcus agalactiae FDAARGOS_254 ARC45071.1    
 A9256_06185   Streptococcus agalactiae FWL1402 ANR97234.1    
 AOY37_06410   Streptococcus agalactiae GBS ST-1 ALP87742.1    
 DK41_06360   Streptococcus agalactiae GBS1-NY AIK71752.1    
 DK42_06655   Streptococcus agalactiae GBS2-NM AIK73870.1    
 DX05_06680   Streptococcus agalactiae GBS6 AIK75919.1    
 GBS85147_1176   Streptococcus agalactiae GBS85147 AKI57601.1    
 A964_1170   Streptococcus agalactiae GD201008-001 AFS45935.1    
 GX026_05610   Streptococcus agalactiae GX026 AKU01911.1    
 GX064_06035   Streptococcus agalactiae GX064 AKU00152.1    
 SAH002_06140 (fragment)   Streptococcus agalactiae H002 AKU03714.1    
 SAHN016_06120   Streptococcus agalactiae HN016 AKT96278.1    
 MSA_13200 (fragment)   Streptococcus agalactiae ILRI005 CCW40178.1    
 SAIL_13150   Streptococcus agalactiae ILRI112 CCW42329.1    
 hyaluronate lyase (HylB;SaHyl;Gbs1270) 4.2.2.1 Streptococcus agalactiae NEM316 CAD46929.1
AAA56749.1
NP_735714.1
Q53591  
 EN72_06630   Streptococcus agalactiae NGBS061 AIF86754.1    
 AMM49_06240   Streptococcus agalactiae NGBS128 AMD32505.1    
 AMR84_06675   Streptococcus agalactiae NGBS357 AOF51244.1    
 EN73_06165   Streptococcus agalactiae NGBS572 AIF88771.1    
 BTH44_05635   Streptococcus agalactiae S13 APO41878.1    
 A9J19_05590   Streptococcus agalactiae S25 ANI27449.1    
 SaSA20_1016 (HylB)   Streptococcus agalactiae SA20-06 AFV72474.1    
 B2G84_06620 (fragment)   Streptococcus agalactiae Sag158 AQY26557.1    
 B1H24_06860   Streptococcus agalactiae Sag37 AQY24485.1    
 AMD29_06425   Streptococcus agalactiae SG-M1 ALB16210.1    
 BB194_06520   Streptococcus agalactiae SG-M158 ASA84053.1    
 BB197_06520   Streptococcus agalactiae SG-M163 ASA82000.1    
 BB164_07095 (fragment)   Streptococcus agalactiae SG-M25 ASA90294.1    
 BB268_06520   Streptococcus agalactiae SG-M29 ASA88157.1    
 BB165_06145   Streptococcus agalactiae SG-M4 ASA99110.1    
 BB313_06515   Streptococcus agalactiae SG-M50 ASA86103.1    
 BB162_06165   Streptococcus agalactiae SG-M6 ASA94416.1    
 RDF_1194   Streptococcus agalactiae SS1 AKI95609.1    
 BBP08_02765   Streptococcus agalactiae WC1535 AOQ20231.1    
 YM001_06060   Streptococcus agalactiae YM001 AKT98224.1    
