Carbohydrate-Binding Module Family 50

Activities in FamilyModules of approx. 50 residues found attached to various enzymes from families GH18, GH19, GH23, GH24, GH25 and GH73, i.e. enzymes cleaving either chitin or peptidoglycan. Binding to chitopentaose demonstrated in the case of Pteris ryukyuensis chitinase A [Ohnuma T et al. (2008) J. Biol. Chem. 283:5178-87 (PMID: 18083709)]. CBM50 modules are also found in a multitude of other enzymes targeting the petidoglycan such as peptidases and amidases. These enzymes are not reported in the list below.
NoteAlso known as LysM domains
External resourcesCAZypedia;
Statistics GenBank accession (32450); Uniprot accession (1529); PDB accession (27); 3D entries (18); cryst (0)
All (46550) Archaea (12) Bacteria (45699) Eukaryota (444) Viruses (387) unclassified (8) Structure (18) Characterized (52)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 cortex-lytic enzyme SleL   Bacillus cereus ATCC 10876 KFL63465.1  
4S3J[A] 1.60
 cortex-lytic enzyme SleL   Bacillus cereus ATCC 10876 KFL63465.1  
4S3J[A] 1.60
 spore cortex-specific N-acetylglucosaminidase (SleL;YaaH;BMQ_0021) 3.2.1.- Bacillus megaterium QM B1551 ADE67156.1
ABS32202.1
YP_003560590.1
A7LFH9
D5DUS2
4S3K[A] 1.70
 spore cortex-specific N-acetylglucosaminidase (SleL;YaaH;BMQ_0021) 3.2.1.- Bacillus megaterium QM B1551 ADE67156.1
ABS32202.1
YP_003560590.1
A7LFH9
D5DUS2
4S3K[A] 1.70
 BSU14040 (YkuD)   Bacillus subtilis subsp. subtilis str. 168 CAA10867.1
CAB13277.1
O34816
1Y7M[A,B] 2.05
2MTZ[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
NMR
3ZQD[A] NMR
4A1I[A,B,C,D,E,F,G,H] 1.76
4A1J[A,B] 2.20
4A1K[A] 1.75
4A52[A] <carb_like_IM2>
NMR
 N-acetylglucosaminidase (AtlA;EF0799;EF_0799) 3.2.1.- Enterococcus faecalis V583 AAO80613.1
AAR60023.1
NP_814543.1
P37710
2MKX[A] NMR
 b0211 (MltD)   Escherichia coli str. K-12 substr. MG1655 AAC73316.1
AAB08633.1
AIZ92633.1
ALI41971.1
AMC97457.1
NP_414747.1
P23931
1E0G[A] NMR
 D,L-endopeptidase (NlpC/P60;P60_tth;TTHA0266)   Thermus thermophilus HB8 BAD70089.1 Q5SLM7
4UZ2[A,B,C,D] 2.50
4UZ3[A,B,C] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
1.75
4XCM[B] 2.65
 D,L-endopeptidase (NlpC/P60;P60_tth;TTHA0266)   Thermus thermophilus HB8 BAD70089.1 Q5SLM7
4UZ2[A,B,C,D] 2.50
4UZ3[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc
β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
1.75
4XCM[A,B] 2.65
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 chitinase A (EaChiA) 3.2.1.14 Equisetum arvense BAI22848.1 C7G3I3
5BUM[A,B] 2.50
 lectin (MGG_03307)   Magnaporthe oryzae 70-15 EDK00177.1  
2L9Y[A] NMR
5C8O[A] 2.09
5C8P[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
2.20
5C8Q[B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
1.90
 chitin elicitor binding protein (CEBiP;OsCEBiP;Os03g0133400)   Oryza sativa Japonica Group BAF10789.1
AAN05509.1
ABF93833.1
BAE95828.1
BAG93257.1
BAS82158.1
Q8H8C7
5JCD[A,B,C] 2.40
5JCE[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
2.51
 chitin elicitor binding protein (CEBiP;OsCEBiP;Os03g0133400)   Oryza sativa Japonica Group BAF10789.1
AAN05509.1
ABF93833.1
BAE95828.1
BAG93257.1
BAS82158.1
Q8H8C7
5JCD[A,B,C] 2.40
5JCE[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
2.51
 LysM effector / extracellular protein 6 (Ecp6)   Passalora fulva ACF19427.1 B3VBK9
4B8V[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc
1.59
4B9H[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc
2.10
 LysM effector / extracellular protein 6 (Ecp6)   Passalora fulva ACF19427.1 B3VBK9
4B8V[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc
1.59
4B9H[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc
2.10
 LysM effector / extracellular protein 6 (Ecp6)   Passalora fulva ACF19427.1 B3VBK9
4B8V[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc
1.59
4B9H[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-α-D-GlcpNAc
2.10
 chitinase A (ChiA;PrChiA) 3.2.1.14 Pteris ryukyuensis BAE98134.1 Q0WYK2
4PXV[A,B,C,D] 1.80
 chitinase/lysozyme (VcLysM1;VcLysM2)   Volvox carteri f. nagariensis AAC13727.1 O65213
5K2L[A] 1.20
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