 SANR_1718   Streptococcus anginosus C238 AGU84133.1    
 ORF   Streptococcus anginosus MAS624 AAQ73521.1 Q6W9E0  
 ANG_0558   Streptococcus anginosus subsp. whileyi MAS624 BAN61028.1    
 hyaluronate lyase 4.2.2.1 Streptococcus constellatus subsp. constellatus ATCC 27823 AAK67165.1 Q934I5  
 ORF (partial)   Streptococcus constellatus subsp. constellatus C-19 AAQ73520.1    
 SCI_1642   Streptococcus constellatus subsp. pharyngis C1050 AGU80540.1    
 SCRE_1598   Streptococcus constellatus subsp. pharyngis C232 AGU73395.1    
 SCR2_1598   Streptococcus constellatus subsp. pharyngis C818 AGU75149.1    
 ORF   Streptococcus constellatus subsp. pharyngis MM9889A AAQ73523.1 Q6W9D8  
 SDSE167_0713 (HylB)   Streptococcus dysgalactiae subsp. equisimilis 167 BAN93105.1    
 SDSE_0694 (HylB)   Streptococcus dysgalactiae subsp. equisimilis AC-2713 CCI62192.1    
 SDE12394_03510   Streptococcus dysgalactiae subsp. equisimilis ATCC 12394 ADX24222.1    
 SDEG_0654 (HylB)   Streptococcus dysgalactiae subsp. equisimilis GGS_124 BAH81156.1 C5WFJ1  
 GGS_0628 (HylB)   Streptococcus dysgalactiae subsp. equisimilis RE378 BAM60784.1    
 SE071780_01514 (fragment)   Streptococcus equi subsp. equi ATCC 39506 ASB97105.1    
 Sez_1299   Streptococcus equi subsp. zooepidemicus MGCS10565 ACG62635.1 B4U3R8  
 BMF34_01220   Streptococcus iniae 89353 APD31157.1    
 DQ08_01045   Streptococcus iniae ISET0901 AHY15097.1    
 DW64_01040   Streptococcus iniae ISNO AHY16967.1    
 QMA0248_0228 (HylB)   Streptococcus iniae QMA0248 ASL34076.1    
 K710_0217   Streptococcus iniae SF1 AGM98022.1    
 SI82_01295   Streptococcus iniae YSFST01-82 AJG25283.1    
 hyaluronate lyase 4.2.2.1 Streptococcus intermedius ATCC 27335 AAK67167.1 Q934I4  
 SIR_1547   Streptococcus intermedius B196 AGU76898.1    
 SII_1533   Streptococcus intermedius C270 AGU78697.1    
 A6J72_07395   Streptococcus intermedius FDAARGOS_233 ARC27012.1    
 SCIM_1362   Streptococcus intermedius JTH08 BAM24016.1    
 RN88_07180   Streptococcus intermedius KCOM 1545 ALF28283.1    
 SITYG_16360   Streptococcus intermedius TYG1620 BAW17615.1    
 STP_1167   Streptococcus parauberis KCTC 11537 AEF25615.1    
 Sequence 4843 from patent US 6800744   Streptococcus pneumoniae AAW09447.1
ABI03997.1
ABI09038.1
ABJ32554.1
ABJ50167.1
ABL17910.1
   
 SP670_0382   Streptococcus pneumoniae 670-6B ADM90457.1 E0TRJ4  
 SP70585_0379   Streptococcus pneumoniae 70585 ACO16655.1 C1CB94  
 T308_01575   Streptococcus pneumoniae A026 AGZ47134.1    
 A66_00307   Streptococcus pneumoniae A66 CRI61018.1    
 SPAP_0347   Streptococcus pneumoniae AP200 ADM83940.1 E0SVG1  
 SPN23F02890   Streptococcus pneumoniae ATCC 700669 CAR68147.1 B8ZL35  
 SPCG_0322   Streptococcus pneumoniae CGSP14 ACB89574.1 B2ISN7  
 SPND122_00329 (fragment)   Streptococcus pneumoniae D122 AOG55280.1    
 SPND141_00331 (fragment)   Streptococcus pneumoniae D141 AOG57361.1    
 SPD_0287   Streptococcus pneumoniae D39 ABJ54273.1 Q04ME3  
 SPG_0285 (HyL)   Streptococcus pneumoniae G54 ACF54992.1 B5E6X4  
 HMPREF1038_00364 (HysA)   Streptococcus pneumoniae gamPNI0373 AFS42440.1    
 SPNHU15_00387   Streptococcus pneumoniae Hu15 ARD36199.1    
 SPNHU17_00385   Streptococcus pneumoniae Hu17 ARD33999.1    
 SPH_0426   Streptococcus pneumoniae Hungary19A-6 ACA36441.1 B1I936  
 SPNINV200_02820   Streptococcus pneumoniae INV200 CBW33916.1 E1XHX5  
 SPJ_0310   Streptococcus pneumoniae JJA ACO18875.1 C1CC91  
 KK0381_20060 (fragment)   Streptococcus pneumoniae KK0381 BAX32126.1    
 KK0381_20050 (HyL) (fragment)   Streptococcus pneumoniae KK0381 BAX32125.1    
 KK0981_23420 (fragment)   Streptococcus pneumoniae KK0981 BAW83838.1    
 KK0981_23410 (HyL) (fragment)   Streptococcus pneumoniae KK0981 BAW83837.1    
 KK1157_21240 (fragment)   Streptococcus pneumoniae KK1157 BAX34421.1    
 ERS445053_00184   Streptococcus pneumoniae NCTC7465 COT00131.1    
 SpnNT_00308 (fragment)   Streptococcus pneumoniae NT_110_58 AJD71249.1    
 SPP_0350   Streptococcus pneumoniae P1031 ACO21275.1 C1CII1  
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP004 AGI41259.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP008 AGI41260.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP010 AGI41261.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP014 AGI41262.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP015 AGI41263.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP017 AGI41264.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP028 AGI41265.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP031 AGI41266.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP034 AGI41267.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP035 AGI41268.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP036 AGI41269.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP037 AGI41270.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP038 AGI41271.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP039 AGI41272.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP041 AGI41273.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP043 AGI41274.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP044 AGI41275.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP066 AGI41276.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP074 AGI41278.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP089 AGI41279.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP090 AGI41280.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP091 AGI41281.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP092 AGI41282.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP094 AGI41283.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP096 AGI41284.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP098 AGI41285.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP100 AGI41286.1    
 hyaluronate lyase, partial (HyL)   Streptococcus pneumoniae SP102 AGI41287.1    
 hyaluronate lyase (HyL)   Streptococcus pneumoniae SP103 AGI41288.1    
 BMJ42_00426   Streptococcus pneumoniae SP49 APJ29761.1    
 BOC71_00314 (fragment)   Streptococcus pneumoniae SP61 APJ31834.1    
 BOC71_00313 (fragment)   Streptococcus pneumoniae SP61 APJ31833.1    
 BOC72_00314 (fragment)   Streptococcus pneumoniae SP64 APJ33859.1    
 BOC72_00313 (fragment)   Streptococcus pneumoniae SP64 APJ33858.1    
 SPNA45_01722   Streptococcus pneumoniae SPNA45 CCM09007.1    
 MYY_0397   Streptococcus pneumoniae ST556 AFC94059.1    
 SPT_0364   Streptococcus pneumoniae Taiwan19F-14 ACO22630.1 C1CPJ1  
 HMPREF0837_10617 (fragment)   Streptococcus pneumoniae TCH8431/19A ADI68845.1 D6ZQF6  
 hyaluronate lyase (Hyl;SpHyl;SP0314) 4.2.2.1 Streptococcus pneumoniae TIGR4 AAK74491.1
NP_344851.1
Q54873 4D0Q[A]
 A6J68_07690   Streptococcus sp. group B FDAARGOS_229 ARC25048.1    
 hyaluronidase (HylA)   Streptococcus suis CAG27053.1 Q6H8Y0  
 hyaluronidase (HylA)   Streptococcus suis CAG27052.1 Q6H8Y1  
 HylA (fragment)   Streptococcus suis CAC87664.1
ADF49630.1
Q8VLQ6  
 hyaluronidase (HylA) (fragment)   Streptococcus suis CAG27068.1 Q6A1P9  
 HAS68_04750   Streptococcus suis 05HAS68 AHF59038.1    
 SSU05_1215 + SSU05_1214 (fragment)   Streptococcus suis 05ZYH33 ABP90180.1
ABP90181.1
   
 hyaluronate lyase (HylA)   Streptococcus suis 1043248 AKC34794.1    
 hyaluronate lyase (HylA)   Streptococcus suis 1097205 AKC34795.1    
 ID09_06430   Streptococcus suis 6407 AIG43680.1    
 AN924_01090   Streptococcus suis 90-1330 AMU78672.1    
 hyaluronidase (HylA) (fragment)   Streptococcus suis 98015 ABD74496.1 Q8VLQ6  
 SSU98_1230 + SSU98_1229 (fragment)   Streptococcus suis 98HAH33 ABP92387.1
ABP92388.1
   
 SSUA7_1066 (fragment)   Streptococcus suis A7 AER44388.1    
 hyaluronidase (HylA) (fragment)   Streptococcus suis CVCC606 ABP35951.1 Q8VLQ6  
 hyaluronidase (HylA) (fragment)   Streptococcus suis CVCC607 ABP35952.1 A4ZX85  
 SSUD9_1371   Streptococcus suis D9 AER17555.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis DAT229 AKC34791.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis DAT261 AKC34790.1    
 A6M16_03715   Streptococcus suis DN13 ANC99638.1    
 BFP66_03605   Streptococcus suis GZ0565 AOM74360.1    
 SSGZ1_1071 (fragment)   Streptococcus suis GZ1 ADE31528.1 D5AI63  
 hyaluronidase   Streptococcus suis HA1001111 ADO66679.1 E3UN55  
 hyaluronidase   Streptococcus suis HA1001112 ADO66680.1 E3UN56  
 hyaluronidase (HylA) (fragment)   Streptococcus suis HA9801 ADC54170.1 D3K641  
 hyaluronidase (HylA) (fragment)   Streptococcus suis JR0507 ADF49631.1 D5LKE5  
 SSUJS14_1182 + SSUJS14_1181 (fragment)   Streptococcus suis JS14 ADV70253.1
ADV70254.1
   
 A9494_05630 (fragment)   Streptococcus suis LSM102 ARX90495.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis MGGUS2 AKC34789.1    
 hyaluronate lyase (HylA)   Streptococcus suis MGGUS5 AKC34796.1    
 hyaluronate lyase (HylA)   Streptococcus suis MGGUS9 AKC34799.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis MNCM01 AKC34787.1    
 hyaluronate lyase (HylA)   Streptococcus suis MNCM04 AKC34797.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis MNCM16 AKC34788.1    
 hyaluronate lyase (HylA)   Streptococcus suis MNCM43 AKC34798.1    
 AA105_07005   Streptococcus suis NSUI002 ALA28993.1    
 APQ97_06125   Streptococcus suis NSUI060 AML46650.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis P1/7 AKC34785.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis P477/03P1 AKC34793.1    
 hyaluronate lyase (HylA) (fragment)   Streptococcus suis P517/03P4 AKC34792.1    
 YYK_05005 (HylA) (fragment)   Streptococcus suis S735 AFR00520.1
AKC34786.1
   
 NJAUSS_1123 (fragment)   Streptococcus suis SC070731 AGG64592.1    
 hyaluronidase (HylA) (fragment)   Streptococcus suis SC152 ABD74495.1 Q8VLQ6  
 hyaluronidase (HylA) (fragment)   Streptococcus suis SC17 ABD74493.1 Q8VLQ6  
 B9H01_05870 (fragment)   Streptococcus suis SC19 ARL70059.1    
 hyaluronidase (HylA) (fragment)   Streptococcus suis SC22 ABD74494.1 Q8VLQ6  
 hyaluronidase (HylA)   Streptococcus suis SEROTYPE 2 CAG27049.1
CAG27048.1
Q6H8Y3
Q6H8Y4
 
 hyaluronidase (HylA)   Streptococcus suis SEROTYPE 2 CAG27050.1 Q6H8Y2
Q6H8Y4
 
 hyaluronidase (HylA) 4.2.2.1 Streptococcus suis SEROTYPE 7 CAC87662.1 Q8VLQ8  
 SSU12_1118 (fragment)   Streptococcus suis SS12 AER15299.1    
 hyaluronidase (HylA) (fragment)   Streptococcus suis SS2-1 ADC54171.1    
 SSUST1_0748   Streptococcus suis ST1 AER21132.1    
 SSUST3_1226   Streptococcus suis ST3 AEB81651.1    
 T15_0747   Streptococcus suis T15 AGZ22850.1    
 YB51_6050   Streptococcus suis YB51 AGW87582.1    
 ZY05719_05815 (fragment)   Streptococcus suis ZY05719 AKG40504.1    
 Trebr_1554   Treponema brennaborense DSM 12168 AEE16977.1    
 BME96_15890   Virgibacillus halodenitrificans PDB-F2 APC49583.1    
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